Supplementary Table 1. Difference in Absolute Log-Dense and Log-Non-Dense Breast Area

Supplementary Table 1. Difference in absolute log-dense and log-non-dense breast area by body size in premenopausal women, ESMaestras (2006)*

Current body mass index (BMI), kg/m2
BMI 18.5-24.9 / BMI 25-29.9 / BMI 30+ / P-trend
Dense area / Ref / 0.22 (0.12, 0.32) / 0.38 (0.26, 0.50) / <0.01
Non-dense area / Ref / 0.32 (0.26, 0.37) / 0.61 (0.55, 0.67) / <0.01
Somatotype before menarche
Type 1 / Type 2 / Type 3 / Type 4+ / P-trend
Dense area / Ref / 0.05 (-0.05, 0.15) / 0.06 (-0.05, 0.16) / -0.02 (-0.13, 0.1) / 0.83
Non-dense area / Ref / 0.04 (-0.02, 0.10) / 0 (-0.06, 0.06) / 0.01 (-0.06, 0.08) / 0.93
Somatotype two years after menarche
Type 1 / Type 2 / Type 3 / Type 4+ / P-trend
Dense area / Ref / 0.1 (-0.02, 0.22) / 0.11 (-0.02, 0.23) / 0.12 (-0.02, 0.25) / 0.12
Non-dense area / Ref / -0.05 (-0.12, 0.02) / 0.01 (-0.07, 0.08) / -0.02 (-0.10, 0.06) / 0.84
Somatotype at ages 18-20
Type 1-2 / Type 3 / Type 4 / Type 5+ / P-trend
Dense area / Ref / 0.02 (-0.08, 0.13) / 0.03 (-0.09, 0.16) / 0.02 (-0.11, 0.15) / 0.72
Non-dense area / Ref / 0.02 (-0.04, 0.08) / 0.04 (-0.03, 0.12) / 0.05 (-0.02, 0.13) / 0.12
Somatotype immediately before first pregnancy
Type 1-2 / Type 3 / Type 4 / Type 5+ / P-trend
Dense area / Ref / 0.03 (-0.09, 0.16) / 0.03 (-0.11, 0.17) / 0.07 (-0.07, 0.22) / 0.35
Non-dense area / Ref / 0.02 (-0.05, 0.09) / 0.06 (-0.02, 0.15) / 0.01 (-0.07, 0.1) / 0.61
Somatotype at ages 25-35
Type 1-3 / Type 4 / Type 5 / Type 6+ / P-trend
Dense area / Ref / -0.02 (-0.12, 0.09) / 0.05 (-0.08, 0.17) / 0.05 (-0.06, 0.17) / 0.27
Non-dense area / Ref / 0.05 (-0.01, 0.12) / 0.07 (0, 0.14) / 0.07 (0, 0.14) / 0.04
Height (cm)
<152 / 152-<156 / 156-<160 / 160+ / P-trend
Dense area / Ref / 0.04 (-0.08, 0.15) / -0.05 (-0.16, 0.07) / 0.01 (-0.11, 0.13) / 0.74
Non-dense area / Ref / 0.09 (0.02, 0.15) / 0.08 (0.02, 0.15) / 0.10 (0.03, 0.16) / 0.01
Sitting height (cm)
≤82 / >82-<85 / 85-<86 / 86+ / P-trend
Dense area / Ref / 0.04 (-0.08, 0.16) / 0.07 (-0.04, 0.19) / 0.04 (-0.08, 0.16) / 0.42
Non-dense area / Ref / 0.02 (-0.05, 0.08) / 0.04 (-0.03, 0.10) / 0.03 (-0.03, 0.10) / 0.25

* Outcomes are log-transformed and multivariable models are adjusted for age (continuous) and state (Veracruz, Jalisco), parity (nulliparous, 1, 2, 3, 4+ children), age at first birth (<25, 25+), breastfeeding (never, <12 months, 12+ months), hormonal contraceptive use (never, ever), smoking (never, past, current), alcohol (none, any), physical activity (low, medium, high), family history of breast cancer (no, yes), history of BBD (no, yes), AmerIndian language (no, yes), and non-dense breast area.

Supplementary Table 2. Difference in absolutelog-dense and log-non-dense breast area by body size in postmenopausal women, ESMaestras (2006)*

Current body mass index (BMI), kg/m2
BMI 18.5-24.9 / BMI 25-29.9 / BMI 30+ / P-trend
Dense area / Ref / 0.07 (-0.09, 0.23) / 0.22 (0.04, 0.40) / 0.03
Non-dense area / Ref / 0.29 (0.21, 0.37) / 0.57 (0.49, 0.66) / <0.01
Somatotype before menarche
Type 1 / Type 2 / Type 3 / Type 4+ / P-trend
Dense area / Ref / 0.04 (-0.11, 0.18) / 0.14 (-0.01, 0.30) / 0.08 (-0.09, 0.24) / 0.14
Non-dense area / Ref / 0.03 (-0.04, 0.11) / -0.01 (-0.10, 0.07) / 0.06 (-0.03, 0.15) / 0.34
Somatotype two years after menarche
Type 1 / Type 2 / Type 3 / Type 4+ / P-trend
Dense area / Ref / 0.03 (-0.13, 0.19) / 0.10 (-0.07, 0.28) / 0.10 (-0.08, 0.28) / 0.19
Non-dense area / Ref / -0.01 (-0.10, 0.07) / -0.05 (-0.14, 0.04) / 0 (-0.10, 0.09) / 0.78
Somatotype at ages 18-20
Type 1-2 / Type 3 / Type 4 / Type 5+ / P-trend
Dense area / Ref / 0.06 (-0.08, 0.20) / 0.15 (-0.03, 0.34) / 0.14 (-0.05, 0.32) / 0.08
Non-dense area / Ref / 0.03 (-0.05, 0.10) / 0 (-0.09, 0.10) / 0.07 (-0.02, 0.17) / 0.21
Somatotype immediately before first pregnancy
Type 1-2 / Type 3 / Type 4 / Type 5+ / P-trend
Dense area / Ref / 0.14 (-0.02, 0.31) / 0.19 (-0.01, 0.39) / 0.27 (0.08, 0.46) / 0.01
Non-dense area / Ref / 0.05 (-0.04, 0.14) / 0.09 (-0.02, 0.20) / 0.02 (-0.08, 0.13) / 0.60
Somatotype at ages 25-35
Type 1-3 / Type 4 / Type 5 / Type 6+ / P-trend
Dense area / Ref / 0.12 (-0.02, 0.27) / 0.17 (0, 0.33) / 0.19 (0.03, 0.35) / 0.01
Non-dense area / Ref / 0.01 (-0.06, 0.09) / 0 (-0.08, 0.09) / -0.01 (-0.09, 0.08) / 0.88
Height (cm)
<152 / 152-<156 / 156-<160 / 160+ / P-trend
Dense area / Ref / 0.08 (-0.06, 0.23) / 0.07 (-0.07, 0.22) / 0.10 (-0.08, 0.27) / 0.25
Non-dense area / Ref / 0.07 (-0.01, 0.14) / 0.06 (-0.02, 0.14) / 0.04 (-0.05, 0.13) / 0.25
Sitting height (cm)
≤82 / >82-<85 / 85-<86 / 86+ / P-trend
Dense area / Ref / 0.06 (-0.11, 0.22) / 0.05 (-0.12, 0.23) / 0.04 (-0.14, 0.21) / 0.64
Non-dense area / Ref / -0.02 (-0.10, 0.07) / -0.02 (-0.11, 0.07) / 0.05 (-0.04, 0.14) / 0.42

* Outcomes are log-transformed and multivariable models are adjusted for age (continuous) and state (Veracruz, Jalisco), parity (nulliparous, 1, 2, 3, 4+ children), age at first birth (<25, 25+), breastfeeding (never, <12 months, 12+ months), hormonal contraceptive use (never, ever), smoking (never, past, current), alcohol (none, any), physical activity (low, medium, high), family history of breast cancer (no, yes), history of BBD (no, yes), AmerIndian language (no, yes), PMH use (never, past), and non-dense breast area.