Table S1: Average maximum reimbursable price per unit for active substances included in one of the three therapeutic classes

Penultimate year before TRP definition / Last year before TRP definition / Period between TRP definition and introduction / First year after TRP introduction / Second year after TRP introduction
Maximum reimbursable price per unit [average (min; max)] in EUR
Proton pump inhibitors
Omeprazole / 0.29 (0.19; 0.39) / 0.24 (0.18; 0.27) / 0.21 (0.17; 0.24) / 0.15 (0.08; 0.17) / 0.12 (0.07; 0.16)
Pantoprazole / 0.22 (0.13; 0.39) / 0.16 (0.13; 0.18) / 0.16 (0.13; 0.18) / 0.15 (0.13; 0.17) / 0.13 (0.11; 0.16)
Esomeprazole / 0.29 (0.23; 0.35) / 0.15 (0.13; 0.17) / 0.13 (0.11; 0.16)
Lansoprazole / 0.47 (0.38; 0.56) / 0.28 (0.17; 0.54) / 0.18 (0.15; 0.23) / 0.15 (0.13; 0.17) / 0.13 (0.11; 0.16)
Lipid-lowering-agents
Simvastatin / 0.17 (0.09; 0.31) / 0.15 (0.09; 0.2) / 0.13 (0.06; 0.18) / 0.10 (0.05; 0.12) / 0.10 (0.05; 0.12)
Lovastatin / 0.05 (0.05; 0.05) / 0.05 (0.05; 0.06)
Pravastatin / 0.25 (0.2; 0.3) / 0.16 (0.15; 0.18) / 0.10 (0.05; 0.12) / 0.09 (0.05; 0.12)
Fluvastatin / 0.23 (0.17; 0.28) / 0.16 (0.16; 0 .16) / 0.12 (0.12; 0.12) / 0.12 (0.12; 0.12)
Atorvastatin / 0.45 (0.16; 0.83) / 0.3 (0.15; 0.5) / 0.27 (0.12; 0.5) / 0.17 (0.12; 0.25) / 0.15 (0.12; 0.24)
Rosuvastatin / 0.55 (0.31; 0.91) / 0.49 (0.28; 0.82) / 0.43 (0.25; 0.75) / 0.18 (0.12; 0.25) / 0.15 (0.12; 0.24)
Ezetimibe / 0.87 (0.84; 0.9) / 0.81 (0.78; 0.84) / 0.78 (0.77; 0.78) / 0.05 (0.05; 0.05) / 0.05 (0.05; 0.06)
Simvastatin/Ezetimibe / 0.20 (0.12; 0.25) / 0.16 (0.12; 0.24)
Simvastatin/Fenofibrate / 0.39 (0.39; 0.4)
Atorvastatin/Amlodipine / 0.22 (0.21; 0.22) / 0.20 (0.19; 0.22)
Angiotenzin-converting-enzyme inhibitors
Captopril / 0.1 (0.09; 0.1) / 0.1 (0.09; 0.1) / 0.1 (0.09; 0.1)
Enalapril / 0.1 (0.06; 0.15) / 0.1 (0.05; 0.14) / 0.09 (0.05; 0.13) / 0.07 (0.04; 0.13) / 0.06 (0.04; 0.11)
Lisinopril / 0.11 (0.05; 0.16) / 0.1 (0.05; 0.14) / 0.10 (0.06; 0.13) / 0.08 (0.06; 0.11) / 0.08 (0.06; 0.1)
Perindopril / 0.43 (0.28; 0.59) / 0.3 (0.19; 0.44) / 0.25 (0.12; 0.35) / 0.10 (0.07; 0.14) / 0.12 (0.09; 0.14)
Ramipril / 0.11 (0.04; 0.2) / 0.11 (0.06; 0.17) / 0.10 (0.06; 0.15) / 0.09 (0.04; 0.14) / 0.08 (0.05; 0.13)
Fozinopril / 0.12 (0.1; 0.15) / 0.21 (0.21; 0.21) / 0.13 (0.11; 0.14) / 0.11 (0.11; 0.11)
Trandolapril / 0.24 (0.06; 0.43) / 0.2 (0.05; 0.43) / 0.16 (0.06; 0.22) / 0.09 (0.05; 0.16) / 0.1 (0.05; 0.16)
Zofenopril / 0.11 (0.07; 0.16) / 0.1 (0.08; 0.13)
Enalapril/Hydrochlorothiazid / 0.19 (0.17; 0.21) / 0.16 (0.15; 0.17) / 0.15 (0.15; 0.16) / 0.13 (0.10; 0.17) / 0.13 (0.10; 0.17)
Lisinopril/Hydrochlorothiazid / 0.21 (0.21; 0.21) / 0.17 (0.17; 0.17) / 0.14 (0.13; 0.15) / 0.13 (0.13; 0.13)
Perindopril/indapamid / 0.42 (0.32; 0.59) / 0.36 (0.29; 0.53) / 0.32 (0.25; 0.4) / 0.22 (0.11; 0.33) / 0.22 (0.09; 0.33)
Ramipril /Hydrochlorothiazid / 0.11 (0.09; 0.12) / 0.09 (0.08; 0.11) / 0.10 (0.08; 0.11) / 0.09 (0.08; 0.11) / 0.09 (0.06; 0.11)
Fosinopril/Hydrochlorothiazid / 0.28 (0.28; 0.28) / 0.25 (0.25; 0.25) / 0.13 (0.12; 0.16) / 0.12 (0.15; 0.12)
Zofenopril/Hydrochlorothiazid / 0.15 (0.15; 0.15)
Enalapril/Lercanidipine / 0.16 (0.13; 0.18)
Perindopril/Amplodipine / 0.36 (0.26; 0.46) / 0.26 (0.21; 0.26) / 0.20 (0.15; 0.26)
Ramipril/Amlodipine / 0.17 (0.12; 0.23)
Trandolapril/Verapamil / 0.25 (0.19; 0.31) / 0.21 (0.2; 0.21)
Perindopril/Indapamide/ Amlodipin / 0.31 (0.23; 0.41)

Missing data are the consequence of that the medicine was not included in GRP or TRP in a certain period.