Supplemental Table 1 The pathways incorporated by up-regulated microRNAs in human right atrial myocardium

KEGG Pathway / In(P-Value) / Genes
Adherens junction / 24.7 / PVRL4, CTNNA1, PTPRM, WAS, PTPN1, LEF1, CSNK2A2, TGFBR1, IGF1R, EGFR, MET, WASF1, VCL, PTPRF, SNAI1, RHOA, WASF3, WASL, PARD3, ACTN1, PVRL3, YES1, ENSG00000158195, SMAD2, LY6G5B, CSNK2A1,CSNK2A1P, SORBS1, TCF7, CTNNA2, BAIAP2, FGFR1, MAPK1, MAP3K7, PTPRJ, RAC1, INSR, SRC, CREBBP, MAPK3, CDC42, PVRL2, TCF7L2, MLLT4, ACVR1B, SSX2IP, NLK, TGFBR2, PVRL1, ACTG1, CDH1, TCF7L1, EP300, ACTN3, LMO7, SMAD4, SNAI2, CTNNB1, SMAD3
Wnt signaling pathway / 21.95 / FZD7, CTNNBIP1, AXIN2, CXXC4, WNT3A, CAMK2D, DAAM2, CUL1, WNT4, PRKY, NFATC2, MAPK8, PRKCA, NKD1, LEF1, DVL3, WNT3, CSNK2A2, FZD5, DOCK5, PPP2R2B, PPP3CC, LRP6, TBL1X, SFRP1, CSNK1A1L, PPP2R1A, RHOA, ROCK1, DKK1, PRKACA, VANGL2, WIF1, SMAD2, LY6G5B, CAMK2G, FZD3, FOSL1, BTRC, CSNK2A1,CSNK2A1P, SKP1A, TCF7, NFATC3, PRKX, TP53, APC, DAAM1, MAP3K7, VANGL1, WNT1, PPP2R2C, RAC1, CREBBP, FBXW11, PPP2CA, SIAH1, FRAT2, SFRP2, DVL2, TCF7L2, ENSG00000187446, PPP3CA, CTBP1, PRICKLE1, CHD8, NLK, WNT11, PSEN1, PLCB1, CCND2, DKK2, PRKCB1, FZD9, PLCB4, PLCB2, FZD4, SENP2, NFAT5, TCF7L1, PRICKLE2, CCND3, MAPK10, EP300, PRKACB, WNT10A, PPP2CB, JUN, FZD6, CTBP2, FZD10, CCND1, CAMK2B, SMAD4, CTNNB1, SMAD3, PPP3CB
MAPK signaling pathway / 20.65 / MAP4K3, TAOK3, MAP4K4, RPS6KA2, MAP2K3, HSPA2, RPS6KA1, FOS, NTRK2, PRKY, NFATC2, MAPK8, PRKCA, AKT1, CSDE1, NTF3, RASGRP2, PDGFRA, EVI1, TGFBR1, EGFR, NFKB1, PPP3CC, MAP2K1, STMN1, GADD45A, MKNK1, MAP3K8, MAP3K4, MAP3K1, GNA12, MAP3K13, FLNB, MAPKAPK3, IL1R1, ENSG00000091436, PDGFB, PPM1B, PRKACA, MAP3K7IP2, CACNB1, TNF, MAPK8IP2, KRAS, CACNA2D1, ATF2, FLNC, CACNB2, PTPN5, PPP5C, MEF2C, ARRB2, FGF23, BDNF, DUSP5, DUSP9, RRAS2, FASLG, MAPK13, FLNA, MAPT, DUSP2, CRKL, TAOK1, MAP3K10, FGFR2, HSPA1A,HSPA1B, NR4A1, STK4, IL1A, ELK4, MAP2K4, RPS6KA4, SOS1, FGF9, FGFR1, DUSP16, PRKX, DDIT3, FGF13, MAP3K3, RPS6KA5, TP53, CRK, MAP2K6, MAPK1, MAP3K7, FGF1, RAC1, SRF, FGF7, MAPK3, FGF2, CDC42, GRB2, PAK2, IKBKB, CACNA2D4, FGF11, FGFR4, RAP1B, ENSG00000187446, PPP3CA, AKT2, ACVR1B, GADD45G, HSPA1L, CACNA2D2, NLK, DUSP10, HSPA8, NF1, DUSP1, TGFBR2, NGFB, FGF5, DUSP3, RAP1A, DUSP6, RASA1, MAPK14, PTPRR, ELK1, PRKCB1, MAP3K12, MAX, EGF, MAP3K14, FAS, RPS6KA3, TGFB2, MAP3K5, RRAS, NTF5, GNG12, MAPK10, PDGFRB, ARRB1, CASP3, PRKACB, MAP2K1IP1, JUN, AKT3, TGFB3, CACNB3, RAF1, PPP3CB
TGF-beta signaling pathway / 18.81 / CHRD, E2F5, CUL1, RBL2, CDKN2B, IFNG, TGFBR1, DOCK5, PPP2R2B, ID2, ID4, LTBP1, BMP6, PPP2R1A, RHOA, ROCK1, TNF, SMURF1, ID3, ZFYVE9, SMAD7, ACVRL1, SMAD2, SMAD6, RBL1, LEFTY1, SMAD5, ID1, ACVR1, SKP1A, ACVR2A, NOG, INHBB, SMAD9, GDF6, MAPK1, THBS1, PPP2R2C, CREBBP, MAPK3, THBS2, PPP2CA, SMAD1, BMP2, ACVR2B, ACVR1B, SMURF2, LEFTY2, TGFBR2, TFDP1, SP1, ZFYVE16, BMP4, BMPR2, PITX2, TGFB2, EP300, DCN, RPS6KB1, PPP2CB, TGFB3, SMAD4, BMPR1A, SMAD3
Focal adhesion / 16.02 / ITGA3, VAV1, ITGB4, BCL2, COL6A3, PDGFD, VASP, MAPK8, PRKCA, AKT1, PGF, PARVB, ITGB1, PDGFRA, FN1, IGF1R, TNC, EGFR, MAP2K1, MET, DIAPH1, TNR, RELN, VCL, COL5A1, FIGF, RHOA, FLNB, ROCK1, CAV3, PDPK1, CAV2, PDGFB, COL1A1, ACTN1, ITGB8, LAMA3, FLNC, FLT1, PAK3, COL3A1, ITGA9, HGF, FLNA, CRKL, ITGA2, ITGA6, PIK3R1, TNN, COL4A4, SOS1, VAV3, COL5A3, VEGFA, PTEN,PTENP1, ENSG00000180209, ITGA10, CRK, MAPK1, THBS1, RAC1, SRC, KDR, MAPK3, PIP5K1C, PAK4, CDC42, GRB2, PAK2, PAK6, VAV2, THBS2, CAV1, RAP1B, COL5A2, ITGB3, SPP1, AKT2, PTK2, PIK3R2, ITGAV, COL1A2, ARHGAP5, PPP1CC, RAP1A, CCND2, ELK1, ACTG1, PRKCB1, EGF, MYLK, ITGB6, LAMC1, IGF1, CCND3, PAK7, MAPK10, ACTN3, PDGFRB, SHC4, BIRC4, PIK3CD, JUN, PIK3R3, COL4A1, AKT3, PDGFC, CCND1, ENSG00000140795, COL11A1, ITGA5, RAF1, CTNNB1
p53 signaling pathway / 14.8 / CCNE2, RRM2B, CCNE1, CCNG1, DDB2, IGFBP3, CDKN1A, ENSG00000120471, GADD45A, CHEK2, CCNB1, RRM2, SESN3, CDK4, CDK6, ENSG00000164054, CCNB3, EI24, STEAP3, BID, RFWD2, PTEN,PTENP1, CHEK1, TP53, THBS1, SERPINE1, CCNG2, PPM1D, SESN1, SIAH1, CASP9, APAF1, TNFRSF10B, GADD45G, RPRM, MDM4, CDK2, CCND2, BAX, PMAIP1, FAS, PERP, IGF1, CCND3, CD82, BBC3, CASP8, CASP3, CCND1
Oxidative phosphorylation / 14.78 / ENSG00000198563, NDUFAB1, ATP6V1C1, ATP6V0E1, PTPMT1, ATP6V1G1, ATP6V1H, NDUFC2, UQCRH, ATP5F1, SDHC, ATP6V1A, COX7A2, ATP6V0C, ATP6V1B2, ATP6V0A2, COX17, ENSG00000107902, ATP5E, COX10, ATP6V1G3
ErbB signaling pathway / 12.97 / CAMK2D, CDKN1B, NCK2, MAPK8, HBEGF, PRKCA, AKT1, CSDE1, NRG3, EIF4EBP1, EGFR, CDKN1A, MAP2K1, ERBB3, KRAS, PAK3, STAT5B, CBL, CAMK2G, CRKL, PIK3R1, MAP2K4, SOS1, CRK, MAPK1, SRC, ABL2, MAPK3, PAK4, GRB2, PAK2, PAK6, AKT2, PTK2, TGFA, BTC, NRG2, PIK3R2, CBLB, NRG1, ELK1, PRKCB1, ABL1, EGF, ERBB4, PAK7, MAPK10, PLCG1, SHC4, RPS6KB1, PIK3CD, ENSG00000109321, JUN, PIK3R3, AKT3, EREG, CAMK2B, RAF1
Regulation of actin cytoskeleton / 12.88 / ITGA3, VAV1, ITGB4, ARPC5, MYH9, WAS, CSDE1, TIAM1, SCIN, ITGB1, CHRM3, PDGFRA, FN1, IQGAP2, EGFR, MAP2K1, WASF1, FGD1, DIAPH1, SSH2, ARPC2, CSK, VCL, RHOA, GNA12, CHRM5, ROCK1, PPP1R12B, WASL, ITGAX, PDGFB, ACTN1, ITGB8, ARHGEF6, KRAS, ENSG00000158195, PAK3, ARPC1A, ITGA9, FGF23, ARPC1B, ARHGEF7, RRAS2, MSN, NCKAP1, PIP5K1B, PIP4K2B, CRKL, ITGA2, FGFR2, CFL2, PIP4K2A, ITGA6, PIK3R1, ABI2, SOS1, VAV3, BAIAP2, FGF9, ENSG00000180209, ITGA10, FGFR1, FGF13, APC, CRK, CFL1, MAPK1, FGF1, RAC1, PIP5K1A, FGF7, MAPK3, PIP5K1C, DIAPH2, PAK4, FGF2, CDC42, PIP4K2C, PAK2, CHRM2, PAK6, VAV2, FGF11, FGFR4, ITGB3, PTK2, PIK3R2, FGF5, ITGAV, PPP1CC, GNA13, ACTG1, GSN, EGF, SLC9A1, ACTC1, MYLK, MYH14, ITGB6, PIP5K3, CYFIP1, MYH10, TMSB4X,TMSL1,TMSL2,TMSL6, RRAS, PAK7, GNG12, ACTN3, PDGFRB, TMSB4Y, PIK3CD, PIK3R3, RDX, ENSG00000140795, PFN2, ITGA5, RAF1
Ubiquitin mediated proteolysis / 12.82 / UBE2D1, DDB2, CDC27, RNF7, CUL1, SOCS1, UBE2M, KLHL9, UBE2D2, UBE2G1, UBE4A, UBE3A, HERC2, UBE2NL, UBE2Z, UBE3C, UBE2R2, HERC3, UBE1, MAP3K1, UBE2Q2, BIRC6, UBE2E3,UBE2E4P, ANAPC1, UBE2J1, CUL3, UBE2I, SMURF1, WWP2, UBE2W, CBL, TCEB1, MID1, PML, UBE2Q1, VHL, UBE2B, BTRC, RFWD2, SKP1A, UBE2L3, UBE2N, CUL4A, FBXW7, TRIM37, UBR5, WWP1, FBXW11, RHOBTB2, SAE2, CUL2, TRIP12, SOCS3, PARK2, SIAH1, UBE4B, UBE1L2, KLHL13, SMURF2, CBLB, NEDD4L, UBE2C, PIAS3, CDC23, SYVN1, UBE2O, ANAPC5, CUL5, NEDD4, UBE2F, ANAPC4, HUWE1, ITCH, BIRC4, PIAS4, UBE2E2, UBE2D3, CUL4B, UBE2E1
Cell cycle / 6.56 / CCNE2, DBF4, CDKN1B, CCNE1, CDC27, CUL1, E2F3, RBL2, CDKN2C, CDKN2B, PCNA, YWHAB, WEE1, E2F1, CDC14B,CDC14C, CDKN1A, GADD45A, SMC1A, YWHAH, CHEK2, CCNB1, ANAPC1, CDK4, CDK6, SMAD2, RBL1, E2F2, BUB3, CCNB3, YWHAE, RB1, CDC14A, CCNA2, SKP1A, YWHAQ, MAD2L2, YWHAZ, CHEK1, HDAC2, CDC25C, TP53, ORC2L, CREBBP, CDC7, GADD45G, TFDP1, YWHAG, CDK2, CCND2, CDC23, ABL1, ANAPC5, CDKN1C, CCND3, ANAPC4, TGFB2, EP300, CDC25A, TGFB3, CCND1, ORC4L, SMAD4, SMAD3
mTOR signaling pathway / 5.59 / RPS6KA2, RPS6KA1, HIF1A, AKT1, PGF, TSC1, EIF4EBP1, ENSG00000167965, FIGF, PDPK1, RPS6, RHEB, PIK3R1, VEGFA, CAB39, MAPK1, ENSG00000164327, MAPK3, PRKAA1, ULK2, AKT2, PIK3R2, DDIT4, RPS6KA3, IGF1, RPS6KB1, PIK3CD, PIK3R3, AKT3, EIF4E
Insulin signaling pathway / 5.55 / PPARGC1A, ACACB, IRS2, ENSG00000132376, FASN, SOCS1, PFKM, PTPN1, PRKY, MAPK8, PHKA2, AKT1, CSDE1, TSC1, PFKP, EIF4EBP1, MAP2K1, SLC2A4, LIPE, PTPRF, MKNK1, SOCS4, PDPK1, PRKACA, RPS6, KRAS, RHEB, PRKAR2B, CBL, GYS1, ENSG00000143933, CRKL, PIK3R1, FLOT2, SORBS1, SOS1, CALM1,CALM2,CALM3, ENSG00000198668, PRKAR2A, PRKX, FOXO1, CRK, MAPK1, IRS1, INSR, MAPK3, PRKAA1, GRB2, SOCS3, PRKCI, IKBKB, RHOQ, AKT2, PHKA1, PIK3R2, CBLB, PPP1CC, ELK1, PPP1R3A, PRKAB2, PDE3A, PRKAR1A, MAPK10, TRIP10, SHC4, RPS6KB1, PRKACB, PIK3CD, PIK3R3, PPP1R3D, AKT3, RAF1, EIF4E
Circadian rhythm / 5.39 / CRY2, BHLHB2, PER3, NR1D1, BHLHB3, PER2, CRY1, NPAS2, ARNTL, PER1, CLOCK
Phosphatidylinositol signaling system / 5 / PIK3C3, ENSG00000132376, SYNJ1, PRKCA, ITPKB, OCRL, PI4KB, INPP4B, PIK3C2B, INPP5B, INPP5A, CDS2, DGKG, ENSG00000143933, PIP5K1B, PIP4K2B, ITPR1, PIP4K2A, PIK3R1, PTEN,PTENP1, CALM1,CALM2,CALM3, ENSG00000198668, IMPA2, PIP5K1A, PIP5K1C, PIP4K2C, DGKI, PIB5PA, ITPK1, PIK3R2, PLCB1, SYNJ2, PRKCB1, PLCB4, PLCB2, PIP5K3, PLCG1, PIK3CD, DGKZ, PIK3R3, DGKH
ECM-receptor interaction / 4.69 / ITGA3, ITGB4, COL6A3, FNDC5, SDC2, ITGB1, FN1, TNC, SDC4, TNR, RELN, COL5A1, COL1A1, ITGB8, LAMA3, COL3A1, ITGA9, SDC3, SDC1, DAG1, ITGA2, ITGA6, SV2A, TNN, COL4A4, COL5A3, ITGA10, SV2B, FNDC3A, THBS1, HSPG2, THBS2, COL5A2, ITGB3, SPP1, ITGAV, COL1A2, ITGB6, LAMC1, AGRN, CD44, COL4A1, COL11A1, ITGA5, FNDC4
Glutathione metabolism / 4.28 / GSTM3, GSTM5, GPX5, GCLC, GPX6, IDH1, GSTM4, GCLM
Gap junction / 3.89 / PDGFD, GNAI2, ENSG00000196230, PRKY, PRKCA, CSDE1, GRM1, PDGFRA, GJA1, NPR2, EGFR, MAP2K1, GNAI3, ADCY1, ADCY5, TUBA4A, GUCY2C, PDGFB, PRKACA, KRAS, HTR2C, ITPR1, PRKG1, SOS1, PRKX, GUCY1A3, MAPK1, SRC, MAPK3, GRB2, ADCY9, ADRB1, GRM5, PLCB1, PRKCB1, PRKG2, EGF, PLCB4, PLCB2, TUBB1, ADCY3, DRD2, GNAI1, PDGFRB, PRKACB, DRD1, PDGFC, RAF1, ADCY6, EDG2
Pyruvate metabolism / 3.69 / ACACB, ACYP1, ME1, HAGH, DLAT, ACSS2, ACYP2, ACAT2, ALDH1A3, PDHA1
PPAR signaling pathway / 3.69 / SLC27A1, GK,GK3P, SCD, ACSL1, LPL, CYP7A1, PDPK1, ACSL4, ME1, OLR1, ACOX1, ACSL3, SORBS1, SCP2, ACAA1, CHKB, ACOX3, SLC27A4, PPARA
Notch signaling pathway / 3.47 / DTX2, APH1A, NUMB, DVL3, NOTCH2, NUMBL, DLL1, HES1, HDAC2, GCN5L2, CREBBP, ADAM17, DVL2, CTBP1, PSEN1, DTX4, JAG1, NCSTN, RBPJ, PCAF, EP300, JAG2, PSEN2, CTBP2
Inositol phosphate metabolism / 3.11 / PIK3C3, ENSG00000132376, SYNJ1, ITPKB, OCRL, PI4KB, INPP4B, INPP5B, INPP5A, PIP5K1B, PIP4K2B, PIP4K2A, PTEN,PTENP1, IPMK, IMPA2, PIP5K1A, PIP5K1C, PIP4K2C, PIB5PA, ITPK1, PLCB1, SYNJ2, PLCB4, PLCB2, PIP5K3, PLCG1, PIK3CD
Cell Communication / 2.99 / ITGB4, COL6A3, KRT13, LMNB1, FN1, KRT28, KRT1, TNC, GJA1, DSC2, TNR, RELN, COL5A1, INA, VIM, KRT5, COL1A1, LAMA3, COL3A1, GJA10, GJA5, COL17A1, KRT81, ITGA6, KRT36, KRT82, TNN, COL4A4, DSG3, COL5A3, KRT2, THBS1, THBS2, COL5A2, SPP1, KRT38, COL1A2, GJA3, ACTG1, KRT72, LAMC1, COL4A1, KRT15, COL11A1
Fatty acid metabolism / 2.95 / HSD17B10, ACSL1, ACSL4, ACOX1, ACSL3, ACAA1, ADHFE1, HADHA, ACAT2, ALDH1A3, CHKB, ACOX3
Basal transcription factors / 2.58 / GTF2I, GTF2E2, TAF4, GTF2H1, TAF9B, TAF5, TBPL1, GTF2E1
Apoptosis / 2.42 / BCL2, IL1RAP, AKT1, NFKB1, PPP3CC, IRAK2, IL1R1, PRKACA, TNF, NFKBIA, PRKAR2B, FASLG, IL1A, PIK3R1, BID, PRKAR2A, DFFA, TP53, IRAK4, TNFRSF10D, IKBKB, CASP9, APAF1, TNFRSF10B, ENSG00000187446, PPP3CA, AKT2, NGFB, PIK3R2, BAX, MAP3K14, FAS, PRKAR1A, CASP8, CASP3, PRKACB, BIRC4, PIK3CD, PIK3R3, BCL2L1, AKT3, PPP3CB
Jak-STAT signaling pathway / 2.33 / IL13RA1, IL12RB2, IL2RG, CSF2, PRLR, SOCS1, IL23R, AKT1, IL6ST, OSM, STAT3, CNTFR, IFNG, LIFR, IL20RA, SOCS4, IL15RA, SOCS5, PIM1, SPRED2, STAT5B, LEPR, CBL, IL7R, PIK3R1, SPRY3, IL20, IL13, SOS1, IFNAR2, IL2RA, IL6, GHR, SPRY4, IL12A, CREBBP, IL22RA1, IL10, IL9, IFNAR1, GRB2, SOCS3, IL4, AKT2, IL2, IL15, PIK3R2, CBLB, LIF, JAK1, PIAS3, CCND2, SPRY1, IL28RA, SPRED1, CCND3, EP300, CLCF1, PIK3CD, IL11, PIK3R3, PIAS4, BCL2L1, AKT3, IL9R, CCND1, JAK2, IL7, SPRY2, IL6R, IL22RA2, MPL
Hedgehog signaling pathway / 2.24 / WNT3A, WNT4, PRKY, WNT3, RAB23, GLI3, CSNK1A1L, BMP6, ZIC2, CSNK1G2, PRKACA, SUFU, BTRC, PRKX, WNT1, FBXW11, PTCH1, GAS1, BMP2, HHIP, CSNK1G3, WNT11, CSNK1G1, GLI2, BMP4, IHH, PRKACB, WNT10A, LRP2
Biosynthesis of steroids / 1.98 / GGPS1, SQLE, VKORC1, HMGCR, DHCR24, NSDHL
Glutamate metabolism / 1.91 / GAD1, ABAT, GLUD1,GLUDP5, GLUD2, GPT2, ADC, GLS, GFPT2, GCLC, GAD2, PPAT, ALDH5A1, GNPNAT1, GLS2, GCLM, GOT2, GOT1
Calcium signaling pathway / 1.88 / ADRA1B, CAMK2D, PDE1C, PRKY, PHKA2, PRKCA, ITPKB, CHRM3, GRM1, ADRB2, PDGFRA, EDNRB, EGFR, LHCGR, PPP3CC, PTGFR, ADCY1, ATP2B4, EDNRA, CHRM5, P2RX4, ERBB3, PRKACA, ATP2A2, ENSG00000143933, VDAC2, CAMK2G, SLC8A1, CAMK4, HTR2C, ITPR1, PTK2B, GRIN1, ATP2B2, PTGER3, SPHK2, ATP2B1, ADORA2A, HTR7, CALM1,CALM2,CALM3, PDE1B, ENSG00000198668, PRKX, NTSR1, OXTR, GRIN2A, ADCY9, CHRM2, TRPC1, PDE1A, ENSG00000187446, PPP3CA, ADRA1A, PHKA1, NOS1, ADRB1, GRM5, HTR4, PLCB1, PRKCB1, ATP2A1, PLCB4, PLCB2, MYLK, ERBB4, ADCY3, GNAL, PLCG1, PDGFRB, PRKACB, DRD1, VDAC3, ENSG00000140795, PPID, CAMK2B, PPP3CB
VEGF signaling pathway / 1.74 / NFATC2, PRKCA, AKT1, CSDE1, PPP3CC, MAP2K1, MAPKAPK3, SH2D2A, KRAS, MAPK13, PIK3R1, SPHK2, VEGFA, NFATC3, MAPK1, RAC1, SRC, KDR, MAPK3, CDC42, CASP9, ENSG00000187446, PPP3CA, AKT2, PTK2, PIK3R2, MAPK14, PRKCB1, NFAT5, PLCG1, PIK3CD, PIK3R3, AKT3, RAF1, PPP3CB
Ubiquinone biosynthesis / 1.7 / COQ2
Propanoate metabolism / 1.67 / ACACB, SUCLG2, ABAT, SUCLA2, ACSS2, HADHA, HIBCH, ACAT2, ALDH1A3, PCCA
Renin-angiotensin system / 1.64 / LNPEP, ACE, ENPEP, NLN
Cell adhesion molecules (CAMs) / 1.55 / CD276, CD4, MPZL1, PTPRM, NRCAM, SDC2, VCAM1, CLDN2, ITGB1, CDH2, VCAN, SDC4, PTPRF, NEGR1, ICOS, ITGB8, PDCD1LG2, PVRL3, CNTNAP2, CD86, ITGA9, MPZ, SDC3, SDC1, NFASC, ITGA6, NEO1, CD80, CLDN10, CLDN11, SPN, SELE, NRXN1, ALCAM, JAM3, CLDN18, CLDN8, PVRL2, PTPRC, NLGN2, NLGN1, CNTNAP1, CADM1, CD6, PVR, ITGAV, PVRL1, CLDN1, CNTN1, CDH1, HLA-G, CD28, CNTN2, NLGN3, CD40LG, NRXN3, HLA-DRB5, ENSG00000178709
Citrate cycle (TCA cycle) / 1.55 / SUCLG2, CLYBL, SUCLA2, DLST,DLSTP, IDH1, SDHC, CS, OGDH
Histidine metabolism / 1.12 / PRMT8, ASPA, MAOA, HDC, LCMT2, PRMT5, PRMT2, PRPS1,PRPS1L1, CARM1, TRMT11, FTCD, HEMK1, PRPS2, ALDH1A3
Pentose phosphate pathway / 1.09 / PFKM, PFKP, PRPS1,PRPS1L1, PGM3, RPIA, RPE, PGM1, PRPS2
Glycerophospholipid metabolism / 1.07 / GPD2, CRLS1, PTDSS1, GPD1, ETNK2, PLD1, PPAP2B, GPAM, PCYT1B, SH3GLB1, MYST3, CDS2, DGKG, PISD, AGPAT3, ESCO1, ARD1A, AGPAT6, DGKI, ENSG00000204310, LYPLA2,LYPLA2P1, AGPAT4, LYCAT, ETNK1, LYPLA1, PHOSPHO1, NAT5, MYST4, SLC12A4, DGKZ, GPD1L, DGKH
Carbon fixation / 1.02 / GPT2, ME1, RPIA, RPE, GOT2, PGK1, GOT1
Regulation of autophagy / 0.95 / PIK3C3, ATG5, BECN1, IFNG, ATG12, GABARAP, GABARAPL1,GABARAPL3, PRKAA1, ULK2
Protein export / 0.16 / SRPR, SRP54, SEC61A2, SRP72
Fatty acid elongation in mitochondria / 0.16 / HSD17B10, HADHA, MECR
Purine metabolism / 0.15 / POLR2B, POLE3, ENSG00000143199, RRM2B, NT5E, AK2, NP, PRUNE, PDE1C, PDE7B, NME4, PDE8A, PDE5A, PDE11A, PDE4B, GMPR, ENPP3, PFAS, NPR2, POLR1B, ADCY1, ADCY5, PRPS1,PRPS1L1, POLR1C, RRM2, GUCY2C, PAPSS2, NME7, ADK, AK3L1,AK3L2, NT5C2, POLR2K, PPAT, XDH, GUCY1A3, PDE2A, ENTPD1, IMPDH1, PDE8B, NT5C3, ADCY9, AMPD3, PDE1A, POLR2D, GDA, PRPS2, ADSS, PDE10A, PDE3A, ADCY3, POLR3G, POLR2A, PDE4A, PDE6D, ENTPD6, ADCY6
Toll-like receptor signaling pathway / 0.01 / MAP2K3, FOS, MAPK8, AKT1, NFKB1, MAP2K1, MAP3K8, CXCL11, MAP3K7IP2, TNF, IL8, CD86, NFKBIA, MAPK13, PIK3R1, CD80, MAP2K4, IFNAR2, IRF7, IRAK4, MAP2K6, IL6, TBK1, MAPK1, MAP3K7, RAC1, IL12A, MAPK3, TRAF3, CXCL10, IFNAR1, IKBKB, SPP1, AKT2, PIK3R2, MAPK14, MAPK10, CASP8, PIK3CD, JUN, PIK3R3, AKT3

Supplemental Table 2 The pathways incorporated by down-regulated microRNAs in human right atrial myocardium

KEGG Pathway / In(P-Value) / Genes
Focal adhesion / 30.04 / ITGA3, ITGB4, PPP1CA, BCL2, COL6A3, PDGFD, PIK3CA, VASP, VWF, GSK3B, MAPK8, PRKCA, AKT1, PGF, COL4A6, ITGB1, PDGFRA, FN1, IGF1R, TNC, MYLK2, MAP2K1, ZYX, MET, DIAPH1, TNR, RELN, VCL, COL5A1, FIGF, RHOA, FLNB, ROCK1, PDPK1, CAV2, PDGFB, COL1A1, ACTN1, SOS2, ITGB8, LAMA3, PRKCG, FLNC, FLT1, LAMC2, PAK3, COL3A1, FYN, ITGA9, HGF, VEGFC, VEGFB, FLNA, CRKL, ITGA2, THBS4, ITGA6, PIK3R1, COL4A4, SOS1, VAV3, COL5A3, PIK3CG, VEGFA, PTEN,PTENP1, ITGA10, PAK1, CRK, SHC1, MAPK1, THBS1, ENSG00000204248, RAC1, SRC, KDR, MAPK3, PIP5K1C, ENSG00000118680, PAK4, CDC42, GRB2, PAK2, PAK6, VAV2, THBS2, CAV1, RAP1B, COL5A2, ITGB3, ENSG00000101608, AKT2, PTK2, PIK3R2, ITGAV, COL1A2, ARHGAP5, PPP1CC, RAP1A, ITGA11, ACTN4, CCND2, ELK1, PRKCB1, MYLK, COL2A1, ITGB6, LAMC1, IGF1, CCND3, MAPK9, PAK7, ILK, MAPK10, ACTN3, ITGA7, PDGFRB, SHC4, BIRC4, PIK3CD, JUN, PIK3R3, CHAD, COL4A1, AKT3, PDGFC, CCND1, COL11A1, ITGA5, RAF1, CTNNB1, PDGFA, LAMA4
Wnt signaling pathway / 29.48 / FZD7, DVL1, CTNNBIP1, AXIN2, APC2, CXXC4, WNT3A, CAMK2D, WNT2B, CUL1, RBX1, GSK3B, WNT4, PRKY, NFATC2, MAPK8, PRKCA, NKD1, LEF1, DVL3, WNT3, CSNK2A2, WNT16, FZD5, DOCK5, PPP2R2B, PPP3CC, LRP6, TBL1X, SFRP1, CSNK1A1L, PPP2R1A, RHOA, ROCK1, DKK1, FZD8, VANGL2, WIF1, PRKCG, SMAD2, LY6G5B, CAMK2G, FZD3, FOSL1, BTRC, CSNK2A1,CSNK2A1P, SKP1A, NFATC3, PRKX, TP53, APC, DAAM1, MAP3K7, VANGL1, WNT1, PPP2R2C, RAC1, CREBBP, FBXW11, PPP2R1B, NFATC4, NFATC1, WNT10B, PPP2CA, SIAH1, FRAT2, SFRP2, ENSG00000100181, DVL2, TCF7L2, ENSG00000187446, PPP3CA, CTBP1, CHD8, NLK, WNT11, PSEN1, FZD1, SOX17, PPARD, PLCB1, CCND2, DKK2, PRKCB1, WNT9A, PLCB4, FZD4, SENP2, NFAT5, TCF7L1, PRICKLE2, CCND3, MAPK9, MAPK10, EP300, PRKACB, WNT10A, PPP2CB, JUN, FZD6, CCND1, CAMK2B, SMAD4, CTNNB1, SMAD3, PPP3CB