Supplementary Material

Supplementary Table 1. Main fMRI studies on ASD social cognition and interaction deficits

Supplementary Table 2. Main fMRI studies on ASD language and behavioral deficits

Supplementary Table 3. Main fMRI resting-state studies on ASD

Supplementary Table 4. Main DTI studies on ASD

Supplementary Table 1. Main fMRI studies on ASD social cognition and interaction deficits

Legend: Shaded cells indicate regions where patients with ASD differ from controls (with either abnormal activity or impaired functional connectivity); Np= number of patients; Nc= number of controls; sib= siblings; p= parents; AS= patients with Asperger syndrome; R-LAT= right-lateralization; PFC= prefrontal cortex; IFG= inferior frontal gyrus; MNs= mirror neuron system; F lobe= frontal lobe; T lobe= temporal lobe; FG= fusiform gyrus; LIMB= limbic system (including amygdala and hippocampus); ACC= anterior cingulate cortex; CING= middle or posterior cingulate; INS= insula; P lobe= parietal lobe; O lobe= occipital lobe; CB= cerebellum; STR= striatum; EVC= early visual cortex; EXT-STR= extra striate visual areas.

Supplementary Table 2. Main fMRI studies on ASD language and behavioral deficits

Legend: Shaded cells indicate regions where patients with ASD differ from controls (with either abnormal activity or impaired functional connectivity measured by fMRI). There are three studies that use a combination of fMRI and DTI techniques, where dotted cells have been used to indicate regions where patients with ASD differ from controls (with abnormal WM integrity measured by DTI); Np= number of patients; Nc= number of controls; R-LAT= right- lateralization; PFC= prefrontal cortex; IFG= inferior frontal gyrus; MNs= mirror neuron system; F lobe= frontal lobe; T lobe =temporal lobe; FG= fusiform gyrus; LIMB= limbic system (including amygdala and hippocampus); ACC= anterior cingulate cortex; CING= middle or posterior cingulate; INS= insula; P lobe= parietal lobe; O lobe= occipital lobe; CB= cerebellum; STR= striatum; EVC= early visual cortex; EXT-STR= extra striate visual areas; AF= arcuate fasciculus.

Supplementary Table 3. Main fMRI resting-state studies on ASD

Legend: Shaded cells indicate regions where patients with ASD differ from controls (with different levels of activity during a passive resting state); Np= number of patients; Nc= number of controls; R-LAT= right-lateralization; PFC= prefrontal cortex, IFG= inferior frontal gyrus; MNs= mirror neuron system; F lobe= frontal lobe; T lobe= temporal lobe; FG= fusiform gyrus; LIMB= limbic system (including amygdala and hippocampus); ACC= anterior cingulate cortex; CING= middle or posterior cingulate; INS= insula; P lobe= parietal lobe; O= occipital; CB= cerebellum; STR= striatum; EVC= early visual cortex; EXT-STR= extra striate visual areas; CC= corpus callosum; AF= arcuate fasciculus

Supplementary Table 4. Main DTI studies on ASD

Legend: Shaded cells indicate affected regions and networks in patients with ASD compared with controls (with abnormal WM integrity); AS= Asperger syndrome; LFA= Low-functioning autism; Np= number of patients; Nc= number of controls; R-LAT= right-lateralization; PFC= prefrontal cortex, IFG= inferior frontal gyrus; MNs= mirror neuron system; F lobe= frontal lobe; T lobe= temporal lobe; FG=fusiform gyrus; LIMB= limbic system (including amygdala and hippocampus); ACC= anterior cingulate cortex; CING= middle or posterior cingulate; INS= insula; P lobe= parietal lobe; O= occipital; CB= cerebellum; STR= striatum; EVC= early visual cortex; EXT-STR= extra striate visual areas; CC= corpus callosum; IC= internal capsule; AF= arcuate fasciculus; LF= longitudinal fasciculus.