The Impact of Various Parental Mental Disorders on Children S Diagnoses: a Systematic Review

The Impact of Various Parental Mental Disorders on Children’s Diagnoses: A Systematic Review

Floor van Santvoort, Clemens M. H. Hosman, Jan M. A. M. Janssens , Karin T. M. van Doesum, Andrea R. Reupert, and Linda M. A. van Loon

Correspondence to: Floor van Santvoort, Pluryn,

Online Resource 1Characteristics of Included Studies and Papers

Parents / Children
Study / Paper: first two authors and year / Parental illnessa / Diagnostic instrumentb / Comorbidityc / Parental genderd / Populatione / Number of childrenf / Child age rangeg / Child Diagnosesh
Ashman, Dawson, 2008 / 1 / 1 / 9 / 1 / 2 / I: 133, C: 26 / 2 / 4, 5
Bell, Chalklin, 2004 / 1 dysth / 1 / 1 / 3 / 2 / I: 97, C: 301 / 2 / 5, 12
Biederman, Rosenbaum, 1991 / 1 / 1 / 9 / 3 / 1 / I uni: 12, I panic: 14, C: 47 / 2 / 1, 4, 5, 11
3 panic
Black, Gaffney, 2003 / 3 OCD / 1 / 1 / 3 / 1 / I: 43, C: 35 / 3 / 1, 2, 3, 4, 5, 6
Breslau, Davis, 1987 / 1 / 1 / 1 / 1 / 2 / I uni: 56, I GAD: 101, C: 275/174 / 3 / 1, 4
3 GAD / 9
Carlson, Weintraub, 1993 / 2 / 1 / 9 / 3 / 1 / I: 134, C: 108 / 4 / 2, 12
Feder, Alonso, 2009 / 1 / 1 / 1 / 1 / 2 / I: 26, C: 32 / 3 / 1, 4, 5, 6, 12
Gibb, Uhrlass, 2009 / 1 / 1 / 1 / 1 / 2 / I: 52, C: 48 / 2 / 1
Gottesman, Laursen, 2010 / 2 / 1 / 9 / 3 / 1 / I: 23298, C: 2239553 / 4 / 2, 3, 12
Henin, Biederman, 2005 / 2 / 1 / 9 / 3 / 1 / I: 117, C: 171 / 3 / 1, 2, 4, 5, 6, 11
Jaser, Fear, 2008 / 1 / 1 / 2 / 1 / 2 / I: 34, C: 38 / 3 / 1
Jones, Field, 2000 / 1 / 1 / 2 / 1 / 2 / I: 28, C: 27 / 1 / 4, 5
Kaplan, Busner, 1996 / 3 panic / 1 / 1 / 1 / 1 / I: 25, C: 25 / 2 / 1, 4, 5, 12
Klein, Clark, 1988 / 1 / 1 / 9 / 3 / 1 / I: 47, C: 38 / 4 / 1, 3, 12
Klein, Depue, 1986 / 2 / 1 / 9 / 3 / 1 / I: 41, C: 26 / 3 / 2
Marmorstein, Malone, 2004 / 1 / 1 / 9 / 1 / 2 / I: 324, C: 928 / 3 / 1, 5
McClellan, Rubert, 1990 / 1 / 1 / 2 / 3 / 1 / I uni: 56, I panic: 60, C: 47 / 2 / 1, 4, 5, 11
3 panic
Merikangas, Dierker, 1998 / 3 diff / 1 / 1 / 3 / 2 / I: 58, C: 57 / 3 / 1, 3, 4, 5, 6, 12
Ohannessian, Hesselbrock, 2005 / 1 / 1 / 1 / 3 / 1 / I: 167, C: 259 / 3 / 1, 4, 5, 6
Orvaschel, Walsh-Allis, 1988 / 1 / 1 / 9 / 3 / 1 / I: 61, C: 45 / 2 / 3, 4, 5, 11, 12
Pawlby, Hay, 2009 / 1 / 1 / 9 / 1 / 2 / I: 82, C: 45 / 3 / 1
Petresco, Gutt, 2009 / 2 / 1 / 1 / 1 / 1 / I: 43, C: 53 / 2 / 1, 2, 3, 4, 5, 12
Schneider, Houweling, 2009 / 3 panic / 1 / 1 / 1 / 1 / I: 73, C: 34 / 3 / 1, 4, 5, 11
Tompson, Pierre, 2010 / 1 / 1 / 9 / 1 / 2 / I: 69, C: 102 / 2 / 1
Warner, Mufson, 1995 / 1 / 1 / 9 / 3 / 1 / I uni: 32, I panic: 17, C: 36 / 3 / 1, 4, 11
3 panic
Young, Vazquez, 2006 / 1 / 1 / 1 / 3 / 2 / I: 26, C: 32 / 2 / 1, 4, 5
1 / Hammen, Adrian, 1987 / 1 / 1 / 9 / 1 / 1 / I uni: 19, I bi: 12, C: 35 / 3 / 3, 12
2
Hammen, Burge, 1990 / 1 / 1 / 9 / 1 / 1 / I uni: 22, I bi: 18, C: 38 / 3 / 1, 2, 4, 5, 6, 11, 12
2
Hammen, Burge, 1991 / 1 / 1 / 9 / 1 / 1 / I uni: 22, I bi: 15, C: 35 / 3 / 1, 12
2
2 / Brennan, Hammen, 2002 / 1 / 1 / 1 / 3 / 2 / I: 200, C: 322 / 3 / 1
Hammen, Brennan, 2003 / 1 / 1 / 9 / 1 / 2 / I: 234, C: 582 / 2 / 1, 4, 5, 6, 11
McClure, Brennan, 2001 / 3 diff / 1 / 1 / 3 / 2 / I: 409, C: 407 / 3 / 4
3 / Beidel, Turner, 1997 / 1 / 1 / 9 / 3 / 2 / I uni: 24, I anx: 28, C: 48 / 2 / 1, 4, 5, 12
3 diff
Turner, Beidel, 2005 / 3 diff / 1 / 1 / 3 / 1 / I: 47, C: 43 / 2 / 1, 4, 5, 12
4 / Biederman, Faraone, 2001 / 1 / 1 / 9 / 3 / 1 / I uni: 59, I panic: 29, C: 113 / 2 / 1, 4, 5
3 panic
Biederman, Petty, 2006 / 1 / 1 / 9 / 3 / 1 / I uni: 53, I panic: 27, C: 103 / 2 / 1, 2, 3, 4, 5
3 panic
Hirshfeld-Becker, Biederman, 2006 / 2 / 1 / 1 / 3 / 1 / I: 34, C: 95 / 2 / 1, 2, 3, 4, 5
Hirshfeld-Becker, Petty, 2008 / 1 / 1 / 1 / 3 / 1 / I: 119, C: 106 / 2 / 1, 2, 4, 5
Micco, Henin, 2009 / 1 / 1 / 1 / 3 / 1 / I uni: 31, I panic: 12, C: 33 / 2 / 1, 4, 5
3 panic
5 / Biel, Klein, 2008 / 1 / 1 / 9 / 3 / 1 / I uni: 75, I anx: 75, C: 80 / 2 / 4
3 diff
Pine, Klein, 2005 / 1 / 1 / 1 / 3 / 1 / I uni: 53, I anx: 24, C: 26 / 3 / 1, 4
3 panic
6 / Bruder-Costello, Warner, 2007 / 1 / 1 / 9 / 3 / 1 / I: 113, C: 56 / 3 / 1
Kramer, Warner, 1998 / 1 / 1 / 9 / 3 / 1 / I: 158, C: 64 / 4 / 1
Merikangas, Weissman, 1985 / 1 / 1 / 9 / 3 / 1 / I: 241, C: 190 / 4 / 1, 4, 6, 7
Nomura, Warner, 2001 / 1 / 1 / 9 / 3 / 1 / I: 129, C: 53 / 3 / 1, 4, 6
Weissman, Fendrich, 1992 / 1 / 1 / 9 / 3 / 1 / I: 121, C: 54 / 4 / 1, 4, 5, 6
Weissman, Prusoff, 1984 / 1 / 1 / 9 / 3 / 1 / I: 107, C: 87 / 3 / 1, 4, 5, 6, 11, 12
Weissman, Warner, 1988 / 1 / 1 / 9 / 3 / 1 / I: 137, C: 83 / 3 / 1, 4, 6, 11, 12
Weissman, Warner, 1997 / 1 / 1 / 9 / 3 / 1 / I: 129, C: 53 / 4 / 1, 2, 3, 4, 5, 6, 11, 12
Weissman, Wickramaratne, 2006 / 1 / 1 / 9 / 3 / 1 / I: 101, C: 50 / 4 / 1, 2, 3, 4, 6, 12
Wickramaratne, Weissman, 1998 / 1 / 1 / 9 / 3 / 1 / I: 129, C: 53 / 4 / 1, 4, 5, 6
7 / Klimes-Dougan, Ronsaville, 2006 / 1 / 1 / 9 / 1 / 2 / I uni: 72, I bi: 43, C: 50 / 3 / 1, 2, 5
2
Radke-Yarrow, Nottelmann, 1992 / 1 / 1 / 1 / 1 / 2 / I uni: 82, I bi: 44, C: 74 / 2 / 1, 4, 5, 11, 12
2
8 / Ellenbogen, Santo, 2010 / 2 / 1 / 9 / 3 / 1 / I: 24, C: 22 / 4 / 1, 2, 6, 12
Linnen, Aan het Rot, 2009 / 2 / 1 / 9 / 3 / 1 / I: 26, C: 24 / 4 / 1, 2, 3, 6
Ostiguy, Ellenbogen, 2009 / 2 / 1 / 9 / 3 / 1 / I: 37, C: 33 / 4 / 1, 2, 3, 4, 5, 6, 12
9 / Grigoroiu-Serbanescu, Christodorescu, 1989 / 2 / 1 / 9 / 3 / 1 / I: 72, C: 72 / 3 / 1, 2, 4, 5, 7, 12
Grigoroiu-Serbanescu, Christodorescu, 1991a / 1 / 1 / 9 / 3 / 1 / I: 96, C: 96 / 3 / 1, 4, 5, 7, 11, 12
Grigoroiu-Serbanescu, Christodorescu, 1991b / 2 / 1 / 9 / 3 / 1 / I: 60, C: 60 / 3 / 12
10 / Halligan, Herbert, 2004 / 1 / 1 / 9 / 1 / 2 / I: 48, C: 39 / 3 / 1
Halligan, Murray, 2007 / 1 / 1 / 9 / 1 / 2 / I: 53, C: 41 / 3 / 1, 4, 5, 12
Murray, Halligan, 2006 / 1 / 1 / 9 / 1 / 2 / I: 51, C: 40 / 3 / 1
11 / Knappe, Beesdo, 2009 / 1 / 1 / 1 / 3 / 2 / I uni: 384, I soc: 137, I anx: 385, C: 260 / 4 / 4
3 social
3 diff
Knappe, Lieb, 2009 / 1 / 1 / 1 / 3 / 2 / I uni: 384, I soc: 137, I anx: 385, C: 260 / 4 / 4
3 social
3 diff
Lieb, Isensee, 2002 / 1 / 1 / 9 / 3 / 2 / I: 996, C: 1231 / 4 / 1, 2, 3, 4, 6
Lieb, Wittchen, 2000 / 1 / 1 / 1 / 3 / 2 / I uni: 381, I soc: 134, I anx: 387, C: 259 / 3 / 4
3 social
3 diff
Martini, Knappe, 2010 / 3 diff / 1 / 1 / 3 / 2 / I: 208, C: 727 / 4 / 4, 5
Schreier, Wittchen, 2008 / 3 social / 1 / 1 / 1 / 2 / I soc: 36, I GAD: 48, I simple: 154, I panic: 75, C: 676 / 4 / 4
3 GAD
3 simple
3 panic
12 / Birmaher, Axelson, 2009 / 2 / 1 / 1 / 3 / 2 / I: 388, C: 64 / 2 / 1, 2, 3, 4, 5, 6, 12
Ladouceur, Almeida, 2008 / 2 / 1 / 9 / 3 / 1 / I: 20, C: 22 / 3 / 1, 2, 3, 12
13 / Singh, DelBello, 2007b / 2 / 1 / 9 / 3 / 1 / I: 37, C: 29 / 2 / 1, 2, 3, 4, 5, 11, 12
Singh, DelBello, 2008a / 2 / 1 / 9 / 3 / 1 / I: 21, C: 24 / 2 / 1, 2, 4, 5, 11, 12, 13
Singh, DelBello, 2007a / 2 / 1 / 9 / 3 / 1 / I: 36, C: 27 / 2 / 3, 4, 5
Singh, DelBello, 2008b / 2 / 1 / 9 / 3 / 1 / I: 31, C: 21 / 2 / 1, 2, 3, 5, 11, 12
14 / Jones, Tai, 2006 / 2 / 1 / 9 / 3 / 1 / I: 25, C: 22 / 3 / 3
Vance, Jones, 2008 / 2 / 1 / 9 / 3 / 1 / I: 23, C: 24 / 3 / 3

a1 = unipolar depression (MDD, dysth = dysthyma), 2 = bipolar disorder, 3 = anxiety disorder (diff = different diagnoses in one group, social = social phobia, simple = simple phobia, GAD = generalized anxiety disorder, panic = panic disorder, OCD = obsessive compulsive disorder, PTSD = posttraumatic stress disorder), 4 = personality disorder (bord = borderline, anti = antisocial); b 1 = clinical instrument, 2 = self-report instrument; c 1 = yes, 2 = no, 9 = not reported; d 1 = mothers, 2 = fathers, 3 = mixed; e1 = patient population, 2 = community population; f I = index group (children with mentally ill parents), C = control group (children with mentally healthy parents), Tot = total group; g 0 = 0-1 years, 1 = 1-4 years, 3 = 4-12 years, 4 = 12-18 years, 5 ≥ 18 years; h 1 = unipolar depression, 2 = bipolar disorder, 3 = affective disorders non-specified, 4 = anxiety disorders, 5 = conduct disorders/ADHD, 6 = substance use disorders, 7 = personality disorders, 11 = co-morbidity, 12 = any mental disorder