Table S2: Top 100 most increased transcripts at 4 weeks in the hippocampus ofGFAPTg;Gfap+/R236H mice relative to wt. Note: Underlined genes are involved in immune function.

Gene / Gene product / Fold Increase / padj / Gene / Gene product / Fold Increase / padj
Lcn2 / Lcn2 (lipocalin 2) / 488.64 / 7.6E-17 / Gm15070 / Trpc5os(transient receptor potential cation channel, subfamily C, member 5, opposite strand) / 36.14 / 4.3E-06
Retnla / Resistin-like alpha / 253.49 / 1.9E-08 / Oasl1 / 2'-5'-oligoadenylate synthase-like protein 1 / 35.58 / 6.5E-09
C3 / C3 (complement 3) / 247.61 / 7.7E-29 / Pappa / Pappalysin-1 / 34.84 / 1.5E-05
Wisp2 / Wisp2 (WNT1-inducible-signaling pathway protein 2) / 220.27 / 5.7E-27 / Siglec1 / CD169 (Sialoadhesin) / 33.95 / 1.3E-04
Cxcl10 / Cxcl10 (C-X-C motif chemokine 10; IP-10) / 193.05 / 1.1E-17 / Hist1h4d / Histone H4 / 33.58 / 4.1E-03
Ifi205 / Interferon-activable protein 205 / 183.41 / 1.4E-04 / Slc25a48 / Slc25a48 (Solute carrier family 25 member 48) / 33.31 / 4.7E-03
Apol9a / Apol9a / 175.00 / 5.7E-06 / Clec7a / Dectin-1 / 33.22 / 6.4E-04
Tgm1 / Protein-glutamine gamma-glutamyltransferase K / 171.56 / 2.3E-21 / Ptx3 / Pentraxin 3 / 31.83 / 7.2E-21
Soat2 / Sterol O-acyltransferase 2 / 166.18 / 4.6E-07 / Gm4902 / Phf11-3 / 31.39 / 2.5E-05
Gdf15 / (Gdf15) Growth/differentiation factor 15 / 165.53 / 1.1E-13 / H2-Q8 / H-2 class I histocompatibility antigen, Q8 alpha chain / 30.68 / 6.8E-06
Mnda / Mnda (Myeloid cell nuclear differentiation antigen) / 129.77 / 5.4E-12 / Slfn1 / Slfn1 (Schlafen 1) / 30.48 / 5.4E-06
Cxcl9 / Cxcl9 (C-X-C motif chemokine 9) / 117.00 / 2.9E-04 / Osgin1 / Osgin1 (Oxidative stress induced growth inhibitor 1) / 29.79 / 5.8E-33
Gbp10 / Guanylate-binding protein 10 / 108.99 / 1.2E-17 / Itgax / CD11c / 29.63 / 4.8E-05
Adm2 / ADM2 / 100.08 / 8.9E-05 / Vdr / VDR (Vitamin D3 receptor) / 29.19 / 7.2E-08
Ces1g / Carboxylic ester hydrolase / 95.97 / 2.7E-06 / Stx11 / Syntaxin-11 / 28.85 / 3.2E-04
Pydc4 / Pydc4 (Pyrin domain-containing protein 2-like protein POP4) / 94.42 / 1.1E-13 / A530064D06Rik / Trem4 (Triggering receptor expressed in myeloid cells 4) / 28.71 / 2.2E-02
Mc2r / ACTH-R (Adrenocorticotropic hormone receptor) / 89.90 / 2.3E-03 / Tnfsf8 / CD30-L (Tumor necrosis factor ligand superfamily member 8) / 28.59 / 6.0E-05
Mmp12 / MMP12 (Matrix metalloproteinase-12) / 83.46 / 1.1E-22 / Tnfaip2 / TNF alpha-induced protein 2 / 28.12 / 7.3E-06
Elovl3 / Elongation of very long chain fatty acids protein 3 / 83.11 / 8.0E-03 / Oas3 / 2'-5'-oligoadenylate synthase 3 / 27.74 / 2.2E-03
Fcgr4 / Fcgr4 (Fc gamma RIIIa receptor) / 76.46 / 1.8E-09 / Trpm1 / Melastatin-1 / 27.11 / 6.0E-06
Sucnr1 / Succinate receptor 1 / 73.80 / 1.4E-06 / Steap4 / Dudulin-4 / 26.57 / 8.9E-104
Spna1 / Erythroid alpha-spectrin / 72.15 / 7.7E-09 / Fosl1 / FRA-1 (Fos-related antigen 1) / 25.49 / 1.7E-02
Ccl5 / CCL5 (C-C motif chemokine 5; RANTES) / 71.47 / 1.7E-10 / Gpr65 / Psychosine receptor(T-cell death-associated gene 8 protein) / 25.37 / 1.0E-03
Gpnmb / Transmembrane glycoprotein NMB / 70.59 / 3.1E-46 / Cdsn / Corneodesmosin / 25.32 / 1.6E-52
Cd300lf / CMRF35-like molecule 1 / 67.88 / 1.5E-03 / Ccl12 / C-C motif chemokine 12 (CCL12; MCP-5) / 25.24 / 2.7E-03
Pyhin1 / Interferon-inducible protein / 64.33 / 9.1E-07 / Bcl3 / BCL-3 (B-cell lymphoma 3 protein) / 24.88 / 4.9E-05
Phf11 / PHD finger protein 11 / 61.51 / 1.4E-03 / H2-Q6 / H2-Q6 (Class Ib MHC antigen Qa-2) / 24.88 / 3.7E-06
Ccl8 / CCL8 (C-C motif chemokine 8; MCP-2) / 60.94 / 3.0E-04 / Ostn / Osteocrin / 24.74 / 4.9E-04
Il1rn / IL1RN (Interleukin-1 receptor antagonist protein) / 60.56 / 6.1E-03 / Atf3 / AFT-3 (Activating transcription factor 3) / 24.30 / 2.8E-05
Cxcl1 / CXCL1 (C-X-C motif chemokine 1) / 60.08 / 1.9E-04 / B430306N03Rik / Treml6 (Triggering receptor expressed on myeloid cells-like 6) / 24.06 / 4.9E-07
Lgals3 / Gal-3 (Galectin-3) / 57.69 / 2.9E-11 / Gprc5a / RAI3 (Retinoic acid-induced protein 3 ) / 23.97 / 1.3E-02
Fam46b / FAM46B / 57.20 / 6.9E-08 / Serpina3i / Serpina3i / 23.71 / 1.4E-03
Slc22a14 / SLC22A14 (Solute carrier family 22 member 14) / 55.62 / 5.9E-10 / Il21 / IL-21 (Interleukin-21) / 23.17 / 1.1E-06
Hist1h1a / H1a (Histone H1.1) / 52.60 / 6.2E-03 / Flnc / Filamin-C / 22.88 / 1.3E-11
Cxcl11 / CXCL11 (C-X-C motif chemokine 11) / 52.11 / 4.6E-02 / Adh7 / ADH7 (Alcohol dehydrogenase 7) / 22.76 / 3.0E-05
Ccl2 / CCL2 (C-C motif chemokine 2; MCP-1) / 47.40 / 2.8E-03 / Gpr126 / Gpr126 / 22.68 / 1.5E-28
Ifi204 / Ifi-204 (Interferon-activable protein 204) / 47.29 / 5.4E-15 / Gm4951 / Gm4951 / 22.16 / 2.9E-07
Plac8 / Placenta-specific gene 8 protein / 47.16 / 1.3E-03 / Clcf1 / BSF-3 (B-cell-stimulating factor 3) / 21.48 / 6.3E-05
H60b / H60b (Histocompatibility-60b) / 46.59 / 8.1E-19 / Casp4 / Caspase-4 / 21.34 / 3.2E-26
Mx1 / Interferon-induced GTP-binding protein Mx1 / 45.75 / 9.1E-05 / Hist1h4h / Histone H4 / 21.21 / 3.7E-51
Cyp2c44 / Cyp2c44 protein / 44.31 / 2.3E-07 / Cd44 / CD44 / 21.13 / 3.3E-15
1300002K09Rik / Stra6l / 44.17 / 7.5E-11 / D14Ertd668e / PHD finger protein 11 / 20.82 / 9.1E-05
Lrp2 / LRP2 (Low-density lipoprotein receptor-related protein 2) / 43.97 / 3.5E-08 / Gbp6 / Gbp6 (GTP-binding protein 6) / 19.92 / 3.8E-14
A430084P05Rik / SLP adapter and CSK-interacting membrane protein / 43.92 / 2.5E-03 / Loxl2 / Lysyl oxidase homolog 2 / 19.90 / 1.7E-76
Apol9b / Apol9b / 42.99 / 3.7E-07 / Rsad2 / Viperin / 19.89 / 1.2E-19
Cyb5r2 / NADH-cytochrome b5 reductase 2 / 41.07 / 4.2E-04 / Mcoln2 / Mucolipin-2 / 19.77 / 4.4E-03
Niacr1 / Hydroxycarboxylic acid receptor 2 / 40.91 / 1.6E-03 / Ly9 / CD229 (T-lymphocyte antigen 9) / 19.70 / 9.6E-05
Trib3 / TRB-3 (Tribbles homolog 3) / 39.27 / 7.5E-04 / H19 / H19 mRNA (Non-Protein Coding) / 19.50 / 7.6E-46
Cd72 / CD72 (Lyb-2) / 38.40 / 7.3E-03 / Vim / Vimentin / 19.39 / 1.7E-210
Zbp1 / ZBP-1 (Insulin-like growth factor 2 mRNA-binding protein 1) / 37.20 / 9.6E-04 / Oas1g / Oas1g / 19.36 / 1.0E-03