Category / Fold after PACAP for
Gene Name / 1/4 h / 24 h / 96 h
Peptides / Hormones / Transmitters
ATL-derived PMA-responsive peptide / 1.64 / 1 / 1
C-type natriuretic peptide I precursor / 1 / 1 / -2.05
Ephrin-A5 / 1 / 1.64 / 1
Follicle stimulating hormone (FSH), beta polypeptide / 2.3 / 1 / 1
Galanin / 1 / 1 / -3.29 / *
Gastrokine 2 / 1 / 1 / -2.27
Glycoprotein M6A / 1 / 1 / -1.58
Neuromedin U / 1.78 / 2.82 / 7.18 / *
PACAP / 3.77 / 1 / 1 / *
Prepronociceptin / 1.66 / 1.78 / 1
Preprourotensin II / 9.23 / 5.77 / 1 / *
Prepro-urotensin II-related peptide / 2.85 / 3.06 / 1 / *
Proenkephalin / 1 / 2.59 / 4.7 / *
Prolactin-b / 3.13 / 3.58 / 1.59 / *
Tcte-1 peptide / 1 / 1 / -1.97
Urocortin 3 / 5.82 / 13.01 / 1 / *
Peptide processing enzymes
Carboxypeptidase Z / 1 / 1.89 / 1
Endothelin converting enzyme-like 1 / 1 / 1 / -2.01
HtrA serine peptidase 3 / 1 / 1.56 / 1
Peptidylglycine alpha-amidating monooxygenase / 1.76 / 1 / 1
Growth factors / Cytokines / Chemokines
Angiopoietin Y1 / 1 / 1 / 1.5
Angiopoietin-2B (Ang-2B) / 1 / 1 / 1.73
Bone morphogenic protein (BMP) 7 (osteogenic protein 1) / 1 / 1 / -2.71
BMP 2 / 2.01 / 1 / 1
CCR4 carbon catabolite repression 4-like (S. cerevisiae) / 1.94 / 1 / 1
Chemokine K203 / 1 / 1 / 2.49
Fibroblast growth factor (FGF) 7 / 3.49 / 1 / 1 / *
FGF 10 / 1 / 1 / 1.9
FGF 12 / 1 / 1.58 / 1
FGF 13 / 1 / 1.64 / 1
FGF 14 / 1 / 1.51 / 1
FGF 19 / 1 / 1 / -2.29
Follistatin / 3.37 / 1 / 1 / *
Follistatin-like 4 / 2.04 / 1 / 1
Hepatoma-derived growth factor, related protein 3 / 1 / 1 / -1.55
Interleukin 16 (lymphocyte chemoattractant factor) / -1.84 / 1 / 1.58
Interleukin 6 (interferon, ) / -1.82 / 1 / 1
Nerve growth factor (NGF), / 1.93 / 1 / 1
Neuregulin 4 / 1 / 1 / -1.74
Neuronal growth regulator 1 / 1 / -1.66 / -2.62
Oxidative stress induced growth inhibitor 1 / 1 / 1 / 1.73
Platelet derived growth factor (PDGF) D / 1 / 1 / 1.73
RANTES factor of late activated T lymphocytes-1 / 1 / 1 / 1.53
Suppressor of cytokine signaling 1 / -1.99 / -1.79 / 1
Suppressor of cytokine signaling 2 / -1.84 / 1 / 1
Table 1. Continued
Category / Fold after PACAP for
Gene Name / 1/4 h / 24 h / 96 h
Growth factors / Cytokines / Chemokines (Continued)
TAFA1 / 1 / 1 / -1.67
Tumor necorosis factor (TNF) alpha-induced protein 8-like 3 / 1.81 / 2.44 / 1
TNF alpha-induced protein 2 / 1 / 3.29 / 1 / *
TNF ligand superfamily member 4 / -1.66 / 1 / 1
Transforming growth factor, beta 3 / 1 / 2.51 / 2.15
Receptors / Effector / Associated proteins
5-hydroxytryptamine receptor 2C / 1.58 / 1 / 1
5-hydroxytryptamine 2C receptor / 2.28 / 1.71 / 1
Acetylcholine (ACh) receptor, muscarinic 4 (mAChR 4) / -1.74 / 1 / -1.51
ACh receptor, nicotinic, alpha 5 (5-nAChR) / 1 / 1 / -2.51
ACh receptor, nicotinic, alpha 7 (7-nAChR) / 1 / 1.97 / 1
Adenosine A1 receptor / 1.51 / 1.64 / 1.5
Alpha1A-adrenoceptor / 1 / 1 / -1.79
Anaplastic lymphoma kinase receptor / 1 / 1.87 / 1
Arrestin domain containing 3 / 2.24 / 1 / 1
Brain-specific angiogenesis inhibitor 3 / -1.63 / 1 / 1
Calcium and integrin binding family member 2 / -1.53 / 1 / 1
Cannabinoid receptor 1 (brain) / 1 / 1.96 / 1
CD36 molecule (thrombospondin receptor) / 1 / 1 / 1.69
CD47 molecule / 1.63 / 1.55 / 1
CD82 molecule / 1 / 1 / 1.64
C-mer proto-oncogene tyrosine kinase / 1 / 1 / 1.53
Coagulation factor II (thrombin) receptor-like 1 / 1 / 1 / 1.62
Complement receptor 1 / 1.66 / 1 / 1
Copine IV / 1 / -1.52 / -1.66
Delta/notch-like EGF repeat containing / 1 / 1 / -1.65
Dopamine receptor, D1 / 2.17 / 1 / 1
Eph receptor A3 / -1.5 / 1 / 1
Eph receptor A5 / 1 / 1 / -1.74
Eph receptor A7 / -1.65 / 1 / -1.94
Fms-related tyrosine kinase 1 / 1 / 1 / -1.53
FSH receptor / -1.66 / -1.86 / -1.6
G protein-coupled receptor 1 / 1 / 1 / 1.56
Glutamate receptor, ionotrophic, AMPA 3 / 1 / -1.59 / -1.92
Glutamate receptor, metabotropic 4 (mGluR4) / 1 / -1.92 / -2.19
Glutamate receptor, metabotropic 8 (mGluR8) / -1.66 / -1.71 / 1
Glutamate receptor, metabotropic 8 (mGluR8) / 1 / 1 / -1.84
GPCR 23 / 1 / 1 / 1.52
G-protein-coupled receptor (GPCR) 149 / 2.29 / 1 / -1.53
Interleukin 1 receptor, type I / 1.5 / 1 / 2.89
Interleukin 1 receptor-like 1 / 1 / -1.62 / -3.19 / *
Interleukin 13 receptor, alpha 2 / 1 / 1 / 1.94
Interleukin 20 receptor, alpha / 1.92 / 2.99 / 1
Interleukin 23 receptor / 1.53 / 1 / 1
Interleukin 7 receptor / 1 / -1.52 / 1
KIAA0550 protein / -1.52 / 1 / 1
Liprin-beta-2 / -1.5 / 1 / 1
Melatonin receptor 1B / 1 / -2.07 / -2.6
Membrane associated guanylate kinase-like protein; DLGH3 / 1 / 1.66 / 1
Metabotropic glutamate receptor 8b (mGluR 8b) / 1 / 1 / -1.71
Table 1. Continued
Category / Fold after PACAP for
Gene Name / 1/4 h / 24 h / 96 h
Receptors / Effector / Associated proteins (Continued)
Metabotropic glutamate receptor 7 (mGluR7) / 1 / 1 / -1.55
mKIAA1232 protein / 1 / 1.51 / 1
Neurotrophic tyrosine kinase, receptor, type 2 (TrkB) / 1.62 / 1 / -1.82
Nuclear receptor subfamily 2, group C, member 2 / -1.76 / 1 / 1
Nuclear receptor subfamily 4, group A, member 2 / 1.85 / 1 / 1
Nuclear receptor subfamily 4, group A, member 3 / 2.16 / 1 / 1
P2Y-like G-protein coupled receptor / 1 / 1 / -1.52
PACAP Type I Receptor (PAC1) / 1 / 1.78 / 1
Parathyroid hormone receptor 1 / 1 / 2.40 / 1
PDZ domain-containing guanine nucleotide exchange factor PDZ-GEF2 / -1.64 / 1 / 1
Pleckstrin homology domain containing, family B (evectins) member 1 / 1 / 1 / -1.53
Plexin A2 / 1 / 1 / 1.95
Plexin A2 / 1 / 1.88 / 1
Plexin-A4 / 1 / 2.12 / 1
Prostaglandin E receptor 4 (subtype EP4) / 1.97 / 1 / 1
Protein tyrosine phosphatase, receptor type, B / 1 / 1.85 / 1
Protein tyrosine phosphatase, receptor type, O / 1 / 1 / -1.78
Putative membrane steroid receptor / 1 / -1.58 / 1
RAP1, GTP-GDP dissociation stimulator 1 / 1 / 2.7 / 1.81
Rap2 interacting protein x / 1 / 1 / -1.51
Receptor (G-protein-coupled) activity modifying protein 3 / 1 / -1.65 / 1
Receptor tyrosine kinase-like orphan receptor 1 / -1.51 / 1 / 1
Regulator of G-protein signalling 17 / 1 / 1 / -1.75
Regulator of G-protein signalling 2, 24kDa / 1.75 / 1 / 1
Regulator of G-protein signalling 20 / 1 / 1 / -1.74
Regulator of G-protein signalling 3 / -2.3 / 1 / 1
Regulator of G-protein signalling 4 / 1 / -1.83 / -2.81
Regulator of G-protein signalling 7 / 1 / 1.91 / 1
Reticulon 4 receptor / -4.96 / 1 / 1.5 / *
Retinal G-protein coupled receptor / 1 / 1.68 / 1
SAM domain and HD domain 1 / 1 / 1 / -1.59
Scavenger receptor class B member 1 / 1 / 1 / -1.59
SH3-domain GRB2-like 2 / 1 / 1.72 / 1
Homer-1b / 1 / 1 / -1.56
Sortilin-related VPS10 domain containing receptor 3 / -1.71 / 1 / 1
Sulfonylurea receptor / 1 / 1 / -1.63
Syndecan 3 / 1 / 1.76 / 1
Teneurin 2 / 1 / 1 / -1.69
Toll-like receptor 7 / 1 / 1 / 1.5
Transient receptor potential cation channel, subfamily C, member 4 / 1 / 1 / -2.01
Transient receptor potential protein / 1 / 1 / 1.56
Transient receptor potential protein-like mRNA, partial sequence / 1 / 1 / 1.52
Tumor necrosis factor receptor superfamily, member 6b, decoy / 1.85 / 1.82 / 1
Tumor-associated calcium signal transducer 1 / 1 / 1.53 / 1
TYRO3 protein tyrosine kinase / 1.66 / 1 / 1
Very low density lipoprotein receptor / -1.5 / 1 / 1
Vitamin D (1,25- dihydroxyvitamin D3) receptor / 1.83 / 1 / 1
Wiskott-Aldrich Syndrome Protein family, member 3 (WASF3) / -1.55 / 1 / -1.73
Transcriptional factors / Associated proteins
Achaete-scute complex homolog 1 (Drosophila) / 1 / 1 / -1.98
Table 1. Continued
Category / Fold after PACAP for
Gene Name / 1/4 h / 24 h / 96 h
Transcriptional factors / Associated proteins (Continued)
Activating transcription factor 3 / 1.59 / -1.97 / 1
AF4/FMR2 family, member 3 / -1.55 / 1 / 1
-cell CLL/lymphoma 6 (zinc finger protein 51) / 1.58 / 1 / 1
bHLH factor Math6 / 1.79 / 1 / 1
bHLH protein Hesr-1/Hey1 / 1 / 1.57 / 1
Bromodomain adjacent to zinc finger domain, 1B / -1.7 / 1 / 1
BTB (POZ) domain containing 8 / 1 / 1.63 / 1
Cajalin 2 / 1 / 1 / -1.52
CCAAT/enhancer binding protein (C/EBP), beta / 1 / 1 / 1.51
Chromobox homolog 4 (Pc class homolog, Drosophila) / 1.54 / 1 / 1
Core histone macroH2A2.2 / 2.43 / 1 / 1
Cyclic AMP responsive element binding protein-like 2 / 1 / 1 / -1.51
Cysteine-rich secretory protein LCCL domain containing 1 / 1 / 1 / 1.78
Dickkopf homolog 1 (Xenopus laevis) / 1 / -1.88 / 1
DNA helicase HEL308 / -1.51 / 1 / 1
Domesticus (clone 1.6 kB) islet-2 / 1.59 / 1.88 / 1
Early B-cell factor 1 / -1.71 / 1 / -1.57
Early growth response 1 / 2.2 / 1.61 / 1.57
ELL associated factor 2 / 2.37 / 1 / 1
Ets domain protein / 1 / 1.6 / 1.62
Ets variant gene 1 / 1 / 1 / 1.55
GLI pathogenesis-related 1 (glioma) / 1 / 1 / 1.52
GPBP-interacting protein 130b / -1.57 / 1 / 1
Heart and neural crest derivatives expressed 2 (HAND2) / 1.73 / 2.43 / 1
HIV-1 Tat interactive protein 2, 30kDa / 1 / 1 / -1.57
IBR domain containing 1 / 3.11 / 1 / 1 / *
Inducible cAMP early repressor (ICER) / 3.69 / 1 / 1 / *
IKAROS family zinc finger 2 (Helios) / -1.72 / 1 / 1
Interferon regulatory factor 4 / 1.75 / 1 / 1
Interferon regulatory factor 6 / 1 / 1.6 / 1
ISL1 transcription factor, LIM/homeodomain, (islet-1) / 1.68 / 1 / 1
Jumonji domain containing 1C / -1.69 / 1 / 1
Jun dimerization protein p21SNFT / 1.55 / 1 / 1
KIAA0298 protein / 1.56 / 1 / 1
KIAA0940 protein / 1 / 1.55 / 1
KIAA1718 protein / 1.67 / 1 / 1
Kruppel-like factor 7 (ubiquitous) / -1.5 / 1 / 1
Lymphoid enhancer-binding factor 1 / -1.65 / 1 / 1
Mesenchyme homeobox 2 / -1.5 / 1 / 1
Myelin transcription factor 1-like / 1 / 1.53 / 1
Osteoblast regulatory factor 3A / 1.51 / 1 / 1
Piwi-like 1 (Drosophila) / 1 / 1.9 / 1
Probox protein / 1 / 1 / 1.52
Rel-associated pp40 (LOC396093), mRNA / 1 / 1.57 / 1
Single stranded DNA binding protein-2 / 1 / 1.59 / 1
SRY (sex determining region Y)-box 11 / -1.58 / 1 / 1
SRY (sex determining region Y)-box 5 / -1.59 / 1 / 1
synovial sarcoma translocation gene on chromosome 18-like 1 / -1.64 / 1 / 1
T-box 20 / 1 / 1.68 / -1.62
teashirt family zinc finger 1 / 1.55 / 1 / 1
Teashirt family zinc finger 3 / 1 / 1 / -1.78
Table 1. Continued
Category / Fold after PACAP for
Gene Name / 1/4 h / 24 h / 96 h
Transcriptional factors / Associated proteins (Continued)
Transcription elongation regulator 1-like / 1 / 1.69 / 1
Transcription factor 7-like 2 (T-cell specific, HMG-box) / 1 / 1.6 / 1
Transcription factor AP-2 gamma / -1.58 / 1 / 1
V-ets erythroblastosis virus E26 oncogene / 1 / 1 / 1.5
V-fos FBJ murine osteosarcoma viral oncogene homolog / 1.62 / 1 / 1
V-maf musculoaponeurotic fibrosarcoma oncogene homolog A / 1 / 1 / 1.84
V-myc myelocytomatosis viral related oncogene, neuroblastoma derived / -1.64 / 1 / 1
Yes-associated protein 1, 65kDa / -1.59 / 1 / 1
Zinc finger and BTB domain containing 38 / -1.64 / 1 / 1
Zinc finger protein 238 / 1.56 / 1 / 1
Zinc finger protein 291 / 1.55 / 1 / 1
Zinc finger protein 295 / -1.56 / 1 / 1
Zinc finger, FYVE domain containing 28 / 1.75 / 1 / 1
Zinc finger, matrin type 4 / 1 / 1.6 / 1
Intracellular signal transduction molecules
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 / 1.55 / 1 / 1
Abl interactor gene family, member 3 (Abi-3; NESH) / 1 / 1 / -2.65
Adenylate cyclase / 1 / 1 / -1.65
Ankyrin repeat and kinase domain containing 1 / 1.57 / 1 / 1
Ankyrin repeat domain 9 / 1 / 1.85 / 1
ARPP-21 protein / 1 / 1.73 / 1
Ataxin 2-binding protein 1 / 1 / 1 / -1.68
BC033915 protein / 1 / 1.51 / 1
Calcipressin 1 large / 1.63 / 1 / 1
Calcium/calmodulin-dependent protein kinase ID / 1.51 / 1 / 1
Calcium/calmodulin-dependent serine protein kinase (MAGUK family) / -1.5 / 1 / 1
Calmodulin-dependent phosphodiesterase / 1 / 1 / -2.3
Cas-Br-M (murine) ecotropic retroviral transforming sequence b / 1.82 / 1 / 1
Caspase recruitment domain protein 7 / -1.7 / 1 / 1
Centaurin, gamma 3 / 1.5 / 1 / 1
Chondrolectin / 1 / -1.92 / -1.93
Dedicator of cytokinesis 9 / 1 / 1.87 / 1
Dedicator of cytokinesis protein 9 / 1 / 1.72 / 1
Diacylglycerol kinase, theta 110kDa / 2.32 / 1 / 1
Downstream of tyrosine kinase 5 / 1 / 1 / -1.74
Dual specificity phosphatase 1 / 1.73 / 1 / 1
Dystrobrevin alpha / 1 / 1 / -1.56
Engulfment and cell motility 1 isoform 1; ced-12 homolog 1 / -1.5 / 1 / 1
FYN oncogene related to SRC, FGR, YES / 1 / 1 / -1.56
GTPase activating Rap/RanGAP domain-like 4 / 1 / 1.88 / 1
GTP-binding protein SB128 / 1.62 / 1 / 1
Guanine nucleotide binding protein (G protein), alpha inhibiting activity 1 / 1 / 1 / -1.51
JNK3 beta2 protein kinase / 1 / 1.76 / 1
Kelch repeat and BTB (POZ) domain containing 2 / 1 / -1.53 / 1
KIAA0712 protein / -1.69 / 1 / 1
KIAA0882 protein / 1 / 1 / -1.55
KIAA1700 protein / 1 / 1 / 1.53
LOC540879 protein / 1 / 1 / 1.52
MGC81705 protein / 1.53 / 1 / 1
MGC83985 protein / -1.54 / 1 / 1
Table 1. Continued
Category / Fold after PACAP for
Gene Name / 1/4 h / 24 h / 96 h
Intracellular signal transduction molecules (Continued)
Mitogen-activated protein kinase 10 / 1 / 1.5 / 1
Mitogen-activated protein kinase 8 / 1 / 1.6 / 1
Muscle RAS oncogene homolog / 1 / 1 / -1.67
Neuroepithelial cell transforming gene 1 / 1.6 / 1 / 1
NOD3 protein; CARD15-like / 1.84 / 1 / 1
Nuclear factor of kappa light polypeptide gene enhancer inhibitor, zeta / 1.63 / 1 / 1
OTTHUMP00000016670 / 1 / 1 / -1.59
PCTAIRE protein kinase 2 / 1.6 / 1 / 1
Phosphatidylinositol 3-kinase regulatory subunit alpha / 1 / -1.52 / -1.84
Phosphodiesterase 10A / 1.67 / 1.51 / 1
Phosphodiesterase 3B, cGMP-inhibited / 2.35 / 1 / 1
Phosphodiesterase 4B, cAMP-specific / 2.44 / 1 / 1
Phosphodiesterase 7B / 1.54 / 1 / 1
Phosphodiesterase 8A / 1 / 1 / 1.53
Phosphodiesterase 8B / 1.63 / 1 / 1
Phosphoinositide-3-kinase, catalytic, beta polypeptide / 1.73 / 1 / 1
Phosphoinositide-3-kinase, regulatory subunit 5, p101 / 1.62 / -1.53 / 1
phospholipase C, beta 1 (phosphoinositide-specific) / 1 / 1.66 / 1
Phospholipase C, eta 1 / 1.97 / 1 / 1
Phosphoprotein associated with glycosphingolipid microdomains 1 / -1.74 / 1 / 1
Pim-3 protein / 3.27 / 2.25 / 1 / *
PREX1 protein / -1.72 / 1 / 1
Protein kinase C, eta / 1.98 / 1 / 1
Protein kinase C, eta / 2.21 / 1.74 / 1
Protein phosphatase 1, regulatory (inhibitor) subunit 14C / 1 / 2.17 / 1.57
Protein phosphatase 1, regulatory (inhibitor) subunit 9A / 1 / 1 / -1.51
Protein phosphatase 1B (formerly 2C), magnesium-dependent, beta isoform / 1 / 1 / -1.75
Protein phosphatase 2C, magnesium-dependent, catalytic subunit / 1 / -1.67 / 1
Protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform / 1 / 1 / -1.57
Protein tyrosine phosphatase, non-receptor type 2 / 1.63 / 1 / 1
Putative serine/threonine kinase SADA gamma / 1 / 1 / -1.52
RAB15 / 1 / 1 / -1.57
Rab26 protein / 1 / 1 / -2.29
RAB31, member RAS oncogene family / 1 / 1 / 1.57
RAP1 GTPase activating protein / 1 / 1.61 / 1
Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 / -1.52 / 1 / 1
RAS guanyl releasing protein 3 (calcium and DAG-regulated) / 1 / 1 / 1.99
RAS p21 protein activator 3 / -1.58 / 1 / 1
RAS, dexamethasone-induced 1 / 1.91 / 1 / 1.86
RAS-like, estrogen-regulated, growth inhibitor / 1 / 1.55 / 1
RAS-like, family 11, member A / 1 / -1.96 / 1
Rho GTPase activating protein 20 / 1.85 / 1 / 1
Rho GTPase activating protein 24 / 1 / 1 / 1.54
Rho guanine nucleotide exchange factor (GEF) 17 / 1 / 2.12 / 1
Rho-GAP domain containing protein ARHGAP12b / 1.58 / 1 / 1
Ring finger and FYVE-like domain containing 1 / 1.56 / 1 / 1
Serine/threonine kinase 17b / -1.56 / 1 / 1.62
Serine/threonine kinase 32A / 1 / 1 / -1.54
Serine/threonine kinase 32B / 1 / 1 / -1.77
Serum/glucocorticoid regulated kinase family, member 3 / 1 / 1 / 1.51
SH3 and cysteine rich domain / 1.82 / 1.93 / 1
Table 1. Continued
Category / Fold after PACAP for
Gene Name / 1/4 h / 24 h / 96 h
Intracellular signal transduction molecules (Continued)
SLIT-ROBO Rho GTPase activating protein 1 / 1.5 / 1 / 1
SNF1-like kinase / 2.74 / 1 / 1
Sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3 / 1 / 2.26 / 1
Sperm associated antigen 9 / 1 / 1 / -1.52
Sprouty homolog 2 (Drosophila) / -1.74 / 1 / 1
TBC1 domain family, member 4 / 1 / 1 / -1.55
Tec protein tyrosine kinase / 1 / 1.72 / 1.87
V-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) / 1 / 1.54 / 1
Vav 2 oncogene / 1 / -1.6 / 1
Channels / Carriers / Pumps
ATPase, Na+/K+ transporting, beta 1 polypeptide / 1 / 1.58 / 1
BA305P22.2.1 (novel protein, isoform 1) / 1 / 1.58 / 1
Breast carcinoma amplified sequence 1 / 1 / 1.56 / 1
Calcium channel, voltage-dependent, beta 4 subunit / 1 / 1 / -1.62
Calcium channel, voltage-dependent, gamma subunit 2 / 1 / 1.89 / 1
Calcium channel, voltage-dependent, gamma subunit 4 / 1 / 1.56 / 1
ChaC, cation transport regulator homolog 1 (E. coli) / 1.5 / 1 / 1
Facilitative glucose transporter GLUT11 / 1 / 1 / -1.52
Kv channel interacting protein 4 / 1 / 1.56 / 1
Leucine-rich, glioma inactivated 1 / 1 / -1.85 / -1.74
Potassium channel tetramerisation domain containing 3 / -1.62 / 1 / 1
Potassium voltage-gated channel, shaker-related subfamily, member 2 / -1.5 / 1 / 1
Potassium voltage-gated channel, subfamily G, member 4 / -1.91 / 1.84 / 1
Solute carrier family 16, member 10; T-type amino acid transporter 1 / 1 / 1.5 / 1
Solute carrier family 16, member 3 (monocarboxylic acid transporter 4) / 2.49 / 1 / 1
Solute carrier family 16, member 6 (monocarboxylic acid transporter 7) / 1.91 / 1 / 1
Solute carrier family 16, member 9 (monocarboxylic acid transporter 9) / 1 / 1 / -1.5
Solute carrier family 18 (vesicular acetylcholine transporter), member 3 / 1 / 2.81 / 1
Solute carrier family 22 (organic cation transporter), member 4 / 1 / -1.51 / 1
Solute carrier family 5 (high-affinity choline transporter), member 7 / 2.15 / 2.79 / 1
Solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 / 2.11 / 3.56 / 2.84 / *
Solute carrier family 6 (neurotransmitter transporter, taurine), member 6 / 1 / 1.56 / 1
Solute carrier family 7 (cationic amino acid transporter, y+ system), member 14 / 1 / 2.07 / 1
Solute carrier family 9 (sodium/hydrogen exchanger), member 9 / 1 / 2.08 / 1
TASK-1 potassium channel / 1 / 1 / -2.26
Voltage-dependent calcium channel gamma-5 subunit / 1 / 2.22 / 1.89
Voltage-gated calcium channel alpha2/delta-1 subunit / 1 / 1 / -2.34
Voltage-gated potassium channel / 1 / 1.81 / 1
Cell cycle / Proliferation / Differentiation
AXIN1 up-regulated 1 / 2.03 / 1 / 1
BCL2-related protein A1 / 1 / 1 / 1.55
BMP/Retinoic acid-inducible neurai-specific protein-2 / 1 / -1.75 / -1.57
Brain-specific protein p25 alpha / 1 / 1 / -1.87
C6orf37 / 1.57 / 1 / 1
Carbonic anhydrase II / 1 / 1.94 / 2.34
Centrosomal protein 192kDa / 2.91 / 1 / 1
C-Maf-inducing protein / 1.57 / 1.78 / 1
Coiled-coil domain containing 57 / 2.33 / 1 / 1
Table 1. Continued
Category / Fold after PACAP for
Gene Name / 1/4 h / 24 h / 96 h
Cell cycle / Proliferation / Differentiation (Continued)
Cyclin-dependent kinase-like 5 / 1.52 / 1 / 1
DBCCR1-like / -1.56 / 1 / 1
Development and differentiation enhancing factor 1 / -1.55 / 1 / 1
Dopey family member 1 / 1.55 / 1 / 1
Echinoderm microtubule associated protein like 1 / 1 / 1.53 / 1
EGF-like repeats and discoidin I-like domains 3 / 1 / 1 / -1.7
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B) / 1.56 / 1 / -1.53
Epithelial membrane protein 1 / 1.51 / 1 / 1
Epithin / 3.28 / 1 / 1 / *
Fibroblast activation protein, alpha / 1 / 1 / 1.62
Frizzled homolog 9 (Drosophila) / 1 / 1 / -1.97
Ganglioside-induced differentiation-associated protein 1-like 1 / 1 / 1 / -2.07
Growth arrest and DNA-damage-inducible, alpha / 3.14 / 1 / 1 / *
Growth arrest and DNA-damage-inducible, gamma / 1 / 1 / -1.52
Human homolog of Drosophila lethal discs large 1 / 1 / 1.92 / 1
Human phosphotyrosine phosphatase kappa / 1 / 1.68 / 1
Inhibin, beta A (activin A, activin AB alpha polypeptide) / 1.57 / 1 / 1
Lethal giant larvae homolog 2 (Drosophila) / -1.82 / 1 / 1
Leucine rich repeat containing 4C / -1.56 / 1 / 1
Leucine-rich repeats and immunoglobulin-like domains 3 / 1 / 1 / 1.58
LRRTM1 protein / 1 / 1 / -1.5
Mab-21-like 1 (C. elegans) / 1 / 1 / -2.12
Microfibrillar-associated protein 3-like / 2.18 / 1 / 1
Myc target 1 / -1.51 / 1 / 1.74
Myogenic differentiation 1 / 1 / 1 / 1.85
Naked cuticle homolog 1 (Drosophila) / 1.58 / 1 / 1
Nephroblastoma overexpressed gene / 1 / 2.08 / 1
Neural precursor cell expressed, developmentally down-regulated 9 / 1 / 1 / -1.59
Neuralized homolog (Drosophila) / 1 / 1 / -1.96
Neuronal transmembrane protein Slitrk4 / 1 / 1.58 / 1
Oxidored-nitro domain-containing protein / 1 / 1 / -1.5
P311 POU / 1 / 1 / -1.59
Paired-like homeobox 2b / 1 / 2 / 1
PC1 / 2.61 / 3.95 / 2.09 / *
PDZ domain containing RING finger 3 / -1.68 / 1 / 1
PiggyBac transposable element derived 5 / 2.26 / 1 / 1
Polo-like kinase 2 (Drosophila) / -1.55 / 1 / 1
Polycystic kidney and hepatic disease 1 / -1.51 / 1 / 1
Quiescence-specific protein / 1 / 1 / -1.6
Retinoic acid receptor responder (tazarotene induced) 1 / 1.67 / 2.39 / 1.57
R-spondin 3 homolog (Xenopus laevis) / 1 / 1 / 1.54
Secreted frizzled-related protein 4 / 5.62 / 2.23 / 1 / *
Secreted frizzled-related protein 4 / 9.1 / 3.86 / 1 / *
Sema domain, (semaphorin) 3C / 1 / 1 / 1.69
Serpin peptidase inhibitor, clade F member 1 / 1 / 1 / -1.58
Serpin peptidase inhibitor, clade I (neuroserpin), member 1 / 1 / 1 / -1.63
SHC (Src homology 2 domain containing) transforming protein 3 / 1 / 1.62 / 1
SLIT and NTRK-like family, member 4 / 1 / 1.62 / 1
SLIT and NTRK-like family, member 6 / 1.55 / 1 / 1.6
Snail like protein / -1.52 / 1 / 1
TBC1 domain family, member 2B / -1.57 / 1 / 1
Table 1. Continued
Category / Fold after PACAP for
Gene Name / 1/4 h / 24 h / 96 h
Cell cycle / Proliferation / Differentiation (Continued)
Tetraspanin 15 / 1.63 / 1 / 1
Tetraspanin 7 / 1 / 1 / -1.58
Tissue factor pathway inhibitor (lipoprotein-associated) / 1 / 1 / 1.62
Tissue factor pathway inhibitor 2 / 2.34 / 1 / 1
TOB protein / 1.89 / 1 / 1
Transforming, acidic coiled-coil containing protein 2 / -1.59 / 1 / 1
Transmembrane 9 superfamily protein member 2 precursor (p76) / 1 / 1 / -1.87
Tripartite motif-containing 2 / -1.67 / 1 / 1
Tripartite motif-containing 9 / 1.54 / 1 / 1
Tumor suppressor candidate 3 / 1 / 1 / -1.6
WEE1 homolog (S. pombe) / 1 / -1.6 / 1
WNT inhibitory factor 1 / 1 / 2.03 / 1
Cytoskeleton / Synapse / Junction Organization
Acp1 protein / 1 / 1 / 2.34
Actin binding LIM protein family member 2 / 1 / 1.74 / 1
Actinin, alpha 1 / -1.53 / 1 / 1
Activated leukocyte cell adhesion molecule / 1 / 1.8 / 1
Adhesion molecule with Ig-like domain 2 / 1 / 1.75 / 1
Adipocyte-specific adhesion molecule / 1 / 1 / 1.53
Axonemal dynein heavy chain DNAH5 / 1 / 1 / 1.96
Bicaudal-D / 1 / 1 / -1.99
Cadherin / 1 / 1 / -1.51
Cadherin 20, type 2 / 1 / 1 / -1.67
Cadherin-8 / 1 / 3.47 / 1 / *
Calponin alpha / 1 / 1.64 / 1
Calsyntenin-2 / 1 / 1 / -1.61
Cell adhesion molecule 2 / 1 / 1 / -2.16
Choline acetyltransferase / 1.51 / 2.22 / 1
Clathrin, light chain (Lca) / 1 / 1 / -1.63
CNS specific microtubule-associated protein tau, adult / 1 / 1 / -1.52
Contactin 5 / 1 / 1.51 / 1
Contactin associated protein-like 5 / 1.68 / 1 / 1
Coronin, actin binding protein, 2A / -1.51 / 1 / 1
Cortactin binding protein 2 / 2.77 / 1 / 1
Densin-180 / 1.65 / 1 / 1
Desmoplakin / 1 / 1.56 / 1
Discs, large homolog 2, chapsyn-110 (Drosophila) / 1 / 1.75 / 1
Docking protein 5 / 1 / -1.66 / 1
Doublecortin and CaM kinase-like 2 / 1 / 1 / -1.74
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 / 1 / 1 / -1.58
Epidermal growth factor receptor pathway substrate 15 / 1 / 1.53 / 1
FERM domain containing 4B / -1.63 / 1 / 1
Fibronectin leucine rich transmembrane protein 3 / 1.58 / 1 / 1.58
FLI-LRR associated protein-1 / 1 / 1.95 / 1
Gap junction protein, alpha 9, 36kDa / 1 / 2.32 / 1
Keratin 23 (histone deacetylase inducible) / 1.51 / 1 / 1
KIAA0799 protein / 1 / 1 / 1.57
KIAA0843 protein / 1 / 1 / -1.84
Leucine rich repeat and fibronectin type III domain containing 5 / 1 / 1 / -2.04
LIM and cysteine-rich domains 1 / -1.58 / 1 / 1
Table 1. Continued
Category / Fold after PACAP for
Gene Name / 1/4 h / 24 h / 96 h
Cytoskeleton / Synapse / Junction Organization (Continued)
MAM domain-containing glycosylphosphatidylinositol anchor 2 / 1 / 1 / -1.74
Microfibrillar associated protein 5 / 1 / 1 / -1.63
Mint2; neuronal munc18-1 binding protein / 1 / 1 / -1.6
Myosin regulatory light chain interacting protein / 1 / 1 / 1.94
Myosin, heavy chain 1, skeletal muscle, adult / 1.51 / 1 / 1
Myosin, light chain 4, alkali; atrial, embryonic / 1 / 1 / -1.68
Myozenin 1 / 1 / -1.52 / 1
Neurofilament, medium polypeptide 150kDa / 1 / 1 / -1.73
Neuroligin 1 / 1 / 1.51 / 1
Neuroligin 4, X-linked / 1 / 1.53 / 1
Neuron navigator 2 / 2.18 / 1 / 1
Neuronal pentraxin II precursor (NP-II) (NP2) / 2.34 / 1 / -2.94
Ninjurin 2 / 1 / 1 / 1.62
P+A524rotocadherin alpha subfamily C, 2 / 1 / 1.5 / 1
Pentraxin-related PTX3 / 1 / 1 / 1.5
Protocadherin-9 / 1 / 1.68 / 1.62
Rabconnectin / 1 / 1.56 / 1
Raftlin, lipid raft linker 1 / 1 / 1.61 / 1
Regulating synaptic membrane exocytosis 4 / 1 / -1.94 / 1
RIM4 gamma / 1 / 1 / -2.49
RIMS binding protein 2 / 2.58 / 1.91 / 1
RUN and FYVE domain containing 2 / 1 / 1.64 / 1
Sarcoglycan, epsilon / 1 / 1 / 1.53
Serine/threonine-protein kinase Nek3 (NimA-related protein kinase 3) / 1 / 1 / -1.53
Shank2E / -2.91 / 1.63 / 1
Stathmin-like 3 / 1 / 1 / -1.58
Stathmin-like-protein RB3 / 1 / 1 / -1.91
Synapsin II isoform IIa / 1 / 2.49 / 1
Synaptosomal-associated protein, 91kDa homolog (mouse) / 1 / 1 / -1.64
Synaptotagmin IV / 1.83 / 1.67 / 1
Synaptotagmin VI / 1 / -2.41 / 1
Synaptotagmin XII / 1 / 1.75 / 1
Synuclein, alpha (non A4 component of amyloid precursor) / 1 / 1 / -1.96
Talin 2 / 1 / 1.52 / 1
Taurine transporter / 1 / 1 / 1.55
Tropomodulin 2 (neuronal) / 1 / 1 / -1.52
Tubulin, beta 3 / 1 / 1 / -1.78
Type I hair keratin KA31 / 8.58 / 1.77 / 1 / *
Vesicle-associated membrane protein 2 (synaptobrevin 2) / 2.09 / 1 / 1
Extracellular matrix
ADAM metallopeptidase with thrombospondin type 1 motif, 17 / 1.61 / 1 / 1
ADAM metallopeptidase with thrombospondin type 1 motif, 3 proprotein / 1 / 1 / 1.5
Aggrecanase-2 / 1 / 1 / 1.61
Alpha 1 (V) collagen / 1 / 1 / 1.59
Collagen type XII alpha 1 chain / 1 / 1 / 1.6
Collagen, type III, alpha 1 (Ehlers-Danlos) / 1 / 1 / 1.56
Collagen, type IV, alpha-5 / 1 / 1 / 1.56
Collagen, type IX, alpha 3 / 1 / 1.51 / 1
Collagen, type XII, alpha 1 / 1 / 1 / 1.92
HSAJ1454 / 1 / 1 / 1.83
Table 1. Continued
Category / Fold after PACAP for
Gene Name / 1/4 h / 24 h / 96 h
Extracellular matrix (Continued)
Kallmann syndrome 1 sequence / 1 / 1 / -1.95
Laminin, alpha 1 / 1 / 1 / 1.52
Matrix Gla protein / 1 / 1 / 2.34
Matrix metallopeptidase 2 / 1 / 1 / 1.51
Matrix-remodelling associated 8 / 1 / 1 / 1.52
MMP24 protein / 1 / 1 / -1.65
Neurofascin / 1 / 1 / -1.75
Olfactomedin 3 / 1 / 1 / -1.62
Osteopontin / 1 / 1 / 1.77
Proteoglycan / 1 / 1 / 1.71
Spondin 2, extracellular matrix protein / 1 / 1 / 1.72
Thrombospondin 1 / 1 / 1 / 1.52
Vitronectin / 1 / 1 / -1.84
Metabolism / Homeostasis
3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase-like 1 / 1 / 1 / -2.03
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 / 1.96 / 1 / 1
Acetyl-Coenzyme A acyltransferase 1 / 1 / 1 / 1.72
ADP-ribosylation factor-like 4A / 1.65 / 1 / 1
ADP-ribosylation factor-like 6 / 1 / 1.56 / 1
Aldo-keto reductase family 1, member B10 (aldose reductase) / 1 / 1 / 1.52
Angiotensin I converting enzyme 2 / 1 / -1.55 / 1
Apolipoprotein A-I / 2.01 / 1 / 1
ATP-binding cassette, sub-family A (ABC1), member 1 / 1 / 1 / 2.29
ATP-binding cassette, sub-family B (MDR/TAP), member 4 / 2.1 / 1.68 / 1
ATP-binding cassette, sub-family C (CFTR/MRP), member 8 / 1 / -1.59 / 1
AVIToxin-VAR1 / 1 / 1 / 1.54
Beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P) / 1.62 / 1 / 1
Butyrylcholinesterase / 1 / 1 / -1.6
C9orf77 protein / 2.36 / 1 / 1
Calpain 5 / -1.5 / 1 / 1
Carbonic anhydrase IV / 1 / 1 / -1.55
Carbonic anhydrase-related protein 10 / 1 / 1 / 1.62
Carboxymethylenebutenolidase homolog (Pseudomonas) / 1.67 / 1 / 2.23
Cholesterol 25-hydroxylase / 2.09 / 1.53 / 1
Coagulation factor V (proaccelerin, labile factor) / 1.66 / 1 / 1
Complement component 4 binding protein, alpha / 1.51 / 1 / 1
Cordon-bleu homolog (mouse) / -1.85 / 1 / 1
Core 2 beta-1,6-N-acetylglucosaminyltransferase 3 / 1 / 1 / 2.4
Cytochrome P450 A 37 / 2.53 / 1.57 / 1.62
Cytochrome P450, family 2, subfamily R, polypeptide 1 / 2.8 / 1.62 / 1
Cytochrome P450, family 24, subfamily A, polypeptide 1 / -1.62 / -1.54 / -1.75
Cytochrome P450, family 4, subfamily v / 1.98 / 1 / 1
Cytochrome P450, family 8, subfamily B / 1 / -1.53 / 1
D7H11orf14 protein / 1 / 1.54 / 1
D-cry / 1 / 1 / -1.61
Deiodinase, iodothyronine, type II / 2.3 / -1.6 / 1
Deleted in bladder cancer 1 / -1.8 / 1 / 1
Digestive tract-specific calpain; calcium-dependent cysteine proteinase / 1 / 1 / 1.81
DnaJ (Hsp40) homolog, subfamily C, member 11 / 1.5 / 1 / 1
E.coli 7,8-diamino-pelargonic acid / 1 / 1.6 / 1
Table 1. Continued
Category / Fold after PACAP for
Gene Name / 1/4 h / 24 h / 96 h
Metabolism / Homeostasis (Continued)
Endothelial lipase / 1 / 1 / 1.63
Enhancer binding factor 2C / -2.1 / 1 / 1
Eukaryotic translation initiation factor 2 alpha kinase PEK / 1 / 1 / -1.58
F-box and WD repeat domain containing 7 / 1.63 / 1 / 1
F-box only protein 2 / 1 / 1 / -1.57
F-box protein 32 / 1 / -1.8 / 1
Ferritoid / 1 / 1.64 / 1
Gamma-glutamyltransferase 1 / 1 / -1.53 / 1
Glucosaminyl (N-acetyl) transferase 4, core 2 / 2.73 / 1 / 1
Glutamic pyruvate transaminase (alanine aminotransferase) 2 / 1.87 / 1 / 1
Glutathione S-transferase A1 / 1 / 1 / 1.79
Glutathione S-transferase omega 1 / 1 / 1 / -1.78
Glycosyltransferase 25 domain containing 2 / 1 / 1 / -1.52
Guanylate cyclase 1, soluble, alpha 3 / 1 / 1 / -1.7
Gypsy retrotransposon integrase 1 / 1.57 / 1 / 1
Heat shock 70kDa protein 14 / 2.42 / 1 / 1
Heat shock protein 25 / 1 / 1 / -1.61
Heme oxygenase (decycling) 1 / 1 / 1 / 1.73
Hemopexin / 1 / 1 / -1.7
Heparan sulfate 6-O-sulfotransferase 3 / 1 / 2.76 / 1
Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 2 / 1.78 / 1 / 1
Hyaluronan synthase 2 / 1.56 / 1 / 1
Insulin induced gene 1 / 1 / 1 / -1.56
Iodotyrosine deiodinase / 1 / 1.83 / 1
KIAA1627 protein / 2.03 / 1 / 1
Leucine aminopeptidase 3 / 1 / 1.58 / 1
Leucine rich repeat neuronal 2 / 1 / 1.84 / 1
Leucine rich repeat transmembrane neuronal 3 / 2.44 / 1 / -2.17
Leucine-rich repeats containing F-box protein FBL3 / 1 / 1 / -1.97
Like-glycosyltransferase / 1 / 2.07 / 1
LON peptidase N-terminal domain and ring finger 3 / 1.84 / 1 / 1
Lysozyme G (1,4-beta-N-acetylmuramidase) (Goose-type lysozyme) / 1 / -3.35 / -3.02 / *
Lysozyme G-like 2 / -1.55 / -4.66 / 1 / *
Malin / -1.52 / 1 / 1
MGC82474 protein / 2.07 / 2.21 / 1.99
Myoferlin / 1 / 1 / 1.61
N-acetylglucosamine-6-sulfatase / 1 / 1 / 1.84
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4 / 1 / -1.96 / 1
N-deacetylase/N-sulfotransferase 4 / 1 / 1 / -2.19
Neutrophil cytosolic factor 1 / 1 / 1 / 1.5
Neutrophil cytosolic factor 4, 40kDa / 1 / 1 / 1.52
Oxysterol binding protein-like 6 / 1 / 1.91 / 1
PASK protein / 1.51 / 1 / 1
Peptidase (mitochondrial processing) beta / -1.57 / 1 / 1
Peripheral myelin protein 2 / 1 / 1 / 1.81
Peroxisomal protein (PeP) / 1 / 1.77 / 1
Phosphatidic acid phosphatase type 2B / 2.33 / 1 / 1
Phosphatidic acid phosphatase type 2B / 2.2 / 1 / 1
Phosphatidylglycerophosphate synthase 1 / 2.67 / 1 / 1
Phospholipid transfer protein / 1 / 1 / 1.61
PLCPI=cysteine proteinase inhibitor / 1 / 1 / 2.2
Table 1. Continued
Category / Fold after PACAP for
Gene Name / 1/4 h / 24 h / 96 h
Metabolism / Homeostasis (Continued)
Polypeptide N-acetylgalactosaminyltransferase 17 / -1.68 / 1 / 1
Polypeptide N-acetylgalactosaminyltransferase 9 / 1 / 1.69 / 1
PPM2C protein / 1 / 1 / -1.87
Procollagen C-endopeptidase enhancer 2 / 1 / 1.69 / 1
Prostaglandin D2 synthase 21kDa (brain) / 1 / 1 / -2.05
Prostaglandin-D synthase / 1 / 1 / 1.59
Prostaglandin-endoperoxide synthase 2 / 1 / 1 / 1.57
Protease / 1 / 1.66 / 1.56
Protein phosphatase 1J / 2.2 / 1.64 / 1
PTPN5 protein / 1 / 1.69 / 1
Pyridoxal kinase / 1 / 1.63 / 1
Ribophorin II / 1 / 1 / -1.53
RW1 protein / 1 / 1 / 1.87
SARM1 protein / 1 / 1 / -1.7
Sepiapterin reductase / 1 / 1.85 / 1
Sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase) / 1 / 1.77 / 1
Serine /threonine protein phosphatase / 1 / 1.84 / 1
SMAD specific E3 ubiquitin protein ligase 1 / -1.61 / 1 / 1
Spermidine/spermine N1-acetyltransferase 1 / 1.6 / 1 / 1
Sphingomyelin phosphodiesterase, acid-like 3A / 1 / 1.87 / 1
ST3 beta-galactoside alpha-2,3-sialyltransferase 1 / 1.5 / 1 / 1
ST3 beta-galactoside alpha-2,3-sialyltransferase 5 / 1 / 1.52 / 1
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 / 1 / 1.84 / 1
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 / 1 / 1 / -1.57
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 / 1.99 / 1.62 / 1
STARD3 N-terminal like / 1.9 / 1 / 1
Steryl-sulfatase precursor / 1.84 / 1 / 1
Sulfide quinone reductase-like (yeast) / 1.51 / 1 / 1
Superoxide dismutase 1, soluble / 1 / -1.54 / 1
TIMP metallopeptidase inhibitor 3 / -1.66 / 1 / 1
Topoisomerase (DNA) III alpha / -1.5 / 1 / 1
Trafficking protein particle complex subunit 3 (BET3 homolog) / 1 / 1 / -1.83
Transmembrane and tetratricopeptide repeat containing 2 / 2.4 / 1 / 1
Tyrosine phosphatase / 1 / 1.63 / 1
Ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) / 1 / 1 / -1.68
Ubiquitin specific peptidase 28 / -1.5 / 1 / 1
UDP-N-acetyl-alpha-D-galactosamine / -1.58 / 1.51 / 1
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-6 / 1.84 / 1 / 1
UDP-N-acteylglucosamine pyrophosphorylase 1 / 3.46 / 1.64 / 1 / *
Uridine phosphorylase 1 / 1 / 1 / -1.54
Von Willebrand factor C domain containing 2 / 1 / 1 / -1.5
Miscellaneous
AGPA3119 / 1 / 1 / -1.71
BC022687 protein / 1 / 1 / 1.52
Chromosome 14 open reading frame 135; F protein-binding protein 2 / 1.51 / 1 / 1
Chromosome 2 open reading frame 32 / 1 / 1 / -1.56
Chromosome 20 open reading frame 39 / 1 / 1 / -1.9
Chromosome 6 open reading frame 60 / 1.64 / 1 / 1
Chromosome X open reading frame 23 / 1 / 1 / -1.9
Coiled-coil domain containing 57 / 4.67 / 1.94 / 1 / *
Table 1. Continued
Category / Fold after PACAP for
Gene Name / 1/4 h / 24 h / 96 h
Miscellaneous (Continued)
Ellis van Creveld syndrome / 1 / 1 / -1.55
Family with sequence similarity 123A / 1 / 1 / -1.73
G2 / 1 / 2.27 / 1
GRGP2438 / 1 / 1 / -1.81
Hole / -1.82 / 1 / -1.84
HSPC223 / 1 / 1 / -1.69
IBRDC3 protein / 1 / 1 / -1.5
Interferon-induced protein with tetratricopeptide repeats 5 / -1.5 / -4.78 / 1 / *
KIAA0888 protein / 2.22 / 1 / 1
KIAA1412 protein / 1.70 / 1 / 1
KIAA1867 protein / 1 / 1 / -1.59
KIAA2019 protein / -1.6 / 1 / 1.57
Leucine zipper protein 2 / 1 / 2.16 / 1
LOC387763 protein / 1 / 1 / -1.56
LOC420939 / 1 / 1 / -1.58
LOC443709 protein / 1 / 1 / -1.54
LRTS841 / 3.6 / 2.41 / 1 / *
MGC79481 protein / 1 / 1 / -1.91
mKIAA0515 protein / -1.5 / 1 / 1
Nucleotide binding protein-like / 1 / 1.78 / 1
Period homolog 3 (Drosophila) / 2.14 / 2.52 / 1
Primglo1 / 1.95 / 1 / 1
Putative protein product of HMFN2073 / 1 / 1 / 1.93
Response gene to complement 32 / 2.77 / 1 / 1
Retinoic acid induced 2 / 1 / 1 / -1.58
RIKEN cDNA 2010011I20 / 1 / 1 / 1.81
RIKEN cDNA 5430407P10 / 1 / 1 / -1.94
RIKEN cDNA 6330442E10 gene / 1 / 1.55 / 1
SH3 domain binding glutamic acid-rich protein / 1 / 2.88 / -1.74
Testis specific leucine rich repeat protein / 1 / 1.81 / 1
Transmembrane activator and CAML interactor / 1 / 1.56 / 1
Transmembrane and coiled-coil domain family 3 / 1.68 / 1 / 1
Transmembrane protein 108 / 1.57 / 1 / 1
VLLH2748 / 1 / 1 / 1.84
Table 1. Parasympathetic Neuron Transcripts Regulated by PACAP Treatment. The fold increase or decrease in transcripts produced by each of the indicated PACAP treatments are depicted with values of ≥1.50 or ≤-1.50, respectively. For simplicity, transcripts from treatments that were at levels not significantly different those in untreated controls (p>0.05) are listed with a value of 1. Asterisks (*) depict cases where PACAP up- or down-regulated the indicated transcript by more than 3-fold (See Table 2).