Table S3. Potential Target Genes Downregulated by Senescence-Induced Mirna Overexpression

Table S3. Potential target genes downregulated by senescence-induced miRNA overexpression in IMR90 fibroblasts.

Affy id / Entrez gene id / Gene symbol / Gene name / Fold change*
211756_at / 5744 / PTHLH / Parathyroid hormone-like hormone / -35.7
240509_s_at / 64388 / GREM2 / Gremlin 2, cysteine knot superfamily, homolog / -10.9
206115_at / 1960 / EGR3 / Early growth response 3 / -10.1
228574_at / 160335 / TMTC2 / Transmembrane and tetratricopeptide repeat containing 2 / -10.1
221898_at / 10630 / PDPN / Podoplanin / -9.4
204359_at / 23768 / FLRT2 / Fibronectin leucine rich transmembrane protein 2 / -6.0
203821_at / 1839 / HBEGF / Heparin-binding EGF-like growth factor / -5.6
203680_at / 5577 / PRKAR2B / Protein kinase, cAMP-dependent, regulatory, type II, beta / -5.6
212188_at / 115207 / KCTD12 / Potassium channel tetramerisation domain containing 12 / -5.3
214043_at / 5789 / PTPRD / Protein tyrosine phosphatase, receptor type, D / -5.2
227971_at / 203447 / NRK / Nik related kinase / -5.0
235579_at / 9169 / SFRS2IP / Splicing factor, arginine/serine-rich 2, interacting protein / -4.6
212670_at / 2006 / ELN / Elastin / -4.3
229572_at / 23545 / ATP6V0A2 / ATPase, H+ transporting, lysosomal V0 subunit a2 / -4.3
225056_at / 57568 / SIPA1L2 / Signal-induced proliferation-associated 1 like 2 / -4.3
212565_at / 23012 / STK38L / Serine/threonine kinase 38 like / -4.0
203184_at / 2201 / FBN2 / Fibrillin 2 / -4.0
238865_at / 132430 / PABPC4L / Poly(A) binding protein, cytoplasmic 4-like / -4.0
212327_at / 22998 / LIMCH1 / LIM and calponin homology domains 1 / -3.9
202668_at / 1948 / EFNB2 / Ephrin-B2 / -3.6
224840_at / 2289 / FKBP5 / FK506 binding protein 5 / -3.6
202948_at / 3554 / IL1R1 / Interleukin 1 receptor, type I / -3.4
217997_at / 22822 / PHLDA1 / Pleckstrin homology-like domain, family A, member 1 / -3.4
213712_at / 54898 / ELOVL2 / Elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 2 / -3.4
226534_at / 4254 / KITLG / KIT ligand / -3.4
1554822_at / 57157 / PHTF2 / Putative homeodomain transcription factor 2 / -3.4
203018_s_at / 117178 / SSX2IP / Synovial sarcoma, X breakpoint 2 interacting protein / -3.3
222450_at / 56937 / PMEPA1 / Prostate transmembrane protein, androgen induced 1 / -3.3
223092_at / 56172 / ANKH / Ankylosis, progressive homolog (mouse) / -3.3
227920_at / 57673 / BEND3 / BEN domain containing 3 / -3.3
212230_at / 8613 / PPAP2B / Phosphatidic acid phosphatase type 2B / -3.2
202817_s_at / 6760 / SS18 / Synovial sarcoma translocation, chromosome 18 / -3.2
228259_s_at / 64097 / EPB41L4A / Erythrocyte membrane protein band 4.1 like 4A / -3.2
228310_at / 55740 / ENAH / Enabled homolog (Drosophila) / -3.2
227231_at / 57482 / KIAA1211 / KIAA1211 / -3.1
213001_at / 23452 / ANGPTL2 / Angiopoietin-like 2 / -3.1
228915_at / 1602 / DACH1 / Dachshund homolog 1 (Drosophila) / -3.0
213310_at / 27161 / EIF2C2 / Eukaryotic translation initiation factor 2C, 2 / -3.0
228988_at / 7552 / ZNF711 / Zinc finger protein 711 / -3.0
226922_at / 5903 / RANBP2 / RAN binding protein 2 / -2.9
229057_at / 6326 / SCN2A / Sodium channel, voltage-gated, type II, alpha subunit / -2.9
213543_at / 6444 / SGCD / Sarcoglycan, delta (35kDa dystrophin-associated glycoprotein) / -2.9
212385_at / 6925 / TCF4 / Transcription factor 4 / -2.8
208051_s_at / 10605 / PAIP1 / Poly(A) binding protein interacting protein 1 / -2.8
209829_at / 9750 / FAM65B / Family with sequence similarity 65, member B / -2.8
236029_at / 120114 / FAT3 / FAT tumor suppressor homolog 3 (Drosophila) / -2.8
235711_at / 5814 / PURB / Purine-rich element binding protein B / -2.8
213438_at / 23114 / NFASC / Neurofascin homolog (chicken) / -2.8
235907_at / 55161 / TMEM33 / Transmembrane protein 33 / -2.7
219572_at / 93664 / CADPS2 / Ca++-dependent secretion activator 2 / -2.7
203579_s_at / 9057 / SLC7A6 / Solute carrier family 7 (cationic amino acid transporter, y+ system), member 6 / -2.7
201586_s_at / 6421 / SFPQ / Splicing factor proline/glutamine-rich / -2.7
221489_s_at / 81848 / SPRY4 / Sprouty homolog 4 (Drosophila) / -2.7
203432_at / 7112 / TMPO / Thymopoietin / -2.7
209588_at / 2048 / EPHB2 / EPH receptor B2 / -2.6
213067_at / 4628 / MYH10 / Myosin, heavy chain 10, non-muscle / -2.6
233970_s_at / 51605 / TRMT6 / tRNA methyltransferase 6 homolog (S. cerevisiae) / -2.6
202969_at / 8445 / DYRK2 / Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 / -2.6
204379_s_at / 2261 / FGFR3 / Fibroblast growth factor receptor 3 / -2.5
215305_at / 5156 / PDGFRA / Platelet-derived growth factor receptor, alpha polypeptide / -2.5
215323_at / 338645 / LUZP2 / Leucine zipper protein 2 / -2.5
202743_at / 8503 / PIK3R3 / Phosphoinositide-3-kinase, regulatory subunit 3 (gamma) / -2.5
225429_at / 5537 / PPP6C / Protein phosphatase 6, catalytic subunit / -2.4
213273_at / 26011 / ODZ4 / Odz, odd Oz/ten-m homolog 4 (Drosophila) / -2.4
214255_at / 57194 / ATP10A / ATPase, class V, type 10A / -2.4
226998_at / 80155 / NAA15 / NMDA receptor regulated 1 / -2.4
204700_x_at / 27042 / C1ORF107 / Chromosome 1 open reading frame 107 / -2.4
225354_s_at / 83699 / SH3BGRL2 / SH3 domain binding glutamic acid-rich protein like 2 / -2.4
235798_at / 100113407 / TMEM170B / Transmembrane protein 170B / -2.4
205100_at / 9945 / GFPT2 / Glutamine-fructose-6-phosphate transaminase 2 / -2.4
203881_s_at / 1756 / DMD / Dystrophin / -2.3
202679_at / 4864 / NPC1 / Niemann-Pick disease, type C1 / -2.3
213793_s_at / 9456 / HOMER1 / Homer homolog 1 (Drosophila) / -2.3
202674_s_at / 4008 / LMO7 / LIM domain 7 / -2.3
216268_s_at / 182 / JAG1 / Jagged 1 (Alagille syndrome) / -2.3
220386_s_at / 27436 / EML4 / Echinoderm microtubule associated protein like 4 / -2.3
227080_at / 90874 / ZNF697 / Hypothetical LOC100130667; zinc finger protein 697 / -2.3
225145_at / 57727 / NCOA5 / Nuclear receptor coactivator 5 / -2.3
213407_at / 23035 / PHLPP2 / PH domain and leucine rich repeat protein phosphatase 2 / -2.3
213725_x_at / 64131 / XYLT1 / Xylosyltransferase I / -2.3
1556361_s_at / 81573 / ANKRD13C / Ankyrin repeat domain 13C / -2.3
212239_at / 5295 / PIK3R1 / Phosphoinositide-3-kinase, regulatory subunit 1 (alpha) / -2.3
206108_s_at / 6431 / SFRS6 / Splicing factor, arginine/serine-rich 6; similar to arginine/serine-rich splicing factor 6 / -2.3
214113_s_at / 9939 / RBM8A / RNA binding motif protein 8A / -2.3
219470_x_at / 54619 / CCNJ / Cyclin J / -2.3
214155_s_at / 113251 / LARP4 / La ribonucleoprotein domain family, member 4 / -2.3
1555427_s_at / 10492 / SYNCRIP / Synaptotagmin binding, cytoplasmic RNA interacting protein / -2.2
234140_s_at / 57620 / STIM2 / Stromal interaction molecule 2 / -2.2
219367_s_at / 8828 / NRP2 / Neuropilin 2 / -2.2
225932_s_at / 3181 / HNRNPA2B1 / Heterogeneous nuclear ribonucleoprotein A2/B1 / -2.2
204225_at / 9759 / HDAC4 / Histone deacetylase 4 / -2.2
216466_at / 89795 / NAV3 / Neuron navigator 3; similar to neuron navigator 3 / -2.2
218871_x_at / 55454 / CSGALNACT2 / Chondroitin sulfate N-acetylgalactosaminyltransferase 2 / -2.2
238007_at / 10778 / ZNF271 / Zinc finger protein 271 / -2.2
224937_at / 5738 / PTGFRN / Prostaglandin F2 receptor negative regulator / -2.2
200644_at / 65108 / MARCKSL1 / MARCKS-like 1 / -2.2
212930_at / 490 / ATP2B1 / ATPase, Ca++ transporting, plasma membrane 1 / -2.1
213170_at / 2882 / GPX7 / Glutathione peroxidase 7 / -2.1
209406_at / 9532 / BAG2 / BCL2-associated athanogene 2 / -2.1
204337_at / 5999 / RGS4 / Regulator of G-protein signaling 4 / -2.1
204666_s_at / 80143 / SIKE1 / Suppressor of IKK epsilon / -2.1
231577_s_at / 2633 / GBP1 / Guanylate binding protein 1, interferon-inducible, 67kDa / -2.1
221485_at / 9334 / B4GALT5 / UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 / -2.1
225726_s_at / 57475 / PLEKHH1 / Pleckstrin homology domain containing, family H (with MyTH4 domain) member 1 / -2.1
215787_at / 59 / ACTA2 / Actin, alpha 2, smooth muscle, aorta / -2.1
1558111_at / 4154 / MBNL1 / Muscleblind-like (Drosophila) / -2.1
204967_at / 357 / SHROOM2 / Shroom family member 2 / -2.1
204602_at / 22943 / DKK1 / Dickkopf homolog 1 (Xenopus laevis) / -2.1
231252_at / 151050 / C2ORF67 / Chromosome 2 open reading frame 67 / -2.1
202068_s_at / 3949 / LDLR / Low density lipoprotein receptor / -2.1
1555274_a_at / 85465 / EPT1 / Selenoprotein I / -2.1
228168_at / 518 / ATP5G3 / ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C3 (subunit 9) / -2.1
242260_at / 9782 / MATR3 / Matrin 3 / -2.1
201326_at / 908 / CCT6A / Chaperonin containing TCP1, subunit 6A (zeta 1) / -2.1
222853_at / 23767 / FLRT3 / Fibronectin leucine rich transmembrane protein 3 / -2.0
223449_at / 57556 / SEMA6A / Sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A / -2.0
219740_at / 79805 / VASH2 / Vasohibin 2 / -2.0
224694_at / 84168 / ANTXR1 / Anthrax toxin receptor 1 / -2.0
205448_s_at / 7786 / MAP3K12 / Mitogen-activated protein kinase kinase kinase 12 / -2.0
223394_at / 29950 / SERTAD1 / SERTA domain containing 1 / -2.0
212944_at / 6526 / SLC5A3 / Solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 / -2.0
204011_at / 10253 / SPRY2 / Sprouty homolog 2 (Drosophila) / -2.0
221841_s_at / 9314 / KLF4 / Kruppel-like factor 4 (gut) / -2.0
212170_at / 10137 / RBM12 / RNA binding motif protein 12; copine I / -2.0
226109_at / 54149 / C21ORF91 / Chromosome 21 open reading frame 91 / -2.0
228776_at / 10052 / GJC1 / Gap junction protein, gamma 1, 45kDa / -2.0
219094_at / 25852 / ARMC8 / Armadillo repeat containing 8 / -2.0
212658_at / 10184 / LHFPL2 / Lipoma HMGIC fusion partner-like 2 / -2.0
225978_at / 57494 / RIMKLB / Ribosomal modification protein rimK-like family member B / -2.0
223079_s_at / 2744 / GLS / Glutaminase / -2.0
227148_at / 130271 / PLEKHH2 / Pleckstrin homology domain containing, family H (with MyTH4 domain) member 2 / -2.0
208707_at / 1983 / EIF5 / Eukaryotic translation initiation factor 5 / -2.0
201370_s_at / 8452 / CUL3 / Cullin 3 / -2.0
220512_at / 10395 / DLC1 / Deleted in liver cancer 1 / -1.9
222589_at / 51701 / NLK / Nemo-like kinase / -1.9
204642_at / 1901 / S1PR1 / Sphingosine-1-phosphate receptor 1 / -1.9
213387_at / 54454 / ATAD2B / ATPase family, AAA domain containing 2B / -1.9
203498_at / 10231 / RCAN2 / Regulator of calcineurin 2 / -1.9
227379_at / 154141 / MBOAT1 / Membrane bound O-acyltransferase domain containing 1 / -1.9
243711_at / 23576 / DDAH1 / Dimethylarginine dimethylaminohydrolase 1 / -1.9
206752_s_at / 1677 / DFFB / DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) / -1.9
203692_s_at / 1871 / E2F3 / E2F transcription factor 3 / -1.9
236535_at / 79677 / SMC6 / Structural maintenance of chromosomes 6 / -1.9
1569183_a_at / 1121 / CHM / Choroideremia (Rab escort protein 1) / -1.9
211932_at / 220988 / HNRNPA3 / Heterogeneous nuclear ribonucleoprotein A3 / -1.9
1556121_at / 4673 / NAP1L1 / Nucleosome assembly protein 1-like 1 / -1.9
221264_s_at / 23435 / TARDBP / TAR DNA binding protein / -1.9
212502_at / 84890 / ADO / 2-aminoethanethiol (cysteamine) dioxygenase / -1.9
203843_at / 6197 / RPS6KA3 / Ribosomal protein S6 kinase, 90kDa, polypeptide 3 / -1.9
205876_at / 3977 / LIFR / Leukemia inhibitory factor receptor alpha / -1.9
203908_at / 8671 / SLC4A4 / Solute carrier family 4, sodium bicarbonate cotransporter, member 4 / -1.9
208900_s_at / 7150 / TOP1 / Topoisomerase (DNA) I / -1.9
52837_at / 85352 / KIAA1644 / KIAA1644 / -1.9
203870_at / 64854 / USP46 / Ubiquitin specific peptidase 46 / -1.9
225539_at / 49854 / ZNF295 / Zinc finger protein 295 / -1.9
210814_at / 7222 / TRPC3 / Transient receptor potential cation channel, subfamily C, member 3 / -1.9
203845_at / 8850 / KAT2B / K(lysine) acetyltransferase 2B / -1.9
225835_at / 6558 / SLC12A2 / Solute carrier family 12 (sodium/potassium/chloride transporters), member 2 / -1.9
209569_x_at / 27065 / D4S234E / DNA segment on chromosome 4 (unique) 234 expressed sequence / -1.9
215611_at / 6938 / TCF12 / Transcription factor 12 / -1.8
205893_at / 22871 / NLGN1 / Neuroligin 1 / -1.8
226075_at / 80176 / SPSB1 / SplA/ryanodine receptor domain and SOCS box containing 1 / -1.8
223288_at / 84640 / USP38 / Ubiquitin specific peptidase 38 / -1.8
207172_s_at / 1009 / CDH11 / Cadherin 11, type 2, OB-cadherin (osteoblast) / -1.8
226619_at / 29843 / SENP1 / SUMO1/sentrin specific peptidase 1 / -1.8
227666_at / 166614 / DCLK2 / Doublecortin-like kinase 2 / -1.8
209068_at / 9987 / HNRPDL / Heterogeneous nuclear ribonucleoprotein D-like / -1.8
1558356_at / 55075 / UACA / Uveal autoantigen with coiled-coil domains and ankyrin repeats / -1.8
214814_at / 91746 / YTHDC1 / YTH domain containing 1 / -1.8
227164_at / 6426 / SFRS1 / Splicing factor, arginine/serine-rich 1 / -1.8
218330_s_at / 89797 / NAV2 / Neuron navigator 2 / -1.8
236248_x_at / 93624 / TADA2B / Transcriptional adaptor 2 (ADA2 homolog, yeast)-beta / -1.8
209348_s_at / 4094 / MAF / V-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian) / -1.8
225163_at / 55691 / FRMD4A / FERM domain containing 4A / -1.8
224956_at / 57532 / NUFIP2 / Nuclear fragile X mental retardation protein interacting protein 2 / -1.8
232067_at / 84553 / C6ORF168 / Chromosome 6 open reading frame 168 / -1.8
222689_at / 55331 / ACER3 / Alkaline ceramidase 3 / -1.8
216262_s_at / 60436 / TGIF2 / TGFB-induced factor homeobox 2 / -1.8
204797_s_at / 2009 / EML1 / Echinoderm microtubule associated protein like 1 / -1.8
229512_at / 54954 / FAM120C / Family with sequence similarity 120C / -1.8
231823_s_at / 285590 / SH3PXD2B / SH3 and PX domains 2B / -1.8