SUPPLEMENTARY TABLES
Supplementary Table 1
Supplementary Table 1. List of antibodies used for immunoblotting.
Supplementary Table 2
Patient / Neoadjuvant Treatment / Outcome / Notes1 / THP (carbo for 2 cycles) / pCR
2 / TCHP (dose reductions) / pCR
3 / TCHP / pCR
4* / T+L then TCHP / pCR / *pre-treatment block not available for Collagen II IHC
5 / TCHP (dose reductions) / pCR
6 / T+L then THP / pCR
7 / TCHP (dose reductions) / pCR
8 / TCHP x 12 (carbo for 6 cycles) / pCR
9 / THP (dose reductions) / pCR
10 / TCHP (dose reductions) / pCR
11 / TCHP / pCR
12 / TCHP / pCR
13 / TCHP (dose reductions) / pCR
14 / TCHP / no pCR
15 / TCHP / no pCR
16 / TCH / no pCR
17 / TCHP / no pCR
18 / TCHP / no pCR
19 / AC-TH / no pCR
20 / TCHP / no pCR / Prior chest radiation/chemo for sarcoma
21 / TCH / no pCR
22 / TH / no pCR
23 / THP / no pCR
24 / T+L then THP / no pCR
25 / TCHP / no pCR
26 / TCHP / no pCR
27 / TCH (treated outside Vanderbilt) / no pCR
28 / TP + TCHP / no pCR
29 / TCHP / no pCR
30 / TCHP (dose reductions) / no pCR
Supplementary Table 2. Patient biopsies used for IHC analysis. Samples from a cohort of 30 patients with HER2+ breast cancer treated with the indicated neoadjuvant therapies were stained with trichrome and/or subjected to collagen II IHC. T=Taxotere (docetaxel); C=carboplatin; H=Herceptin (trastuzumab); P=Perjeta (pertuzumab); L=lapatinib; AC=Adriamycin/cyclophosphamide.
Supplementary Table 3
Gene / #564 model-Fold Change (log2) / #564 model- P Value / #564 model- Q Value / #564 model-Actual fold change / #635 model-Actual fold changePck1 / 7.04434 / 2.00E-04 / 0.006809 / 131.9950484
Lep / 6.85358 / 0.00205 / 0.042839 / 115.6466769
Ces1d / 6.31777 / 5.00E-05 / 0.002275 / 79.76975822 / 35.26854
NA / 5.93492 / 2.00E-04 / 0.006809 / 61.17710785
Car3 / 5.92382 / 5.00E-05 / 0.002275 / 60.70822134
Retn / 5.61462 / 1.00E-04 / 0.003924 / 48.99694861
Cyp2e1 / 5.57254 / 5.00E-05 / 0.002275 / 47.58846451
Tshr / 5.54032 / 0.0015 / 0.033722 / 46.53744174
5730408K05Rik,Mir5136 / 5.49941 / 5.00E-05 / 0.002275 / 45.23633051 / 22.48756
Gabra3 / 5.45153 / 0.00015 / 0.005482 / 43.75967141
Cd209d / 5.3754 / 1.00E-04 / 0.003924 / 41.51037327
Col6a6 / 5.32062 / 2.00E-04 / 0.006809 / 39.96374835
Stk32b / 5.16769 / 0.0022 / 0.045238 / 35.94427252
Adipoq / 5.09785 / 5.00E-05 / 0.002275 / 34.24567757
NA / 5.0322 / 0.0018 / 0.03877 / 32.72224893
Cidec / 5.025 / 5.00E-05 / 0.002275 / 32.55935015
Mpz / 4.98116 / 5.00E-05 / 0.002275 / 31.58483214
Ccdc3 / 4.97689 / 1.00E-04 / 0.003924 / 31.49148751
Clec3b / 4.93012 / 5.00E-05 / 0.002275 / 30.48695167
Slc36a2 / 4.87927 / 5.00E-05 / 0.002275 / 29.43110899
Efhd1 / 4.86563 / 5.00E-05 / 0.002275 / 29.15416301
Fgf10 / 4.79221 / 0.00015 / 0.005482 / 27.70760295
Ephx2 / 4.783 / 5.00E-05 / 0.002275 / 27.53128418
Cd209a / 4.78172 / 0.00015 / 0.005482 / 27.50686848
Pcolce2 / 4.76921 / 5.00E-05 / 0.002275 / 27.26938011
Ablim3 / 4.76394 / 5.00E-05 / 0.002275 / 27.1699499
Fabp4 / 4.73578 / 5.00E-05 / 0.002275 / 26.64476124
Selp / 4.72925 / 5.00E-05 / 0.002275 / 26.52443288
Pi16 / 4.72582 / 5.00E-05 / 0.002275 / 26.46144608
A530016L24Rik / 4.72439 / 5.00E-05 / 0.002275 / 26.43523048
Cd209g / 4.7224 / 5.00E-05 / 0.002275 / 26.39879184
Dpt / 4.69951 / 5.00E-05 / 0.002275 / 25.98325018
Wnt2 / 4.69668 / 5.00E-05 / 0.002275 / 25.93233122
Cadm3,Darc / 4.68804 / 5.00E-05 / 0.002275 / 25.77749201
Tnxb / 4.67824 / 5.00E-05 / 0.002275 / 25.60298294
Efemp1 / 4.65643 / 5.00E-05 / 0.002275 / 25.21883979
Gdf10 / 4.6533 / 1.00E-04 / 0.003924 / 25.16418555
NA / 4.64426 / 5.00E-05 / 0.002275 / 25.00699848
Ffar2 / 4.64263 / 5.00E-05 / 0.002275 / 24.97876078
Irf4 / 4.63793 / 5.00E-05 / 0.002275 / 24.89751759
Sfrp4 / 4.62554 / 5.00E-05 / 0.002275 / 24.68461091
Abcd2 / 4.61812 / 5.00E-05 / 0.002275 / 24.55798013
Olfml1 / 4.61111 / 5.00E-05 / 0.002275 / 24.43894327
Figf / 4.59416 / 5.00E-05 / 0.002275 / 24.15349406
Lgi2 / 4.56959 / 5.00E-05 / 0.002275 / 23.74562789
C6 / 4.56485 / 5.00E-05 / 0.002275 / 23.66773924
Cd36 / 4.56042 / 5.00E-05 / 0.002275 / 23.59517555
NA / 4.50555 / 0.001 / 0.024363 / 22.71463157
Aldh1a7 / 4.48804 / 5.00E-05 / 0.002275 / 22.44061019
Mir3966 / 4.48252 / 2.00E-04 / 0.006809 / 22.35491259
Tmeff2 / 4.47148 / 5.00E-05 / 0.002275 / 22.18449796
Apod / 4.45227 / 5.00E-05 / 0.002275 / 21.89106139 / 6.823775
Dgat2 / 4.43174 / 5.00E-05 / 0.002275 / 21.58175077
Sncg / 4.40355 / 5.00E-05 / 0.002275 / 21.16414057
Pnpla3 / 4.39926 / 5.00E-05 / 0.002275 / 21.10130033
Chp2 / 4.3939 / 5.00E-05 / 0.002275 / 21.02304878
1100001G20Rik / 4.38874 / 5.00E-05 / 0.002275 / 20.94799122
Slc1a3 / 4.38035 / 5.00E-05 / 0.002275 / 20.82652162
Pla2g2d / 4.35688 / 2.00E-04 / 0.006809 / 20.49045336
Hal / 4.34925 / 5.00E-05 / 0.002275 / 20.3823713
Akr1c18 / 4.34194 / 5.00E-05 / 0.002275 / 20.27935694
Fmo1 / 4.32231 / 1.00E-04 / 0.003924 / 20.00529503
Adh1 / 4.31267 / 0.00015 / 0.005482 / 19.87206648
Tmem100 / 4.3089 / 5.00E-05 / 0.002275 / 19.82020528
Bmp6 / 4.307 / 0.0024 / 0.047882 / 19.79411966
Fcna / 4.28941 / 5.00E-05 / 0.002275 / 19.55424597
Ces2g / 4.27894 / 5.00E-05 / 0.002275 / 19.41284959
Cdo1 / 4.26867 / 5.00E-05 / 0.002275 / 19.27514757
Clec10a / 4.25783 / 5.00E-05 / 0.002275 / 19.13086233
Tnfaip6 / 4.22719 / 5.00E-05 / 0.002275 / 18.72884465
Atp1a2 / 4.2242 / 5.00E-05 / 0.002275 / 18.69006913
C1qtnf7 / 4.22048 / 5.00E-05 / 0.002275 / 18.64193872
Ms4a8a / 4.21666 / 0.00025 / 0.008221 / 18.59264347
Tek / 4.21462 / 5.00E-05 / 0.002275 / 18.56637168
Galnt16 / 4.18537 / 5.00E-05 / 0.002275 / 18.19373702
Wnt16 / 4.15369 / 5.00E-05 / 0.002275 / 17.79857704
Gsta3 / 4.14493 / 0.00075 / 0.019538 / 17.69083207 / 6.500564
Lyve1 / 4.13842 / 5.00E-05 / 0.002275 / 17.611184
Clip4 / 4.12235 / 5.00E-05 / 0.002275 / 17.41610373
Lpl / 4.10837 / 1.00E-04 / 0.003924 / 17.24815329
Dpp4 / 4.1069 / 5.00E-05 / 0.002275 / 17.23058764
Cd5l / 4.09223 / 5.00E-05 / 0.002275 / 17.05626674
Pparg / 4.07645 / 5.00E-05 / 0.002275 / 16.8707242
Galnt15 / 4.05822 / 5.00E-05 / 0.002275 / 16.65888572
Gm15987 / 4.05513 / 0.001 / 0.024363 / 16.62324349
Rai2 / 4.0385 / 0.00015 / 0.005482 / 16.43272689
Spon2 / 4.0271 / 5.00E-05 / 0.002275 / 16.30338917
Fbln7 / 4.02051 / 1.00E-04 / 0.003924 / 16.22908773
C4b / 4.01711 / 5.00E-05 / 0.002275 / 16.19088566
Ildr2 / 4.00126 / 5.00E-05 / 0.002275 / 16.01397995
Nat8l / 4.00033 / 5.00E-05 / 0.002275 / 16.00366024
Cited1 / 3.98671 / 5.00E-05 / 0.002275 / 15.85328598
Nov / 3.98486 / 5.00E-05 / 0.002275 / 15.83296999
Mctp1 / 3.97384 / 5.00E-04 / 0.014333 / 15.71249086
Enpep / 3.95414 / 5.00E-05 / 0.002275 / 15.49939503
Cd163 / 3.95216 / 5.00E-05 / 0.002275 / 15.47813776 / 9.221139
Thbd / 3.95075 / 5.00E-05 / 0.002275 / 15.46301778
Sult1a1 / 3.94948 / 5.00E-05 / 0.002275 / 15.44941173
Adcyap1r1 / 3.94444 / 0.00035 / 0.01071 / 15.39553396
Apoc1 / 3.94214 / 5.00E-05 / 0.002275 / 15.37100936
Sel1l3 / 3.91975 / 5.00E-05 / 0.002275 / 15.13429955 / 11.80037
Serpina3m,Serpina3n / 3.91636 / 5.00E-05 / 0.002275 / 15.09877919
C4a / 3.89199 / 5.00E-05 / 0.002275 / 14.84587272
Cd209f / 3.8696 / 5.00E-05 / 0.002275 / 14.61724988
Ptger3 / 3.8671 / 5.00E-04 / 0.014333 / 14.59194205
Prdm8 / 3.85577 / 6.00E-04 / 0.016377 / 14.47779512
Ptgis / 3.76064 / 5.00E-05 / 0.002275 / 13.55393638
Fgf9 / 3.7595 / 0.0023 / 0.046611 / 13.54323046
Col28a1 / 3.75138 / 5.00E-05 / 0.002275 / 13.46721846
Pla2g5 / 3.74285 / 0.00025 / 0.008221 / 13.38782785
Rbp4 / 3.71178 / 5.00E-05 / 0.002275 / 13.10258897
Wfikkn2 / 3.70775 / 0.002 / 0.042022 / 13.06603949
Pamr1 / 3.69341 / 5.00E-05 / 0.002275 / 12.93680989
Scn7a / 3.69316 / 5.00E-05 / 0.002275 / 12.93456831
Gpr133 / 3.69243 / 5.00E-05 / 0.002275 / 12.92802511
Igfbp6 / 3.68897 / 5.00E-05 / 0.002275 / 12.89705711
Bmp3 / 3.68052 / 0.00015 / 0.005482 / 12.82173863
Reg1 / 3.67009 / 1.00E-04 / 0.003924 / 12.72937782
Thbs4 / 3.64852 / 5.00E-05 / 0.002275 / 12.54047422
Aldh1l1 / 3.60393 / 5.00E-05 / 0.002275 / 12.15880889
Alox5 / 3.5995 / 1.00E-04 / 0.003924 / 12.1215308
Cyyr1 / 3.59531 / 5.00E-05 / 0.002275 / 12.08637747
Ccl6 / 3.58883 / 5.00E-05 / 0.002275 / 12.03221211
Klf15 / 3.58584 / 0.00015 / 0.005482 / 12.00730105
Barx2 / 3.58552 / 4.00E-04 / 0.012025 / 12.00463804 / 6.227422
Cldn10 / 3.57313 / 5.00E-05 / 0.002275 / 11.90198253
Folr2 / 3.56292 / 5.00E-05 / 0.002275 / 11.81804916
Mmp27 / 3.56114 / 0.00025 / 0.008221 / 11.80347702
Aqp7 / 3.55258 / 0.00035 / 0.01071 / 11.73365033
Cyp4b1 / 3.54483 / 5.00E-05 / 0.002275 / 11.67078745
Enpp2 / 3.5295 / 1.00E-04 / 0.003924 / 11.54743084
1700019D03Rik / 3.52384 / 5.00E-04 / 0.014333 / 11.50221656
Lrrn4cl / 3.52006 / 5.00E-05 / 0.002275 / 11.47211909
Nnmt / 3.51065 / 5.00E-05 / 0.002275 / 11.39753552
Cd200r1 / 3.50636 / 5.00E-05 / 0.002275 / 11.36369413
Has1 / 3.50208 / 0.00095 / 0.023669 / 11.33003176
Aldh1a1,E030003E18Rik / 3.4778 / 5.00E-05 / 0.002275 / 11.14094728
Vtn / 3.47198 / 0.00015 / 0.005482 / 11.09609393
Fam179a / 3.4687 / 5.00E-05 / 0.002275 / 11.07089536
Scara3 / 3.46669 / 5.00E-05 / 0.002275 / 11.05548184
Tmem56 / 3.45998 / 5.00E-05 / 0.002275 / 11.00418199
Crlf1 / 3.45867 / 5.00E-05 / 0.002275 / 10.99419448 / 9.875303
Syt15 / 3.4436 / 5.00E-05 / 0.002275 / 10.87994984
Dio2 / 3.44031 / 1.00E-04 / 0.003924 / 10.85516688
NA / 3.43864 / 5.00E-05 / 0.002275 / 10.84260869
Eda / 3.42552 / 0.00105 / 0.025421 / 10.74445202
Adh7 / 3.42452 / 0.00165 / 0.0363 / 10.73700711
Ebf2 / 3.39511 / 5.00E-05 / 0.002275 / 10.52034419
Vsig4 / 3.37323 / 0.001 / 0.024363 / 10.36199581
Slc10a6 / 3.37213 / 5.00E-05 / 0.002275 / 10.35409819
Fam124a / 3.36536 / 0.00035 / 0.01071 / 10.30562431
Col2a1 / 3.34959 / 5.00E-05 / 0.002275 / 10.19358769 / 9.608059
Hmgcs2 / 3.34257 / 4.00E-04 / 0.012025 / 10.14410726
Tppp3 / 3.32932 / 5.00E-05 / 0.002275 / 10.05136827
Pir / 3.32243 / 0.00035 / 0.01071 / 10.00347955
Orm1 / 3.31839 / 5.00E-05 / 0.002275 / 9.975505842
Saa1 / 3.31369 / 5.00E-05 / 0.002275 / 9.9430606
Mrc1 / 3.31347 / 5.00E-05 / 0.002275 / 9.941544475
Cma1 / 3.30523 / 3.00E-04 / 0.009481 / 9.884924864
Ret / 3.28788 / 1.00E-04 / 0.003924 / 9.766759691
Sirpb1a / 3.28192 / 0.00095 / 0.023669 / 9.726494899
Ccl8 / 3.26083 / 5.00E-05 / 0.002275 / 9.585342615
Adamts5 / 3.24909 / 5.00E-05 / 0.002275 / 9.507657941
4931408D14Rik / 3.24538 / 0.0017 / 0.037083 / 9.483239685
Clec9a / 3.24097 / 1.00E-04 / 0.003924 / 9.454295777
Gypc / 3.23775 / 5.00E-05 / 0.002275 / 9.433217944
F13a1 / 3.2306 / 5.00E-05 / 0.002275 / 9.386582552
Tppp / 3.22929 / 0.00015 / 0.005482 / 9.37806319
Gpnmb / 3.21589 / 2.00E-04 / 0.006809 / 9.291361397
Bmper / 3.20346 / 5.00E-05 / 0.002275 / 9.211652577
Adamtsl1 / 3.19892 / 5.00E-05 / 0.002275 / 9.182710099
Wfdc17 / 3.19852 / 5.00E-05 / 0.002275 / 9.180164464
Hp / 3.18942 / 0.00025 / 0.008221 / 9.122441537
Atp6v0d2 / 3.18673 / 7.00E-04 / 0.018581 / 9.105447991
Comp / 3.16919 / 0.00015 / 0.005482 / 8.99541599 / 17.70064
Prelp / 3.15733 / 5.00E-05 / 0.002275 / 8.921770269
Mgll / 3.15643 / 5.00E-05 / 0.002275 / 8.916206315
Heph / 3.15341 / 5.00E-05 / 0.002275 / 8.897561502
Tusc5 / 3.14643 / 5.00E-05 / 0.002275 / 8.854617579
Lims2 / 3.1329 / 5.00E-05 / 0.002275 / 8.771964661
Cmah / 3.12983 / 5.00E-05 / 0.002275 / 8.753318102
Epdr1 / 3.12951 / 5.00E-05 / 0.002275 / 8.751376769
Col14a1 / 3.11687 / 5.00E-05 / 0.002275 / 8.675037535
Ifitm6 / 3.1157 / 0.0016 / 0.035402 / 8.668005086
Gstk1 / 3.11149 / 6.00E-04 / 0.016377 / 8.642747421
Gja5 / 3.10095 / 2.00E-04 / 0.006809 / 8.579835575
Mgl2 / 3.09693 / 4.00E-04 / 0.012025 / 8.555961555
Fez1 / 3.09196 / 0.00015 / 0.005482 / 8.526537479
Acta1 / 3.08478 / 5.00E-05 / 0.002275 / 8.484208055 / 5.517884
Htra3 / 3.08297 / 5.00E-05 / 0.002275 / 8.473570473
Osr2 / 3.07995 / 0.001 / 0.024363 / 8.455851262
Npr3 / 3.07845 / 5.00E-05 / 0.002275 / 8.447064107 / 4.902355
Penk / 3.07744 / 5.00E-05 / 0.002275 / 8.441152567
NA / 3.07706 / 0.00025 / 0.008221 / 8.438929494
Islr2 / 3.06577 / 5.00E-05 / 0.002275 / 8.37314727
Tpsb2 / 3.05368 / 0.00025 / 0.008221 / 8.303272235
Matn4 / 3.05365 / 5.00E-05 / 0.002275 / 8.303099575
Saa2 / 3.05143 / 5.00E-05 / 0.002275 / 8.290332701
Lrp3 / 3.05112 / 0.00045 / 0.013169 / 8.288551502
Mal / 3.04953 / 3.00E-04 / 0.009481 / 8.279421688
Dok2 / 3.049 / 0.00015 / 0.005482 / 8.276380652
Prnd / 3.04711 / 5.00E-05 / 0.002275 / 8.265545294
Clec1a / 3.04188 / 0.00225 / 0.04596 / 8.235635618
NA / 3.04045 / 0.00015 / 0.005482 / 8.227476497
Sgcd / 3.03758 / 0.00055 / 0.015422 / 8.21112558
Maob / 3.03499 / 4.00E-04 / 0.012025 / 8.196397771
Ebf3 / 3.03329 / 0.00015 / 0.005482 / 8.186745232
Slc16a9 / 3.03173 / 0.0011 / 0.026342 / 8.17789761
C1s,Gm5077 / 3.02308 / 5.00E-05 / 0.002275 / 8.1290119
Nfasc / 3.01486 / 5.00E-05 / 0.002275 / 8.082827171
Dcn / 2.99759 / 5.00E-05 / 0.002275 / 7.986647278
Serpinb9b / 2.99453 / 0.001 / 0.024363 / 7.969725309
Thbs3 / 2.96966 / 5.00E-05 / 0.002275 / 7.833516038
Fpr1 / 2.95216 / 5.00E-04 / 0.014333 / 7.73906888
Eepd1 / 2.9402 / 5.00E-05 / 0.002275 / 7.675176886
Cilp / 2.94019 / 5.00E-05 / 0.002275 / 7.675123686
Timd4 / 2.93796 / 5.00E-05 / 0.002275 / 7.663269272
Gimap3 / 2.91962 / 0.00085 / 0.021667 / 7.566467934
Lgi3 / 2.91785 / 0.0011 / 0.026342 / 7.55719055
Cpm / 2.91767 / 5.00E-05 / 0.002275 / 7.556247725
Abi3bp / 2.91416 / 5.00E-05 / 0.002275 / 7.537886123
Meox2 / 2.90776 / 3.00E-04 / 0.009481 / 7.504521051
Mcpt4 / 2.90705 / 0.00045 / 0.013169 / 7.500828726
Pf4 / 2.89801 / 5.00E-05 / 0.002275 / 7.453975101
Mustn1 / 2.8974 / 1.00E-04 / 0.003924 / 7.450824079
2610019F03Rik / 2.89549 / 0.00035 / 0.01071 / 7.440966377
Igf1 / 2.87538 / 5.00E-05 / 0.002275 / 7.337964881
Camk4 / 2.85981 / 0.00055 / 0.015422 / 7.259197158
Clec14a / 2.85808 / 5.00E-05 / 0.002275 / 7.250497548
Nxpe5 / 2.85208 / 5.00E-05 / 0.002275 / 7.220406193
Il27ra / 2.84859 / 7.00E-04 / 0.018581 / 7.202960536
Mmp12 / 2.84704 / 5.00E-05 / 0.002275 / 7.195225988
Agtr1a / 2.84463 / 0.00055 / 0.015422 / 7.183216507
A530064D06Rik / 2.83621 / 0.0022 / 0.045238 / 7.141415207
Tnfsf14 / 2.83293 / 0.00215 / 0.044626 / 7.12519748
Adcy5 / 2.82857 / 5.00E-05 / 0.002275 / 7.103696771
Ugt1a1,Ugt1a10,Ugt1a2,Ugt1a5,Ugt1a6a,Ugt1a6b,Ugt1a7c,Ugt1a9 / 2.82758 / 5.00E-05 / 0.002275 / 7.098823775
Ggt5 / 2.82666 / 5.00E-05 / 0.002275 / 7.094298331
Acss3 / 2.81319 / 2.00E-04 / 0.006809 / 7.028369307
Gnai1 / 2.80739 / 8.00E-04 / 0.020563 / 7.000170201
Fxyd1 / 2.80544 / 5.00E-05 / 0.002275 / 6.990714904
Ltbp4 / 2.79463 / 5.00E-05 / 0.002275 / 6.938529783
Ptprb / 2.77917 / 5.00E-05 / 0.002275 / 6.864573083
Lgr5 / 2.77379 / 5.00E-05 / 0.002275 / 6.839021856 / 6.666756
Larp6 / 2.76989 / 0.00075 / 0.019538 / 6.820559073
Slc25a23 / 2.76957 / 1.00E-04 / 0.003924 / 6.819046392 / 3.585051
Svep1 / 2.76816 / 5.00E-05 / 0.002275 / 6.812385138
Fbln1 / 2.73961 / 5.00E-05 / 0.002275 / 6.678897622
Aoc3 / 2.72903 / 5.00E-05 / 0.002275 / 6.630097103
Abat / 2.72827 / 6.00E-04 / 0.016377 / 6.626605342
Slc2a13 / 2.72709 / 0.00055 / 0.015422 / 6.621187567
Tnfrsf19 / 2.72359 / 0.00165 / 0.0363 / 6.605143935
Hspa12a / 2.71867 / 0.00055 / 0.015422 / 6.582656882
Hpse / 2.71758 / 5.00E-05 / 0.002275 / 6.577685363
Fam169b / 2.71581 / 0.00195 / 0.041196 / 6.569620343
Gpr27 / 2.71398 / 0.0014 / 0.031986 / 6.56129233
Fcgrt / 2.7138 / 5.00E-05 / 0.002275 / 6.560473752
Podn / 2.71267 / 5.00E-05 / 0.002275 / 6.555337231
Ccdc149 / 2.71179 / 0.00075 / 0.019538 / 6.551339894
Lilrb3 / 2.70904 / 1.00E-04 / 0.003924 / 6.538863921
Pygl / 2.70625 / 5.00E-05 / 0.002275 / 6.526230758
Ly9 / 2.70501 / 0.00205 / 0.042839 / 6.520623857
Tmem252 / 2.70433 / 4.00E-04 / 0.012025 / 6.517551149
F10 / 2.70329 / 0.00045 / 0.013169 / 6.512854515
Mirlet7i / 2.70303 / 2.00E-04 / 0.006809 / 6.511680886
Kcnk3 / 2.69639 / 0.00065 / 0.017525 / 6.481779755
Dpep1 / 2.68583 / 5.00E-05 / 0.002275 / 6.434508712
Cd37 / 2.67647 / 5.00E-05 / 0.002275 / 6.392897665
C2 / 2.66572 / 5.00E-05 / 0.002275 / 6.345439096
Cxcl9 / 2.65619 / 5.00E-05 / 0.002275 / 6.303661213
Lrrn2 / 2.64632 / 0.00185 / 0.039681 / 6.260682764
Evc / 2.64511 / 2.00E-04 / 0.006809 / 6.25543408
Clec4d / 2.63966 / 3.00E-04 / 0.009481 / 6.231847804
Gfra1 / 2.63594 / 5.00E-05 / 0.002275 / 6.215799637
Abca9 / 2.63569 / 5.00E-05 / 0.002275 / 6.214722614
Slc43a1 / 2.6295 / 0.00035 / 0.01071 / 6.188114965
Aoah / 2.62939 / 0.00205 / 0.042839 / 6.187643163
Ebf1 / 2.62408 / 5.00E-05 / 0.002275 / 6.164910713
Gpr68 / 2.62149 / 0.0015 / 0.033722 / 6.153853078
Tshz2 / 2.61962 / 5.00E-05 / 0.002275 / 6.145881712
Wif1 / 2.61467 / 6.00E-04 / 0.016377 / 6.124830843 / 5.545644
C1ra / 2.61274 / 5.00E-05 / 0.002275 / 6.116642681
Ndn / 2.6082 / 1.00E-04 / 0.003924 / 6.097424545
Emilin2 / 2.59755 / 5.00E-05 / 0.002275 / 6.05257898
AW551984 / 2.59516 / 0.0014 / 0.031986 / 6.042560446
Vwf / 2.59352 / 5.00E-05 / 0.002275 / 6.0356954
Fmod / 2.58535 / 5.00E-05 / 0.002275 / 6.001611781
Cygb / 2.58249 / 5.00E-05 / 0.002275 / 5.989725965 / 3.343192
Prex2 / 2.58136 / 2.00E-04 / 0.006809 / 5.985036311
Tspan18 / 2.57493 / 5.00E-05 / 0.002275 / 5.958420741
Gata6 / 2.57431 / 0.0016 / 0.035402 / 5.955860652
Cdkn1c / 2.56742 / 1.00E-04 / 0.003924 / 5.927484561
Pth1r / 2.56524 / 5.00E-05 / 0.002275 / 5.918534535
Sema3g / 2.56363 / 5.00E-05 / 0.002275 / 5.91193333
Fam174b / 2.56211 / 4.00E-04 / 0.012025 / 5.905707893 / 3.595083
Lama2 / 2.56017 / 5.00E-05 / 0.002275 / 5.897771792
Pdzk1ip1 / 2.55583 / 0.00155 / 0.034594 / 5.880056428
Sncaip / 2.55304 / 0.00115 / 0.027243 / 5.868696089
Cers4 / 2.55302 / 0.0017 / 0.037083 / 5.868614732
Ccdc152 / 2.55271 / 0.00045 / 0.013169 / 5.867353846
Flnc / 2.55267 / 5.00E-05 / 0.002275 / 5.86719117
Ndrg4 / 2.55213 / 5.00E-05 / 0.002275 / 5.864995495
Cpeb1 / 2.55001 / 0.00015 / 0.005482 / 5.856383377
Dact1 / 2.54719 / 2.00E-04 / 0.006809 / 5.844947231
Flrt2 / 2.547 / 5.00E-05 / 0.002275 / 5.844177514
Efr3b / 2.53818 / 0.0022 / 0.045238 / 5.808557788
Btnl9 / 2.53636 / 0.00085 / 0.021667 / 5.80123475
Lepr / 2.52522 / 1.00E-04 / 0.003924 / 5.756612093
Kmo / 2.52521 / 0.00145 / 0.032693 / 5.756572191
Sell / 2.50818 / 0.0013 / 0.030239 / 5.689019397
Itga7 / 2.50747 / 5.00E-05 / 0.002275 / 5.686220323
Gbp8 / 2.5059 / 1.00E-04 / 0.003924 / 5.68003571
Fmo2 / 2.50482 / 5.00E-05 / 0.002275 / 5.675785233
Shc2 / 2.50432 / 5.00E-05 / 0.002275 / 5.673818496
Gimap8 / 2.49634 / 2.00E-04 / 0.006809 / 5.642521459
Cd34 / 2.49515 / 5.00E-05 / 0.002275 / 5.637869171
Arsi / 2.4951 / 5.00E-05 / 0.002275 / 5.637673781
Ablim1 / 2.49311 / 5.00E-05 / 0.002275 / 5.629902744
Gas7 / 2.49193 / 5.00E-05 / 0.002275 / 5.625299852
Ccr2 / 2.49097 / 5.00E-05 / 0.002275 / 5.621557903
Dkk2 / 2.49009 / 2.00E-04 / 0.006809 / 5.618129969
Lhx6 / 2.48895 / 0.00125 / 0.029297 / 5.613692345
Aqp1 / 2.4881 / 5.00E-05 / 0.002275 / 5.610385871
Gfpt2 / 2.48695 / 5.00E-05 / 0.002275 / 5.605915507
Npl / 2.48422 / 2.00E-04 / 0.006809 / 5.595317509
Gpc3 / 2.47362 / 1.00E-04 / 0.003924 / 5.554357355
Cxcl12 / 2.47197 / 5.00E-05 / 0.002275 / 5.548008508
Pdzd2 / 2.46673 / 5.00E-05 / 0.002275 / 5.527894185 / 3.835607
Lyz1,Lyz2 / 2.46416 / 5.00E-05 / 0.002275 / 5.518055625
Masp1 / 2.45933 / 1.00E-04 / 0.003924 / 5.499612612 / 3.889326
Agpat9 / 2.45494 / 1.00E-04 / 0.003924 / 5.482903188
Pla2r1 / 2.45248 / 0.0018 / 0.03877 / 5.473562025
Evc2 / 2.45102 / 8.00E-04 / 0.020563 / 5.46802561
Dpysl3 / 2.44722 / 5.00E-05 / 0.002275 / 5.453642005
Serpinb1a / 2.44626 / 2.00E-04 / 0.006809 / 5.450014242
Sorbs1 / 2.44291 / 5.00E-05 / 0.002275 / 5.437373756
Cav1 / 2.44192 / 5.00E-05 / 0.002275 / 5.433643825
Glul / 2.43875 / 5.00E-05 / 0.002275 / 5.421717714
B430306N03Rik / 2.43844 / 0.00035 / 0.01071 / 5.420552844
Hoxc8 / 2.43743 / 3.00E-04 / 0.009481 / 5.416759359
NA / 2.43664 / 5.00E-05 / 0.002275 / 5.413794027
C1qtnf9 / 2.43437 / 1.00E-04 / 0.003924 / 5.405282423
Cfh / 2.43292 / 5.00E-05 / 0.002275 / 5.399852501
Myh11 / 2.41647 / 5.00E-05 / 0.002275 / 5.33863161
Irs3 / 2.41484 / 0.0022 / 0.045238 / 5.332603271
Clec4a1 / 2.41411 / 3.00E-04 / 0.009481 / 5.32990567
Wbscr17 / 2.41136 / 1.00E-04 / 0.003924 / 5.319755722
Npy1r / 2.40492 / 0.0014 / 0.031986 / 5.296061957
Slc24a3 / 2.40339 / 5.00E-05 / 0.002275 / 5.29044838
Meox1 / 2.40219 / 4.00E-04 / 0.012025 / 5.286049739
Slc1a5 / 2.39892 / 5.00E-05 / 0.002275 / 5.274081993
Tpsab1 / 2.39674 / 0.0016 / 0.035402 / 5.266118552
Hoxd9 / 2.39198 / 0.0023 / 0.046611 / 5.248772254
Mfap5 / 2.3914 / 5.00E-05 / 0.002275 / 5.246662539
Mmd / 2.38771 / 5.00E-05 / 0.002275 / 5.233260228
Abcc5 / 2.38014 / 5.00E-05 / 0.002275 / 5.205872578
Npr1 / 2.37633 / 0.00145 / 0.032693 / 5.192142575
Itgbl1 / 2.37531 / 5.00E-05 / 0.002275 / 5.188472975
Adam33 / 2.37107 / 9.00E-04 / 0.022754 / 5.173246729
Papss2 / 2.36961 / 5.00E-05 / 0.002275 / 5.168014078
Ctsk / 2.36716 / 5.00E-05 / 0.002275 / 5.159245149
Olfml2a / 2.36642 / 5.00E-05 / 0.002275 / 5.156599502
Calcrl / 2.35319 / 5.00E-05 / 0.002275 / 5.109527907
Gstm1 / 2.35265 / 5.00E-05 / 0.002275 / 5.107615771 / 2.996572
Gsg1l / 2.34837 / 0.00195 / 0.041196 / 5.092485615
Fosb / 2.34171 / 1.00E-04 / 0.003924 / 5.069031046
Rarres2 / 2.32822 / 5.00E-05 / 0.002275 / 5.021853701
Sema3b / 2.325 / 1.00E-04 / 0.003924 / 5.010657754
Slc9a9 / 2.31599 / 6.00E-04 / 0.016377 / 4.979462426
Vgll3 / 2.31458 / 0.00035 / 0.01071 / 4.974598188
Hnmt / 2.30592 / 0.00085 / 0.021667 / 4.944826837
Sh3tc1 / 2.3052 / 0.00015 / 0.005482 / 4.942359658
Pdk4 / 2.30117 / 2.00E-04 / 0.006809 / 4.928573018
Itih5 / 2.29649 / 5.00E-05 / 0.002275 / 4.912610982
Pira6 / 2.28861 / 0.00115 / 0.027243 / 4.885851449
B3galnt1 / 2.28754 / 5.00E-04 / 0.014333 / 4.882229115
Ssc5d / 2.28709 / 5.00E-05 / 0.002275 / 4.880706506
Ccdc129 / 2.28498 / 0.0014 / 0.031986 / 4.873573492
Tenm4 / 2.28411 / 5.00E-05 / 0.002275 / 4.870635428
Lmcd1 / 2.27751 / 5.00E-05 / 0.002275 / 4.848404274
Dzip1 / 2.27724 / 0.001 / 0.024363 / 4.847496982
Robo4 / 2.26926 / 5.00E-05 / 0.002275 / 4.82075797
Cfp / 2.2689 / 5.00E-05 / 0.002275 / 4.819555182
Cd300lg / 2.26808 / 5.00E-05 / 0.002275 / 4.816816619
Edn1 / 2.26798 / 5.00E-05 / 0.002275 / 4.816482754
Tmem8 / 2.26792 / 5.00E-05 / 0.002275 / 4.816282446
H19 / 2.2669 / 5.00E-05 / 0.002275 / 4.812878489
Dennd2a / 2.26665 / 3.00E-04 / 0.009481 / 4.812044553
Peli2 / 2.26108 / 5.00E-05 / 0.002275 / 4.793501886
Cthrc1 / 2.26022 / 5.00E-05 / 0.002275 / 4.7906453
Ednrb / 2.25957 / 5.00E-05 / 0.002275 / 4.788487381
Mecom / 2.25536 / 7.00E-04 / 0.018581 / 4.774534227
Ccbp2 / 2.25377 / 0.00075 / 0.019538 / 4.769275093
Synpo2 / 2.25167 / 6.00E-04 / 0.016377 / 4.762337942
Gstm2 / 2.24427 / 5.00E-05 / 0.002275 / 4.737973075
Cyp7b1 / 2.23535 / 1.00E-04 / 0.003924 / 4.708769165
Fam213b / 2.23485 / 1.00E-04 / 0.003924 / 4.707137513
Fbn2 / 2.22862 / 0.00035 / 0.01071 / 4.686854474
Nbl1 / 2.22727 / 5.00E-05 / 0.002275 / 4.682470807
Cd302 / 2.22676 / 0.00065 / 0.017525 / 4.680815822
Rasgrp2 / 2.22474 / 0.00215 / 0.044626 / 4.67426653
Apoe / 2.22118 / 2.00E-04 / 0.006809 / 4.662746511
Lrrc17 / 2.2187 / 1.00E-04 / 0.003924 / 4.654738111
C130074G19Rik / 2.2177 / 5.00E-05 / 0.002275 / 4.651512811
Serping1 / 2.21379 / 4.00E-04 / 0.012025 / 4.638923323
Csn1s2a / 2.21294 / 5.00E-05 / 0.002275 / 4.63619099
Ushbp1 / 2.21216 / 1.00E-04 / 0.003924 / 4.633685088
Stard8 / 2.20992 / 5.00E-05 / 0.002275 / 4.626496181
Atp2b4 / 2.20854 / 5.00E-05 / 0.002275 / 4.622072854
Nsg1 / 2.20393 / 5.00E-05 / 0.002275 / 4.607327015
Tns1 / 2.19241 / 5.00E-05 / 0.002275 / 4.570683747
Zfp608 / 2.18722 / 1.00E-04 / 0.003924 / 4.554270555
Slco2b1 / 2.17302 / 0.00015 / 0.005482 / 4.509664165
Apba1 / 2.16288 / 3.00E-04 / 0.009481 / 4.478079063
Ncald / 2.15489 / 5.00E-05 / 0.002275 / 4.453346909 / 4.87354
Bicc1 / 2.15474 / 1.00E-04 / 0.003924 / 4.45288391
Lrrk2 / 2.13985 / 0.00095 / 0.023669 / 4.407162218
Rgl1 / 2.13284 / 5.00E-05 / 0.002275 / 4.385799927
Adcy4 / 2.1281 / 5.00E-05 / 0.002275 / 4.371413949
Lum / 2.12756 / 0.00045 / 0.013169 / 4.369778037
Pde8a / 2.1272 / 0.00045 / 0.013169 / 4.36868777
Pcdh17 / 2.12552 / 6.00E-04 / 0.016377 / 4.363603449
Celsr1 / 2.12519 / 6.00E-04 / 0.016377 / 4.362605439 / 9.148435
Podxl2 / 2.1242 / 0.00075 / 0.019538 / 4.359612778
Sytl2 / 2.12344 / 0.0012 / 0.028297 / 4.357316774
Csf2rb2 / 2.11487 / 5.00E-05 / 0.002275 / 4.331509856
Gm4841 / 2.11002 / 3.00E-04 / 0.009481 / 4.316972792
Mmp3 / 2.10794 / 5.00E-05 / 0.002275 / 4.310753297
Arhgef10 / 2.10692 / 5.00E-04 / 0.014333 / 4.307706628
Galnt6 / 2.10542 / 2.00E-04 / 0.006809 / 4.303230144
Mrgprf / 2.10296 / 0.0016 / 0.035402 / 4.295898777
Slfn5 / 2.10173 / 5.00E-05 / 0.002275 / 4.292237779
Bnc2 / 2.09689 / 2.00E-04 / 0.006809 / 4.277862168
Fgd5 / 2.09397 / 0.00045 / 0.013169 / 4.269212575
Pkdcc / 2.09315 / 1.00E-04 / 0.003924 / 4.266786727
Dnase1l3 / 2.09195 / 0.00025 / 0.008221 / 4.263239189
Cped1 / 2.08968 / 0.00065 / 0.017525 / 4.256536495
Il6st / 2.08755 / 5.00E-05 / 0.002275 / 4.250256767
Gm13889 / 2.08698 / 5.00E-05 / 0.002275 / 4.248577848
Cul9 / 2.07509 / 8.00E-04 / 0.020563 / 4.213707
Tmem45a / 2.07464 / 5.00E-05 / 0.002275 / 4.212392882
Tbxas1 / 2.06795 / 5.00E-05 / 0.002275 / 4.192904585
Col15a1 / 2.06789 / 5.00E-05 / 0.002275 / 4.19273021
Atp2a3 / 2.06158 / 6.00E-04 / 0.016377 / 4.174432264 / 3.606926
Cyp27a1 / 2.06066 / 0.00145 / 0.032693 / 4.171771097
Cd248 / 2.05098 / 5.00E-05 / 0.002275 / 4.143873608
Duoxa1 / 2.05082 / 6.00E-04 / 0.016377 / 4.143414063 / 3.723527
Tbcel / 2.05064 / 0.00235 / 0.047251 / 4.142897136
Pdpn / 2.05006 / 5.00E-05 / 0.002275 / 4.141231921
Erg / 2.04867 / 0.001 / 0.024363 / 4.137243871
S1pr1 / 2.04784 / 5.00E-05 / 0.002275 / 4.134864348
Plcb4 / 2.04758 / 2.00E-04 / 0.006809 / 4.134119237
Hgf / 2.04751 / 0.00035 / 0.01071 / 4.133918654
Medag / 2.04684 / 5.00E-05 / 0.002275 / 4.131999272
Mir1903,Nrp1 / 2.04656 / 5.00E-05 / 0.002275 / 4.131197406
Ubd / 2.04199 / 5.00E-05 / 0.002275 / 4.118131789
Zeb1 / 2.0412 / 1.00E-04 / 0.003924 / 4.115877374
Hspb8 / 2.03611 / 5.00E-05 / 0.002275 / 4.101381654
Abcc4 / 2.0296 / 0.00085 / 0.021667 / 4.082916321
Rcan2 / 2.02351 / 0.00065 / 0.017525 / 4.06571757
Aplnr / 2.01945 / 5.00E-05 / 0.002275 / 4.054292003
Gm14548,Lilra6,Pira1,Pira11,Pira2,Pira7 / 2.01652 / 0.00135 / 0.031121 / 4.046066411
Gxylt2 / 2.01643 / 2.00E-04 / 0.006809 / 4.045814012
Ifi27l2a / 2.01495 / 5.00E-05 / 0.002275 / 4.04166571
Itm2a / 2.01325 / 5.00E-05 / 0.002275 / 4.036906017
Cpxm1 / 2.01045 / 5.00E-05 / 0.002275 / 4.029078739
Entpd2 / 2.00964 / 2.00E-04 / 0.006809 / 4.026817251 / 3.278316
Clic6 / 1.99939 / 5.00E-05 / 0.002275 / 3.998309078 / 4.182296
Timp2 / 1.99529 / 3.00E-04 / 0.009481 / 3.986962401
Frmd4b / 1.98709 / 0.00035 / 0.01071 / 3.964365555 / 2.886918
NA / 1.97454 / 0.00015 / 0.005482 / 3.930029114
Cpxm2 / 1.97247 / 5.00E-05 / 0.002275 / 3.924394294
Sepp1 / 1.96165 / 5.00E-05 / 0.002275 / 3.895072009
Cd300lb / 1.94827 / 0.00115 / 0.027243 / 3.859114903
Clec4n / 1.94799 / 5.00E-05 / 0.002275 / 3.858365994
Itgam / 1.94579 / 5.00E-05 / 0.002275 / 3.852486764
Pla1a / 1.94185 / 5.00E-05 / 0.002275 / 3.841979976
Lpar1 / 1.94129 / 1.00E-04 / 0.003924 / 3.840488954
Csgalnact1 / 1.94077 / 1.00E-04 / 0.003924 / 3.83910495
Pik3r5 / 1.94042 / 5.00E-05 / 0.002275 / 3.838173691
1500015O10Rik / 1.93646 / 5.00E-05 / 0.002275 / 3.827652876 / 6.435668
Olfm1 / 1.93307 / 2.00E-04 / 0.006809 / 3.818669335
Pcsk5 / 1.92547 / 5.00E-05 / 0.002275 / 3.798605789
Tacr1 / 1.92371 / 0.0011 / 0.026342 / 3.793974547
Sqrdl / 1.91682 / 2.00E-04 / 0.006809 / 3.775898542
Slc11a1 / 1.91457 / 5.00E-05 / 0.002275 / 3.770014311
Mir5129,Zeb2 / 1.91309 / 2.00E-04 / 0.006809 / 3.766148795
Lrrc32 / 1.90968 / 5.00E-05 / 0.002275 / 3.757257518
Ldb2 / 1.90877 / 0.0011 / 0.026342 / 3.754888323
Rnf144a / 1.9027 / 0.00065 / 0.017525 / 3.739123181
Pcdh19 / 1.9001 / 6.00E-04 / 0.016377 / 3.732390667
Srpx / 1.89171 / 0.00025 / 0.008221 / 3.710747924
Stc1 / 1.88329 / 0.0017 / 0.037083 / 3.689153964 / 2.784079
AI467606 / 1.88216 / 0.00095 / 0.023669 / 3.686265542
Txnip / 1.87918 / 5.00E-05 / 0.002275 / 3.678659129
Serpinf1 / 1.8734 / 5.00E-05 / 0.002275 / 3.663950468
Hmcn1 / 1.86962 / 2.00E-04 / 0.006809 / 3.65436313
Ndrg2 / 1.86901 / 0.00015 / 0.005482 / 3.652818319
Myct1 / 1.86863 / 0.0014 / 0.031986 / 3.651856309
Dpp7 / 1.86503 / 0.0022 / 0.045238 / 3.642755083
Col8a2 / 1.86337 / 5.00E-05 / 0.002275 / 3.63856605
Il1rl1 / 1.85558 / 0.00245 / 0.048816 / 3.618972136
Cxcl10 / 1.85511 / 8.00E-04 / 0.020563 / 3.617793343
Sdk1 / 1.84356 / 0.00235 / 0.047251 / 3.588945462
NA / 1.84338 / 0.0011 / 0.026342 / 3.58849771
Fibin / 1.84048 / 5.00E-05 / 0.002275 / 3.581291619
Kcna6 / 1.84015 / 0.00055 / 0.015422 / 3.580472534
Slc27a1 / 1.83831 / 0.001 / 0.024363 / 3.575908943
Mmp23 / 1.83503 / 1.00E-04 / 0.003924 / 3.567788267
Nudt16 / 1.82776 / 0.0019 / 0.040472 / 3.549854763
Tie1 / 1.82145 / 1.00E-04 / 0.003924 / 3.534362459
Nfam1 / 1.81985 / 0.001 / 0.024363 / 3.530444898
Kdr / 1.81585 / 1.00E-04 / 0.003924 / 3.520669984
Cxcl14 / 1.811 / 5.00E-05 / 0.002275 / 3.508854195
Sema3c / 1.81026 / 5.00E-05 / 0.002275 / 3.507054864
Ccl11 / 1.80963 / 5.00E-05 / 0.002275 / 3.505523728
Ly6d / 1.80949 / 0.00145 / 0.032693 / 3.505183566 / 11.43207
Pcolce / 1.80865 / 5.00E-05 / 0.002275 / 3.503143289
Ccdc109b / 1.80799 / 0.00125 / 0.029297 / 3.501541048
Nid1 / 1.80226 / 3.00E-04 / 0.009481 / 3.487661442
Gfra2 / 1.80103 / 0.00105 / 0.025421 / 3.48468923
Loxl1 / 1.8002 / 5.00E-05 / 0.002275 / 3.482685022
Wfdc2 / 1.80008 / 5.00E-05 / 0.002275 / 3.482395353 / 2.511089
Cers6 / 1.79956 / 3.00E-04 / 0.009481 / 3.481140397
Agpat4 / 1.79948 / 0.00135 / 0.031121 / 3.480947366
Atp6v0e2 / 1.79529 / 0.0023 / 0.046611 / 3.470852364
C130021I20Rik / 1.79434 / 0.00105 / 0.025421 / 3.468567595 / 3.724237
Wnt9a / 1.79344 / 0.00045 / 0.013169 / 3.466404465
Phgdh / 1.79243 / 5.00E-05 / 0.002275 / 3.463978558 / 6.265002
Cbr3 / 1.79126 / 0.00125 / 0.029297 / 3.461170472
Gpr116 / 1.79056 / 5.00E-05 / 0.002275 / 3.459491509
Fhl1 / 1.78934 / 5.00E-05 / 0.002275 / 3.456567263
Wisp2 / 1.78794 / 5.00E-05 / 0.002275 / 3.453214616
Exph5 / 1.78726 / 0.001 / 0.024363 / 3.451587361
Cd274 / 1.78709 / 5.00E-05 / 0.002275 / 3.451180667
Fst / 1.78429 / 1.00E-04 / 0.003924 / 3.44448907
Siglec1 / 1.77688 / 5.00E-05 / 0.002275 / 3.42684277
Ang,Rnase4 / 1.77631 / 5.00E-05 / 0.002275 / 3.425489113
Ccdc80 / 1.77286 / 0.00095 / 0.023669 / 3.41730733
Rassf2 / 1.76772 / 1.00E-04 / 0.003924 / 3.40515389
Gpc6 / 1.76688 / 5.00E-05 / 0.002275 / 3.403171838
Aif1l / 1.76463 / 0.00145 / 0.032693 / 3.397868452 / 4.810477
Iglon5 / 1.76275 / 0.0016 / 0.035402 / 3.393443517
Nos3 / 1.75165 / 0.00195 / 0.041196 / 3.367434771
Trem2 / 1.74962 / 5.00E-05 / 0.002275 / 3.362699823
Hoxd8 / 1.74764 / 0.00195 / 0.041196 / 3.358087914
Ctsf / 1.74556 / 0.00025 / 0.008221 / 3.353249892
Nfatc2 / 1.74303 / 0.0014 / 0.031986 / 3.347374577
Gbp5 / 1.74277 / 5.00E-05 / 0.002275 / 3.346771373
Mageh1 / 1.74148 / 0.0024 / 0.047882 / 3.343780162
Fry / 1.74062 / 0.0019 / 0.040472 / 3.341787507
Syk / 1.73577 / 5.00E-05 / 0.002275 / 3.330572069
Fndc1 / 1.73158 / 0.001 / 0.024363 / 3.320913165
Cdh13 / 1.73081 / 5.00E-05 / 0.002275 / 3.319141189
NA / 1.72973 / 5.00E-05 / 0.002275 / 3.316657414
Eltd1 / 1.72705 / 5.00E-04 / 0.014333 / 3.310501996
Has2 / 1.72634 / 0.001 / 0.024363 / 3.308873184
Il16 / 1.71234 / 0.00145 / 0.032693 / 3.276918972
C1rl / 1.70778 / 0.0022 / 0.045238 / 3.266577798
Fli1 / 1.69699 / 0.00185 / 0.039681 / 3.242238006
Pid1 / 1.69456 / 8.00E-04 / 0.020563 / 3.236781547
Lsp1 / 1.68867 / 5.00E-05 / 0.002275 / 3.223593881
9930013L23Rik / 1.68588 / 9.00E-04 / 0.022754 / 3.21736586
Pde3b / 1.68124 / 0.00105 / 0.025421 / 3.207034781
Map6 / 1.67965 / 0.00035 / 0.01071 / 3.203502242
Npas2 / 1.67798 / 0.0023 / 0.046611 / 3.199796154
Procr / 1.67129 / 0.0021 / 0.043765 / 3.184992555
Lrp1 / 1.66944 / 0.00015 / 0.005482 / 3.180910985
Foxp1 / 1.64968 / 1.00E-04 / 0.003924 / 3.137640363
Mxra7 / 1.64894 / 0.00065 / 0.017525 / 3.13603139
Rasip1 / 1.64836 / 0.00155 / 0.034594 / 3.134770879
Angptl4 / 1.64512 / 5.00E-05 / 0.002275 / 3.12773872
Klf4 / 1.64404 / 5.00E-05 / 0.002275 / 3.125398174
Gp49a / 1.64324 / 0.00045 / 0.013169 / 3.123665566
Cd93 / 1.64209 / 5.00E-05 / 0.002275 / 3.121176624
Ramp2 / 1.64119 / 0.00015 / 0.005482 / 3.11923014
Hsd11b1 / 1.63378 / 5.00E-05 / 0.002275 / 3.103250159 / 3.182786
Gm4951 / 1.63341 / 5.00E-05 / 0.002275 / 3.102454388
Itga11 / 1.63202 / 0.00055 / 0.015422 / 3.099466691
Gimap6 / 1.63187 / 0.0013 / 0.030239 / 3.09914445
Chst1 / 1.63028 / 9.00E-04 / 0.022754 / 3.095730752 / 3.927156
Adamts2 / 1.62534 / 0.00025 / 0.008221 / 3.085148642
Il33 / 1.62493 / 5.00E-05 / 0.002275 / 3.084271997 / 5.064062
Ccnd2 / 1.62167 / 0.00025 / 0.008221 / 3.07731046
Gbgt1 / 1.62096 / 0.00225 / 0.04596 / 3.075796382
Olfml2b / 1.61763 / 5.00E-05 / 0.002275 / 3.068705077
Chst15 / 1.61388 / 0.00145 / 0.032693 / 3.060738944
Glipr2 / 1.6134 / 3.00E-04 / 0.009481 / 3.059720773
Scamp5 / 1.61156 / 0.00165 / 0.0363 / 3.055820921
Adam23 / 1.58282 / 0.0024 / 0.047882 / 2.995548102
Plvap / 1.57845 / 5.00E-05 / 0.002275 / 2.986488155
Tspan11 / 1.57724 / 0.00075 / 0.019538 / 2.983984414
Plek / 1.57519 / 1.00E-04 / 0.003924 / 2.979747327
Rgs4 / 1.57182 / 0.00155 / 0.034594 / 2.972795041 / 2.580195
Eln / 1.5702 / 5.00E-05 / 0.002275 / 2.969458767
Gbp1 / 1.56987 / 3.00E-04 / 0.009481 / 2.968779615
Slc7a8 / 1.56762 / 0.00075 / 0.019538 / 2.964153171
Ckb / 1.56353 / 5.00E-05 / 0.002275 / 2.95576178
Lmo2 / 1.56318 / 0.00115 / 0.027243 / 2.955044795
Pecam1 / 1.56265 / 0.0013 / 0.030239 / 2.953959405
Emp3 / 1.55936 / 5.00E-05 / 0.002275 / 2.947230711
Mmrn2 / 1.55762 / 0.00015 / 0.005482 / 2.943678269
Csf2rb / 1.55152 / 1.00E-04 / 0.003924 / 2.931258091
Hlx / 1.55079 / 0.0013 / 0.030239 / 2.929775257
Ppap2b / 1.5409 / 5.00E-05 / 0.002275 / 2.909759671 / 2.285914
Colec12 / 1.54035 / 5.00E-05 / 0.002275 / 2.908650592
Slit3 / 1.5378 / 5.00E-05 / 0.002275 / 2.903514019
Plat / 1.53226 / 0.00055 / 0.015422 / 2.892385803
Cdh5 / 1.53129 / 5.00E-05 / 0.002275 / 2.890441753
Cpz / 1.53054 / 0.00175 / 0.038012 / 2.888939517
Parvb / 1.52983 / 0.00145 / 0.032693 / 2.88751812
Irs2 / 1.52403 / 0.00035 / 0.01071 / 2.875932868
Rasgrp3 / 1.51915 / 0.0019 / 0.040472 / 2.866221292
Gatsl2 / 1.519 / 0.00225 / 0.04596 / 2.865923301
Tgfbr3 / 1.5173 / 5.00E-05 / 0.002275 / 2.862548228
Renbp / 1.51444 / 0.0018 / 0.03877 / 2.856879131
Csrp2 / 1.51298 / 1.00E-04 / 0.003924 / 2.853989446
Ttc28 / 1.51192 / 9.00E-04 / 0.022754 / 2.851893288
C5ar1 / 1.50738 / 0.0011 / 0.026342 / 2.842932805
Supplementary Table 3. List of genes that are significantly upregulated in TPB-resistant tumors relative to untreated parental tumors. RNA-seq was performed on 6 samples from #564 TPB-resistant tumors (treated with TPB) and 3 samples from #564 drug-sensitive (parental) tumors. Genes that were upregulated at least 2.8-fold, q<0.05 in TPB-resistant tumors (model #564) are shown. Pink = ECM genes; blue = cell adhesion genes; lavender = ECM and cell adhesion genes. In addition, RNA-seq was performed on 6 samples from #635 TPB-resistant tumors (treated with TPB) and 3 samples from #635 drug-sensitive tumors. Upregulated genes from #564 TPB-resistant tumors that were also upregulated in #635 TPB-resistant tumors are indicated (q<0.05).
Supplementary Table 4
Arm THP / Arm HPSymbol / ProbeSet / Parametric p-value / FDR / Geom mean- no pCR / Geom mean pCR / Fold-change (no pCR/pCR) / Parametric p-value / FDR / Geom mean- no pCR / Geom mean pCR / Fold-change (no pCR/pCR)
COL2A1 / 213492_at / 0.0055117 / 0.171 / 23.96 / 14.86 / 1.61 / 0.121252 / 0.626 / 25.26 / 15.95 / 1.58
CELSR1 / 41660_at / 0.0803016 / 0.323 / 193.47 / 140.27 / 1.38 / 0.004116 / 0.354 / 176.95 / 94.37 / 1.88
SELL / 204563_at / 0.482258 / 0.7 / 71.17 / 60.96 / 1.17 / 0.0309495 / 0.411 / 49.51 / 91.87 / 0.54
PODXL2 / 219152_at / 0.0306927 / 0.238 / 35.61 / 31 / 1.15 / 0.547437 / 0.783 / 34.84 / 36.8 / 0.95
SELP / 206049_at / 0.267921 / 0.504 / 26.17 / 22.8 / 1.15 / 0.349555 / 0.748 / 22.14 / 25.94 / 0.85
ADAMTSL1 / 1552457_a_at / 0.0923823 / 0.33 / 6.97 / 6.13 / 1.14 / 0.648627 / 0.826 / 6.67 / 6.39 / 1.04
HPSE / 219403_s_at / 0.220988 / 0.468 / 16.77 / 14.83 / 1.13 / 0.522308 / 0.773 / 16.3 / 17.75 / 0.92
EDA / 206217_at / 0.0630391 / 0.279 / 16.26 / 14.52 / 1.12 / 0.166465 / 0.663 / 15.27 / 17.26 / 0.88
CADM3 / 213948_x_at / 0.115918 / 0.356 / 16.71 / 15.08 / 1.11 / 0.503429 / 0.773 / 15.5 / 16.42 / 0.94
BARX2 / 210419_at / 0.0533183 / 0.279 / 50.6 / 46.07 / 1.1 / 0.249268 / 0.671 / 49.46 / 53.9 / 0.92
PARVB / 37966_at / 0.106941 / 0.356 / 38.37 / 34.89 / 1.1 / 0.455355 / 0.773 / 38.79 / 42.08 / 0.92
LTBP4 / 227989_at / 0.400555 / 0.676 / 44.04 / 40.8 / 1.08 / 0.171203 / 0.663 / 41.32 / 48.5 / 0.85
ITGAM / 205786_s_at / 0.541967 / 0.741 / 75.34 / 70.02 / 1.08 / 0.259473 / 0.671 / 60.67 / 74.05 / 0.82
TEK / 206702_at / 0.503902 / 0.71 / 28 / 26.27 / 1.07 / 0.612838 / 0.826 / 26.56 / 28.06 / 0.95
ELN / 212670_at / 0.613131 / 0.792 / 124.01 / 115.69 / 1.07 / 0.356091 / 0.748 / 120.32 / 140.97 / 0.85
SIGLEC1 / 219519_s_at / 0.561495 / 0.743 / 64.66 / 61.47 / 1.05 / 0.526013 / 0.773 / 61.17 / 65.9 / 0.93
ANGPTL4 / 221009_s_at / 0.567108 / 0.743 / 69.89 / 66.58 / 1.05 / 0.667334 / 0.827 / 68.96 / 65.22 / 1.06
PODN / 226522_at / 0.480378 / 0.7 / 33.39 / 32.19 / 1.04 / 0.0776474 / 0.529 / 33.46 / 38.1 / 0.88
SDK1 / 229407_at / 0.539389 / 0.741 / 10.86 / 10.4 / 1.04 / 0.108942 / 0.596 / 11.35 / 13.42 / 0.85
FBLN7 / 229247_at / 0.564067 / 0.743 / 34.42 / 32.94 / 1.04 / 0.834106 / 0.881 / 34.27 / 35.13 / 0.98
THBS4 / 204776_at / 0.680271 / 0.844 / 86.39 / 83.48 / 1.03 / 0.276362 / 0.671 / 86.11 / 97.86 / 0.88
ABI3BP / 223395_at / 0.864751 / 0.946 / 71.23 / 69.11 / 1.03 / 0.166079 / 0.663 / 59.02 / 81.17 / 0.73
EMILIN2 / 224374_s_at / 0.843015 / 0.936 / 48.05 / 47.3 / 1.02 / 0.809209 / 0.875 / 50.78 / 49.44 / 1.03
ITGA7 / 216331_at / 0.845116 / 0.936 / 42.43 / 41.72 / 1.02 / 0.646447 / 0.826 / 41.99 / 43.91 / 0.96
TMEM8A / 221882_s_at / 0.993408 / 0.998 / 36.61 / 36.59 / 1 / 0.251463 / 0.671 / 40.52 / 36.67 / 1.1
ADAM33 / 232570_s_at / 0.994655 / 0.998 / 30.04 / 30.03 / 1 / 0.273474 / 0.671 / 30.31 / 33.98 / 0.89
LOXL1 / 203570_at / 0.997827 / 0.998 / 56.96 / 56.97 / 1 / 0.165775 / 0.663 / 57.06 / 68.48 / 0.83
ADAM23 / 244463_at / 0.818221 / 0.928 / 14.29 / 14.49 / 0.99 / 0.0230308 / 0.411 / 14.03 / 16.81 / 0.83
PLEK / 203471_s_at / 0.935007 / 0.971 / 125.44 / 126.68 / 0.99 / 0.0267074 / 0.411 / 109.42 / 160.76 / 0.68
VWF / 202112_at / 0.8864 / 0.959 / 54.31 / 54.95 / 0.99 / 0.238792 / 0.671 / 52.79 / 60.77 / 0.87
CTHRC1 / 225681_at / 0.912424 / 0.971 / 1094.32 / 1106.01 / 0.99 / 0.790787 / 0.875 / 1145.57 / 1198.23 / 0.96
EPDR1 / 223253_at / 0.937817 / 0.971 / 45.92 / 46.32 / 0.99 / 0.281548 / 0.671 / 50.26 / 59.4 / 0.85
COMP / 205713_s_at / 0.939406 / 0.971 / 54.52 / 55.1 / 0.99 / 0.753351 / 0.875 / 56.24 / 59.66 / 0.94
WNT16 / 224022_x_at / 0.723723 / 0.876 / 6.01 / 6.16 / 0.98 / 0.521701 / 0.773 / 6 / 6.34 / 0.95
CPXM1 / 227860_at / 0.773798 / 0.9 / 58.17 / 59.6 / 0.98 / 0.499863 / 0.773 / 59.56 / 63.65 / 0.94
CDH5 / 204677_at / 0.633156 / 0.807 / 75.3 / 77.35 / 0.97 / 0.103226 / 0.596 / 74.93 / 85.8 / 0.87
MMRN2 / 236262_at / 0.812597 / 0.928 / 49.9 / 51.69 / 0.97 / 0.39558 / 0.748 / 38.42 / 44.12 / 0.87
PCDH19 / 227282_at / 0.472772 / 0.7 / 12.02 / 12.64 / 0.95 / 0.774814 / 0.875 / 13.44 / 13.95 / 0.96
NFASC / 213438_at / 0.743399 / 0.876 / 54.12 / 56.8 / 0.95 / 0.216222 / 0.671 / 51.47 / 64.59 / 0.8
PRELP / 228224_at / 0.652564 / 0.82 / 65.33 / 69.39 / 0.94 / 0.453852 / 0.773 / 58.23 / 67.82 / 0.86
CILP / 206227_at / 0.74412 / 0.876 / 228.76 / 243.88 / 0.94 / 0.22865 / 0.671 / 234.7 / 341.6 / 0.69
OLFML2B / 213125_at / 0.400726 / 0.676 / 83.6 / 89.83 / 0.93 / 0.484984 / 0.773 / 90.16 / 99.82 / 0.9
ANG / 205141_at / 0.407288 / 0.676 / 44.82 / 48.44 / 0.93 / 0.99995 / 1 / 45.76 / 45.76 / 1
WISP2 / 205792_at / 0.461545 / 0.7 / 39.01 / 41.93 / 0.93 / 0.854927 / 0.893 / 43.06 / 44.43 / 0.97
SLC1A3 / 202800_at / 0.489432 / 0.7 / 141.44 / 152.91 / 0.93 / 0.135541 / 0.663 / 134.51 / 169.26 / 0.79
RET / 211421_s_at / 0.733386 / 0.876 / 35.32 / 38.11 / 0.93 / 0.477805 / 0.773 / 30.18 / 24.95 / 1.21
FBLN1 / 202995_s_at / 0.485401 / 0.7 / 32.27 / 35.15 / 0.92 / 0.0108942 / 0.354 / 32.49 / 50.46 / 0.64
CPXM2 / 226824_at / 0.280682 / 0.512 / 23.85 / 25.89 / 0.92 / 0.401737 / 0.748 / 25.55 / 27.92 / 0.91
TIMP2 / 224560_at / 0.366698 / 0.643 / 1267.14 / 1373.49 / 0.92 / 0.275153 / 0.671 / 1255.85 / 1461.85 / 0.86
LYVE1 / 220037_s_at / 0.449433 / 0.7 / 13.72 / 14.95 / 0.92 / 0.420491 / 0.767 / 13.14 / 14.63 / 0.9
COL6A6 / 230867_at / 0.454264 / 0.7 / 16.24 / 17.79 / 0.91 / 0.0410254 / 0.459 / 14.83 / 20.27 / 0.73
FMOD / 202709_at / 0.42223 / 0.689 / 62.11 / 68.09 / 0.91 / 0.277941 / 0.671 / 61.91 / 54.06 / 1.15
GPC3 / 209220_at / 0.118656 / 0.356 / 20.63 / 23.25 / 0.89 / 0.015222 / 0.354 / 20.63 / 25.6 / 0.81
COL28A1 / 242345_at / 0.250665 / 0.494 / 19.39 / 21.78 / 0.89 / 0.190445 / 0.671 / 20.75 / 17.33 / 1.2
LY9 / 231124_x_at / 0.334993 / 0.599 / 46.96 / 52.7 / 0.89 / 0.531323 / 0.773 / 48.92 / 56.29 / 0.87
OLFML2A / 213075_at / 0.186718 / 0.439 / 50.62 / 57.75 / 0.88 / 0.0444417 / 0.459 / 52.01 / 68.21 / 0.76
THBS3 / 209561_at / 0.075767 / 0.32 / 49.85 / 57.82 / 0.86 / 0.810964 / 0.875 / 52.75 / 51.46 / 1.03
COL15A1 / 203477_at / 0.144226 / 0.395 / 346.42 / 402.09 / 0.86 / 0.10254 / 0.596 / 333.32 / 442.59 / 0.75
ENTPD2 / 230430_at / 0.0465843 / 0.279 / 37.22 / 44.41 / 0.84 / 0.657086 / 0.826 / 36.41 / 39.15 / 0.93
NID1 / 202007_at / 0.175722 / 0.43 / 238.81 / 283.85 / 0.84 / 0.347136 / 0.748 / 252.53 / 299.23 / 0.84
LUM / 229554_at / 0.218323 / 0.468 / 49.79 / 59.6 / 0.84 / 0.818173 / 0.875 / 55.14 / 57.79 / 0.95
TNXB / 1565242_at / 0.0360002 / 0.258 / 14.48 / 17.53 / 0.83 / 0.532169 / 0.773 / 15.33 / 16.55 / 0.93
CD34 / 209543_s_at / 0.061192 / 0.279 / 65.41 / 78.86 / 0.83 / 0.0125992 / 0.354 / 67.05 / 88.08 / 0.76
TNFAIP6 / 206026_s_at / 0.255074 / 0.494 / 96.97 / 117.45 / 0.83 / 0.402187 / 0.748 / 110.75 / 90.75 / 1.22
GPC6 / 227059_at / 0.113053 / 0.356 / 17.34 / 21.05 / 0.82 / 0.587357 / 0.815 / 18.98 / 20.78 / 0.91
ITGBL1 / 205422_s_at / 0.221598 / 0.468 / 152.95 / 187.35 / 0.82 / 0.515547 / 0.773 / 157.86 / 186.47 / 0.85
SVEP1 / 219552_at / 0.0626772 / 0.279 / 17.95 / 22.04 / 0.81 / 0.207483 / 0.671 / 18.37 / 22.28 / 0.82
MMP3 / 205828_at / 0.235569 / 0.476 / 36.48 / 44.96 / 0.81 / 0.557929 / 0.786 / 41.66 / 47.99 / 0.87
FBN2 / 203184_at / 0.27096 / 0.504 / 25.16 / 31.02 / 0.81 / 0.522897 / 0.773 / 25.29 / 29.64 / 0.85
CCDC80 / 225241_at / 0.130392 / 0.379 / 154.61 / 193.11 / 0.8 / 0.0516207 / 0.48 / 168.88 / 246.8 / 0.68
COL8A2 / 52651_at / 0.151041 / 0.401 / 52.37 / 65.09 / 0.8 / 0.268032 / 0.671 / 56.17 / 68.77 / 0.82
ADAMTS2 / 226311_at / 0.158004 / 0.408 / 78.74 / 98.18 / 0.8 / 0.894811 / 0.914 / 88.35 / 90.91 / 0.97
SORBS1 / 218087_s_at / 0.230589 / 0.476 / 47.22 / 58.76 / 0.8 / 0.788508 / 0.875 / 44.43 / 41.81 / 1.06
AOC3 / 204894_s_at / 0.0564593 / 0.279 / 65.09 / 82.26 / 0.79 / 0.391365 / 0.748 / 63.86 / 73.99 / 0.86
PDPN / 221898_at / 0.113815 / 0.356 / 47.31 / 59.84 / 0.79 / 0.374803 / 0.748 / 53.28 / 63.19 / 0.84
TGFBR3 / 204731_at / 0.169202 / 0.425 / 27.47 / 34.98 / 0.79 / 0.699923 / 0.856 / 22.99 / 25.14 / 0.91
DPT / 213068_at / 0.210472 / 0.468 / 174.68 / 224.01 / 0.78 / 0.300034 / 0.698 / 175.14 / 228.88 / 0.77
LAMA2 / 216840_s_at / 0.058271 / 0.279 / 57.47 / 74.75 / 0.77 / 0.606727 / 0.826 / 64.26 / 70.52 / 0.91
PECAM1 / 208982_at / 0.049016 / 0.279 / 384.16 / 507.67 / 0.76 / 0.18237 / 0.671 / 372.61 / 487.94 / 0.76
DCN / 211896_s_at / 0.0868187 / 0.323 / 273.81 / 361.4 / 0.76 / 0.352726 / 0.748 / 289.07 / 359.65 / 0.8
NRP1 / 212298_at / 0.0212677 / 0.198 / 100.24 / 133.87 / 0.75 / 0.402193 / 0.748 / 109.47 / 130.45 / 0.84
GPNMB / 1554018_at / 0.0142805 / 0.198 / 43.98 / 59.82 / 0.74 / 0.879622 / 0.909 / 51.76 / 53.09 / 0.97
COL14A1 / 212865_s_at / 0.189017 / 0.439 / 126.64 / 170.38 / 0.74 / 0.805498 / 0.875 / 142.55 / 153.75 / 0.93
ITGA11 / 222899_at / 0.0836487 / 0.323 / 47.68 / 65.06 / 0.73 / 0.81846 / 0.875 / 60.31 / 57.29 / 1.05
CDH13 / 204726_at / 0.017779 / 0.198 / 44.35 / 61.79 / 0.72 / 0.780122 / 0.875 / 45.26 / 47.66 / 0.95
PCDH17 / 228863_at / 0.0234423 / 0.198 / 46.05 / 64.02 / 0.72 / 0.817264 / 0.875 / 55.1 / 52.73 / 1.04
CD36 / 209555_s_at / 0.140053 / 0.395 / 78.8 / 111.14 / 0.71 / 0.97923 / 0.99 / 77.81 / 77.22 / 1.01
CD93 / 202878_s_at / 0.0130729 / 0.198 / 151 / 215.48 / 0.7 / 0.653718 / 0.826 / 161.14 / 176.87 / 0.91
WNT2 / 205648_at / 0.0039709 / 0.171 / 26.05 / 38.82 / 0.67 / 0.0614678 / 0.52 / 26.47 / 36.5 / 0.73
HMCN1 / 235944_at / 0.0086281 / 0.198 / 48.19 / 73.33 / 0.66 / 0.0796324 / 0.529 / 51.12 / 78.62 / 0.65
MFAP5 / 213764_s_at / 0.0200673 / 0.198 / 132.54 / 200.22 / 0.66 / 0.0715813 / 0.529 / 145.48 / 239.14 / 0.61
MMP12 / 204580_at / 0.0166111 / 0.198 / 26.72 / 45.76 / 0.58 / 0.655167 / 0.826 / 36.2 / 42 / 0.86
ADAMTS5 / 229357_at / 0.0004943 / 0.046 / 45.37 / 79.36 / 0.57 / 0.148829 / 0.663 / 47.63 / 65.8 / 0.72
Supplementary Table 4. Expression of ECM/cell adhesion genes in pre-treatment tumor biopsies from patients in the NeoSphere trial. Gene expression levels of 93 ECM and cell adhesion genes that were significantly upregulated in TPB-resistant tumors (model #564) were measured in RNA from pre-treatment tumor biopsies from 88 patients with newly diagnosed HER2+ breast cancer treated with docetaxel/trastuzumab/pertuzumab (THP) and 94 patients treated with trastuzumab/pertuzumab (HP). The ratio of expression in tumor biopsies from patients with no pCR)/patients with pCR is shown. Blue = genes with significantly higher expression in samples with no pCR (parametric p<0.05; Wilcoxon test).