Table 6 Genes altered ≥2-fold after DNMT3Bknocked-down treatment in hepatocellular carcinoma cell line SMMC-7721

Accession / function / Symbol
cell cycle related genes
NM_000189 / cell cycle / HK2
NM_003903 / cell cycle / CDC16
NM_000189 / cell cycle / HK2
NM_133433 / cell cycle / IDN3
NM_000575 / cell cycle / IL1A
NM_014751 / cell cycle / MTSS1
NM_005157 / cell cycle ,regulation of transcription / ABL1
cell differentiation related genes
NM_006096 / cell differentiation / NDRG1
NM_017617 / cell differentiation / NOTCH1
NM_031921 / cell division / TOB3
NM_001657 / cell proliferation / AREG
NM_005557 / cell proliferation / KRT16
NM_005807 / cell proliferation / PRG4
NM_004335 / cell proliferation / BST2
NM_013402 / regulation of cell differentiation / FADS1
apoptosis related genes
NM_000575 / anti-apoptosis ，apoptosis / IL1A
NM_145341 / apoptosis / PDCD4
cell adhesion related genes
NM_000072 / cell adhesion / CD36
NM_000228 / cell adhesion / LAMB3
NM_014751 / cell adhesion / MTSS1
NM_000638 / cell adhesion / VTN
regulation of transcription related genes
NM_002582 / regulation of transcription / PARN
NM_003926 / regulation of transcription / MBD3
NM_001428 / regulation of transcription / ENO1
NM_182931 / regulation of transcription / MLL5
NM_138473 / regulation of transcription / SP1
NM_003216 / regulation of transcription / TEF
NM_005253 / regulation of transcription / FOSL2
NM_002096 / regulation of transcription / GTF2F1
NM_002967 / regulation of transcription / SAFB
NM_012289 / regulation of transcription / KEAP1
NM_182917 / regulation of translational / EIF4G1
NM_005157 / regulation of transcription / ABL1
signal transduction ralated genes
NM_000700 / signal transduction / ANXA1
NM_002223 / signal transduction / ITPR2
NM_138769 / signal transduction / ARHT2
NM_016614 / signal transduction / TTRAP
NM_006113 / signal transduction / VAV3
NM_004218 / signal transduction / RAB11B
NM_145173 / signal transduction / DIRAS1
NM_003224 / signal transduction / ARFRP1
others
NM_003528 / nucleosome assembly / HIST2H2BE
NM_019075 / metabolism / UGT1A10
NM_021910 / chloride transport ,ion transport / FXYD3
NM_017510 / intracellular protein transport / HSGP25L2G
NM_057089 / intracellular protein transport / AP1S1
NM_000941 / electron transport / POR
X52973 / metabolism ,response to toxin / CES1
NM_000499 / electron transport ,transport / CYP1A1
NM_015270 / intracellular signaling cascade / ADCY6
NM_006700 / nucleic acid binding ,zinc ion binding / FLN29
NM_002638 / copulation / PI3
NM_020196 / DNA repair / XAB2
NM_022154 / metal ion transport / SLC39A8
NM_001354 / canalicular bile acid transport ,digestion ,lipid metabolism ,steroid metabolism ,transport , / AKR1C2
NM_004966 / RNA processing / HNRPF
NM_002428 / protein modification / MMP15
NM_021910 / chloride transport ,ion transport / FXYD3
NM_005104 / spermatogenesis / BRD2
NM_016219 / carbohydrate metabolism ,oligosaccharide metabolism / MAN1B1
NM_024830 / muscle development / FLJ12443
NM_006412 / metabolism / AGPAT2
NM_002203 / cell-matrix adhesion / ITGA2
NM_001074 / metabolism / UGT2B7
NM_001818 / androgen metabolism / AKR1C4
NM_032466 / muscle contraction / ASPH
NM_001336 / proteolysis and peptidolysis / CTSZ
NM_005346 / mRNA catabolism ,protein folding / HSPA1B
NM_019075 / metabolism / UGT1A10
NM_001686 / ion transport ，proton transport / ATP5B
NM_000592 / complement activation / C4A
NM_006247 / mitosis ,positive regulation of I-kappaB kinase/NF-kappaB cascade / PPP5C
NM_001752 / electron transport / CAT
NM_002156 / mitochondrial matrix protein import / HSPD1
NM_001920 / organogenesis / DCN
NM_001920 / organogenesis / DCN
NM_006816 / protein transport / LMAN2
NM_016022 / Notch receptor processing / APH-1A
NM_031921 / cell division / TOB3
NM_002837 / phosphate metabolism / PTPRB
NM_000392 / transport / ABCC2
NM_021910 / ion transport / FXYD3
NM_001442 / transport / FABP4
NM_178225 / ubiquitin cycle / FBXW5
NM_004563 / gluconeogenesis / PCK2
NM_002273 / cytoskeleton organization and biogenesis / KRT8
NM_000773 / electron transport / CYP2E1
NM_006445 / nuclear mRNA splicing, via spliceosome / PRPF8
NM_000240 / electron transport ，neurotransmitter catabolism / MAOA
NM_003969 / ubiquitin cycle / UBE2M
NM_001628 / carbohydrate metabolism / AKR1B1
NM_002233 / cation transport ，potassium ion transport ， / KCNA4
NM_004204 / GPI anchor biosynthesis ，carbohydrate metabolism ， / PIGQ
NM_004818 / nuclear mRNA splicing, via spliceosome / DDX23
NM_022977 / fatty acid metabolism ,learning and/or memory ,lipid metabolism ,metabolism / FACL4
NM_018427 / transcription from RNA polymerase I promoter / RRN3
NM_001956 / cell-cell signaling ,pathogenesis ,protein kinase C activation ,regulation of vasoconstriction ,transmembrane receptor protein tyrosine kinase signaling pathway / EDN2
BC060848 / protein modification / MIDN
NM_017458 / response to drug / MVP
NM_032038 / tetracycline transport / SPINL
NM_020230 / RNA splicing / PPAN
NM_001897 / cell motility / CSPG4
NM_021979 / male meiosis / HSPA2
NM_005066 / RNA splicing ，nuclear mRNA splicing, via spliceosome / SFPQ
NM_001216 / one-carbon compound metabolism / CA9
NM_016234 / fatty acid metabolism ，lipid metabolism ，metabolism / FACL5
NM_000331 / acute-phase response / SAA1
NM_024573 / unknown / C6orf211
AK127640 / unknown / GRINA
NM_177543 / unknown / PPAP2C
NM_001998 / unknown / FBLN2
NM_003087 / unknown / SNCG
NM_006472 / unknown / TXNIP
NM_018006 / unknown / FLJ10140
NM_012382 / unknown / OSRF
NM_018110 / unknown / DOK4
NM_144568 / unknown / C14orf9
NM_024568 / unknown / CHD1L
NM_015014 / unknown / KIAA0117
NM_017633 / unknown / C6orf37
NM_002276 / unknown / KRT19
BX538238 / unknown / PRO1073
NM_014883 / unknown / FAM13A1
NM_182741 / unknown / MUC1
NM_175868 / unknown / MAGEA6
NM_006751 / unknown / SSFA2