SUPPLEMENTARY INFORMATION

DECREASED SPECTRAL ENTROPY MODULATION IN PATIENTS WITH SCHIZOPHRENIA DURING A P300 TASK for European Archives of Psychiatry and Clinical Neurosciences Journal

Alejandro Bachiller, Alvaro Díez, Vanessa Suazo, Cristina Domínguez, Marta Ayuso, Roberto Hornero, Jesús Poza, Vicente Molina*

*Corresponding Author:

Psychiatry Department, School of Medicine, University of Valladolid, Avenida de Ramón y Cajal, 7 CP 47005 Valladolid, Spain

Tel: +34 983423200

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Patients / Controls
All patients / CP / MTP
Fp1 / -0.008(0.025) / -0.008 (0.023) / -0.008 (0.025) / -0.021 (0.028)
Fp2 / -0.006(0.023) / -0.011 (0.023) / -0.003 (0.022) / -0.019 (0.032)
F3 / -0.006(0.017) / -0.008 (0.018) / -0.003 (0.015) / -0.025 (0.029)
F4 / -0.095(0.016) / -0.010 (0.015) / -0.009 (0.018) / -0.022 (0.024)
C3 / -0.005(0.014) / -0.005 (0.015) / -0.006 (0.014) / -0.026 (0.024)
C4 / -0.003(0.013) / -0.007 (0.011) / -0.002 (0.016) / -0.021 (0.023)
P3 / -0.001(0.018) / -0.003 (0.019) / 0.002 (0.017) / -0.020 (0.031)
P4 / 0.001(0.012) / -0.003 (0.013) / 0.004 (0.011) / -0.018 (0.027)
O1 / -0.006(0.012) / -0.009 (0.013) / -0.002 (0.012) / -0.010 (0.022)
O2 / -0.007(0.014) / -0.010 (0.014) / -0.005 (0.014) / -0.007 (0.025)
F7 / -0.001(0.022) / -0.003 (0.021) / 0.002 (0.025) / -0.016 (0.025)
F8 / -0.004(0.018) / -0.007 (0.017) / -0.001 (0.019) / -0.016 (0.027)
T5 / -0.006(0.015) / -0.010 (0.015) / -0.001 (0.014) / -0.015 (0.022)
T6 / -0.003(0.014) / -0.006 (0.014) / 0.002 (0.016) / -0.012 (0.021)
Fz / -0.009(0.017) / -0.012 (0.015) / -0.006 (0.019) / -0.030 (0.029)
Pz / -0.003(0.018) / -0.003 (0.020) / -0.001 (0.017) / -0.026 (0.038)
Cz / -0.014(0.012) / -0.011 (0.010) / -0.018 (0.015) / -0.042 (0.037)

Table S1 SE parameter differences between active and baseline SE values, displayed as mean (SD) by electrode and group

Patients / Controls
All patients / CP / MTP
Fp1 / -0.035 (0.092) / -0.057 (0.097) / -0.006 (0.087) / -0.066 (0.103)
Fp2 / -0.041 (0.081) / -0.049 (0.097) / -0.033 (0.062) / -0.068 (0.101)
F3 / -0.033 (0.083) / -0.036 (0.084) / -0.030 (0.083) / -0.100 (0.111)
F4 / -0.070 (0.071) / -0.076 (0.077) / -0.061 (0.064) / -0.088 (0.082)
C3 / -0.030 (0.080) / -0.041 (0.085) / -0.022 (0.062) / -0.122 (0.092)
C4 / -0.041 (0.064) / -0.042 (0.069) / -0.029 (0.061) / -0.101 (0.078)
P3 / -0.030 (0.081) / -0.041 (0.085) / -0.009 (0.074) / -0.076 (0.089)
P4 / -0.017 (0.063) / -0.031 (0.066) / 0.000 (0.058) / -0.069 (0.076)
O1 / -0.053 (0.077) / -0.071 (0.077) / -0.030 (0.072) / -0.060 (0.077)
O2 / -0.042 (0.054) / -0.050 (0.051) / -0.031 (0.058) / -0.049 (0.083)
F7 / -0.034 (0.090) / -0.048 (0.074) / -0.016 (0.108) / -0.045 (0.081)
F8 / -0.034 (0.074) / -0.049 (0.086) / -0.015 (0.055) / -0.056 (0.098)
T5 / -0.042 (0.096) / -0.055 (0.114) / -0.026 (0.070) / -0.080 (0.086)
T6 / -0.025 (0.061) / -0.046 (0.057) / 0.002 (0.058) / -0.067 (0.089)
Fz / -0.063 (0.073) / -0.072 (0.072) / -0.052 (0.075) / -0.115 (0.084)
Pz / -0.034 (0.067) / -0.042 (0.078) / -0.024 (0.054) / -0.078 (0.097)
Cz / -0.078 (0.069) / -0.067 (0.061) / -0.091 (0.077) / -0.156 (0.113)

Table S2 MF differences between active and baseline MF values, displayed as mean (SD) by electrode and group

Fig. S1 Receiver operator characteristics (ROC) curve, showing the classification performance of SE to discriminate between: patients (P) and controls (C), minimally-treated patients (MTP) and C, and chronic patients (CP) and MTP. a) ROC curve using LDA with LOO-CV; and b) ROC curve using LDA.

Fig. S2 Associations between SE values and positive and total PANSS scores in the patients

Fig. S3 SE differences pre- and post-haloperidol in 5 healthy controls (individual spatial maps of the differences between baseline and active conditions are shown)

Fig. S4 Association between differences in SE and MF values at Fz (p<0.001 in all three groups)

Fig. S5 RP in each band at baseline and active conditions. In each row, RP topographic maps are shown for each group, followed by a map depicting the significance of the differences in the corresponding band in the corresponding group and band.

In the lower part of the figure, the statistical significance of the comparison of differences between each pair of groups is represented.

CP: chronic (stable) patients; MTP: minimally-treated patients; C: controls; P: patients; BL: Baseline window; P300: Active window

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