Table 1. Active and Planned Collaborative Studies

Collaborative Studies / Participants
Anticarcinogenicity of chlorophylls, dietary indoles, dietary estrogens, and tea polyphenols; Assessment of potential adverse effects (Obj. 1 and 2) / CA-B, CA-D, CA-ARS, GA-ARS, HI, IL, MD, OR, UT,
Anti-inflammatory, immune-enhancing and reproductive effects of phytochemicals, omega-3 fatty acids, dietary indoles, and dietary supplements (Obj. 1 and 2) / CA-B, CA-ARS, CO, GA-ARS, MD, MI, OR, UT
Genotoxic, carcinogenic, immunotoxic and developmental effects of mycotoxins, phytoestrogens, plant alkaloids, plant-derived cell-signaling modulators (Obj. 2) / CA-B, CA-D, GA-ARS, IL, MD, MI, OR, UT
Bioassay-directed fractionation and identification of functional natural products (Obj. 3) / CA-B, CA-ARS, CO, CA-D, GA-ARS, HI, IL, MI, OR, UT
Anti-microbial and other functional activities of plant metabolites (Obj. 1 and 3) / CO, CA-ARS
Effects of pre- and post-harvest agricultural practices on beneficial or adverse effects of natural bioactive constituents (Obj. 4) / CO, GA-ARS, MI, OR, TX, UT

Table 2. Resources

Station / PI / Special Research Capability
CA-B / Bjeldanes / Chemistry, molecular biology, toxicology and chemopreventive activity of dietary indoles
CA-D / Denison / Receptor-mediated mechanisms of gene expression; identification and characterization of naturally-occurring receptor ligands
CA-ARS / Friedman / Antibacterial, antitoxin, and antiviral effects of natural products.Minimizing levels of induced toxicants in foods
CO / Vivanco / Induction and production of phytochemicals by cell culture; natural product isolation, chemical instrumental analysis, structure elucidation
GA-ARS / Riley / Toxicity and mechanisms of action of mycotoxins and plant toxins and development of strategies to reduce mycotoxin exposure
HI / Pratibha / Anti-obesity, anti-diabetic effects of natural products in animal and cell culture models, signal transduction mechanisms
IL / Helferich / Dietary estrogens and their influence on hormone-dependent cancer
MD / Magnuson / Toxicity of dietary supplements, anticarcinogenic activity and mechanisms of action of phytochemicals in colon cancer
MI / Pestka / Modulation of inflammatory and immune responses by natural products
OR / Williams / Carcinogenesis, tumor pathology, chemoprevention in fish and transgenic rodents; translation to humans
TX / Phillips / Clay-based methods for mycotoxin enterosorption; characterization of safety and efficacy in animals and humans
UT / Coulombe / Characterization of oxidative and detoxification enzymes; chemoprevention in animal models.