Supplementary Table 1. Demographic Characteristics of 77 Glioma Patients

Supplementary Table 1. Demographic characteristics of 77 glioma patients

Grade II (n=18) / Grade III (n=16) / Grade IV (n=43)
Gender – no. (%)
Male / 9 (50) / 10 (62.5) / 26 (60.5)
Female / 9 (50) / 6 (37.5) / 17 (39.5)
Age – yr
Median (range) / 40 (28~71) / 41 (14~76) / 65(17-85)
Age – no. (%)
< 50 yr / 14 (77.8) / 11 (68.8) / 8 (21.1)
≧50 yr / 4 (22.2) / 5 (31.2) / 35 (78.9)
KPS– no. (%)
< 70 / 2 (11.1) / 5 (31.2) / 21 (48.8)
≧70 / 16 (55.6) / 11 (68.8) / 22 (51.2)
Extent of Surgery– no. (%)
Gross total resection / 10 (55.6) / 6 (37.5) / 21 (48.8)
Subtotal resection / 3 (16.7) / 3 (18.8) / 11 (25.6)
Partial resection / 4 (22.2 ) / 2 (12.5) / 10 (23.3)
Biopsy / 1 (5.5) / 5 (18.7) / 10 (23.3)
LAPTM4B-35 – no. (%)
Low expression / 15 (83.3) / 7 (43.8) / 16 (37.2)
High expression / 3 (16.7 ) / 9 (56.2) / 27 (62.8)

KPS, Karnofsky Performance Status; LAPTM4B-35, lysosome-associated protein transmembrane4 beta-35

Supplementary Table 2.Association analysis between LAPTM4B-35 expression and clinical features of GBM patients

LAPTM4B-35 expression / p* value
n / Low (n=16) / High (n=23)
Gender – no.
Male / 24 / 10 / 14 / 0.593
Female / 15 / 6 / 9
Age – no.
< 50 yr / 8 / 6 / 2 / 0.045
≧50 yr / 31 / 10 / 21
Tumor Size
< 5cm / 25 / 9 / 16 / 0.503
≧5cm / 14 / 7 / 7
KPS – no.
< 70 / 17 / 4 / 13 / 0.099
≧70 / 22 / 12 / 10
Extent of Surgery – no.
Gross total & Subtotal resection / 20 / 11 / 9 / 0.105
Partial resection & Biopsy / 19 / 5 / 14
MGMT – no.
Methylated / 18 / 5 / 13 / 0.192
Unmethylated / 21 / 11 / 10
IDH1-R132H mutation – no.
Present / 2 / 1 / 1 / 0.658
Absent / 37 / 15 / 22

KPS, Karnofsky Performance Status; MGMT, O6-methylguanine DNA methyltransferase;

IDH1, isocitrate dehydrogenase 1, LAPTM4B-35, lysosome-associated protein transmembrane4 beta-35;*Fisher’s exact test