Supporting Online Material For s2

McCabe et al.

Supplementary Online Material For

The D2 antagonist sulpiride modulates the neural processing of both rewarding and aversive stimuli in healthy volunteers.

Ciara McCabe*, Anna Huber, Catherine, J. Harmer

Philip, J. Cowen,

* To whom correspondence should be addressed. E-mail:

This doc includes:

Supplementary Tables S1-S3

Fig S1

TABLE S 3: Regions showing main effect of task in the placebo group.
Brain Region / Montreal Neurological Institute (MNI) Coordinates / Z-score / Significance
(p-value)
X / Y / Z
Chocolate stimuli:
Medial frontal gyrus / -4 / 24 / 46 / 6.56 / <0.001
Anterior cingulate / 8 / 22 / 40 / 4.85 / <0.001
Ventral striatum / 8 / 10 / -2
Putamen / -18 / 6 / 0 / 4.58 / 0.007
Insula / -38 / 20 / 0 / 5.07 / <0.001
Precentral gyrus / 62 / 0 / 28 / 5.09 / <0.001
Ventral posterior cingulate / -2 / -32 / 28 / 4.7 / 0.01
Caudate / 10 / 10 / 2 / 5.69 / <0.001
-14 / 10 / 2 / 4.71 / 0.007
Strawberry stimuli:
Insula / 44 / 12 / 0 / 6.44 / <0.001
-36 / -8 / 12 / 5.68 / <0.001
LOFC / 32 / 30 / -4 / 4.97 / <0.001
Anterior cingulate / 0 / 0 / 30 / 5.63 / <0.001
Cingulate gyrus / -4 / -34 / 26 / 5.36 / <0.001
Paracingulate gyrus / -4 / 12 / 50 / 5.53 / <0.001
Thalamus / -8 / -16 / 8 / 5.26 / 0.01
Putamen / -18 / 4 / 4 / 5.04 / 0.003
Threshold P value =0.001; Whole brain cluster corrected (FWE).