Supplementary Table 1. Individual Risk of Bias Items for Randomized Controlled Trials

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Supplementary Table 1. Individual Risk of Bias Items for Randomized Controlled Trials of Pharmacological Therapies Versus Placebo in OIC.

Study / Method of Generation of Randomization Schedule Stated? / Method of Concealment of Treatment Allocation Stated? / Blinding? / >10% Difference in Follow-up Between Treatment Arms? / Evidence of Selective Reporting of Outcomes? / Intention-to-treat Analysis Extractable?
Yuan 2000 18 / Yes / Yes / Double / No / No / Yes
Thomas 2008 19 / Yes / No / Double / No / No / Yes
Slatkin 2009 20 / Yes / Yes / Double / No / No / Yes
Michna 2011 9 / Yes / Yes / Double / No / No / No
Anissian 2012 21 / No / Yes / Double / Yes / No / No
Rauck 2012 22 / Yes / Yes / Double / No / No / Yes
Liu 2002 23 / No / No / Double / No / No / Yes
Simpson 2008 25 / Yes / Yes / Double / No / No / Yes
Meissner 2009 24 / Yes / Yes / Double / No / No / Yes
Lowenstein 2009 10 / Yes / Yes / Double / No / No / No
Paulson 2005 26 / No / Yes / Double / Yes / No / Yes
Webster 2008 27 / Yes / Yes / Double / No / No / Yes
Irving 2011 28 / No / No / Double / No / No / Yes
Jansen 2011 11 / No / No / Double / No / No / Yes
Sloots 2010 31 / Yes / No / Double / No / No / No
Cryer 2010 29 / No / No / Double / No / No / No
Mazen Jamal 2012 30 / No / No / Double / Unclear / No / No