Supplementary Table 1: Predictions for human proteins based on the complete GO annotation data set. The column denoted by “Protein (H)” contains a human protein for which we predict a GO term. The column denoted by “Protein (Y)” contains a yeast protein that is aligned to the corresponding human protein and that is annotated with the GO term that we assign to the human protein. The predicted GO term is given in the column denoted by “GO term accession.” Its name and ontology (i.e., molecular function (F), biological process (P), or cellular component (C)) are given in the columns denoted by “GO name” and “GO ontology,” respectively.

Protein(H) / Protein(Y) / GO term accession / GO name / Go ontology
C9orf16 / CMP2 / GO:0005737 / cytoplasm / C
C9orf16 / CMP2 / GO:0005955 / calcineurin complex / C
OCM / TFC1 / GO:0000127 / transcription factor TFIIIC complex / C
OCM / TFC1 / GO:0005634 / nucleus / C
TRAP1 / PRP39 / GO:0005634 / nucleus / C
TRAP1 / PRP39 / GO:0000243 / commitment complex / C
TRAP1 / PRP39 / GO:0005685 / snRNP U1 / C
TRAP1 / PRP39 / GO:0005622 / intracellular / C
MKRN1 / GLC8 / GO:0005737 / cytoplasm / C
MKRN1 / GLC8 / GO:0005634 / nucleus / C
EXOSC8 / MRPL20 / GO:0005840 / ribosome / C
EXOSC8 / MRPL20 / GO:0005739 / mitochondrion / C
EXOSC8 / MRPL20 / GO:0005762 / mitochondrial large ribosomal subunit / C
EXOSC8 / MRPL20 / GO:0030529 / ribonucleoprotein complex / C
TLX2 / DBP7 / GO:0005634 / nucleus / C
TLX2 / DBP7 / GO:0005730 / nucleolus / C
FANCD2 / CCL1 / GO:0000109 / nucleotide-excision repair complex / C
FANCD2 / CCL1 / GO:0005739 / mitochondrion / C
FANCD2 / CCL1 / GO:0005675 / holo TFIIH complex / C
ARID4B / YLL023C / GO:0016021 / integral to membrane / C
ARID4B / YLL023C / GO:0016020 / membrane / C
ARID4B / YLL023C / GO:0005783 / endoplasmic reticulum / C
6-Sep / ORC2 / GO:0005634 / nucleus / C
6-Sep / ORC2 / GO:0005664 / nuclear origin of replication recognition complex / C
6-Sep / ORC2 / GO:0005656 / pre-replicative complex / C
6-Sep / ORC2 / GO:0000808 / origin recognition complex / C
6-Sep / ORC2 / GO:0031261 / DNA replication preinitiation complex / C
IFIT3 / SCS2 / GO:0005635 / nuclear envelope / C
IFIT3 / SCS2 / GO:0005783 / endoplasmic reticulum / C
IFIT3 / SCS2 / GO:0005634 / nucleus / C
IFIT3 / SCS2 / GO:0016020 / membrane / C
IFIT3 / SCS2 / GO:0031965 / nuclear membrane / C
IFIT3 / SCS2 / GO:0030176 / integral to endoplasmic reticulum membrane / C
IFIT3 / SCS2 / GO:0005934 / cellular bud tip / C
IFIT3 / SCS2 / GO:0016021 / integral to membrane / C
IFIT2 / HSK3 / GO:0005819 / spindle / C
IFIT2 / HSK3 / GO:0042729 / C
IFIT2 / HSK3 / GO:0005634 / nucleus / C
IFIT2 / HSK3 / GO:0005874 / microtubule / C
IFIT2 / HSK3 / GO:0000776 / kinetochore / C
IFIT2 / HSK3 / GO:0000777 / condensed chromosome kinetochore / C
USP21 / NNF2 / GO:0005624 / membrane fraction / C
USP21 / NNF2 / GO:0016021 / integral to membrane / C
USP21 / NNF2 / GO:0016020 / membrane / C
USP21 / NNF2 / GO:0005783 / endoplasmic reticulum / C
USP20 / YRB30 / GO:0005737 / cytoplasm / C
USP20 / YRB30 / GO:0005634 / nucleus / C
CHIC2 / RPC82 / GO:0005737 / cytoplasm / C
CHIC2 / RPC82 / GO:0005634 / nucleus / C
CHIC2 / RPC82 / GO:0005666 / DNA-directed RNA polymerase III complex / C
MAP3K9 / ZPR1 / GO:0005737 / cytoplasm / C
MAP3K9 / ZPR1 / GO:0005634 / nucleus / C
JMJD5 / UBA2 / GO:0005634 / nucleus / C
JMJD5 / UBA2 / GO:0031510 / SUMO activating enzyme complex / C
C10orf119 / ERG1 / GO:0016021 / integral to membrane / C
C10orf119 / ERG1 / GO:0016020 / membrane / C
C10orf119 / ERG1 / GO:0005811 / lipid particle / C
C10orf119 / ERG1 / GO:0005792 / microsome / C
C10orf119 / ERG1 / GO:0005783 / endoplasmic reticulum / C
RGS6 / HOS4 / GO:0034967 / Set3 complex / C
ODC1 / CMK2 / GO:0005737 / cytoplasm / C
MAPK3 / DBP9 / GO:0005634 / nucleus / C
MAPK3 / DBP9 / GO:0005730 / nucleolus / C
FOXRED1 / YDR061W / GO:0005739 / mitochondrion / C
WSB1 / INO80 / GO:0005634 / nucleus / C
WSB1 / INO80 / GO:0031011 / Ino80 complex / C
NME5 / PCL7 / GO:0005737 / cytoplasm / C
NME5 / PCL7 / GO:0000307 / cyclin-dependent protein kinase holoenzyme complex / C
NME5 / PCL7 / GO:0005634 / nucleus / C
OFD1 / CSR1 / GO:0005737 / cytoplasm / C
OFD1 / CSR1 / GO:0005792 / microsome / C
OFD1 / CSR1 / GO:0005829 / cytosol / C
OFD1 / CSR1 / GO:0005811 / lipid particle / C
OFD1 / CSR1 / GO:0005739 / mitochondrion / C
OFD1 / CSR1 / GO:0005768 / endosome / C
SURF2 / DRE2 / GO:0005737 / cytoplasm / C
SURF2 / DRE2 / GO:0005758 / mitochondrial intermembrane space / C
SURF2 / DRE2 / GO:0005829 / cytosol / C
PHKG2 / ARC15 / GO:0005737 / cytoplasm / C
PHKG2 / ARC15 / GO:0005856 / cytoskeleton / C
PHKG2 / ARC15 / GO:0030479 / actin cortical patch / C
PHKG2 / ARC15 / GO:0031315 / extrinsic to mitochondrial outer membrane / C
PHKG2 / ARC15 / GO:0005885 / Arp2/3 protein complex / C
PHKG2 / ARC15 / GO:0005938 / cell cortex / C
PHKG2 / ARC15 / GO:0044448 / cell cortex part / C
BCL7A / YER077C / GO:0005739 / mitochondrion / C
CTDSPL / SEY1 / GO:0005737 / cytoplasm / C
CTDSPL / SEY1 / GO:0016021 / integral to membrane / C
CTDSPL / SEY1 / GO:0016020 / membrane / C
CTDSPL / SEY1 / GO:0005783 / endoplasmic reticulum / C
CTDSPL / SEY1 / GO:0032541 / cortical endoplasmic reticulum / C
NKIRAS2 / URH1 / GO:0005737 / cytoplasm / C
NKIRAS2 / URH1 / GO:0005634 / nucleus / C
MTM1 / YER140W / GO:0016021 / integral to membrane / C
MTM1 / YER140W / GO:0016020 / membrane / C
MTM1 / YER140W / GO:0005739 / mitochondrion / C
PCYT2 / SDH1 / GO:0005743 / mitochondrial inner membrane / C
PCYT2 / SDH1 / GO:0016020 / membrane / C
PCYT2 / SDH1 / GO:0005749 / mitochondrial respiratory chain complex II / C
PCYT2 / SDH1 / GO:0005739 / mitochondrion / C
PCYT2 / SDH1 / GO:0031966 / mitochondrial membrane / C
LTB / TRX2 / GO:0005737 / cytoplasm / C
LTB / TRX2 / GO:0005794 / Golgi apparatus / C
LTB / TRX2 / GO:0000324 / fungal-type vacuole / C
LTB / TRX2 / GO:0005634 / nucleus / C
LTB / TRX2 / GO:0016020 / membrane / C
LTB / TRX2 / GO:0005829 / cytosol / C
ZFAND5 / YMR310C / GO:0005634 / nucleus / C
TAF1L / SQT1 / GO:0005737 / cytoplasm / C
TAF1L / SQT1 / GO:0005829 / cytosol / C
TAF1L / SQT1 / GO:0022626 / cytosolic ribosome / C
CHERP / RPL37A / GO:0005737 / cytoplasm / C
CHERP / RPL37A / GO:0030529 / ribonucleoprotein complex / C
CHERP / RPL37A / GO:0005840 / ribosome / C
CHERP / RPL37A / GO:0005622 / intracellular / C
CHERP / RPL37A / GO:0022625 / cytosolic large ribosomal subunit / C
TPD52L1 / CDC3 / GO:0031105 / septin complex / C
TPD52L1 / CDC3 / GO:0005628 / prospore membrane / C
TPD52L1 / CDC3 / GO:0000144 / cellular bud neck septin ring / C
TPD52L1 / CDC3 / GO:0001400 / mating projection base / C
TPD52L1 / CDC3 / GO:0016020 / membrane / C
TPD52L1 / CDC3 / GO:0005619 / ascospore wall / C
TPD52L1 / CDC3 / GO:0005935 / C
GALNT5 / NIF3 / GO:0005737 / cytoplasm / C
GALNT5 / NIF3 / GO:0005739 / mitochondrion / C
CXorf26 / URA10 / GO:0005737 / cytoplasm / C
ASMTL / RNH202 / GO:0005634 / nucleus / C
ASMTL / RNH202 / GO:0032299 / ribonuclease H2 complex / C
MAGEA12 / AIM45 / GO:0005759 / mitochondrial matrix / C
MAGEA12 / AIM45 / GO:0005739 / mitochondrion / C
LRP4 / TAH18 / GO:0005739 / mitochondrion / C
DDX24 / RPL11B / GO:0005737 / cytoplasm / C
DDX24 / RPL11B / GO:0030529 / ribonucleoprotein complex / C
DDX24 / RPL11B / GO:0005840 / ribosome / C
DDX24 / RPL11B / GO:0005622 / intracellular / C
DDX24 / RPL11B / GO:0022625 / cytosolic large ribosomal subunit / C
CCND1 / RPL12B / GO:0005737 / cytoplasm / C
CCND1 / RPL12B / GO:0030529 / ribonucleoprotein complex / C
CCND1 / RPL12B / GO:0005840 / ribosome / C
CCND1 / RPL12B / GO:0005622 / intracellular / C
CCND1 / RPL12B / GO:0022625 / cytosolic large ribosomal subunit / C
PCID2 / BDH1 / GO:0005737 / cytoplasm / C
ALS2CR12 / TFC6 / GO:0000127 / transcription factor TFIIIC complex / C
ALS2CR12 / TFC6 / GO:0005634 / nucleus / C
PLCG1 / RPS9B / GO:0005737 / cytoplasm / C
PLCG1 / RPS9B / GO:0032040 / small-subunit processome / C
PLCG1 / RPS9B / GO:0015935 / small ribosomal subunit / C
PLCG1 / RPS9B / GO:0005730 / nucleolus / C
PLCG1 / RPS9B / GO:0005634 / nucleus / C
PLCG1 / RPS9B / GO:0030686 / 90S preribosome / C
PLCG1 / RPS9B / GO:0005622 / intracellular / C
PLCG1 / RPS9B / GO:0005840 / ribosome / C
PLCG1 / RPS9B / GO:0030529 / ribonucleoprotein complex / C
PLCG1 / RPS9B / GO:0022627 / cytosolic small ribosomal subunit / C
PRX / IMH1 / GO:0005737 / cytoplasm / C
PRX / IMH1 / GO:0005794 / Golgi apparatus / C
PRX / IMH1 / GO:0005829 / cytosol / C
PRX / IMH1 / GO:0016020 / membrane / C
PRCC / YLR132C / GO:0005737 / cytoplasm / C
PRCC / YLR132C / GO:0005634 / nucleus / C
PRCC / YLR132C / GO:0005739 / mitochondrion / C
MTPN / GND1 / GO:0005737 / cytoplasm / C
MTPN / GND1 / GO:0005739 / mitochondrion / C
CUL4B / PIH1 / GO:0005737 / cytoplasm / C
CUL4B / PIH1 / GO:0005634 / nucleus / C
CUL4B / PIH1 / GO:0005732 / small nucleolar ribonucleoprotein complex / C
DDX1 / MRPS9 / GO:0030529 / ribonucleoprotein complex / C
DDX1 / MRPS9 / GO:0005622 / intracellular / C
DDX1 / MRPS9 / GO:0005840 / ribosome / C
DDX1 / MRPS9 / GO:0005739 / mitochondrion / C
DDX1 / MRPS9 / GO:0005763 / mitochondrial small ribosomal subunit / C
PSKH1 / RNT1 / GO:0005654 / nucleoplasm / C
PSKH1 / RNT1 / GO:0005622 / intracellular / C
PSKH1 / RNT1 / GO:0005730 / nucleolus / C
UBL5 / BCY1 / GO:0030552 / cAMP binding / F
UBL5 / BCY1 / GO:0008603 / cAMP-dependent protein kinase regulator activity / F
UBL5 / BCY1 / GO:0000166 / nucleotide binding / F
UBL5 / BCY1 / GO:0004862 / cAMP-dependent protein kinase inhibitor activity / F
UBL5 / BCY1 / GO:0004691 / cAMP-dependent protein kinase activity / F
UBL5 / BCY1 / GO:0004690 / cyclic nucleotide-dependent protein kinase activity / F
C9orf16 / CMP2 / GO:0016787 / hydrolase activity / F
C9orf16 / CMP2 / GO:0004721 / phosphoprotein phosphatase activity / F
C9orf16 / CMP2 / GO:0005516 / calmodulin binding / F
C9orf16 / CMP2 / GO:0005506 / iron ion binding / F
C9orf16 / CMP2 / GO:0046872 / metal ion binding / F
C9orf16 / CMP2 / GO:0008270 / zinc ion binding / F
MFRP / TFS1 / GO:0005543 / phospholipid binding / F
MFRP / TFS1 / GO:0008289 / lipid binding / F
MFRP / TFS1 / GO:0030414 / peptidase inhibitor activity / F
MFRP / TFS1 / GO:0004867 / serine-type endopeptidase inhibitor activity / F
NRSN2 / PDR17 / GO:0008526 / phosphatidylinositol transporter activity / F
MKRN1 / GLC8 / GO:0008047 / enzyme activator activity / F
EXOSC8 / MRPL20 / GO:0003735 / structural constituent of ribosome / F
MFAP4 / DAM1 / GO:0005200 / structural constituent of cytoskeleton / F
DLK1 / VMA4 / GO:0015078 / hydrogen ion transmembrane transporter activity / F
DLK1 / VMA4 / GO:0046961 / proton-transporting ATPase activity, rotational mechanism / F
NPTX2 / ATP16 / GO:0016787 / hydrolase activity / F
NPTX2 / ATP16 / GO:0015078 / hydrogen ion transmembrane transporter activity / F
NPTX2 / ATP16 / GO:0046961 / proton-transporting ATPase activity, rotational mechanism / F
NPTX2 / ATP16 / GO:0046933 / hydrogen ion transporting ATP synthase activity, rotational mechanism / F
FANCD2 / CCL1 / GO:0016251 / general RNA polymerase II transcription factor activity / F
FANCD2 / CCL1 / GO:0016538 / cyclin-dependent protein kinase regulator activity / F
KREMEN1 / DBP6 / GO:0016787 / hydrolase activity / F
KREMEN1 / DBP6 / GO:0008026 / ATP-dependent helicase activity / F
KREMEN1 / DBP6 / GO:0004004 / ATP-dependent RNA helicase activity / F
KREMEN1 / DBP6 / GO:0004386 / helicase activity / F
KREMEN1 / DBP6 / GO:0003723 / RNA binding / F
KREMEN1 / DBP6 / GO:0003676 / nucleic acid binding / F
KREMEN1 / DBP6 / GO:0000166 / nucleotide binding / F
KREMEN1 / DBP6 / GO:0005524 / ATP binding / F
CHIC2 / RPC82 / GO:0003899 / DNA-directed RNA polymerase activity / F
CHIC2 / RPC82 / GO:0008270 / zinc ion binding / F
CHIC2 / RPC82 / GO:0003677 / DNA binding / F
JMJD5 / UBA2 / GO:0019948 / SUMO activating enzyme activity / F
JMJD5 / UBA2 / GO:0008641 / small protein activating enzyme activity / F
JMJD5 / UBA2 / GO:0000166 / nucleotide binding / F
JMJD5 / UBA2 / GO:0003824 / catalytic activity / F
JMJD5 / UBA2 / GO:0005488 / binding / F
JMJD5 / UBA2 / GO:0016874 / ligase activity / F
JMJD5 / UBA2 / GO:0005524 / ATP binding / F
C10orf119 / ERG1 / GO:0008144 / drug binding / F
C10orf119 / ERG1 / GO:0004506 / squalene monooxygenase activity / F
C10orf119 / ERG1 / GO:0050660 / FAD binding / F
C10orf119 / ERG1 / GO:0016491 / oxidoreductase activity / F
NEFH / ORC4 / GO:0003688 / DNA replication origin binding / F
NEFH / ORC4 / GO:0003677 / DNA binding / F
FOXRED1 / YDR061W / GO:0000166 / nucleotide binding / F
FOXRED1 / YDR061W / GO:0017111 / nucleoside-triphosphatase activity / F
FOXRED1 / YDR061W / GO:0016887 / ATPase activity / F
FOXRED1 / YDR061W / GO:0005524 / ATP binding / F
WSB1 / INO80 / GO:0016787 / hydrolase activity / F
WSB1 / INO80 / GO:0016887 / ATPase activity / F
WSB1 / INO80 / GO:0000166 / nucleotide binding / F
WSB1 / INO80 / GO:0003676 / nucleic acid binding / F
WSB1 / INO80 / GO:0003677 / DNA binding / F
WSB1 / INO80 / GO:0004386 / helicase activity / F
WSB1 / INO80 / GO:0005524 / ATP binding / F
CRISP3 / MCM5 / GO:0009378 / four-way junction helicase activity / F
CRISP3 / MCM5 / GO:0042623 / ATPase activity, coupled / F
CRISP3 / MCM5 / GO:0004003 / ATP-dependent DNA helicase activity / F
CRISP3 / MCM5 / GO:0003682 / chromatin binding / F
CRISP3 / MCM5 / GO:0017111 / nucleoside-triphosphatase activity / F