Supplementary table 1: Distribution of virulence factors in verocytotoxin-producing Escherichia coli isolates from humans.
Serogroupa / H-type (number of isolates)a / Clinical symptoms (number of isolates)b / Total / Virulence genes (number of isolates positive for)vtx1 / vtx2 / eae / ehxA / saa / subA / sab
O1 / H7 (1) / HUS (1) / 1 / 0 / 1 / 0 / 0 / 0 / 0 / 0
O2 / H6 (3) / HUS (1); D (2) / 3 / 0 / 3 / 2 / 0 / 0 / 0 / 0
O3 / H- (2) / AP (1); NA (1) / 2 / 0 / 2 / 0 / 2 / 2 / 0 / 0
O4 / H16 (1); H- (1) / D (1); AP (1) / 2 / 1 / 1 / 1 / 1 / 0 / 0 / 0
O5 / H- (3) / D (2); NA (1) / 3 / 3 / 0 / 2 / 3 / 0 / 0 / 0
O6 / H10 (1) / D (1) / 1 / 1 / 0 / 0 / 0 / 0 / 0 / 0
O8 / H9 (2); H14 (2); H- (1) / D (3); NA (2) / 5 / 0 / 5 / 0 / 0 / 0 / 0 / 0
O15 / H27 (1); H- (2) / BD (1); D (1); NA (1) / 3 / 3 / 3 / 0 / 0 / 0 / 0 / 0
O20 / H4 (1); H45 (1) / D (2) / 2 / 1 / 1 / 0 / 1 / 0 / 0 / 0
O24 / H10 (1) / AP (1) / 1 / 1 / 0 / 0 / 0 / 0 / 0 / 0
O26 / H11 (18); H- (4) / BD (2); D (18); AP (2) / 22 / 22 / 0 / 22 / 20 / 0 / 0 / 0
O38 / H26 (2) / D (1); NA (1) / 2 / 2 / 2 / 0 / 2 / 0 / 0 / 0
O45 / H- (1) / NA (1) / 1 / 0 / 1 / 1 / 0 / 0 / 0 / 0
O55 / H12 (3); H19 (1) / D (2); NA (2) / 4 / 4 / 0 / 1 / 1 / 3 / 0 / 0
O63 / H6 (7) / D (7) / 7 / 0 / 7 / 7 / 0 / 0 / 0 / 0
O76 / H19 (1) / D (1) / 1 / 1 / 0 / 0 / 1 / 0 / 0 / 0
O78 / H- (1) / D (1) / 1 / 1 / 0 / 0 / 1 / 0 / 0 / 0
O79 / H14 (2) / D (2) / 2 / 2 / 0 / 0 / 0 / 0 / 0 / 0
O80 / H- (2) / D (2) / 2 / 0 / 2 / 2 / 2 / 0 / 0 / 0
O84 / H28 (3); H- (2) / D (3); NA (2) / 5 / 3 / 2 / 5 / 4 / 0 / 0 / 0
O87 / Hunt (1) / NA (1) / 1 / 0 / 1 / 0 / 0 / 0 / 0 / 0
O91 / H14 (1); H21 (1); H- (5) / BD (1); D (1); AP (2); NA (3) / 7 / 5 / 6 / 0 / 5 / 1 / 0 / 0
O98 / H- (2) / D (2) / 2 / 2 / 0 / 2 / 2 / 0 / 0 / 0
O103 / H2 (16) / HUS (1); D (10); AP (2); O (3) / 16 / 15 / 1 / 15 / 15 / 0 / 0 / 0
O104 / H2 (1) / NA (1) / 1 / 0 / 1 / 0 / 0 / 0 / 0 / 0
O105 / H18 (1) / NA (1) / 1 / 0 / 1 / 0 / 1 / 1 / 1 / 0
O111 / H8 (7); H (8); Hunt (1) / HUS (2); BD (1); D (10); AP (2); NA (1) / 16 / 16 / 4 / 16 / 16 / 0 / 0 / 0
O113 / H2 (1); H4 (3); H21 (3); H- (1); Hunt (2) / D (3); AP (4); NA (3) / 10 / 1 / 10 / 1 / 4 / 2 / 2 / 0
O115 / H- (1) / D (1) / 1 / 1 / 0 / 1 / 1 / 0 / 0 / 0
O117 / H7 (2) / D (1); AP (1) / 2 / 2 / 0 / 0 / 0 / 0 / 0 / 0
O118 / H16 (2); H25 (1); H- (1); Hunt (1) / HUS (1); BD (2); D (1); NA (1) / 5 / 4 / 1 / 5 / 4 / 0 / 0 / 0
O121 / H-(3) / HUS (3) / 3 / 0 / 3 / 3 / 3 / 0 / 0 / 0
O127 / H40 (1) / D (1) / 1 / 1 / 0 / 1 / 0 / 0 / 0 / 0
O128ab / H2 (1); H- (3) / D (3); AP (1) / 4 / 3 / 4 / 0 / 3 / 0 / 0 / 0
O128ac / H- (1) / D (1) / 1 / 0 / 1 / 1 / 0 / 0 / 0 / 0
O132 / H34 (1) / D (1) / 1 / 0 / 1 / 1 / 0 / 0 / 0 / 0
O136 / H20 (1) / D (1) / 1 / 1 / 0 / 0 / 0 / 0 / 0 / 0
O145 / H16 (1); H28 (4); H- (13) / HUS (8); BD (1); D (4); AP (4); NA (1) / 18 / 7 / 11 / 18 / 18 / 0 / 0 / 0
O146 / H21 (9); H28 (2); H- (2); Hunt (3) / BD (3); D (11); NA (2) / 16 / 11 / 12 / 0 / 14 / 1 / 0 / 0
O147 / H- (1) / D (1) / 1 / 0 / 1 / 1 / 1 / 0 / 0 / 0
O150 / H- (1) / AP (1) / 1 / 1 / 0 / 1 / 1 / 0 / 0 / 0
O153 / H19 (1); H- (1) / D (1); NA (1) / 2 / 1 / 1 / 2 / 1 / 0 / 0 / 0
O156 / H12 / NA (1) / 1 / 1 / 0 / 1 / 1 / 0 / 0 / 0
O157 / H7 (19); H- (15) / HUS (4); BD (10); D (19); NA (1) / 34 / 15 / 34 / 34 / 33 / 0 / 0 / 0
O162 / H28 (2); H- (1) / AP (2); NA (1) / 3 / 1 / 2 / 0 / 1 / 1 / 1 / 1
O165 / H25 (1) / NA (1) / 1 / 0 / 1 / 1 / 1 / 0 / 0 / 0
O166 / H28 (1); H- (1) / D (2); NA (1) / 2 / 2 / 1 / 0 / 2 / 0 / 0 / 0
O168 / H- (1) / D (1) / 1 / 0 / 1 / 1 / 0 / 0 / 0 / 0
O171 / H29 (1) / AP (1) / 1 / 0 / 1 / 0 / 0 / 0 / 0 / 0
O172 / H- (2) / HUS (2) / 2 / 0 / 2 / 2 / 2 / 0 / 0 / 0
O174 / H21 (1) / AP (1) / 1 / 0 / 1 / 0 / 0 / 0 / 0 / 0
O176 / H- (1) / D (1) / 1 / 1 / 0 / 0 / 1 / 0 / 0 / 0
O177 / H11 (1) / BD (1) / 1 / 1 / 0 / 1 / 0 / 0 / 0 / 0
O178 / H19 (1) / HUS (1) / 1 / 0 / 1 / 0 / 1 / 1 / 1 / 0
O181 / H40 (1) / D (1) / 1 / 1 / 0 / 0 / 0 / 1 / 0 / 0
OX182 / H5 (1); H34 (1) / D (1); AP (1) / 2 / 2 / 0 / 1 / 1 / 0 / 0 / 0
OX183 / H18 (3) / BD (1); D (1); AP (1) / 3 / 3 / 2 / 0 / 3 / 3 / 3 / 1
Orough / H4 (1); H10 (1); H19 (1); H21 (1); H- (3); Hunt (2) / BD (1); D (6); AP (1); NA (1) / 9 / 6 / 5 / 3 / 4 / 0 / 0 / 0
Ount / H14 (2); H- (5); Hunt (3) / HUS (1); D (6); AP (1); NA (2) / 10 / 5 / 5 / 6 / 5 / 1 / 0 / 0
a Orough, O antigen autoagglutinating; Ount, O antigen untypable; Hunt, H antigen untypable
b HUS, hemolytic uremic syndrome; BD, bloody diarrhea; D, diarrhea; AP, abdominal pain; O, disease other than HUS or diarrhea; NA, diagnosis not available
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