Supplementary Material to: Stem Cell Factor (SCF) is a putative biomarker of antidepressant response to chronotherapeutics.
Table_S1. Correlation between grey matter volumes and baseline SCF in bipolar patients.Data are shown for the main effects surviving a threshold of p<0.001 in the whole brain. Cluster size (n voxels), MNI coordinates (x, y, z) of voxels, Side, Brodmann's area (BA), Region, T values, Z values, and level of significance (value p, value pFWE).
Cluster(n voxels) / Signal peak / BA / Side / Region / T / Z / value p / value pFWE
308 / 21 -54 64 / 7 / Right / Superior parietal lobule / 5.55 / 4.57 / <0.001 / 0.035
237 / -40 36 17 / 46 / Left / Middle frontal gyrus / 4.85 / 4.13 / <0.001 / n.s.
219 / -28 -72 47 / 7 / Left / Superior parietal lobule / 4.76 / 4.08 / <0.001 / n.s.
443 / -51 -65 21 / 39 / Left / Middle temporal gyrus / 4.47 / 3.89 / <0.001 / n.s.
83 / 48 -34 51 / 40 / Right / Postcentral gyrus / 4.44 / 3.86 / <0.001 / n.s.
47 / 45 19 21 / 46 / Right / Middle frontal gyrus / 4.41 / 3.84 / <0.001 / n.s.
355 / -21 -77 -45 / / / Left / Pyramid / 4.34 / 3.79 / <0.001 / n.s.
110 / 44 -47 28 / 31 / Right / Cingulate gyrus / 4.18 / 3.68 / <0.001 / n.s.
176 / 4 -51 26 / 31 / Right / Cingulate gyrus / 4.12 / 3.64 / <0.001 / n.s.
253 / 49 -11 -4 / 22 / Right / Superior temporal gyrus / 4.12 / 3.64 / <0.001 / n.s.
144 / -37 -21 -19 / 20 / Left / Inferior temporal lobule / 4.10 / 3.62 / <0.001 / n.s.
39 / -63 -26 -12 / 21 / Left / Middle temporal gyrus / 4.10 / 3.62 / <0.001 / n.s.
172 / 63 -39 -16 / 21 / Right / Middle temporal gyrus / 4.04 / 3.58 / <0.001 / n.s.
122 / 27 -41 3 / / / Right / Caudate tail / 3.96 / 3.52 / <0.001 / n.s.
101 / -45 -48 51 / 40 / Left / Inferior parietal lobule / 3.92 / 3.50 / <0.001 / n.s.
110 / -63 -42 -19 / 20 / Left / Middle temporal gyrus / 3.87 / 3.46 / <0.001 / n.s.
30 / 37 40 26 / 10 / Right / Middle frontal gyrus / 3.73 / 3.35 / <0.001 / n.s.
Table_S2. Correlation between grey matter volumes and SCF after treatment in bipolar patients.Data are shown for the main effects surviving a threshold of p<0.001 in the whole brain. Cluster size (n voxels), MNI coordinates (x, y, z) of voxels, Side, Brodmann's area (BA), Region, T values, Z values, and level of significance (value p, value pFWE).
Cluster(n voxels) / Signal peak / BA / Side / Region / F / Z / value p / value pFWE
785 / -63 -27 -16 / 21 / Left / Middle Temporal Gyrus / 7.55 / 5.19 / <0.001 / 0.004
896 / 58 -27 15 / 40 / Right / Postcentral Gyrus / 6.91 / 4.94 / <0.001 / 0.012
203 / -20 7 62 / 6 / Left / Superior Frontal Gyrus / 6.05 / 4.55 / <0.001 / 0.055
234 / 36 44 -13 / 11 / Right / Superior Frontal Gyrus / 5.19 / 4.12 / <0.001 / n.s.
363 / 4 -0 62 / 6 / Right / Medial Frontal Gyrus / 4.71 / 3.85 / <0.001 / n.s.
101 / 21 0 58 / 6 / Right / Medial Frontal Gyrus / 5.63 / 4.35 / <0.001 / n.s.
71 / -42 33 20 / 46 / Left / Middle Frontal Gyrus / 4.36 / 3.64 / <0.001 / n.s.
101 / -28 -72 47 / 7 / Left / Superior Parietal Lobule / 4.95 / 3.99 / <0.001 / n.s.
57 / 33 -71 44 / 7 / Right / Superior Parietal Lobule / 4.22 / 3.55 / <0.001 / n.s.
1821 / 3 31 30 / 32 / Right / Cingulate Gyrus / 5.72 / 4.39 / <0.001 / n.s.
333 / 3 46 9 / 32 / Right / Anterior Cingulate / 5.38 / 4.22 / <0.001 / n.s.
95 / -14 48 -1 / 32 / Left / Anterior Cingulate / 4.46 / 3.7 / <0.001 / n.s.
36 / -38 -0 -18 / 38 / Left / Superior Temporal Gyrus / 3.86 / 3.32 / <0.001 / n.s.
36 / -12 42 14 / 10 / Left / Medial Frontal Gyrus / 3.71 / 3.21 / <0.001 / n.s.
108 / 56 -57 -9 / 37 / Right / Inferior Temporal Gyrus / 5.64 / 4.35 / <0.001 / n.s.
872 / 6 -33 45 / 31 / Right / Paracentral Lobule / 5.38 / 4.22 / <0.001 / n.s.
100 / 38 -30 -25 / 36 / Right / Parahippocampal Gyrus / 5.03 / 4.03 / <0.001 / n.s.
42 / -14 -33 -6 / 27 / Left / Parahippocampal Gyrus / 4.07 / 3.45 / <0.001 / n.s.
33 / -27 -44 2 / / / Left / Hyppocampus / 4.48 / 3.71 / <0.001 / n.s.
77 / -33 -33 -6 / / / Left / Hyppocampus / 4.06 / 3.45 / <0.001 / n.s.
86 / -34 -27 -30 / / / Left / Culmen / 4.61 / 3.79 / <0.001 / n.s.
191 / 44 -50 -27 / / / Right / Culmen / 4.41 / 3.67 / <0.001 / n.s.
81 / -39 -69 -13 / 19 / Left / Fusiform Gyrus / 3.96 / 3.38 / <0.001 / n.s.
Table_S3. Correlation between grey matter volumesand delta SCF in bipolar patients.Data are shown for the main effects surviving a threshold of p<0.001 in the whole brain. Cluster size (n voxels), MNI coordinates (x, y, z) of voxels, Side, Brodmann's area (BA), Region, T values, Z values, and level of significance (value p, value pFWE).
Cluster(n voxels) / Signal peak / BA / Side / Region / T / Z / value p / value pFWE
1124 / 3 34 27 / 32 / Right / Anterior cingulate / 6.48 / 4.65 / <0.001 / 0.038
49 / 2 45 6 / 32 / Right / Anterior cingulate / 4.23 / 3.51 / <0.001 / n.s.
71 / 21 -27 -12 / 28 / Right / Parahyppocampal gyrus / 4.98 / 3.93 / <0.001 / n.s.
136 / 15 13 14 / / / Right / Caudate body / 4.72 / 3.79 / <0.001 / n.s.
37 / 54 -48 -9 / 37 / Right / Inferior temporal gyrus / 4.57 / 3.71 / <0.001 / n.s.
155 / 1 -20 45 / 31 / Right / Paracentral lobule / 4.34 / 3.57 / <0.001 / n.s.
Table_S4.Effect of the fMRI task. Data are shown for the main effects surviving a threshold of p<0.001 in the whole brain.Cluster size (n voxels), MNI coordinates (x, y, z) of voxels, Side, Brodmann's area (BA), Region, F values, Z values, and level of significance (value p, value pFWE).
Cluster(n voxels) / Signal peak / BA / Side / Region / F / Z / value p / value pFWE
10342 / -38 -30 62 / 4 / Left / Precentral gyrus / 16.94 / 7.71 / <0.001 / <0.001
-40 -22 58 / 4 / Precentral gyrus / 15.09 / 7.35 / <0.001 / <0.001
-52 -20 22 / 43 / Postcentral gyrus / 12.32 / 6.69 / <0.001 / <0.001
750 / 58 -18 46 / 1 / Right / Postcentral gyrus / 6.30 / 4.62 / <0.001 / 0.022
56 -18 20 / 43 / Postcentral gyrus / 5.82 / 4.38 / <0.001 / n.s
1581 / 54 10 2 / 22 / Right / Superior temporal lobe / 7.06 / 4.95 / <0.001 / 0.005
64 10 22 / 45 / Inferior Frontal gyrus / 6.39 / 4.66 / <0.001 / 0.019
32 -8 -6 / / / Putamen / 6.33 / 4.63 / <0.001 / 0.021
144 / -22 58 22 / 10 / Left / Medial frontal gyrus / 4.45 / 3.62 / <0.001 / n.s
-4 56 36 / 9 / Superior frontal gyrus / 4.26 / 3.50 / <0.001 / n.s
-14 58 28 / 10 / Superior frontal gyrus / 4.08 / 3.38 / <0.001 / n.s
43 / 2 56 14 / 10 / Right / Medial frontal gyrus / 4.18 / 3.45 / <0.001 / n.s
2 60 6 / 10 / Medial frontal gyrus / 3.93 / 3.28 / <0.001 / n.s
30 / -34 24 2 / 13 / Left / Insula / 4.14 / 3.42 / <0.001 / n.s
Table_S5. Correlation between BOLD fMRI signal change before/after treatment and delta SCF in bipolar patients.Data are shown for the main effects surviving a threshold of p<0.001 in the whole brain. Cluster size (n voxels), MNI coordinates (x, y, z) of voxels, Side, Brodmann's area (BA), Region, T values, Z values, and level of significance (value p, value pFWE).
Cluster(n voxels) / Signal peak / BA / Side / Region / T / Z / value p / value pFWE
30 / 46 -64 52 / 7 / Right / Superior parietal lobule / 8.18 / 4.88 / <0.001 / 0.019
53 / -10 38 32 / 9 / Left / Middle frontal gyrus / 7.50 / 4.68 / <0.001 / 0.040
42 / 12 42 26 / 9 / Right / Middle frontal gyrus / 5.19 / 3.81 / <0.001 / n.s
45 / -40 36 16 / 46 / Left / Inferior frontal gyrus / 4.78 / 3.62 / <0.001 / n.s
Supplementary Figure 1. Pre-rolandic ACC grey matter area (peak effect at MNI coordinates 18, 1, 44) where a significant interaction of treatment and response was detected on BOLD fMRI neural correlates of response inhibition to negative vs positive morally tuned stimuli, and direction of the effect. Changes of neural responses are expressed as percent of whole brain mean BOLD signal. Bars are means, whiskers are 95% confidence limits.
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