The Future Begins Yesterday – Making Medicines, Improving Lives

Worksheet

Introduction:

  1. TrueFalse

Drug development is a long process that requires a lot of time and a lot of money.

  1. On average, how long does it take from the initial discovery of a molecule to the time that molecule becomes an approved drug? ______
  2. Fill in the missing processes in drug development and testing:

______

Discovery Chemistry and In Vitro Biology:

  1. Only 1 out of ______molecules discovered will become a drug.
  2. Something that dissolves another substance to form a solution is a ______.
  3. In Vitro means: ______

______.

  1. An analysis or test is an ______.

In Vivo Biology and Toxicology:

  1. In Vivo Biology means ______.
  2. The study of the effects of chemicals on organisms is ______.
  3. Why do nude mice need a sterile environment? ______

______.

  1. A remote instrument that measures data is a ______.

Clinical Development:

  1. A negative side effect from a drug is an ______.
  2. Examples of reactions that indicate a trial drug should no longer be given to a patient include:
  3. Headache
  4. Nausea
  5. ______
  6. ______
  7. The clinical team is responsible for:
  8. Planning for clinical trials
  9. Recruiting patients
  10. ______

Development and Manufacturing:

  1. It is important that the final product has the same structure, ______, and shape that it should have.
  2. Manufacturing larger quantities of a compound is defined as ______.
  3. Name some of the manufacturing jobs at Eli Lilly Company:
  4. Operations
  5. ______
  6. Technical Services
  7. ______

The Future Begins Yesterday – Making Medicines, Improving Lives

Worksheet - KEY

Introduction:

  1. TrueFalse

Drug development is a long process that requires a lot of time and a lot of money.

  1. On average, how long does it take from the initial discovery of a molecule to the time that molecule becomes an approved drug? More than 10 years
  2. Fill in the missing processes in drug development and testing:

Development and Manufacturing

Discovery Chemistry and In Vitro Biology:

  1. Only 1 out of10,000 molecules discovered will become a drug.
  2. Something that dissolves another substance to form a solution is a Solvent.
  3. In Vitro means: Occurs in a test tube, or “in plastic”
  4. An analysis or test is anAssay.

In Vivo Biology and Toxicology:

  1. In Vivo Biology meansInside the organism.
  2. The study of the effects of chemicals on organisms is Toxicology.
  3. Why do nude mice need a sterile environment? Because they can get sick very easily
  4. A remote instrument that measures data is a Telemetry device.

Clinical Development:

  1. A negative side effect from a drug is an Adverse reaction.
  2. Examples of reactions that indicate a trial drug should no longer be given to a patient include:
  1. Headache
  2. Nausea
  3. Dizziness
  4. Weakness
  1. The clinical team is responsible for:
  1. Planning for clinical trials
  2. Recruiting patients
  3. Designing tests

Development and Manufacturing:

  1. It is important that the final product has the same structure,Size, and shape that it should have.
  2. Manufacturing larger quantities of a compound is defined asScale up.
  3. Name some of the manufacturing jobs at Eli Lilly Company:
  1. Operations
  2. Engineering
  3. Technical Services
  4. Management