Supplementary Table1: Maximum AE grade per AE type per patient in thesafety population

Chemotherapy(N=154) / Tamoxifen(N=79) / Wilcoxon Test
Toxicity / Grade 1 / Grade 2 / Grade 3 / Grade 4 / Grade 1 / Grade 2 / Grade 3 / Grade 4 / P-value
Allergy / 4 (3%) / 1 (1%) / 1 (1%) / 1 (1%) / 3 (4%) / 0.81
Arthralgia / 24 (16%) / 5 (3%) / 1 (1%) / 6 (8%) / 1 (1%) / 0.05
Myalgia / 23 (15%) / 6 (4%) / 1 (1%) / 5 (6%) / 3 (4%) / 0.10
Nausea / 47 (31%) / 19 (12%) / 11 (7%) / 8 (10%) / 6 (8%) / 4 (5%) / 1 (1%) / 0.002
Vomiting / 13 (8%) / 18 (12%) / 10 (6%) / 1 (1%) / 5 (6%) / 4 (5%) / 4 (5%) / 2 (3%) / 0.28
Mucositis / 18 (12%) / 12 (8%) / 1 (1%) / 1 (1%) / 0.001
Neurohearing / 5 (3%) / 1 (1%) / 1 (1%) / 0.06
Motor neuropathy / 13 (8%) / 3 (2%) / 2 (1%) / 1 (1%) / 0.01
Neurosensory / 36 (23%) / 8 (5%) / 4 (3%) / 13 (16%) / 1 (1%) / 0.03
PPE / 19 (12%) / 10 (6%) / 8 (5%) / 1 (1%) / <0.001
Othertoxicity / 33 (21%) / 32 (21%) / 17 (11%) / 3 (2%) / 7 (9%) / 12 (15%) / 5 (6%) / 1 (1%) / 0.01
Anemia / 85 (55%) / 25 (16%) / 1 (1%) / 1 (1%) / 29 (37%) / 3 (4%) / <0.001
Leukopenia / 41 (27%) / 18 (12%) / 10 (13%) / 2 (3%) / 1 (1%) / 0.001
Neutropenia / 36 (23%) / 20 (13%) / 7 (9%) / 1 (1%) / <0.001
Thrombocytopenia / 7 (5%) / 1 (1%) / 1 (1%) / 5 (6%) / 1 (1%) / 0.56

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