SUPPLEMENTARY MATERIAL

Infections in patients receiving subcutaneous biological treatments
for moderate to severe psoriasis
Andrea Messori, Sabrina Trippoli
HTA Unit, ESTAV Toscana Centro,
Regional Health Service, 50100 Firenze, ITALY

Figure S1. Prisma schematic.

The figure summarizes the phases of our literature search and their respective results. The search term used for the PubMed query was “(adalimumab OR ustekinumab OR etanercept OR secukinumab) AND safety”; filters were applied to randomized controlled trials and to articles published in year 2000 or later. The last search was run on 15 July 2015.


Table S1. Bibliography of the randomized studies included in our analysis.
Study No. / First author or trial acronym and year of publication / Bibliographic details
1 / Menter et al. (2008) / Menter A, Tyring SK, Gordon K, et al. Adalimumab therapy for moderate to severe psoriasis: a randomized, controlled phase III trial. J Am Acad Dermatol 2008; 58:106–15.
2 / Asashina et al. (2010) / Asahina A, Nakagawa H, Etoh T, et al. Adalimumab in Japanese patients with moderate to severe chronic plaque psoriasis: efficacy and safety results from a Phase II/III randomized controlled study. J Dermatol 2010; 37:299–310.
3 / Papp et al. (2008) / Papp KA, Langley RG, Lebwohl M, et al. Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 52-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 2). Lancet 2008;371:1675–84.
4 / Igarashi et al. (2012) / Igarashi A, Kato T, Kato M, et al. Efficacy and safety of ustekinumab in Japanese patients with moderate-to-severe plaque-type psoriasis: long-term results from a phase 2/3 clinical trial. J Dermatol 2012; 39:242–52.
5 / Leonardi et al. (2008) / Leonardi CL, Kimball AB, Papp KA, et al. Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 76-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 1). Lancet 2008;371:1665–74.
6 / Tsai et al. (2011) / Tsai TF, Ho JC, Song M, et al. Efficacy and safety of ustekinumab for the treatment of moderate-to-severe psoriasis: a phase III, randomized, placebo-controlled trial in Taiwanese and Korean patients (PEARL). J Dermatol Sci 2011; 63:154–63.
7 / Zhu et al. (2013) / Zhu X, Zheng M, Song M et al. Efficacy and safety of ustekinumab in Chinese patients with moderate to severe plaque-type psoriasis: results from a phase 3 clinical trial (LOTUS). J Drugs Dermatol. 2013;12(2):166-74.
8 / Tyring et al. (2006) / Tyring S, Gottlieb A, Papp K et al. Etanercept and clinical outcomes, fatigue, and depression in psoriasis: double-blind placebo-controlled randomised phase III trial. Lancet. 2006;367(9504):29-35.
9 / Papp et al. (2005) / Papp KA, Tyring S, Lahfa M et al. A global phase III randomized controlled trial of etanercept in psoriasis: safety, efficacy, and effect of dose reduction. Br J Dermatol. 2005 J;152(6):1304-12.
10 / Leonardi et al. (2003) / Leonardi CL, Powers JL, Matheson RT et al. Etanercept as monotherapy in patients with psoriasis. N Engl J Med. 2003;349(21):2014-22.
11 / Van de Kerkhof et al. (2003) / Van de Kerkhof PC, Segaert S, Lahfa M et al. Once weekly administration of etanercept 50 mg is efficacious and well tolerated in patients with moderate-to-severe plaque psoriasis: a randomized controlled trial with open-label extension. Br J Dermatol.;159(5):1177-85. doi: 10.1111/j.1365-2133.2008.08771.
12 / FIXTURE (2014) / Langley RG,Elewski BE,Lebwohl M,et al.; ERASURE Study Group;FIXTURE Study Group. Secukinumab in plaque psoriasis--results of two phase 3 trials. N Engl J Med.2014 Jul 24;371(4):326-38.
13 / ERASURE (2014) / Langley RG,Elewski BE,Lebwohl M,et al.; FIXTURE Study Group. Secukinumab in plaque psoriasis--results of two phase 3 trials. N Engl J Med.2014 Jul 24;371(4):326-38. d

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