Table 1. DRD2 SNP Genotypic and Allelic Frequenciesa (online)

Genotypes / Alleles
SNP (alleles) / Sample / N / N11 (%) / N12 (%) / N22 (%) / N1 (%) / N2 (%)
-141 INDEL / AN / 180 [98] / 0 (0) / 18 (10) / 162 (90) / 18 (5) / 342 (95)
(1=-, 2=C) / RANb / 96 / 0 (0) / 9 (9) / 87 (91) / 9 (5) / 183 (95)
PANc / 84 / 0 (0) / 9 (11) / 75 (89) / 9 (5) / 159 (95)
Control / 91 [93] / 0 (0) / 14 (15) / 77 (85) / 14 (8) / 168 (92)
IVS2-2730T>C / AN / 114 [86] / 51 (45) / 43 (38) / 20 (18) / 145 (64) / 83 (36)
(1=T, 2=C) / RAN / 59 / 32 (54) / 18 (31) / 9 (15) / 82 (69) / 36 (31)
PAN / 55 / 19 (35) / 25 (45) / 11 (20) / 63 (57) / 47 (43)
Control / 85 [87] / 32 (38) / 40 (47) / 13 (15) / 104 (61) / 66 (39)
932C>G / AN / 174 [95] / 167 (96) / 7 (4) / 0 (0) / 341 (98) / 7 (2)
(1=C, 2=G)
939C>T / AN / 183 [96] / 99 (54) / 77 (42) / 7 (4) / 275 (75) / 91 (25)
(1=C, 2=T) / RAN / 96 / 53 (55) / 40 (42) / 3 (3) / 146 (76) / 46 (24)
PAN / 87 / 46 (53) / 37 (42) / 4 (5) / 129 (74) / 45 (26)
Control / 92 [94] / 53 (58) / 34 (37) / 5 (5) / 140 (76) / 44 (24)
957C>T / AN / 183 [96] / 69 (38) / 82 (45) / 32 (17) / 220 (60) / 146 (40)
(1=C, 2=T) / RAN / 96 / 41 (43) / 41 (43) / 14 (15) / 123 (64) / 69 (36)
PAN / 87 / 28 (32) / 41 (47) / 18 (21) / 97 (56) / 77 (44)
Control / 85 [87] / 29 (34) / 42 (49) / 14 (17) / 100 (59) / 70 (41)
+725 3’G>T / AN / 114 [86] / 86 (75) / 24 (21) / 4 (4) / 196 (86) / 32 (14)
(1=G, 2=T) / RAN / 59 / 46 (78) / 13 (22) / 0 (0) / 105 (89) / 13 (11)
PAN / 55 / 40 (73) / 11 (20) / 4 (7) / 91 (83) / 19 (17)
Control / 88 [90] / 58 (66) / 29 (33) / 1 (1) / 145 (82) / 31 (18)
TaqIA C>T / AN / 122 [97] / 5 (4) / 36 (30) / 81 (66) / 46 (19) / 198 (81)
(1=C, 2=T) / RAN / 63 / 0 (0) / 22 (35) / 41 (65) / 22 (17) / 104 (83)
PAN / 59 / 5 (8) / 14 (24) / 40 (68) / 24 (20) / 94 (80)
Control / 84 [86] / 2 (2) / 35 (42) / 47 (56) / 39 (23) / 129 (77)

a AN : Anorexia Nervosa Sample; Control: European-American Female Control Sample; N total sample size, number in brackets is the completion rate in percent; N11 (%): number and percentage of observed genotype 11; N12 (%): number and percentage of observed genotype 12; N22 (%): number and percentage of observed genotype 22. bRAN=restricting AN probands within the proband sample. cPAN=purging AN probands within the proband sample. Control=EAF control sample.


Table 2. DRD2 SNP case:control contingency analyses (χ2 (p value a)) (online)

AN

/

RANb

/

PANc

Genotypes / Alleles / Genotypes / Alleles / Genotypes / Alleles
-141 INDEL / 1.848 (0.173) / 1.744 (0.187) / 1.564
(0.211) / 1.462
(0.227) / 0.835 (0.361) / 0.776
(0.378)
IVS2-2730T>C / 1.754 (0.416) / 0.244 (0.662) / 4.525 (0.104) / 2.105 (0.147) / 0.538 (0.764) / 0.423
(0.516)
939C>T / 0.898 (0.638) / 0.060 (0.807) / 0.902 (0.622*) / 0.000 (0.992) / 0.594 (0.742*) / 0.182
(0.67)
957C>T / 0.505 (0.777) / 0.080 (0.777) / 1.406 (0.495) / 1.046 (0.306) / 0.506 (0.776) / 0.333
(0.564)
+725 3’G>T / 4.443 (0.099*) / 0.966 (0.326) / 2.870 (0.190*) / 2.415 (0.120) / 5.905 (0.042*) / 0.005
(0.941)
TaqIA C>T / 3.438 (0.173*) / 1.156 (0.282) / 2.423 (0.365*) / 1.450 (0.229) / 6.683 (0.045*) / 0.334
(0.564)

aAll χ2 and p values reported are Pearson χ2 and p values, except in cases where cell size <6, and Fisher (*) two-sided significance tests are reported. bRAN=restricting AN. cPAN=purging AN.

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Andrew W. Bergen, Ph.D. January 31st, 2005

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Andrew W. Bergen, Ph.D. January 31st, 2005