E-Appendix 1

The GA9006 site principal investigators included G Birnbaum, MD (Minneapolis Clinic of Neurology, Golden Valley, MN), J Cohen, MD (Cleveland Clinic Foundation, Cleveland, OH), C Ford, MD PhD (MIND Imaging Center, Albuquerque, NM), A Goodman, (University of Rochester, Rochester, NY), B Green, MD (St. John’s Mercy Medical Center, St. Louis, MO), K Johnson, MD (University of Maryland, Baltimore, MD), M Levin, MD (University of Tennessee, Memphis, TN), D Mattson, MD, PhD (Indiana University School of Medicine, Indianapolis, IN), J Licht, MD (Center for Neurologic Study, La Jolla, CA), J Rose, MD (VA Medical Center, Salt Lake City, UT), H Rossman, DO (MIND, Farmington Hills, MI), T Scott, MD (Alleghany Neurological Associates, Pittsburgh, PA), J Dunn, MD (MS Hub Medical Group, Seattle, WA), D Wynn, MD (Consultants in Neurology, Northbrook, IL), M Tullman, MD (Mt. Sinai, New York, NY), J Huddlestone, MD (Neurology and Neurosurgery Associates, Tacoma, WA), A Turel, MD (Geisinger Medical Center, Danville, PA), G Parry, MD (University of Minnesota, Minneapolis, MN).

The GA9006 Steering Committee included J Cohen, MD (Chair, Cleveland Clinic Foundation, Cleveland, OH); M Filippi, MD (San Raffaele Scientific Institute, Milan, Italy); and A Goodman, MD (University of Rochester, Rochester, NY). The Data Safety Monitoring Committee included L Metz, MD (Chair, Foothills Hospital, Calgary, Alberta, Canada) and S Zamvil, MD PhD (University of California San Francisco, San Francisco, CA. The Publication Committee included J Cohen, MD (Cleveland Clinic Foundation, Cleveland, OH); M Filippi, MD (San Raffaele Scientific Institute, Milan, Italy); A Goodman, MD (University of Rochester, Rochester, NY); D Ladkani, PhD (Teva Pharmaceuticals, Petach Tiqva, Israel); and D Wynn, MD (Consultants in Neurology, Northbrook, IL). Staff of the MRI Analysis Center, Neuroimaging Research Unit, Department of Neurology, Scientific Institute and University Hospital San Raffaele, Milan, Italy included M Filippi, MD; M Rovaris, MD; M Rocca, MD; P Valsasina, PhD; and G Comi, MD.