Supplementary Figure 2. Comparison of Deduced Amino Acid Sequences of the VP7 Antigenic
Supplementary Figure 2. Comparison of deduced amino acid sequences of the VP7 antigenic sites (A-D and F) [1] of rotavirus G11 with different G genotypes from the global collection available in the GenBank database. Recent G genotypes present in rotavirus vaccines were also examined. The Korean G11 study strain is boxed and in boldface type.
Strains / Region D / Region A / Region B / Region C / Region FRVA/Pig-tc/MEX/YM/1983/G11P9[7] / 65 76
....|....|..
TPYMNSTMSETF / 87 101
....|....|....|
HEAATQIADDKWKDT / 142 152
....|....|.
MKYDGNSQLDM / 208 221
....|....|....
LTTDPTTFEEVASA / 235 245
|....|....|
HKLDVTTATCT
Global G11
RVA/Pig-tc/VEN/A253/1988/G11P9[7]
RVA/Human-wt/BGD/Dhaka6/2001/G11P[25]
RVA/Human-wt/BGD/Matlab36/2002/G11P[8]
RVA/Human-wt/NPL/KTM368/2004/G11P[25]
RVA/Human-X/NPL/04N368/2004/G11P[25]
RVA/Human-wt/ECU/EC2184/2005/G11P[6]
RVA/Human-wt/KOR/CUK1/2005/G11P[4]
RVA/Human-wt/KOR/CAU-1/2008/G11P[X]
RVA/Pig-wt/KOR/JJ37-pp1/2010/G11P[7]
RVA/Human-wt/KOR/CAU12-2/2012/G11P[25]
RVA/Human-X/KOR/GJ0703034/XXXX/G11P[25] / ...... T....
......
......
......
......
...T......
......
......
...A...V....
......
...... / R......
N......
N......
N......
N......
G...... E....
N......
N......
N..S...... R..
N......
N...... / ......
......
......
......
......
......
......
......
......
......
...... / ...... T
S...... I...
S...... I...
S......
S......
......
S......
S......
...N.A...... F.
S......
S...... / ......
......
......
......
......
......
......
......
......
...... T...
......
Recent G genotypes
RVA/Human-tc/USA/Wa/1974/G1P1A[8]
RVA/Human-tc/USA/DS-1/1976/G2P1B[4]
RVA/Human-tc/JPN/AU-1/1982/G3P3[9]
RVA/Human-tc/GBR/ST3/1975/G4P2A[6]
RVA/Pig-tc/USA/OSU/1977/G5P9[7]
RVA/Cow-tc/FRA/RF/1982/G6P[1]
RVA/Turkey-tc/IRL/Ty-3/1979/G7P[17]
RVA/Human-tc/IND/69M/1980/G8P4[10]
RVA/Human-tc/USA/WI61/1983/G9P1A[8]
RVA/Human-tc/GBR/A64/1987/G10P11[14]
RVA/Human-tc/PHL/L26/1987/G12P[4]
RVA/Horse-tc/GBR/L338/1991/G13P[18]
RVA/Horse-tc/ARG/E403/2006/G14P[12]
RVA/Cow-tc/ARG/B383/1998/G15P[11]
RVA/Mouse-tc/USA/ETD_822/XXXX/G16P[16]
RVA/Turkey-tc/IRL/Ty-1/1979/G17P[17]
RVA/Pigeon-tc/JPN/PO-13/1983/G18P[17]
RVA/Chicken-tc/DEU/02V0002G3/2003/G19P[30]
RVA/Human-wt/ECU/Ecu534/2006/G20P[28]
RVA/Cow-wt/JPN/AzuK-1/2006/G21P[29]
RVA/Turkey-tc/DEU/03V0002E10/2003/G22P[35]
RVA/Pheasant-wt/HUN/Phea14246/2008/G23P[?]
RVA/Cow-tc/JPN/Dai-10/2007/G24P[33]
RVA/Bat-wc/KEN/KE4852/07/2007/G25P[6]
RVA/Pig-wt/JPN/TJ4-1/2010/G26P[?]
RVA/SugarGlider-wt/JPN/SG33/2010/G27P[X] / AV.T...QE.V.
AV.T...SG.P.
..T...RE.V..
.A.A...QDNN.
...... T....
.A.AD..Q..P.
VVLA.S.QDQIG
.N.Q.VSNP.P.
.A.A..SQLD..
.A.A...QDNN.
.A.V...QQ.S.
.A.A...QE.N.
.A.V...QENI.
NA.A.V.DDKP.
.A.A...QP.P.
VAVP.K.DDQIG
VAVP.K.DDQIG
ITVQ.Q.AEPIG
.TLA..S.EN..
AA.S...EENI.
VT.Q.Q.SEPIG
VTVL...QTQIG
YINT.T.IEKP.
.A.A..SQQ.IQ
...A...RE...
.V.A...QQ... / T..S...N.GD...S
A..KNE.S..E.EN.
T....E.N.NS....
S..P...S.TE....
N....E...T..TE.
V..SNE...TE....
KA.D.E...PE..A.
V..E.E...SS....
A..S...G.TE....
S..P...S.TE....
NSVT.E.T.PD.TH.
N.VVSELN..S..N.
T...... D.SS....
TI.SSDLN.PD..N.
K....E.K.NS....
K.....MN.AE..S.
N..E.E.N.NE....
A..S.E...TE..QP
T..R.E.N.NS.T..
N.VIS..N......
T...NE...SE..Q.
K..SDE.K.SE..N.
NDVL.E.Q......
T..K...S....T..
V..KNE.N.GS.T..
T..Q.E.N.NS.... / ....QSLE...
.R..NT.E..A
....ATL....
IRFVFGEE..I
...... L....
....STQE...
AH.TNDVA..I
...NA..E...
....STLE...
IRFVSGEE..I
VQ.QNSLA..V
V..STEL...I
....EAL....
...ES.LEM..
....ASL.M..
A...Q.ET...
V...Q.AG...
I.....QG..I
....A.L....
...ADSES...
V.....QG..I
KYT.S.VA..I
.R.YE.MT...
....QAQE...
...QSDL....
....STL.... / Q..NVDS..MI.EN
K...VN...I...S
....TN...... T.
Q..NTA...T..DS
S...INS..T..N.
.I.N.D...T..TT
Q..NTD...ILTMS
....T...... T.
T..NTA...... AS
Q..NTA...T..DS
T...VA...... N.
....TE...... L
...NVA...... TS
V...TNS..T..VN
....V.....I.T.
K...VS....LTTT
Q...VA...QLTAT
K...VS...QLTT.
Q...VS...... N.
V...VN....L.TT
K...L....QLTAS
Q..NVN...Q.TAS
T...VN...VL.NT
I..QTS...... AQ
...NTD....I.TN
....TA...... T. / ..INL..T...
..INISIN...
...N...N...
...NI.ST...
...... S...
...N......
..VNY.V...K
Y.IN...T...
...... T...
...NI.ST...
..INI.LN...
..INL......
..IN...T...
...... N....
...N......
..ANY.IS...
..VNY.I....
..I.Y.VT...
......
Y.INI..QK..
..I.Y.VT...
..I.Y.SN...
Y.INIS.QS..
......
..ININ.....
...N......
G genotypes in current human rotavirus vaccines
RVA/Vaccine/USA/Rotarix-A41CB052A/1988/G1P1A[8]
RVA/Vaccine/USA/RotaTeq-WI79-9/1992/G1P7[5]
RVA/Vaccine/USA/RotaTeq-SC2-9/1992/G2P7[5]
RVA/Vaccine/USA/RotaTeq-WI78-8/1992/G3P7[5]
RVA/Vaccine/USA/RotaTeq-BrB-9/1996/G4P7[5] / .V.A...QEGI.
AV.T...QE.V.
AV.T...SG...
.S.T...RE.V.
.A.A...QDNN. / T..S...N.GE...S
T..S...N.GD....
A..KNE.S..E.EN.
T....E.N.NS....
S..P...S.TE.... / ....Q.LE...
....QSLE...
.R..NT.E..A
....ATL....
IRFASGEE..V / Q..NVDS..M..EN
Q..NVDS..MI.EN
K...VS...I...S
....AN...... T.
Q...TA...T..DS / ..INL..T...
..INL..T...
..INISIS...
...K...D...
...... ST...
1.Laird AR, Gentsch JR, Nakagomi T, Nakagomi O, Glass RI (2003) Characterization of serotype G9 rotavirus strains isolated in the United States and India from 1993 to 2001. J Clin Microbiol 41: 3100-3111