Table 1 (Supplemental): Clinical characteristics of endometrial cancer cases

Black / White
N / % / N / %
Histology
Endometrioid / 356 / 69% / 4956 / 87%
Clear cell / 15 / 3% / 63 / 1%
Serous / 46 / 9% / 220 / 4%
MMMT / 46 / 9% / 87 / 2%
Mixed / 11 / 2% / 92 / 2%
Mucinous / 5 / 1% / 96 / 2%
Other / 20 / 4% / 119 / 2%
Unknown / 17 / 3% / 60 / 1%
Grade
1 / 68 / 13% / 1644 / 29%
2 / 109 / 21% / 1199 / 21%
3 / 109 / 21% / 627 / 11%
4 / 25 / 5% / 109 / 2%
Unknown / 205 / 40% / 2114 / 37%
Stage (SEER)
Local / 224 / 43% / 3100 / 54%
Regional / 79 / 15% / 511 / 9%
Distant / 36 / 7% / 131 / 2%

Table 2 (Supplemental): Associations between subject characteristics, risk factors, and endometrial cancer excluding women who report estrogen only hormone therapy use, by race

Blacks (n=1,616) / White (n=13,946)
Cases (n=442) / Controls (n=1,174) / ORa / (95% CI) / Cases (n=4,172) / Controls (n=9,774) / ORa / (95% CI)
BMI
< 18.5 / 8 / 22 / Ref / 66 / 240 / Ref
18.5-24.9 / 57 / 316 / 1267 / 4772
25-29.9 / 110 / 378 / 1.62 / (1.10-2.39) / 1079 / 2874 / 1.49 / (1.35-165)
≥ 30 / 264 / 455 / 3.48 / (2.40-5.03) / 1757 / 1887 / 3.55 / (3.20-3.93)
Unknown / 3 / 3 / - / - / 3 / 1 / - / -
p-trend / <.001 / <.001
Education
Up to HS graduate / 213 / 525 / Ref / 1227 / 2782 / Ref
Post-high school / 217 / 617 / 0.91 / (0.69-1.21) / 2886 / 6864 / 1.04 / (0.95-1.15)
Unknown / 12 / 32 / - / - / 59 / 128 / - / -
Smoking
Never / 211 / 490 / ref / 2118 / 4728 / ref
Past / 135 / 411 / 0.73 / (0.56-0.97) / 1410 / 3479 / 0.86 / (0.79-0.94)
Current / 51 / 206 / 0.72 / (0.49-1.05) / 289 / 1136 / 0.63 / (0.54-0.73)
Unknown / 45 / 67 / - / - / 355 / 431 / - / -
Oral Contraception
Never / 251 / 678 / ref / 2322 / 5416 / ref
Ever / 184 / 482 / 1.16 / (0.88-1.53) / 1809 / 4253 / 1.07 / (0.98-1.17)
Unknown / 7 / 14 / - / - / 41 / 105 / - / -
Never (up to 1 yr) / 293 / 752 / ref / 2447 / 5306 / ref
1-4 years / 68 / 177 / 0.67 / (0.39-1.15) / 766 / 1519 / 1.03 / (0.86-1.25)
5-9 years / 38 / 110 / 0.83 / (0.45-1.51) / 425 / 1028 / 0.93 / (0.76-1.14)
10+ years / 27 / 97 / 0.58 / (0.30-1.11) / 253 / 1013 / 0.54 / (0.43-0.68)
Unknown / 16 / 38 / - / - / 281 / 908 / - / -
p-trend / 0.210 / <.001
Nulliparityb
Nulliparous / 66 / 121 / 1.55 / (1.07-2.25) / 957 / 1542 / 1.66 / (1.50-1.85)
1 or more births / 369 / 1031 / ref / 3177 / 8164 / ref
Unknown / 7 / 22 / - / - / 38 / 68 / - / -
Parity
Nulliparous / 66 / 121 / ref / 957 / 1542 / ref
1 / 65 / 155 / 0.80 / (0.50-1.28) / 473 / 991 / 0.72 / (0.62-0.84)
2 / 79 / 247 / 0.61 / (0.39-0.96) / 1197 / 2675 / 0.70 / (0.62-0.79)
3 / 85 / 217 / 0.75 / (0.48-1.17) / 948 / 2687 / 0.55 / (0.48-0.62)
4 / 65 / 158 / 0.78 / (0.48-1.25) / 385 / 1145 / 0.50 / (0.43-0.59)
5+ / 75 / 254 / 0.40 / (0.25-0.63) / 174 / 666 / 0.35 / (0.28-0.44)
Unknown / 7 / 22 / - / - / 38 / 68 / - / -
p trend / <.001 / <.001
Age at first birthc
Never gave birth / 66 / 121 / - / - / 957 / 1542 / - / -
Less than 20 / 155 / 450 / ref / 439 / 1015 / Ref
20 to 24 / 123 / 332 / 1.16 / (0.84-1.60) / 1532 / 3769 / 1.00 / (0.86-1.15)
25 to 29 / 51 / 131 / 1.47 / (0.96-2.25) / 853 / 2328 / 0.89 / (0.76-1.04)
30+ years / 29 / 84 / 1.32 / (0.78-2.23) / 359 / 1045 / 0.82 / (0.68-0.99)
Unknown / 18 / 56 / - / - / 32 / 75 / - / -
p trend / 0.09 / 0.01
Age at menarche
Less than 10 / 12 / 19 / 1.10 / (0.76-1.59) / 87 / 81 / 1.28 / (1.14-1.44)
10 to 11 / 67 / 150 / 800 / 1297
12 to 13 / 210 / 548 / ref / 2117 / 4823 / ref
14 to 15 / 126 / 405 / 0.93 / (0.71-1.24) / 1056 / 3276 / 0.86 / (0.78-0.95)
16+ years / 20 / 44 / 89 / 249
Unknown / 7 / 8 / - / - / 23 / 48 / - / -
Diabetes
No / 295 / 932 / ref / 3154 / 8580 / ref
Yes / 107 / 193 / 1.52 / (1.12-2.07) / 637 / 700 / 1.32 / (1.16-1.51)
Unknown / 40 / 49 / - / - / 381 / 494 / - / -
Hypertension
No / 118 / 334 / ref / 1480 / 3451 / ref
Yes / 185 / 471 / 0.90 / (0.65-1.23) / 1137 / 2517 / 0.99 / (0.89-1.10)
Unknown / 139 / 369 / - / - / 1555 / 3806 / - / -

(a) Adjusted for age, BMI, smoking, OC use, diabetes, study site, age at menarche, and parity as a continuous variable.

(b) Adjusted for age, BMI, smoking, OC use, diabetes, study site, and age at menarche.

(c) Excludes women who never gave birth.