Supplementary Table 1 Characteristics of 44 Tag-Snps in Enacgenes

Supplementary Table 1 Characteristics of 44 tag-SNPs in ENaCgenes

Gene / SNP / Chr* / Physical
Position / Alleles# / Call Rate / MAF / HWE
P-value / Platform
SCNN1A / rs4149621 / 12 / 6451561 / T/C / 0.999 / 0.076 / 0.318 / Affymetrix6.0
rs4149570 / 12 / 6451590 / A/G / 0.998 / 0.499 / 0.181 / Affymetrix6.0
rs11064145 / 12 / 6455098 / T/G / 1.000 / 0.204 / 0.670 / Affymetrix6.0
rs13306613 / 12 / 6464809 / C/T / 0.999 / 0.057 / 0.518 / Affymetrix6.0
rs3782724 / 12 / 6466081 / A/T / 0.999 / 0.244 / 0.574 / Affymetrix6.0
rs7956915 / 12 / 6470260 / A/G / 1.000 / 0.404 / 0.389 / Affymetrix6.0
rs11064153 / 12 / 6488450 / T/C / 1.000 / 0.358 / 0.031 / Affymetrix6.0
rs11064155 / 12 / 6490184 / T/C / 1.000 / 0.333 / 0.468 / Affymetrix6.0
rs11831297 / 12 / 6490609 / A/G / 1.000 / 0.252 / 0.760 / Affymetrix6.0
SCNN1G / rs4421986 / 16 / 23191250 / A/G / 1.000 / 0.060 / 0.152 / Affymetrix6.0
rs4073291 / 16 / 23195993 / A/C / 0.998 / 0.160 / 0.102 / Affymetrix6.0
rs4967948 / 16 / 23199244 / G/A / 0.975 / 0.012 / 0.021 / SNPlex
rs5735 / 16 / 23200848 / T/C / 0.914 / 0.173 / 0.139 / SNPlex
rs4247210 / 16 / 23205657 / G/C / 0.973 / 0.155 / 0.790 / SNPlex
rs13331086 / 16 / 23208117 / T/G / 1.000 / 0.066 / 0.851 / Affymetrix6.0
rs4299163 / 16 / 23212019 / G/C / 0.962 / 0.102 / 0.841 / SNPlex
rs4401050 / 16 / 23217402 / C/T / 0.966 / 0.096 / 0.020 / SNPlex
rs4499238 / 16 / 23221379 / T/C / 0.999 / 0.102 / 0.130 / Affymetrix6.0
rs5723 / 16 / 23226787 / C/G / 0.972 / 0.061 / 0.288 / SNPlex
rs5728 / 16 / 23227362 / A/G / 0.966 / 0.200 / 0.957 / SNPlex
rs9930846 / 16 / 23228535 / T/C / 0.975 / 0.062 / 0.553 / SNPlex
SCNN1B / rs6497659 / 16 / 23286037 / A/T / 0.999 / 0.425 / 0.042 / Affymetrix6.0
rs9931113 / 16 / 23289839 / A/C / 0.991 / 0.343 / 0.441 / Affymetrix6.0
rs1004749 / 16 / 23314851 / A/C / 0.963 / 0.344 / 0.149 / SNPlex
rs3785368 / 16 / 23320780 / G/A / 0.999 / 0.351 / 0.389 / Affymetrix6.0
rs7205273 / 16 / 23324849 / C/T / 0.952 / 0.258 / 0.087 / SNPlex
rs239345 / 16 / 23345938 / T/A / 0.987 / 0.287 / 0.079 / Affymetrix6.0
rs7190829 / 16 / 23347304 / A/G / 0.999 / 0.185 / 0.592 / Affymetrix6.0
rs12447134 / 16 / 23350669 / A/C / 0.998 / 0.082 / 0.443 / Affymetrix6.0
rs239349 / 16 / 23352848 / G/A / 0.975 / 0.480 / 0.156 / SNPlex
rs238547 / 16 / 23360199 / C/T / 0.976 / 0.029 / 0.507 / SNPlex
rs8044970 / 16 / 23361830 / T/G / 1.000 / 0.383 / 0.262 / Affymetrix6.0
rs8044984 / 16 / 23361853 / T/G / 0.999 / 0.310 / 0.131 / Affymetrix6.0
rs152733 / 16 / 23362678 / T/C / 0.999 / 0.448 / 0.376 / Affymetrix6.0
rs3785361 / 16 / 23363399 / A/T / 0.979 / 0.292 / 0.464 / Affymetrix6.0
rs63982 / 16 / 23364081 / A/C / 1.000 / 0.379 / 0.961 / Affymetrix6.0
rs238551 / 16 / 23375921 / A/G / 0.965 / 0.493 / 0.784 / SNPlex
rs239350 / 16 / 23379479 / T/C / 0.998 / 0.126 / 0.074 / Affymetrix6.0
rs889299 / 16 / 23381914 / G/A / 0.996 / 0.336 / 0.469 / Affymetrix6.0
rs4967999 / 16 / 23387535 / C/T / 0.994 / 0.443 / 0.708 / Affymetrix6.0
rs168748 / 16 / 23388255 / G/A / 0.965 / 0.449 / 0.846 / SNPlex

Supplementary Table 1 Con’t

Gene / SNP / Chr* / Physical
Position / Alleles# / Call Rate / MAF / HW
P-value / Platform
rs2303153 / 16 / 23390201 / G/C / 0.966 / 0.114 / 0.877 / SNPlex
rs250567 / 16 / 23394399 / C/T / 1.000 / 0.110 / 0.554 / Affymetrix6.0
rs181835 / 16 / 23397113 / A/G / 0.972 / 0.327 / 0.893 / SNPlex

*: Chromosome; #: Major allele/Minor allele.

Supplementary Table 2 Associations of SNPs in SCNN1A, SCNN1G and SCNN1B genes with BP under additive and codominantmodels

Gene / SNP / Homozygote of
major allele / Heterozygote / Homozygote of
minor allele / Pa / Pb
SBP
SCNN1A / rs4149621 / 116.7(116.1,117.4) / 115.5(114.0,116.9) / 115.5 (107.5,123.4) / 0.116 / 0.283
rs4149570 / 116.3(115.1, 117.6) / 116.6(115.7, 117.5) / 116.7(115.6, 117.9) / 0.631 / 0.888
rs11064145 / 116.5(115.7, 117.3) / 116.8(115.7,117.9) / 115.3(112.7,117.9) / 0.884 / 0.557
rs13306613 / 116.5 (115.8,117.1) / 117.6 (115.7,119.0) / 110.0 (97.8, 122.3) / 0.531 / 0.347
rs3782724 / 116.7(115.9,117.5) / 116.3 (115.4,117.3) / 116.4 (113.6,119.2) / 0.548 / 0.772
rs7956915 / 116.3 (115.4, 117.3) / 116.8 (116.0, 117.7) / 116.2 (114.5,117.8) / 0.918 / 0.623
rs11064153 / 115.8 (115.0, 116.7) / 117.3 (116.4, 118.3) / 116.3(114.8,117.8) / 0.164 / 0.055
rs11064155 / 116.9 (116.0,117.9) / 116.5 (115.6,117.3) / 115.3 (113.5, 117.2) / 0.158 / 0.334
rs11831297 / 116.3 (115.4, 117.1) / 116.6 (115.7, 117.6) / 118.7(116.2, 121.2) / 0.124 / 0.182
SCNN1G / rs4421986 / 116.6 (115.9, 117.3) / 116.5 (114.7, 118.2) / 108.9 (94.5, 123.2) / 0.721 / 0.571
rs4073291 / 117.0 (116.3,117.7) / 115.6 (114.5, 116.7) / 115.5 (111.3,119.7) / 0.040 / 0.093
rs4967948 / 122.2 (121.4,122.9) / 120.0 (116.6, 123.4) / 130.1 (120.5,139.6) / 0.532 / 0.123
rs5735 / 122.6(121.7,123.5) / 120.8 (119.6,122.1) / 120.3 (116.5,124.0) / 0.016 / 0.047
rs4247210 / 122.1 (121.2,122.9) / 122.1 (120.8,123.5) / 122.1 (118.1,126.1) / 0.942 / 0.996
rs13331086 / 116.5 (115.8,117.2) / 116.9 (115.2, 118.5) / 113.5 (105.8,121.0) / 0.889 / 0.659
rs4299163 / 122.3 (121.4, 123.1) / 121.0(119.4,122.6) / 119.0(113.8, 124.3) / 0.089 / 0.217
rs4401050 / 122.5(121.7,123.3) / 121.2 (119.6,122.8) / 117.9(112.9, 122.9) / 0.035 / 0.067
rs4499238 / 116.8 (116.1,117.5) / 115.6 (114.1, 117.1) / 112.2(108.1, 116.4) / 0.027 / 0.037
rs5723 / 122.1 (121.3,122.8) / 122.7 (120.7, 124.7) / 124.0(114.7, 133.4) / 0.493 / 0.786
rs5728 / 122.6(121.7,123.5) / 121.9 (120.7, 123.1) / 120.4(117.6,123.2) / 0.119 / 0.251
rs9930846 / 122.1(121.3, 122.9) / 122.1 (120.2, 124.1) / 121.6 (112.7, 130.5) / 0.975 / 0.993
SCNN1B / rs6497659 / 117.4 (116.3, 118.5) / 116.1 (115.3, 116.9) / 116.4 (114.9, 117.9) / 0.154 / 0.132
rs9931113 / 116.2 (115.3, 117.1) / 117.0 (116.1, 117.8) / 116.3 (114.7, 118.0) / 0.509 / 0.433
rs1004749 / 121.5 (120.5, 122.6) / 122.5 (121.5, 123.5) / 122.5(120.6, 124.5) / 0.184 / 0.312

Supplementary Table 2 Con’t

Gene / SNP / Homozygote of
major allele / Heterozygote / Homozygote of
minor allele / Pa / Pb
SCNN1B / rs3785368 / 116.5 (115.6, 117.4) / 116.8 (116.0, 117.7) / 115.7(114.0, 117.4) / 0.716 / 0.445
rs7205273 / 122.4 (121.5, 123.4) / 121.9 (120.8, 123.0) / 119.7(117.4, 121.8) / 0.045 / 0.061
rs239345 / 116.7 (115.9, 117.5) / 116.7 (115.9, 117.6) / 114.6(112.6, 116.6) / 0.209 / 0.141
rs7190829 / 116.6 (115.8, 117.4) / 116.5 (115.4, 117.5) / 116.3(113.4, 119.1) / 0.772 / 0.956
rs12447134 / 116.9 (116.3, 117.6) / 114.9 (113.3, 116.4) / 108.1(102.9, 113.2) / 1.28×10-3 / 4.63×10-4 c
rs239349 / 122.9 (121.6, 124.1) / 121.9 (121.0, 122.9) / 121.9(120.6, 123.2) / 0.273 / 0.421
rs238547 / 122.2 (121.4, 122.9) / 121.4 (119.0, 123.9) / 117.8(107.3, 128.3) / 0.500 / 0.666
rs8044970 / 117.0 (116.0, 118.0) / 116.3 (115.4, 117.2) / 116.2(114.6, 117.7) / 0.251 / 0.470
rs8044984 / 116.8 (115.9, 117.7) / 116.5 (115.6, 117.4) / 115.8(113.9, 117.7) / 0.324 / 0.599
rs152733 / 116.0 (114.9, 117.1) / 116.6 (115.8, 117.4) / 117.1(115.7, 118.5) / 0.181 / 0.403
rs3785361 / 116.9 (116.0, 117.7) / 116.4 (115.5, 117.4) / 116.0(114.0, 119.0) / 0.322 / 0.613
rs63982 / 117.1 (116.1, 118.0) / 116.7 (115.8, 117.5) / 114.7(113.3, 116.0) / 0.010 / 0.011
rs238551 / 122.2 (120.9, 123.5) / 122.3 (121.3, 123.2) / 121.7(120.4, 122.9) / 0.558 / 0.710
rs239350 / 116.5 (115.8, 117.2) / 116.8 (115.5, 118.1) / 116.1(111.0, 121.3) / 0.741 / 0.898
rs889299 / 116.4 (115.5, 117.3) / 116.7 (115.9, 117.6) / 116.0(114.2, 117.9) / 0.987 / 0.727
rs4967999 / 116.5 (115.5, 117.6) / 116.5 (115.7, 117.3) / 117.0(115.7, 118.3) / 0.630 / 0.800
rs168748 / 121.8 (120.6, 123.1) / 122.2 (121.3, 123.1) / 122.4(120.9, 123.8) / 0.577 / 0.848
rs2303153 / 122.2 (121.4, 123.0) / 121.7 (120.3, 123.2) / 122.3(117.8, 126.8) / 0.630 / 0.851
rs250567 / 116.6 (115.9, 117.3) / 116.1 (114.8, 117.4) / 121.1(115.9, 126.2) / 0.821 / 0.176
rs181835 / 122.0 (121.0, 123.0) / 122.1 (121.3, 123.1) / 123.1(121.0, 125.1) / 0.443 / 0.615
DBP
SCNN1A / rs4149621 / 73.8 (73.3, 74.4) / 73.5 (72.3, 74.7) / 77.7 (70.8, 84.6) / 0.872 / 0.455
rs4149570 / 73.5 (72.6, 74.4) / 73.6 (73.0, 74.3) / 74.4 (73.5, 75.3) / 0.161 / 0.281
rs11064145 / 73.9 (73.2, 74.5) / 73.7 (72.8, 74.5) / 74.0 (71.9, 76.1) / 0.829 / 0.909
rs13306613 / 73.7 (73.2, 74.2) / 75.0 (73.6, 76.4) / 66.9 (63.7, 70.1) / 0.192 / 2.82×10-5 c

Supplementary Table 2 Con’t

Gene / SNP / Homozygote of
major allele / Heterozygote / Homozygote of
minor allele / Pa / Pb
SCNN1A / rs3782724 / 73.8 (73.2, 74.4) / 73.8 (73.0, 74.6) / 73.7 (71.6, 75.7) / 0.904 / 0.990
rs7956915 / 73.5 (72.7, 74.2) / 74.1 (73.5, 74.8) / 73.5 (72.3, 74.7) / 0.706 / 0.332
rs11064153 / 73.4 (72.7, 74.0) / 74.4 (73.7, 75.1) / 73.4 (72.1, 74.6) / 0.403 / 0.054
rs11064155 / 74.0 (73.3, 74.8) / 73.7 (73.0, 74.4) / 73.3 (71.9, 74.6) / 0.299 / 0.580
rs11831297 / 73.6 (73.0, 74.2) / 73.9 (73.2, 74.7) / 74.9 (73.0, 76.8) / 0.221 / 0.435
SCNN1G / rs4421986 / 73.8 (73.2, 74.3) / 74.2 (72.8, 75.6) / 68.6 (61.0, 76.2) / 0.707 / 0.292
rs4073291 / 74.1 (73.5, 74.6) / 73.3 (72.5, 74.1) / 72.4 (69.3, 75.5) / 0.079 / 0.211
rs4967948 / 73.7 (73.2, 74.1) / 73.2 (71.1, 75.3) / 74.2 (70.0, 78.3) / 0.704 / 0.880
rs5735 / 73.9 (73.3, 74.4) / 73.0 (72.2, 73.8) / 70.8 (68.5, 73.2) / 5.41×10-3 / 0.015
rs4247210 / 73.7 (73.1, 74.2) / 73.8 (73.0, 74.6) / 71.7 (69.4, 74.0) / 0.601 / 0.204
rs13331086 / 73.7 (73.2, 74.3) / 74.2 (72.9, 75.6) / 71.9 (67.8, 76.1) / 0.604 / 0.524
rs4299163 / 73.7 (73.2, 74.2) / 73.1 (72.1, 74.0) / 70.0 (66.8, 73.1) / 0.047 / 0.050
rs4401050 / 73.8 (73.3, 74.3) / 73.1 (72.2, 74.1) / 70.2 (66.8, 73.6) / 0.032 / 0.048
rs4499238 / 73.9 (73.4, 74.5) / 73.5 (72.4, 74.5) / 71.8 (68.8, 74.8) / 0.232 / 0.322
rs5723 / 73.6 (73.1, 74.1) / 74.2 (73.0, 75.4) / 72.0 (66.7, 77.3) / 0.535 / 0.572
rs5728 / 73.8 (73.2, 74.4) / 73.5 (72.8, 74.3) / 72.4 (70.4, 74.4) / 0.242 / 0.397
rs9930846 / 73.6 (73.1, 74.1) / 74.0 (72.8, 75.3) / 70.4 (65.6, 75.1) / 0.833 / 0.322
SCNN1B / rs6497659 / 74.6 (73.8, 75.5) / 73.4 (72.7, 74.0) / 73.5 (72.4, 74.6) / 0.041 / 0.031
rs9931113 / 73.9 (73.2, 74.6) / 73.8 (73.1, 74.5) / 73.5 (72.5, 74.7) / 0.551 / 0.831
rs1004749 / 73.5 (72.8, 74.2) / 73.8 (73.2, 74.4) / 73.6 (72.8, 74.8) / 0.650 / 0.761
rs3785368 / 74.0 (73.3, 74.7) / 73.8 (73.1, 74.5) / 73.1 (71.8, 74.4) / 0.233 / 0.432
rs7205273 / 73.8 (73.2, 74.4) / 73.7 (73.0, 74.4) / 72.0 (70.7, 73.4) / 0.098 / 0.057
rs239345 / 74.1 (73.4, 74.7) / 73.7 (72.9, 74.4) / 72.2 (70.6, 73.8) / 0.061 / 0.093
rs7190829 / 73.7 (73.1, 74.3) / 74.0 (73.2, 74.8) / 73.8 (71.6, 76.3) / 0.611 / 0.839
rs12447134 / 74.0 (73.5, 74.5) / 72.9 (71.8, 74.1) / 68.9 (65.3, 72.7) / 0.019 / 0.010

Supplementary Table 2 Con’t

Gene / SNP / Homozygote of
major allele / Heterozygote / Homozygote of
minor allele / Pa / Pb
SCNN1B / rs239349 / 74.1 (73.3, 74.9) / 73.7 (73.2, 74.3) / 73.0 (72.1, 73.9) / 0.054 / 0.148
rs238547 / 73.7 (73.3, 74.2) / 72.6 (71.1, 74.1) / 77.3 (68.7, 86.0) / 0.258 / 0.226
rs8044970 / 73.8 (73.1, 74.5) / 73.7 (73.0, 74.4) / 74.0 (73.0, 75.1) / 0.826 / 0.896
rs8044984 / 73.8 (73.1, 74.5) / 73.8 (73.1, 74.5) / 73.9 (72.6, 75.2) / 0.992 / 0.978
rs152733 / 73.7 (72.9, 74.5) / 73.8 (73.1, 74.4) / 74.0 (73.0, 75.0) / 0.600 / 0.867
rs3785361 / 73.8 (73.2, 74.5) / 73.9 (73.1, 74.7) / 73.7 (72.4, 75.0) / 0.945 / 0.958
rs63982 / 73.9 (73.2, 74.6) / 74.1 (73.4, 74.7) / 72.6 (71.5, 73.7) / 0.108 / 0.052
rs238551 / 73.6 (72.8, 74.4) / 73.6 (73.0, 74.2) / 73.7 (72.9, 74.6) / 0.783 / 0.951
rs239350 / 73.7 (73.2, 74.3) / 74.1 (73.1, 75.0) / 74.7 (70.2, 79.1) / 0.473 / 0.772
rs889299 / 73.8 (73.1, 74.5) / 73.8 (73.1, 74.5) / 73.5 (72.2, 74.9) / 0.838 / 0.925
rs4967999 / 73.8 (72.9, 74.6) / 73.8 (73.1, 74.5) / 74.1 (73.2, 75.1) / 0.586 / 0.796
rs168748 / 73.6 (72.8, 74.3) / 73.5 (72.9, 74.1) / 74.0 (73.1, 75.0) / 0.482 / 0.596
rs2303153 / 73.5 (73.0, 74.0) / 73.8 (72.9, 74.7) / 74.7 (71.3, 78.1) / 0.476 / 0.724
rs250567 / 74.0 (73.5, 74.6) / 72.7 (71.6, 73.7) / 77.6 (73.7, 81.4) / 0.296 / 8.65×10-3
rs181835 / 73.4 (72.8, 74.1) / 73.7 (73.1, 74.3) / 74.4 (73.1, 75.7) / 0.182 / 0.389
MAP
SCNN1A / rs4149621 / 88.1 (87.6, 88.7) / 87.5 (86.3, 88.9) / 90.4 (83.2, 97.7) / 0.457 / 0.475
rs4149570 / 87.8 (86.9, 88.8) / 88.0 (87.3, 88.7) / 88.5 (87.6, 89.4) / 0.279 / 0.493
rs11064145 / 88.1 (87.5, 88.7) / 88.1 (87.2, 88.9) / 87.7 (85.6, 89.8) / 0.807 / 0.939
rs13306613 / 88.0 (87.4, 88.5) / 89.1 (87.7, 90.5) / 81.4 (75.4, 87.4) / 0.269 / 0.029
rs3782724 / 88.1 (87.5, 88.8) / 88.0 (87.2, 88.8) / 87.9 (85.8, 90.1) / 0.782 / 0.957
rs7956915 / 87.8 (87.0, 88.5) / 88.4 (87.7, 89.0) / 87.7 (86.5, 89.0) / 0.754 / 0.376
rs11064153 / 87.5 (86.8, 88.2) / 88.7 (88.0, 89.4) / 87.7 (86.5, 88.9) / 0.245 / 0.038
rs11064155 / 88.4 (87.6, 89.1) / 88.0 (87.3, 88.6) / 87.3 (85.8, 88.7) / 0.194 / 0.421
rs11831297 / 87.8 (87.2, 88.5) / 88.2 (87.4, 88.9) / 89.5 (87.5, 91.5) / 0.145 / 0.276

Supplementary Table 2 Con’t

Gene / SNP / Homozygote of
major allele / Heterozygote / Homozygote of
minor allele / Pa / Pb
SCNN1G / rs4421986 / 73.8 (73.2, 74.3) / 74.2 (72.8, 75.6) / 68.6 (61.0, 76.2) / 0.938 / 0.020
rs4073291 / 88.4 (87.8, 89.0) / 87.4 (86.6, 88.2) / 86.8 (83.5, 90.1) / 0.043 / 0.117
rs4967948 / 89.8 (89.3, 90.4) / 88.8 (86.4, 91.1) / 92.9 (89.5, 96.3) / 0.594 / 0.160
rs5735 / 90.1 (89.5, 90.7) / 89.0 (88.1, 89.8) / 87.4 (84.9, 89.8) / 4.36×10-3 / 0.016
rs4247210 / 89.8 (89.2, 90.4) / 89.9 (89.0, 90.8) / 88.5 (85.9, 91.1) / 0.804 / 0.575
rs13331086 / 88.0 (87.5, 88.6) / 88.4 (87.1, 89.8) / 85.8 (80.8, 90.7) / 0.704 / 0.553
rs4299163 / 89.9 (89.3, 90.5) / 89.1 (88.0, 90.1) / 86.4 (82.8, 89.9) / 0.045 / 0.080
rs4401050 / 90.1 (89.5, 90.6) / 89.2 (88.1, 90.3) / 86.2 (83.0, 89.4) / 0.020 / 0.020
rs4499238 / 88.2 (87.7, 88.8) / 87.5 (86.4, 88.7) / 85.2 (82.0, 88.5) / 0.085 / 0.122
rs5723 / 89.8 (89.2, 90.3) / 90.4 (89.0, 91.7) / 89.3 (83.3, 95.3) / 0.479 / 0.694
rs5728 / 90.1 (89.4, 90.7) / 89.7 (88.9, 90.5) / 88.4 (86.4, 90.4) / 0.145 / 0.258
rs9930846 / 89.8 (89.2, 90.3) / 90.1 (88.7, 91.4) / 87.3 (82.0, 92.7) / 0.911 / 0.591
SCNN1B / rs6497659 / 88.9 (88.0, 89.7) / 87.6 (87.0, 88.3) / 87.8 (86.7, 88.9) / 0.055 / 0.038
rs9931113 / 88.0 (87.3, 88.8) / 88.2 (87.5, 88.9) / 87.8 (86.5, 89.0) / 0.883 / 0.843
rs1004749 / 89.5 (88.8, 90.3) / 90.0 (89.4, 90.7) / 89.9 (88.6, 91.2) / 0.386 / 0.535
rs3785368 / 88.2 (87.5, 88.9) / 88.2 (87.5, 88.8) / 87.3 (85.9, 88.6) / 0.345 / 0.439
rs7205273 / 90.0 (89.3, 90.7) / 89.7 (89.0, 90.5) / 87.9 (86.5, 89.4) / 0.047 / 0.033
rs239345 / 88.3 (87.6, 88.9) / 88.0 (87.3, 88.8) / 86.3 (84.7, 87.9) / 0.072 / 0.075
rs7190829 / 88.0 (87.4, 88.7) / 88.2 (87.4, 89.0) / 88.0 (85.7, 90.2) / 0.814 / 0.944
rs12447134 / 88.3 (87.8, 88.8) / 86.9 (85.7, 88.2) / 82.1 (78.2, 85.9) / 4.23×10-3 / 1.61×10-3
rs239349 / 90.4 (89.5, 91.3) / 89.8 (89.2, 90.4) / 89.3 (88.4, 90.2) / 0.083 / 0.219
rs238547 / 73.7 (73.3, 74.2) / 72.6 (71.1, 74.1) / 77.3 (68.7, 86.0) / 0.301 / 0.872
rs8044970 / 88.2 (87.4, 89.0) / 87.9 (87.2, 88.6) / 88.1 (86.9, 89.2) / 0.712 / 0.864
rs8044984 / 88.2 (87.5, 88.9) / 88.0 (87.3, 88.7) / 87.9 (86.5, 89.2) / 0.672 / 0.914
rs152733 / 87.8 (87.0, 88.6) / 88.1 (87.4, 88.7) / 88.4 (87.3, 89.4) / 0.354 / 0.650

Supplementary Table 2 Con’t

Gene / SNP / Homozygote of
major allele / Heterozygote / Homozygote of
minor allele / Pa / Pb
SCNN1B / rs3785361 / 88.2 (87.5, 88.9) / 88.1 (87.3, 88.9) / 87.8 (86.3, 89.2) / 0.613 / 0.860
rs63982 / 88.3 (87.6, 89.0) / 88.3 (87.6, 88.9) / 86.6 (85.5, 87.7) / 0.031 / 0.020
rs238551 / 89.8 (88.9, 90.7) / 89.8 (89.2, 90.5) / 89.7 (88.8, 90.6) / 0.933 / 0.980
rs239350 / 88.0 (87.4, 88.6) / 88.3 (87.3, 89.3) / 88.5 (83.9, 93.1) / 0.561 / 0.841
rs889299 / 88.0 (87.3, 88.7) / 88.1 (87.4, 88.8) / 87.7 (86.3, 89.1) / 0.859 / 0.848
rs4967999 / 88.0 (87.2, 88.9) / 88.0 (87.4, 88.7) / 88.4 (87.4, 89.4) / 0.597 / 0.769
rs168748 / 89.7 (88.8, 90.5) / 89.7 (89.1, 90.4) / 90.2 (89.1, 91.2) / 0.476 / 0.711
rs2303153 / 89.7 (89.2, 90.3) / 89.8 (88.8, 90.8) / 90.6 (87.3, 94.0) / 0.797 / 0.441
rs250567 / 88.2 (87.7, 88.8) / 87.2 (86.1, 88.2) / 92.1 (88.1, 96.1) / 0.536 / 0.024
rs181835 / 89.6 (88.9, 90.3) / 89.8 (89.1, 90.5) / 90.6 (89.2, 92.1) / 0.235 / 0.441

aP value for additive model

bP value for codominant model

c Statistically significant after Bonferroni correction

Supplementary Table 3 Associations of SNPs in SCNN1A, SCNN1G and SCNN1B genes with BP under dominant and recessive models

Gene / SNP / Dominant Model / Recessive Model
Homozygote of
major allele / Carrier of
minor allele / P / Carriers of
major allele / Homozygote of
minor allele / P
SBP
SCNN1A / rs4149621 / 116.7 (116.1, 117.4) / 115.5 (114.0, 116.9) / 0.112 / 116.6 (115.9, 117.2) / 115.5 (107.6, 123.4) / 0.792
rs4149570 / 116.3 (115.1, 117.6) / 116.7 (115.9, 117.4) / 0.661 / 116.5 (115.8, 117.3) / 116.7 (115.6, 117.9) / 0.744
rs11064145 / 116.5 (115.7, 117.3) / 116.6 (115.6, 117.7) / 0.840 / 116.6 (116.0, 117.3) / 115.3 (112.7, 117.9) / 0.344
rs13306613 / 116.5 (115.8, 117.1) / 117.2 (115.5, 118.9) / 0.409 / 116.6 (115.9, 117.2) / 110.0 (97.7, 122.2) / 0.292
rs3782724 / 116.7 (115.9, 117.5) / 116.3 (115.4, 117.2) / 0.477 / 116.6 (115.9, 117.2) / 116.4 (113.6, 119.2) / 0.917
rs7956915 / 116.3 (115.4, 117.3) / 116.7 (115.9, 117.5) / 0.554 / 116.6 (115.9, 117.3) / 116.2 (114.5, 117.8) / 0.616
rs11064153 / 115.8 (115.0, 116.7) / 117.1 (116.3, 118.0) / 0.030 / 116.6 (115.9, 117.3) / 116.3 (114.8, 117.8) / 0.703
rs11064155 / 116.9 (116.0, 117.9) / 116.3 (115.5, 117.1) / 0.285 / 116.7 (116.0, 117.4) / 115.3 (113.5, 117.2) / 0.179
rs11831297 / 116.3 (115.4, 117.1) / 116.9 (116.0, 117.8) / 0.297 / 116.4 (115.8, 117.0) / 118.7 (116.2, 121.2) / 0.071
SCNN1G / rs4421986 / 116.6 (115.9, 117.3) / 116.4 (114.6, 118.1) / 0.818 / 116.6 (115.9, 117.2) / 108.9 (94.5, 123.2) / 0.291
rs4073291 / 117.0 (116.3, 117.7) / 115.6 (114.5, 116.7) / 0.029 / 116.6 (116.0, 117.2) / 115.6 (111.4, 119.8) / 0.639
rs4967948 / 122.2 (121.4, 122.9) / 120.5 (117.2, 123.9) / 0.339 / 122.1 (121.4, 122.9) / 130.1 (120.7, 139.5) / 0.097
rs5735 / 122.6 (121.7, 123.5) / 120.8 (119.5, 122.0) / 0.014 / 122.1 (121.3, 122.9) / 120.5 (116.8, 124.2) / 0.404
rs4247210 / 122.1 (121.2, 122.9) / 122.1 (120.8, 123.5) / 0.934 / 122.1 (121.3, 122.8) / 122.1 (118.0, 126.1) / 0.996
rs13331086 / 116.5 (115.8, 117.2) / 116.8 (115.1, 118.4) / 0.785 / 116.6 (115.9, 117.2) / 113.4 (105.8, 121.0) / 0.418
rs4299163 / 122.2 (121.4, 123.1) / 120.9 (119.3, 122.5) / 0.121 / 122.0 (121.3, 122.8) / 119.2 (114.1, 124.4) / 0.293
rs4401050 / 122.5 (121.7, 123.3) / 121.0 (119.5, 122.6) / 0.068 / 122.3 (121.6, 123.1) / 118.1 (113.1, 123.1) / 0.099
rs4499238 / 116.8 (116.1, 117.5) / 115.4 (114.0, 116.8) / 0.062 / 116.6 (116.0, 117.3) / 112.3 (108.2, 116.4) / 0.041
rs5723 / 122.1 (121.3, 122.8) / 122.7 (120.8, 124.7) / 0.516 / 122.1 (121.4, 122.9) / 123.9 (114.6, 133.3) / 0.703
rs5728 / 122.6 (121.7, 123.5) / 121.7 (120.6, 122.9) / 0.198 / 122.4 (121.6, 123.1) / 120.5 (117.7, 123.3) / 0.204
rs9930846 / 122.1 (121.3, 122.9) / 122.1 (120.2, 124.0) / 0.993 / 122.1 (121.4, 122.9) / 121.6 (112.7, 130.5) / 0.906
SCNN1B / rs6497659 / 117.4 (116.3, 118.5) / 116.2 (115.4, 116.9) / 0.049 / 116.6 (115.9, 117.3) / 116.4 (115.0, 117.9) / 0.857
rs9931113 / 116.2 (115.3, 117.1) / 116.8 (116.1, 117.6) / 0.264 / 116.6 (115.9, 117.3) / 116.3 (114.7, 118.0) / 0.744

Supplementary Table 3 Con’t

Gene / SNP / Dominant Model / Recessive Model
Homozygote of
major allele / Carrier of
minor allele / P / Carriers of
major allele / Homozygote of minor allele / P
SCNN1B / rs1004749 / 121.5 (120.5, 122.6) / 122.5 (121.6, 123.5) / 0.127 / 122.1 (121.3, 122.8) / 122.5 (120.5, 124.4) / 0.706
rs3785368 / 116.5 (115.6, 117.4) / 116.1 (115.8, 117.4) / 0.796 / 116.7 (116.0, 117.3) / 115.7 (114.0, 117.4) / 0.269
rs7205273 / 122.4 (121.4, 123.4) / 121.5 (120.5, 122.5) / 0.179 / 122.2 (121.4, 123.0) / 119.8 (117.7, 121.9) / 0.028
rs239345 / 116.7 (115.8, 117.5) / 116.4 (115.6, 117.2) / 0.608 / 116.7 (116.0, 117.3) / 114.6 (112.6, 116.6) / 0.048
rs7190829 / 116.6 (115.8, 117.4) / 116.5 (115.5, 117.5) / 0.801 / 116.6 (115.9, 117.2) / 116.3 (113.4, 119.2) / 0.835
rs12447134 / 116.9 (116.3, 117.6) / 114.5 (113.0, 116.1) / 4.78×10-3 / 116.6 (116.0, 117.3) / 108.2 (103.1, 113.3) / 1.43×10-3
rs239349 / 122.9 (121.6, 124.1) / 121.9 (121.1, 122.7) / 0.189 / 122.2 (121.4, 123.1) / 121.9 (120.7, 123.2) / 0.698
rs238547 / 122.2 (121.4, 122.9) / 121.4 (118.9, 123.8) / 0.536 / 122.1 (121.4, 122.9) / 118.0 (107.5, 128.4) / 0.439
rs8044970 / 117.0 (116.0, 118.0) / 116.3 (115.5, 117.0) / 0.226 / 116.6 (116.0, 117.3) / 116.2 (114.7, 117.7) / 0.600
rs8044984 / 116.8 (115.9, 117.7) / 116.3 (115.5, 117.2) / 0.438 / 116.7 (116.0, 117.3) / 115.8 (113.9, 117.7) / 0.397
rs152733 / 116.0 (114.9, 117.1) / 116.8 (116.0, 117.5) / 0.230 / 116.4 (115.7, 117.1) / 117.1 (115.7, 118.5) / 0.353
rs3785361 / 116.9 (116.0, 117.7) / 116.3 (115.5, 117.2) / 0.373 / 116.7 (116.0, 117.3) / 116.0 (114.0, 118.0) / 0.519
rs63982 / 117.1 (116.1, 118.0) / 116.2 (115.5, 117.0) / 0.127 / 116.8 (116.2, 117.5) / 114.7 (113.3, 116.0) / 3.51×10-3
rs238551 / 122.2 (120.8, 123.5) / 122.1 (121.3, 122.9) / 0.883 / 122.2 (121.4, 123.1) / 121.7 (120.4, 122.9) / 0.411
rs239350 / 116.5 (115.8, 117.2) / 116.8 (115.5, 118.0) / 0.694 / 116.6 (115.9, 117.2) / 116.1 (111.0, 121.2) / 0.856
rs889299 / 116.4 (115.5, 117.3) / 116.6 (115.8, 117.4) / 0.737 / 116.6 (115.9, 117.2) / 116.0 (114.2, 117.8) / 0.567
rs4967999 / 116.5 (115.5, 117.6) / 116.6 (115.9, 117.4) / 0.862 / 116.5 (115.8, 117.2) / 117.0 (115.7, 118.3) / 0.506
rs168748 / 121.8 (120.6, 123.1) / 122.2 (121.4, 123.1) / 0.586 / 122.1 (121.3, 122.9) / 122.3 (120.8, 123.8) / 0.722
rs2303153 / 122.2 (121.4, 123.0) / 121.8 (120.4, 123.2) / 0.594 / 122.1 (121.3, 122.8) / 122.4 (118.0, 126.8) / 0.906
rs250567 / 116.6 (115.9, 117.3) / 116.4 (115.1, 117.7) / 0.769 / 116.5 (115.9, 117.1) / 121.1 (116.0, 126.3) / 0.080
rs181835 / 122.0 (121.0, 123.0) / 122.3 (121.3, 123.2) / 0.709 / 122.0 (121.3, 122.8) / 123.1 (121.0, 125.1) / 0.326
DBP
SCNN1A / rs4149621 / 73.8 (73.3, 74.4) / 73.6 (72.4, 74.8) / 0.724 / 73.8 (73.3, 74.3) / 77.7 (70.8, 84.6) / 0.263
rs4149570 / 73.6 (72.7, 74.5) / 73.9 (73.3, 74.5) / 0.518 / 73.6 (73.0, 74.2) / 74.4 (73.5, 75.3) / 0.116

Supplementary Table 3 Con’t

Gene / SNP / Dominant Model / Recessive Model
Homozygote of
major allele / Carrier of
minor allele / P / Carriers of
major allele / Homozygote of minor allele / P
SCNN1A / rs11064145 / 73.9 (73.2, 74.5) / 73.7 (72.9, 74.5) / 0.737 / 73.8 (73.3, 74.3) / 74.0 (71.9, 76.1) / 0.860
rs13306613 / 73.7 (73.2, 74.2) / 74.8 (73.4, 76.2) / 0.118 / 73.8 (73.3, 74.3) / 66.7 (63.4, 70.0) / 2.51×10-3
rs3782724 / 73.8 (73.2, 74.4) / 73.8 (73.0, 74.5) / 0.938 / 73.8 (73.3, 74.3) / 73.7 (71.6, 75.7) / 0.889
rs7956915 / 73.5 (72.7, 74.2) / 74.0 (73.4, 74.6) / 0.284 / 73.9 (73.3, 74.4) / 73.5 (72.3, 74.7) / 0.540
rs11064153 / 73.3 (72.7, 74.0) / 74.1 (73.5, 74.8) / 0.061 / 73.9 (73.4, 74.4) / 73.3 (72.1, 74.5) / 0.362
rs11064155 / 74.0 (73.3, 74.8) / 73.6 (73.0, 74.2) / 0.376 / 73.9 (73.3, 74.4) / 73.3 (71.9, 74.6) / 0.426
rs11831297 / 73.6 (73.0, 74.2) / 74.0 (73.3, 74.8) / 0.342 / 73.7 (73.2, 74.2) / 74.8 (72.9, 76.8) / 0.259
SCNN1G / rs4421986 / 73.8 (73.2, 74.3) / 74.1 (72.8, 75.5) / 0.610 / 73.8 (73.3, 74.3) / 68.5 (61.0, 76.0) / 0.163
rs4073291 / 74.1 (73.5, 74.6) / 73.2 (72.4, 74.0) / 0.086 / 73.8 (73.3, 74.4) / 72.5 (69.4, 75.6) / 0.413
rs4967948 / 73.7 (73.2, 74.1) / 73.2 (71.2, 75.2) / 0.676 / 73.7 (73.2, 74.1) / 74.2 (70.0, 78.3) / 0.803
rs5735 / 73.8 (73.3, 74.4) / 72.8 (72.1, 73.6) / 0.018 / 73.6 (73.1, 74.1) / 71.0 (68.6, 73.3) / 0.03
rs4247210 / 73.7 (73.1, 74.2) / 73.6 (72.8, 74.4) / 0.954 / 73.7 (73.2, 74.2) / 71.7 (69.4, 73.9) / 0.081
rs13331086 / 73.7 (73.2, 74.3) / 74.2 (72.9, 75.5) / 0.529 / 73.8 (73.3, 74.3) / 71.8 (67.7, 76.0) / 0.350
rs4299163 / 73.7 (73.2, 74.2) / 72.9 (71.9, 73.8) / 0.108 / 73.6 (73.1, 74.1) / 70.1 (67.0, 73.2) / 0.028
rs4401050 / 73.8 (73.3, 74.3) / 73.0 (72.1, 73.9) / 0.084 / 73.7 (73.2, 74.2) / 70.3 (66.9, 73.7) / 0.054
rs4499238 / 73.9 (73.4, 74.5) / 73.4 (72.4, 74.4) / 0.341 / 73.8 (73.3, 74.3) / 71.8 (68.8, 74.8) / 0.191
rs5723 / 73.6 (73.1, 74.1) / 74.1 (72.9, 75.3) / 0.434 / 73.7 (73.2, 74.2) / 71.9 (66.6, 77.2) / 0.517
rs5728 / 73.8 (73.2, 74.4) / 73.4 (72.7, 74.1) / 0.396 / 73.7 (73.2, 74.2) / 72.4 (70.5, 74.4) / 0.214
rs9930846 / 73.6 (73.1, 74.1) / 73.9 (72.7, 75.1) / 0.644 / 73.7 (73.2, 74.1) / 70.3 (65.5, 75.1) / 0.165
SCNN1B / rs6497659 / 74.6 (73.8, 75.5) / 73.4 (72.8, 74.0) / 8.85×10-3 / 73.8 (73.3, 74.4) / 73.6 (72.5, 74.7) / 0.639
rs9931113 / 73.9 (73.2, 74.6) / 73.7 (73.1, 74.4) / 0.640 / 73.8 (73.3, 74.4) / 73.5 (72.4, 74.7) / 0.626
rs1004749 / 73.5 (72.8, 74.2) / 73.8 (73.2, 74.3) / 0.496 / 73.7 (73.2, 74.1) / 73.6 (72.4, 74.8) / 0.908
rs3785368 / 73.8 (73.2, 74.5) / 73.9 (73.2, 74.6) / 0.422 / 73.9 (73.4, 74.4) / 73.7 (72.4, 75.0) / 0.234
rs7205273 / 73.7 (73.2, 74.3) / 73.4 (72.8, 74.1) / 0.422 / 73.7 (73.2, 74.2) / 72.0 (70.7, 73.4) / 0.018

Supplementary Table 3 Con’t

Gene / SNP / Dominant Model / Recessive Model
Homozygote of
major allele / Carrier of
minor allele / P / Carriers of
major allele / Homozygote of minor allele / P
SCNN1B / rs239345 / 74.1 (73.4, 74.7) / 73.5 (72.8, 74.2) / 0.206 / 73.9 (73.4, 74.4) / 72.2 (70.6, 73.8) / 0.043
rs7190829 / 73.7 (73.1, 74.3) / 74.0 (73.3, 74.7) / 0.561 / 73.8 (73.3, 74.3) / 73.8 (71.6, 76.0) / 0.984
rs12447134 / 74.0 (73.5, 74.5) / 72.8 (71.6, 73.9) / 0.047 / 73.8 (73.3, 74.3) / 69.1 (65.5, 72.7) / 9.12×10-3
rs239349 / 74.1 (73.3, 74.9) / 73.5 (73.0, 74.0) / 0.193 / 73.9 (73.3, 74.4) / 73.0 (72.2, 73.9) / 0.082
rs238547 / 73.7 (73.3, 74.2) / 72.7 (71.2, 74.2) / 0.191 / 73.7 (73.2, 74.1) / 77.6 (69.0, 86.3) / 0.373
rs8044970 / 73.8 (73.1, 74.5) / 73.8 (73.2, 74.4) / 0.987 / 73.8 (73.2, 74.3) / 74.0 (73.0, 75.1) / 0.653
rs8044984 / 73.8 (73.1, 74.5) / 73.8 (73.1, 74.4) / 0.919 / 73.8 (73.3, 74.3) / 73.9 (72.6, 75.2) / 0.878
rs152733 / 73.7 (72.9, 74.5) / 73.8 (73.3, 74.42) / 0.704 / 73.8 (73.2, 74.3) / 74.0 (73.0, 75.0) / 0.640
rs3785361 / 74.0 (73.3, 74.7) / 73.7 (73.0, 74.3) / 0.951 / 73.9 (73.3, 74.4) / 73.7 (72.4, 75.0) / 0.790
rs63982 / 73.9 (73.2, 74.6) / 73.7 (73.1, 74.3) / 0.672 / 74.0 (73.5, 74.5) / 72.6 (71.5, 73.7) / 0.015
rs238551 / 73.6 (72.8, 74.4) / 73.6 (73.1, 74.2) / 0.898 / 73.6 (73.1, 74.1) / 73.7 (72.9, 74.5) / 0.754
rs239350 / 73.7 (73.2, 74.3) / 74.1 (73.1, 75.0) / 0.496 / 73.8 (73.3, 74.3) / 74.6 (70.1, 79.1) / 0.726
rs889299 / 73.8 (73.1, 74.5) / 73.8 (73.1, 74.4) / 0.975 / 73.8 (73.3, 74.4) / 73.5 (72.2, 74.9) / 0.702
rs4967999 / 73.8 (73.0, 74.6) / 73.9 (73.3, 74.5) / 0.799 / 73.8 (73.2, 74.3) / 74.1 (73.2, 75.1) / 0.500
rs168748 / 73.6 (72.8, 74.3) / 73.7 (73.1, 74.2) / 0.842 / 73.5 (73.0, 74.0) / 74.0 (73.1, 75.0) / 0.313
rs2303153 / 73.5 (73.0, 74.0) / 73.8 (72.9, 74.7) / 0.548 / 73.6 (73.1, 74.0) / 74.7 (71.3, 78.1) / 0.514
rs250567 / 74.0 (73.5, 74.6) / 73.0 (71.9, 74.0) / 0.073 / 73.8 (73.2, 74.3) / 77.7 (73.9, 81.6) / 0.041
rs181835 / 73.4 (72.8, 74.1) / 73.8 (73.3, 74.4) / 0.323 / 73.5 (73.1, 74.0) / 74.3 (73.1, 75.6) / 0.236
MAP
SCNN1A / rs4149621 / 88.1 (87.6, 88.7) / 87.6 (86.4, 88.8) / 0.373 / 88.0 (87.5, 88.6) / 90.5 (83.2, 97.7) / 0.515
rs4149570 / 87.8 (86.9, 88.8) / 88.2 (87.6, 88.7) / 0.562 / 87.9 (87.3, 88.5) / 88.5 (87.6, 89.4) / 0.248
rs11064145 / 88.1 (87.5, 88.7) / 88.0 (87.2, 88.8) / 0.885 / 88.1 (87.6, 88.6) / 87.7 (85.6, 89.8) / 0.725
rs13306613 / 88.0 (87.4, 88.5) / 89.0 (87.6, 90.3) / 0.175 / 88.1 (87.6, 88.6) / 81.3 (75.3, 87.3) / 0.028
rs3782724 / 88.1 (87.5, 88.8) / 88.0 (87.2, 88.7) / 0.767 / 88.1 (87.6, 88.6) / 88.0 (85.8, 90.1) / 0.917

Supplementary Table 3 Con’t

Gene / SNP / Dominant Model / Recessive Model
Homozygote of
major allele / Carrier of
minor allele / P / Carriers of
major allele / Homozygote of minor allele / P
SCNN1A / rs7956915 / 87.8 (87.0, 88.5) / 88.2 (87.6, 88.8) / 0.331 / 88.1 (87.6, 88.7) / 87.7 (86.4, 89.0) / 0.561
rs11064153 / 87.5 (86.8, 88.2) / 88.5 (87.8, 89.1) / 0.032 / 88.1 (87.6, 88.7) / 87.7 (86.4, 88.9) / 0.470
rs11064155 / 88.3 (87.6, 89.1) / 87.8 (87.2, 88.5) / 0.285 / 88.2 (87.6, 88.7) / 87.3 (85.9, 88.7) / 0.280
rs11831297 / 87.8 (87.2, 88.5) / 88.3 (87.6, 89.1) / 0.284 / 88.0 (87.4, 88.5) / 89.5 (87.5, 91.5) / 0.135
SCNN1G / rs4421986 / 88.0 (87.5, 88.6) / 88.2 (86.8, 89.6) / 0.827 / 88.1 (87.6, 88.6) / 82.1 (73.0, 91.1) / 0.192
rs4073291 / 88.4 (87.8, 89.0) / 87.4 (86.5, 88.2) / 0.039 / 88.1 (87.6, 88.6) / 86.9 (83.6, 90.2) / 0.479
rs4967948 / 89.8 (89.3, 90.4) / 89.0 (86.8, 91.3) / 0.477 / 89.8 (89.3, 90.3) / 92.9 (89.6, 96.3) / 0.069
rs5735 / 90.1 (89.5, 90.7) / 88.8 (88.0, 89.7) / 8.45×10-3 / 89.8 (89.3, 90.3) / 87.6 (85.1, 90.0) / 0.077
rs4247210 / 89.8 (89.2, 90.4) / 89.8 (88.9, 90.7) / 0.970 / 89.8 (89.3, 90.4) / 88.5 (85.9, 91.1) / 0.308
rs13331086 / 88.0 (87.5, 88.6) / 88.4 (87.1, 89.7) / 0.611 / 88.1 (87.6, 88.6) / 85.7 (80.7, 90.7) / 0.351
rs4299163 / 89.9 (89.3, 90.5) / 88.9 (87.9, 90.0) / 0.088 / 89.8 (89.2, 90.3) / 86.5 (83.0, 90.0) / 0.072
rs4401050 / 90.1 (89.5, 90.6) / 89.0 (88.0, 90.0) / 0.057 / 89.9 (89.4, 90.5) / 86.3 (83.1, 89.5) / 0.029
rs4499238 / 88.2 (87.7, 88.8) / 87.4 (86.3, 88.5) / 0.157 / 88.1 (87.6, 88.6) / 85.3 (82.0, 88.5) / 0.089
rs5723 / 89.8 (89.2, 90.3) / 90.3 (89.0, 91.7) / 0.428 / 89.8 (89.3, 90.4) / 89.2 (83.1, 95.2) / 0.828
rs5728 / 90.1 (89.4, 90.7) / 89.5 (88.8, 90.3) / 0.263 / 89.9 (89.4, 90.5) / 88.5 (86.5, 90.5) / 0.154
rs9930846 / 89.8 (89.2, 90.3) / 90.0 (88.7, 91.3) / 0.775 / 89.8 (89.3, 90.3) / 87.3 (81.9, 92.6) / 0.348
SCNN1B / rs6497659 / 88.9 (88.0, 89.7) / 87.7 (87.1, 88.2) / 0.011 / 88.1 (87.5, 88.6) / 87.9 (86.8, 89.0) / 0.724
rs9931113 / 88.0 (87.3, 88.8) / 88.1 (87.5, 88.7) / 0.892 / 88.1 (87.6, 88.7) / 87.8 (86.5, 89.0) / 0.351
rs1004749 / 89.5 (88.8, 90.3) / 90.0 (89.4, 90.7) / 0.271 / 89.8 (89.3, 90.3) / 89.9 (88.5, 91.2) / 0.936
rs3785368 / 88.1 (87.4, 88.9) / 88.0 (87.4, 88.1) / 0.687 / 88.2 (87.6, 88.7) / 87.3 (85.9, 88.6) / 0.200
rs7205273 / 90.0 (89.3, 90.6) / 89.5 (88.8, 90.2) / 0.257 / 89.9 (89.3, 90.4) / 88.0 (86.5, 89.4) / 0.011
rs239345 / 88.3 (87.6, 88.9) / 87.8 (87.1, 88.5) / 0.288 / 88.2 (87.6, 88.7) / 86.3 (84.7, 87.9) / 0.028
rs7190829 / 88.0 (87.4, 88.7) / 88.2 (87.4, 88.9) / 0.763 / 88.1 (87.6, 88.6) / 88.0 (85.7, 90.2) / 0.918
rs12447134 / 88.3 (87.8, 88.8) / 86.7 (85.5, 87.9) / 0.014 / 88.1 (87.6, 88.6) / 82.2 (78.3, 86.0) / 2.67×10-3

Supplementary Table 3 Con’t

Gene / SNP / Dominant Model / Recessive Model
Homozygote of
major allele / Carrier of
minor allele / P / Carriers of
major allele / Homozygote of minor allele / P
SCNN1B / rs239349 / 90.4 (89.5, 91.2) / 89.7 (89.1, 90.2) / 0.136 / 90.0 (89.4, 90.6) / 89.3 (88.4, 90.2) / 0.203
rs238547 / 89.9 (89.4, 90.4) / 88.9 (87.3, 90.6) / 0.268 / 89.8 (89.3, 90.4) / 91.0 (81.9, 100.1) / 0.803
rs8044970 / 88.2 (87.4, 89.0) / 88.0 (87.4, 88.6) / 0.605 / 88.1 (87.5, 88.6) / 88.1 (86.9, 89.2) / 0.987
rs8044984 / 88.2 (87.5, 88.9) / 88.0 (87.3, 88.6) / 0.709 / 88.1 (87.6, 88.6) / 87.9 (86.5, 89.2) / 0.770
rs152733 / 87.8 (87.0, 88.6) / 88.2 (87.6, 88.7) / 0.431 / 88.0 (87.4, 88.5) / 88.4 (87.3, 89.4) / 0.484
rs3785361 / 88.2 (87.5, 88.9) / 88.0 (87.3, 88.7) / 0.718 / 88.1 (87.6, 88.7) / 87.8 (86.3, 89.2) / 0.630
rs63982 / 88.3 (87.6, 89.0) / 87.9 (87.3, 88.5) / 0.344 / 88.3 (87.7, 88.8) / 86.6 (85.5, 87.7) / 5.18×10-3
rs238551 / 89.8 (88.9, 90.7) / 89.8 (89.2, 90.4) / 0.969 / 89.8 (89.2, 90.4) / 89.7 (88.8, 90.6) / 0.858
rs239350 / 88.0 (87.4, 88.6) / 88.3 (87.3, 89.3) / 0.559 / 88.1 (87.6, 88.6) / 88.5 (83.9, 93.0) / 0.868
rs889299 / 88.0 (87.3, 88.7) / 88.1 (87.4, 88.7) / 0.932 / 88.1 (87.5, 88.6) / 87.7 (86.3, 89.1) / 0.609
rs4967999 / 88.0 (87.2, 88.9) / 88.1 (87.5, 88.7) / 0.847 / 88.0 (87.5, 88.6) / 88.4 (87.4, 89.4) / 0.470
rs168748 / 89.7 (88.8, 90.5) / 89.9 (89.3, 90.5) / 0.701 / 89.7 (89.2, 90.3) / 90.2 (89.1, 91.2) / 0.413
rs2303153 / 89.7 (89.2, 90.3) / 89.8 (88.8, 90.8) / 0.882 / 89.7 (89.2, 90.3) / 90.6 (87.3, 94.0) / 0.603
rs250567 / 88.2 (87.7, 88.8) / 87.5 (86.4, 88.5) / 0.183 / 88.0 (87.5, 88.5) / 92.2 (88.2, 96.2) / 0.038
rs181835 / 89.6 (88.9, 90.3) / 90.0 (89.3, 90.6) / 0.430 / 89.7 (89.2, 90.3) / 90.6 (89.2, 92.0) / 0.236

Supplementary Table 4 Gene-based gene-gene interaction between ENaC genes

Interaction term / SBP / DBP / MAP
SCNN1A×SCNN1G / 0.0142a / 0.0578 / 0.0112a
SCNN1A×SCNN1B / 0.0378 / 0.5282 / 0.5482
SCNN1G×SCNN1B / 0.6752 / 0.9738 / 0.9824

a Statistically significant after Bonferroni correction