1

Table S2Genes under-expressed by at least 2 fold, in the CD34+/CD38- fraction versus CD34+CD38+, in at least 3 AML samples.

HSC data
Source1
Gene name / Symbol / Fold change2
Growth factors / AML1 / AML2 / AML3 / AML4 / AML5
Insulin-like growth factor binding protein 7 / IGFBP7 / G, I / -1.2 / -2.0 / -11.9 / -10.1 / -1.6
Insulin-like growth factor binding protein 2, 36kDa / IGFBP2 / -2.6 / -4.3 / -0.7 / -2.8 / -6.7
Growth differentiation factor 3 / GDF3 / I / -1.5 / -4.4 / -3.4 / -0.4 / -2.8
Endothelial cell growth factor 1 (platelet-derived) / ECGF1 / T / -2.6 / -3.2 / -2.2 / -1.0 / -1.0
Fibroblast growth factor 21 / FGF21 / -2.6 / -1.0 / -1.0 / -2.7 / -2.5
Transcription / AML1 / AML2 / AML3 / AML4 / AML5
v-maf musculoaponeurotic fibrosarcoma oncogene B (avian) / MAFB / I,T / -3.3 / -5.9 / -5.9 / -81.4 / -7.3
Myeloid cell nuclear differentiation antigen / MNDA / G, T / -2.1 / -5.1 / -0.7 / -10.1 / -33.9
CCAAT/enhancer binding protein (C/EBP), delta / CEBPD / G / -1.1 / -4.7 / -3.2 / -14.3 / -0.7
One cut domain, family member 2 / ONECUT2 / -1.5 / -4.8 / -2.0 / -0.3 / -5.8
PR domain containing 1, with ZNF domain / PRDM1 / -2.5 / -1.4 / -0.4 / -2.4 / -5.2
Early growth response 2 / EGR2 / -3.8 / -0.8 / -2.2 / -1.6 / -3.0
Zinc finger protein, X-linked / ZFX / -3.1 / -2.2 / -3.6 / -0.6 / -1.0
Zinc finger protein 589 / ZNF589 / -1.6 / -2.4 / -3.2 / -3.5 / -0.4
Elongation factor, RNA polymerase II, 2 / ELL2 / -2.7 / -2.9 / -0.3 / -0.4 / -2.0
E2F8 protein / E2F8 / -2.6 / -2.2 / -0.4 / -1.0 / -2.0
RE1-silencing transcription factor / REST / I / -2.4 / -2.1 / -1.4 / -0.3 / -2.4
Signal transduction / AML1 / AML2 / AML3 / AML4 / AML5
Formyl peptide receptor 1 / FPR1 / -2.5 / -1.3 / -1.9 / -17.4 / -3.0
Ras-related associated with diabetes / RRAD / -1.6 / -0.3 / -13.3 / -3.8 / -2.7
Membrane-spanning 4-domains, subfamily A, 6A / MS4A6A / T / -4.0 / -2.3 / -0.5 / -9.6 / -1.1
Secreted and transmembrane 1 / SECTM1 / T / -1.5 / -3.3 / -0.6 / -9.3 / -2.2
Adenylate cyclase 2 (brain) / ADCY2 / -1.6 / -3.1 / -8.2 / -3.1 / -1.0
Lectin, galactoside-binding, soluble, 1 (galectin 1) / LGALS1 / G, I / -1.5 / -6.9 / -3.4 / -2.2 / -1.1
EGF-like-domain, multiple 3 / EGFL3 / -6.9 / -3.2 / -4.4 / -2.5 / -1.0
SAM domain and HD domain 1 / SAMHD1 / T / -2.6 / -5.8 / -0.8 / -2.1 / -1.9
Deafness locus associated putative guanine nucleotide exchange factor / DELGEF / -2.4 / -2.1 / -5.5 / -0.3 / -3.1
Chemokine (C-C motif) ligand 5 / CCL5 / T / -3.7 / -1.2 / -2.8 / -2.6 / -5.1
G protein-coupled receptor 65 / GPR65 / G, T / -3.0 / -3.1 / -0.4 / -5.1 / -0.4
G protein-coupled receptor 109B / GPR109B / G / -2.6 / -5.1 / -1.3 / -1.5 / -2.8
Leucine zipper-EF-hand containing transmembrane protein 1 / LETM1 / G / -1.3 / -4.8 / -0.6 / -3.0 / -3.1
Tensin / TNS / -1.6 / -3.1 / -4.7 / -2.7 / -1.6
CDNA FLJ12996 fis, clone NT2RP3000235 / --- / -1.3 / -4.5 / -4.4 / -0.2 / -2.0
Mitogen-activated protein kinase kinase kinase 2 / MAP3K2 / -0.9 / -4.3 / -2.4 / -1.3 / -2.6
Prostaglandin E receptor 3 (subtype EP3) / PTGER3 / I / -0.9 / -2.7 / -4.2 / -1.2 / -2.3
Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog / FGR / T / -2.5 / -2.8 / -0.9 / -4.1 / -1.5
Interleukin 2 receptor, beta / IL2RB / -1.3 / -3.1 / -2.9 / -1.2 / -4.0
CCAAT/enhancer binding protein (C/EBP), epsilon / CEBPE / -2.1 / -3.7 / -3.1 / -0.7 / -2.7
Neuronal PAS domain protein 3 / NPAS3 / -2.4 / -1.6 / -0.2 / -2.0 / -3.7
Transcribed sequence with weak similarity to protein sp:P39195 / --- / -3.0 / -3.3 / -3.6 / -0.9 / -0.2
Rho guanine nucleotide exchange factor (GEF) 15 / ARHGEF15 / -1.6 / -1.4 / -2.1 / -3.5 / -3.6
PAS domain containing serine/threonine kinase / PASK / -1.2 / -3.5 / -2.4 / -0.6 / -3.2
V-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 / YES1 / -3.1 / -0.5 / -3.5 / -0.2 / -2.7
Caspase 1, apoptosis-related cysteine protease / CASP1 / T / -1.4 / -2.8 / -1.3 / -2.2 / -3.5
Testis expressed sequence 14 / TEX14 / -3.4 / -2.5 / -1.0 / -2.5 / -1.1
Complement component 3a receptor 1 / C3AR1 / -2.3 / -3.3 / -2.3 / -1.4 / -2.5
Neutrophil cytosolic factor 1 / NCF1 / T / -1.8 / -2.6 / -1.4 / -3.2 / -2.1
Likely ortholog of mouse Shc SH2-domain binding protein 1 / SHCBP1 / G / -2.3 / -1.2 / -3.2 / -1.0 / -2.9
Polo-like kinase 1 (Drosophila) / PLK1 / -1.7 / -1.0 / -3.2 / -2.2 / -2.0
Protein phosphatase 1, regulatory (inhibitor) 12B / PPP1R12B / -1.3 / -2.3 / -3.0 / -0.2 / -2.7
Mitogen-activated protein kinase 13 / MAPK13 / I / -2.2 / -2.0 / -0.7 / -2.9 / -3.0
Chemokine (C-X-C motif) ligand 2 / CXCL2 / -1.4 / -2.0 / -1.1 / -2.8 / -2.4
G protein-coupled receptor 18 / GPR18 / -2.3 / -2.1 / -0.4 / -2.8 / -1.4
Protein phosphatase 3, catalytic subunit, gamma / PPP3CC / -0.9 / -2.0 / -2.6 / -1.2 / -2.7
Cannabinoid receptor 1 (brain) / CNR1 / -2.3 / -2.3 / -2.4 / -1.0 / -0.6
Polo-like kinase 4 (Drosophila) / PLK4 / -1.1 / -2.3 / -1.8 / -2.2 / -2.2
ECM and cell adhesion / AML1 / AML2 / AML3 / AML4 / AML5
Chondroitin sulfate proteoglycan 2 (versican) / CSPG2 / T / -1.9 / -5.4 / -2.6 / -98.4 / -1.0
S100 calcium binding protein A8 (calgranulin A) / S100A8 / -4.1 / -10.1 / -0.6 / -21.8 / -12.7
Lectin, galactoside-binding, soluble, 3 / LGALS3 / T / -2.2 / -3.6 / -1.4 / -14.4 / -5.1
Lysozyme (renal amyloidosis) / LYZ / G / -2.8 / -1.6 / -6.6 / -14.3 / -6.7
Collagen, type XVIII, alpha 1 / COL18A1 / I / -2.2 / -0.8 / -8.4 / -0.5 / -2.8
Matrix metalloproteinase 9 / MMP9 / -1.1 / -2.2 / -1.4 / -2.2 / -4.3
Collagen, type VI, alpha / COL6A2 / -1.0 / -2.8 / -3.8 / -1.1 / -2.2
Glypican 5 / GPC5 / -1.0 / -2.5 / -2.2 / -1.0 / -2.9
Cell cycle / AML1 / AML2 / AML3 / AML4 / AML5
Putative lymphocyte G0/G1 switch gene / G0S2 / -2.1 / -4.3 / -6.7 / -25.8 / -1.2
Cell division cycle associated 8 / CDCA8 / -10.3 / -1.0 / -3.2 / -0.3 / -2.7
Extra spindle poles like 1 (S. cerevisiae) / ESPL1 / -2.2 / -8.4 / -3.9 / -1.8 / -0.8
Cyclin B2 / CCNB2 / G / -3.4 / -0.7 / -7.8 / -2.5 / -3.1
Baculoviral IAP repeat-containing 5 (survivin) / BIRC5 / G, I / -6.8 / -0.2 / -5.3 / -5.0 / -1.5
BUB1 budding uninhibited by benzimidazoles 1, beta (yeast) / BUB1B / G / -1.7 / -6.5 / -2.4 / -6.0 / -1.0
CDC6 cell division cycle 6 homolog (S. cerevisiae) / CDC6 / -2.3 / -4.4 / -6.5 / -1.1 / -1.6
CDC45 cell division cycle 45-like (S. cerevisiae) / CDC45L / I / -1.4 / -6.4 / -3.8 / -2.7 / -2.7
Cell division cycle 2, G1 to S and G2 to M / CDC2 / -2.9 / -1.0 / -5.9 / -1.5 / -4.7
Kinesin family member C1 / KIFC1 / -3.3 / -5.1 / -1.3 / -2.8 / -1.0
CDC20 cell division cycle 20 homolog (S. cerevisiae) / CDC20 / G, I / -3.0 / -1.0 / -2.8 / -3.2 / -4.7
Cyclin A2 / CCNA2 / -3.3 / -4.4 / -2.7 / -0.5 / -2.8
E2F transcription factor 2 / E2F2 / -3.1 / -4.4 / -1.0 / -1.0 / -2.9
BUB1 budding uninhibited by benzimidazoles 1 (yeast) / BUB1 / G / -2.0 / -0.4 / -4.2 / -2.8 / -0.8
G-2 and S-phase expressed 1 / GTSE1 / I / -2.0 / -2.1 / -4.2 / -2.7 / -2.7
Cyclin B1 / CCNB1 / G / -2.3 / -3.0 / -3.4 / -2.5 / -0.8
Cell division cycle 25C / CDC25C / -2.5 / -3.4 / -3.0 / -1.0 / -1.1
Protein kinase, cGMP-dependent, type II / PRKG2 / -0.5 / -2.1 / -2.9 / -0.3 / -3.4
Cyclin-dependent kinase inhibitor 3 / CDKN3 / G / -2.0 / -1.5 / -3.3 / -2.5 / -0.7
E2F transcription factor 1 / E2F1 / -1.7 / -3.2 / -1.1 / -2.7 / -2.3
Kinesin family member 2C / KIF2C / G / -2.0 / -2.1 / -0.9 / -2.1 / -0.4
Protein binding and receptor activity / AML1 / AML2 / AML3 / AML4 / AML5
CD14 antigen / CD14 / T / -2.4 / -2.8 / -1.0 / -106.4 / -3.2
S100 calcium binding protein A9 (calgranulin B) / S100A9 / T / -4.1 / -7.9 / -0.9 / -12.6 / -53.9
Cystatin A (stefin A) / CSTA / G, T / -3.9 / -4.1 / -2.4 / -37.6 / -4.2
Ficolin (collagen/fibrinogen domain containing) 1 / FCN1 / T / -2.7 / -5.4 / -2.7 / -31.0 / -3.3
CD1D antigen, d polypeptide / CD1D / T / -2.2 / -17.7 / -1.0 / -6.1 / -1.0
Azurocidin 1 (cationic antimicrobial protein 37) / AZU1 / T / -3.4 / -16.2 / -5.8 / -2.7 / -4.0
Neutrophil cytosolic factor 2 / NCF2 / T / -2.4 / -15.9 / -0.7 / -1.5 / -2.1
CD163 antigen / CD163 / T / -2.1 / -1.9 / -3.0 / -14.2 / -1.0
Tumor necrosis factor, alpha-induced protein 6 / TNFAIP6 / -2.1 / -1.2 / -1.0 / -11.6 / -4.9
Chemokine (C-X3-C motif) receptor 1 / CX3CR1 / -2.6 / -11.6 / -1.0 / -5.1 / -0.7
C-type lectin, superfamily member 5 / CLECSF5 / -2.0 / -0.7 / -2.8 / -1.2 / -9.0
Chemokine (C-C motif) receptor 1 / CCR1 / -3.0 / -4.5 / -4.6 / -8.8 / -1.5
Maternal embryonic leucine zipper kinase / MELK / G / -2.4 / -1.9 / -6.4 / -2.6 / -8.6
PRO2275 mRNA, complete cds / --- / -4.0 / -1.5 / -1.7 / -8.6 / -4.0
Chemokine (C-C motif) ligand 4 / CCL4 / T / -3.3 / -3.6 / -2.5 / -8.0 / -1.5
Syntaxin 11 / STX11 / T / -1.4 / -4.1 / -1.0 / -7.6 / -2.4
CDC42 effector protein (Rho GTPase binding) 3 / CDC42EP3 / T / -2.0 / -1.5 / -0.9 / -2.8 / -7.0
CD86 antigen / CD86 / T / -6.6 / -5.0 / -1.0 / -1.8 / -3.4
Phospholipase A2-activating protein / PLAA / I / -1.2 / -6.3 / -3.4 / -1.3 / -3.2
Integrin, alpha 2b / ITGA2B / -6.2 / -0.9 / -2.6 / -4.4 / -0.3
Chemokine (C-X-C motif) receptor 3 / CXCR3 / -6.2 / -2.8 / -3.9 / -1.6 / -1.0
Nuclear receptor subfamily 4, group A, member 1 / NR4A1 / I / -0.9 / -2.2 / -6.2 / -2.6 / -0.3
Leukocyte immunoglobulin-like receptor, B4 / LILRB4 / T / -2.5 / -5.9 / -2.5 / -3.0 / -2.0
Membrane-spanning 4-domains, A3 / MS4A3 / G, T / -5.7 / -0.5 / -2.2 / -1.0 / -5.7
Vitamin D (1,25- dihydroxyvitamin D3) receptor / VDR / I / -1.0 / -5.6 / -4.8 / -4.4 / -1.0
Homer homolog 3 (Drosophila) / HOMER3 / -2.8 / -2.8 / -2.8 / -5.5 / -1.9
Complement component 1, q subcomponent, receptor 1 / C1QR1 / I,T / -3.2 / -5.5 / -0.3 / -4.3 / -0.5
Caspase recruitment domain family, member 9 / CARD9 / -5.1 / -0.4 / -3.0 / -2.3 / -1.0
S100 calcium binding protein P / S100P / -4.3 / -4.7 / -1.0 / -5.1 / -3.2
Toll-like receptor 2 / TLR2 / -2.0 / -5.1 / -1.3 / -2.8 / -0.9
Membrane-spanning 4-domains, A4 / MS4A4A / T / -3.7 / -0.4 / -1.0 / -4.9 / -2.2
CD38 antigen (p45) / CD38 / G / -2.8 / -4.4 / -1.6 / -2.3 / -3.3
Laminin, alpha 4 / LAMA4 / -0.5 / -4.4 / -4.3 / -2.5 / -4.0
CD226 antigen / CD226 / -3.6 / -1.0 / -4.4 / -2.5 / -2.2
Melanoma antigen, family F, 1 / MAGEF1 / -2.3 / -0.5 / -1.0 / -4.3 / -2.8
Purinergic receptor P2X, ligand-gated ion channel, 5 / P2RX5 / G / -4.2 / -0.9 / -2.5 / -2.0 / -2.1
Ectodermal-neural cortex (with BTB-like domain) / ENC1 / -3.1 / -3.1 / -1.0 / -4.1 / -0.8
HRAS-like suppressor 2 / HRASLS2 / -2.4 / -4.1 / -0.7 / -3.4 / -0.4
Chromosome condensation protein G / HCAP-G / -2.9 / -3.1 / -4.0 / -0.9 / -0.5
Protein tyrosine phosphatase, non-receptor type substrate 1 / PTPNS1 / -1.6 / -4.0 / -2.1 / -1.3 / -2.3
Low density lipoprotein-related protein 2 / LRP2 / -0.3 / -3.7 / -3.3 / -1.0 / -2.8
Arachidonate 5-lipoxygenase / ALOX5 / T / -1.5 / -3.4 / -3.6 / -2.2 / -3.1
Adaptor-related protein complex 1, sigma 1 subunit / AP1S1 / -0.9 / -3.4 / -3.0 / -3.6 / -0.7
Sodium channel, nonvoltage-gated 1 alpha / SCNN1A / -1.1 / -0.2 / -2.9 / -2.9 / -3.3
Cystatin SN / CST1 / -3.3 / -2.9 / -0.4 / -1.5 / -2.8
CD68 antigen / CD68 / -1.0 / -3.2 / -1.5 / -2.9 / -2.5
Sodium channel, nonvoltage-gated 1, gamma / SCNN1G / -0.4 / -2.3 / -3.2 / -0.9 / -2.6
Olfactory receptor, family 2, F1 / OR2F1 / -2.5 / -1.0 / -3.2 / -1.8 / -2.8
Hyaluronan-mediated motility receptor / HMMR / G / -2.8 / -2.1 / -3.1 / -2.6 / -0.2
Kallikrein 6 (neurosin, zyme) / KLK6 / -0.4 / -3.1 / -2.4 / -0.5 / -2.2
Interferon, alpha 10 / IFNA10 / -2.2 / -2.3 / -2.9 / -0.9 / -0.3
Integrin, alpha M / ITGAM / T / -2.0 / -2.8 / -0.5 / -2.1 / -0.8
Mannose receptor, C type 2 / MRC2 / -2.0 / -2.4 / -1.6 / -2.7 / -1.2
Protein phosphatase 3, catalytic subunit, gamma / PPP3CC / -0.9 / -2.0 / -2.6 / -1.2 / -2.7
Immunoglobulin superfamily, member 4B / IGSF4B / -2.2 / -2.0 / -2.4 / -1.0 / -1.0
Protein degradation / AML1 / AML2 / AML3 / AML4 / AML5
Ubiquitin protein ligase E3B / UBE3B / -1.3 / -5.1 / -4.6 / -0.9 / -2.5
DNA structure and nucleus / AML1 / AML2 / AML3 / AML4 / AML5
Lamin B1 / LMNB1 / G / -1.0 / -13.8 / -3.4 / -0.8 / -2.0
DNA replication complex GINS protein PSF2 / Pfs2 / G / -1.3 / -2.3 / -7.5 / -2.6 / -2.0
Polymerase (DNA directed), mu / POLM / -2.7 / -4.8 / -0.4 / -0.4 / -2.2
Polymerase (DNA-directed), alpha / POLA2 / G, I / -1.3 / -2.6 / -2.3 / -4.0 / -1.1
Histone 1, H4g / HIST1H4G / -1.3 / -3.3 / -2.4 / -0.9 / -3.4
Nucleolar and spindle associated protein 1 / NUSAP1 / -2.8 / -3.4 / -2.4 / -1.6 / -1.3
Chromosome 22 open reading frame 19 / C22orf19 / -1.6 / -3.2 / -1.6 / -2.2 / -2.4
Pleckstrin homology-like domain, family A, 1 / PHLDA1 / -2.6 / -3.2 / -0.9 / -2.3 / -0.9
AAIR8193 / UNQ8193 / -0.4 / -1.1 / -2.9 / -2.2 / -3.2
Kinesin family member 20A / KIF20A / -2.9 / -1.0 / -2.5 / -3.1 / -0.8
Centromere protein A, 17kDa / CENPA / G / -2.0 / -2.2 / -0.2 / -0.5 / -2.9
Capping protein (actin filament), gelsolin-like / CAPG / -1.4 / -2.8 / -2.1 / -1.3 / -2.3
ZW10 interactor / ZWINT / G / -2.0 / -2.2 / -2.6 / -1.5 / -1.4
DNA repair / AML1 / AML2 / AML3 / AML4 / AML5
Topoisomerase (DNA) II alpha 170kDa / TOP2A / G / -4.6 / -3.8 / -4.8 / -7.3 / -1.2
Thymidylate synthetase / TYMS / G, I / -1.7 / -3.5 / -5.4 / -4.8 / -1.9
Flap structure-specific endonuclease 1 / FEN1 / G,I / -1.2 / -2.0 / -4.5 / -4.1 / -2.0
Ligase I, DNA, ATP-dependent / LIG1 / G, I / -1.3 / -2.8 / -2.5 / -4.4 / -3.0
RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae) / RAD51 / G, I / -1.3 / -2.4 / -3.0 / -1.0 / -3.7
Telomerase-associated protein 1 / TEP1 / -1.5 / -3.5 / -1.1 / -2.8 / -2.8
SMC1 structural maintenance of chromosomes 1-like 1 (yeast) / SMC1L1 / -1.5 / -2.1 / -3.0 / -0.9 / -2.4
SMC2 structural maintenance of chromosomes 2-like 1 (yeast) / SMC2L1 / -2.3 / -2.5 / -2.2 / -1.5 / -1.1
Inflamatory response / AML1 / AML2 / AML3 / AML4 / AML5
Interleukin 1, beta / IL1B / -1.8 / -3.1 / -3.5 / -25.5 / -3.7
Elastase 2, neutrophil / ELA2 / G, T / -9.5 / -24.0 / -4.7 / -0.5 / -2.9
Interferon, gamma-inducible protein 30 / IFI30 / -2.7 / -22.1 / -1.6 / -5.5 / -1.7
Interleukin 1 receptor antagonist / IL1RN / -2.4 / -3.4 / -1.9 / -17.8 / -6.3
Solute carrier family 11, member 1 / SLC11A1 / T / -1.8 / -2.5 / -2.8 / -14.1 / -1.0
Immunoglobulin kappa light chain mRNA / --- / -2.6 / -1.7 / -0.6 / -2.6 / -13.1
Fc fragment of IgA, receptor for" / FCAR / -4.0 / -1.0 / -1.0 / -11.8 / -4.8
Leukocyte immunoglobulin-like receptor, B1 / LILRB1 / -2.8 / -4.0 / -1.2 / -9.7 / -1.0
Immunoglobulin lambda-like polypeptide 1 / IGLL1 / G / -3.4 / -5.2 / -8.6 / -1.4 / -1.2
Fc fragment of IgG, high affinity Ia, receptor for (CD64) / FCGR1A / -2.3 / -7.6 / -1.8 / -2.9 / -3.5
Colony stimulating factor 2 / CSF2 / -3.4 / -5.3 / -6.3 / -0.7 / -0.3
B cell RAG associated protein / BRAG / -1.7 / -4.5 / -2.6 / -5.2 / -0.5
Leukocyte immunoglobulin-like receptor, A2 / LILRA2 / T / -0.9 / -3.3 / -1.1 / -4.2 / -5.1
Immunoglobulin kappa constant / IGKC / G / -2.9 / -1.7 / -0.7 / -3.1 / -5.0
Leukocyte immunoglobulin-like receptor, B6 / ILT8 / -1.2 / -4.7 / -3.7 / -3.3 / -2.2
Immunoglobulin superfamily, member 6 / IGSF6 / -2.5 / -4.7 / -0.3 / -3.8 / -0.9
Fc fragment of IgG, low affinity IIa, receptor for (CD32) / FCGR2A / T / -3.4 / -1.1 / -4.6 / -2.1 / -0.6
Immune associated nucleotide 4 like 1 (mouse) / IAN4L1 / -1.0 / -2.9 / -3.6 / -4.6 / -4.6
Leukocyte immunoglobulin-like receptor, A1 / LILRA1 / T / -1.2 / -4.2 / -1.9 / -2.8 / -4.5
T cell receptor alpha locus / --- / -2.1 / -4.3 / -1.7 / -2.1 / -1.2
Leukocyte immunoglobulin-like receptor, B3 / LILRB3 / T / -2.5 / -4.2 / -2.0 / -2.3 / -0.6
Heparanase / HPSE / -4.1 / -3.5 / -0.7 / -2.0 / -2.3
Paired immunoglobin-like type 2 receptor alpha / PILRA / T / -2.8 / -1.6 / -1.2 / -3.8 / -2.1
Immunoglobulin lambda joining 3 / IGLJ3 / G, T / -2.1 / -2.8 / -0.9 / -3.4 / -1.6
Acyloxyacyl hydrolase (neutrophil) / AOAH / -3.1 / -0.9 / -1.3 / -2.9 / -2.3
T cell receptor gamma variable 9 / TRGV9 / G / -2.0 / -2.1 / -1.4 / -1.0 / -2.6
Others / AML1 / AML2 / AML3 / AML4 / AML5
Charcot-Leyden crystal protein / CLC / G / -3.9 / -5.9 / -2.3 / -0.8 / -72.8
Ig superfamily protein / Z39IG / -3.2 / -2.0 / -0.3 / -34.6 / -3.0
Proteinase 3 / PRTN3 / G, I , T / -3.3 / -16.0 / -0.7 / -0.6 / -6.7
Complement component 1, q subcomponent, alpha polypeptide / C1QA / -5.2 / -3.8 / -6.4 / -13.8 / -1.0
Ribonuclease, RNase A family, 2 / RNASE2 / G, T / -5.6 / -8.5 / -13.7 / -6.3 / -2.9
Ribonucleotide reductase M2 polypeptide / RRM2 / G / -2.6 / -3.2 / -13.4 / -3.2 / -2.4
Solute carrier family 15, member 3 / SLC15A3 / T / -3.1 / -12.4 / -0.6 / -4.4 / -0.7
KIAA0101 gene product / KIAA0101 / G / -1.6 / -4.5 / -9.9 / -6.4 / -3.5
S100 calcium binding protein A12 (calgranulin C) / S100A12 / T / -1.2 / -3.3 / -0.4 / -9.5 / -5.7
Similar to RIKEN cDNA 4930457P18 / LOC123872 / -1.0 / -1.3 / -3.8 / -8.2 / -3.4
AarF domain containing kinase 2 / ADCK2 / -1.0 / -7.2 / -0.3 / -3.2 / -2.5
Cathepsin G / CTSG / G, I / -2.7 / -6.9 / -3.4 / -1.7 / -4.1
Histidine ammonia-lyase / HAL / -0.9 / -6.9 / -0.5 / -4.5 / -2.4
Hypothetical protein FLJ22353 / FLJ22353 / -1.0 / -3.8 / -2.2 / -1.0 / -6.8
Gamma-glutamyltransferase-like activity 1 / GGTLA1 / -3.3 / -6.6 / -1.9 / -2.3 / -0.4
Vesicle-associated membrane protein 1 / VAMP1 / -1.2 / -2.3 / -6.4 / -1.2 / -2.7
Motile sperm domain containing 3 / MOSPD3 / -1.7 / -2.2 / -1.4 / -6.4 / -2.1
Hypothetical protein LOC146909 / LOC146909 / G / -2.2 / -5.7 / -4.0 / -2.6 / -1.5
Protein predicted by clone 23627 / HSU79266 / G / -2.3 / -5.5 / -1.0 / -1.1 / -5.7
Formyltetrahydrofolate dehydrogenase / FTHFD / -3.9 / -5.5 / -1.4 / -0.7 / -3.7
Alkaline phosphatase, placental-like 2 / ALPPL2 / -0.4 / -1.0 / -5.5 / -4.8 / -3.4
Lectin, galactoside-binding, soluble, 2 / LGALS2 / T / -2.1 / -4.0 / -1.0 / -1.6 / -5.4
Hypothetical protein FLJ20422 / FLJ20422 / -0.7 / -5.2 / -3.6 / -3.5 / -1.6
ASF1 anti-silencing function 1 homolog B (S. cerevisiae) / ASF1B / -2.4 / -2.0 / -1.7 / -0.9 / -5.1
Dihydrofolate reductase / DHFR / -1.5 / -5.0 / -2.8 / -4.2 / -1.6
Cytochrome P450, family 1, B1 / CYP1B1 / T / -2.3 / -5.0 / -3.5 / -4.6 / -0.5
Histamine N-methyltransferase / HNMT / T / -1.0 / -1.6 / -4.9 / -2.9 / -2.8
Triosephosphate isomerase 1 / TPI1 / -0.8 / -3.5 / -2.1 / -4.9 / -0.7
Transcribed sequence with weak similarity to protein ref:NP_060265.1 / --- / -2.6 / -4.9 / -1.6 / -4.9 / -1.1
Fibrinogen-like 2 / FGL2 / T / -3.5 / -4.7 / -2.1 / -2.8 / -1.8
GM2 ganglioside activator / GM2A / -2.2 / -4.7 / -4.4 / -1.2 / -1.2
Glucosidase I / GCS1 / I / -1.1 / -2.0 / -4.7 / -0.9 / -2.3
ADP-ribosyltransferase 1 / ART1 / I / -1.5 / -2.3 / -2.5 / -1.7 / -4.7
Solute carrier family 22, 4 / SLC22A4 / G / -1.1 / -4.6 / -0.8 / -2.1 / -2.7
Chromosome 22 open reading frame 18 / C22orf18 / G / -1.4 / -4.0 / -4.5 / -1.5 / -2.0
Hypothetical protein FLJ11850 / FLJ11850 / -4.5 / -0.5 / -2.0 / -0.3 / -2.6
Fer-1-like 4 (C. elegans) / FER1L4 / -1.4 / -3.0 / -2.2 / -0.9 / -4.5
Solute carrier family 6, member 6 / SLC6A6 / -1.0 / -4.5 / -0.8 / -2.1 / -4.2
Rabconnectin-3 / RC3 / -2.4 / -4.4 / -2.5 / -2.1 / -2.2
Centaurin, alpha 2 / CENTA2 / T / -2.7 / -4.4 / -0.9 / -3.2 / -0.8
Histone 1, H3h / HIST1H3H / -3.2 / -0.2 / -2.3 / -1.0 / -4.3
Tubulin, beta polypeptide paralog / MGC8685 / -1.0 / -2.1 / -4.2 / -2.4 / -2.0
Solute carrier family 16, member 6 / SLC16A6 / -2.0 / -2.5 / -1.1 / -4.2 / -3.1
Carbonic anhydrase XII / CA12 / -0.8 / -4.1 / -2.2 / -2.9 / -0.4
Origin recognition complex, subunit 1-like (yeast) / ORC1L / -2.6 / -3.9 / -1.0 / -3.3 / -2.9
Hypothetical protein MGC29875 / MGC29875 / -1.2 / -2.1 / -0.6 / -2.8 / -3.9
Hypothetical protein FLJ21816 / FLJ21816 / -0.9 / -3.8 / -3.6 / -2.4 / -0.5
Protein arginine N-methyltransferase 7 / PRMT7 / -3.8 / -3.8 / -1.1 / -1.0 / -2.5
Acetyl-Coenzyme A acyltransferase 2 / ACAA2 / -3.3 / -3.8 / -3.2 / -0.5 / -0.2
Farnesyltransferase, CAAX box, beta / FNTB / -3.7 / -2.2 / -2.8 / -0.7 / -1.7
Erythroblast membrane-associated protein / ERMAP / -1.2 / -3.7 / -2.3 / -0.6 / -2.1
Calcium channel, voltage-dependent, alpha 1G / CACNA1G / -2.0 / -3.7 / -0.3 / -0.5 / -2.7
CDNA FLJ14019 fis, clone HEMBA1002503 / --- / -2.2 / -2.2 / -3.6 / -1.1 / -0.7
WINS1 protein with Drosophila Lines (Lin) homologous domain / WINS1 / -2.0 / -2.3 / -1.6 / -3.5 / -1.4
Chromosome 8 open reading frame 1 / C8orf1 / -0.5 / -3.0 / -2.4 / -0.6 / -3.4
Spermatogenesis associated 6 / SPATA6 / -1.0 / -3.3 / -2.1 / -2.0 / -1.3
CDNA FLJ20178 fis, clone COL09990 / --- / -1.1 / -3.3 / -2.5 / -2.9 / -0.2
Hypothetical protein FLJ20156 / FLJ20156 / -1.9 / -3.3 / -2.0 / -1.6 / -2.5
Hypothetical protein DKFZp434N2030 / --- / -2.9 / -2.1 / -3.3 / -1.9 / -1.6
NDRG family member 2 / NDRG2 / I / -0.4 / -3.3 / -2.9 / -0.9 / -2.5
Desmin / DES / -0.9 / -2.2 / -0.3 / -2.4 / -3.3
Lysophospholipase II / LYPLA2 / G / -0.9 / -2.4 / -0.9 / -2.5 / -3.2
UDP-N-acetyl-alpha-D-galactosamine / GALNT12 / -0.5 / -2.9 / -2.7 / -3.2 / -2.4
KIAA0335 gene product / KIAA0335 / -0.6 / -3.1 / -0.5 / -2.9 / -2.8
Hypothetical protein FLJ45455 / FLJ45455 / -2.9 / -2.2 / -3.0 / -2.0 / -3.0
TcD37 homolog / HTCD37 / -2.8 / -2.9 / -1.7 / -1.6 / -2.1
Aldehyde dehydrogenase 4 family, member A1 / ALDH4A1 / -2.9 / -0.5 / -2.2 / -1.0 / -2.1
Multiple inositol polyphosphate histidine phosphatase, 1 / MINPP1 / G / -2.4 / -2.1 / -2.8 / -1.5 / -0.7
Hypothetical protein FLJ14082 / FLJ14082 / -1.0 / -2.4 / -2.7 / -2.6 / -0.9
HDCMA18P protein / HDCMA18P / -1.2 / -0.5 / -2.7 / -2.7 / -2.5
Albumin / ALB / -1.0 / -2.0 / -2.6 / -2.2 / -2.0
Coagulation factor C homolog, cochlin / COCH / G / -2.2 / -2.6 / -2.4 / -1.1 / -0.9
Hypothetical protein dJ462O23.2 / DJ462O23.2 / -1.1 / -2.2 / -2.6 / -0.5 / -2.4
Hypothetical protein FLJ10986 / FLJ10986 / -1.6 / -2.4 / -2.3 / -0.9 / -2.6
Hypothetical protein MGC33887 / MGC33887 / -2.3 / -2.4 / -0.4 / -0.5 / -2.2

1. Datasets were obtained from: G, Georgantas [20]; I, Ivanova [21]; T, Toren [22].
2.The indicated fold change is the ratio of CD34+CD38- versus CD34+CD38+ cell populations of each AML patient. The "-" sign indicates under expression. Abbreviations: LSC, leukemic stem cells; HSC, hematopoietic stem cells.