Supplementary Table 4:
Comparison of histology and immunohistochemistry of CD133+ xenotransplanted tumors and original patient tumors.
Patient Tumor / Patient Histology / Patient IHC / Mouse # / Recapitulates Patient Histology? / Recapitulates Patient IHC?1
Desmoplastic
Medulloblastoma / Highly cellular small round blue cell tumor with > 50% nodularity and rosettes: desmoplastic features / Nestin +
Synaptophysin +
GFAP -
MIB-1 30% / 1,2,4 / Yes: small round blue cell tumor with nodularity and rosettes, primitive desmoplastic features / Nestin +
Synaptophysin - GFAP -
MIB-1 50%
Desmin -
2
Medulloblastoma / Highly cellular small round blue cell tumor, anaplastic / Nestin +
Synaptophysin +
GFAP -
MIB-1 15% / 6,7,8 / Yes: small round blue cell tumor, anaplastic / Nestin +
few GFAP+
MIB-1 50%
3
Medulloblastoma / Highly cellular small round blue cell tumor / Nestin +
MAP2 +
GFAP –
MIB-1 50% / 12 / Yes: small round blue cell tumor / Nestin +
few GFAP
MIB-1 80%
4
GBM / Nuclear pleomorphism, mitoses, vascular endothelial proliferation, necrosis / Nestin +
CD133+
GFAP +
MAP2 +
MIB-1 50% / 14,15 / Yes: Nuclear pleomorphism, mitoses, vascular endothelial proliferation, necrosis / Nestin +
CD133+
GFAP +
MAP2 +
MIB-1 75%
5
GBM / Nuclear pleomorphism, mitoses, vascular endothelial proliferation, necrosis / Nestin +
CD133+
GFAP +
MAP2 +
MIB-1 60%
p53 + / 20,21 / Yes: Nuclear pleomorphism, mitoses, vascular endothelial proliferation, necrosis / Nestin +
CD133+
GFAP +
MAP2 +
MIB-1 70%
p53+
6
GBM / Pleomorphic tumour with abundant bizarre multinucleated cells and 4 classical GBM diagnostic features / Nestin +
Vimentin+
GFAP +
MAP2 +
p53 +
MIB-1 40-90% / 25,26 / Yes: Pleomorphic tumour with abundant bizarre multinucleated cells and 4 classical GBM diagnostic features / Nestin +
p53 +
GFAP +
7
GBM / Highly anaplastic diffusely infiltrating tumour with 4 classical GBM diagnostic features / - / 29, 30, 31 / Yes: Highly anaplastic diffusely infiltrating tumour / Nestin +
p53 +
GFAP +