Supplemental Tables
Suppl. Table 1. Clinical characteristics of the pre-eclampsia patients informative for XCI status
PATIENT / DATEOF BIRTH / DIAGNOSIS / PREGNANCY
HISTORY / GW OF
DISEASE / GW OF
DELIVERY / IUGR/
BIRTH WEIGHT(gr) / SEX OF
CHILD
³90 percent skewing
04-176* / 1977 / HELLP / G3, P1 / 24 / 30 / -/1,200 / F
04-182* / 1972 / MP / G9, P4 / 32 / 40 / -/3,000 / M
04-187 / 1969 / SP / G6, P4 / 35 / 38 / -/2,400 / F
04-190* / 1980 / SP / G1, P1 / 29 / 29 / +/850 / M
04-287 / 1970 / SP / G1, P1 / 30 / 30 / -/1,550 / M
04-291 / 1966 / SP / G6, P5 / 35 / 37 / -/2,350 / F
04-298* / 1980 / SP / G1, P1 / 39 / 39 / -/3,000 / F
04-378 / 1962 / MP / G3, P3 / 40 / 40 / -/3,350 / M
06-237 / 1972 / MP / G3, P3 / 35 / 38 / +/2,500 / M
06-241 / 1968 / MP / G6, P6 / 36 / 38 / -/3,650 / F
80-89 percent skewing
04-192* / 1979 / SP / G1, P1 / 29 / 33 / +/1,500 / M
04-368 / 1981 / SP / G1, P1 / 26 / 41 / -/2,400 / F
04-372 / 1969 / SP / G3, P3 / 36 / 39 / -/2,800 / M
04-376 / 1970 / MP / G4, P3 / 36 / 40 / -/3,500 / M
04-401 / 1982 / SP / G2, P1 / 34 / 36 / -/2,450 / M
06-242 / 1978 / MP / G1, P1 / 36 / 38.5 / -/3,600 / M
70-79 percent skewing
04-186 / 1985 / SP / G1, P1 / 32 / 33 / +/1,100 / F
04-284* / 1975 / HELLP / G4, P3 / 32 / 33 / -/2,100 / M
04-289* / 1975 / SP / G2, P2 / 38 / 38 / +/2,450 / M
04-365 / 1982 / SP / G1, P1 / 32 / 36 / -/2,500 / M
06-238 / 1980 / SP / G1, P1 / 26 / 34 / +/1,000 / F
06-239 / 1979 / SP / G3, P2 / 18 / 20 / ?/500 (ex) / F
60-69 percent skewing
04-178 / 1985 / SP / G1, P1 / 34 / 35 / -/2,050 / M
04-181 / 1977 / HELLP / G2, P2 / 33 / 33 / +/1,600 / M
04-184 / 1967 / MP / G6, P4 / 39 / 40 / ?/3,300 / F
04-285 / 1960 / SP / G3, P1 / 16 / 20 / -/400 / M
04-288 / 1972 / SP / G1, P1 / 23 / 34 / +/1,250 / F
04-364 / 1964 / SP / G6, P5 / 24 / 25 / ?/900 / F
04-370 / 1966 / MP / G3, P3 / 39 / 39 / -/2,850 / F
04-374 / 1977 / SP / G1, P1 / 39 / 40 / -/2,800 / F
04-402 / 1983 / E / G1, P1 / 38 / 38 / -/3,000 / M
04-403 / 1969 / SP / G4, P4 / 34 / 34 / ?/1,800 / F
06-236 / 1973 / MP / G1, P1 / 36 / 38 / -/3,300 / M
06-245 / 1973 / MP / G3, P3 / 32 / 37 / +/2,350 (ex) / F
06-246 / 1984 / SP / G1, P1 / 26 / 34 / +/1,150 / F
50-59 percent skewing
04-180 / 1976 / MP / G4, P4 / 34 / 35 / -/2,100 / F
04-188 / 1975 / SP / G2, P2 / 31 / 32 / -/1,800 / M
04-189 / 1977 / SP / G1, P1 / 27 / 33 / -/1,400 / M
04-292 / 1966 / SP / G1, P1 / 32 / 37 / -/2,000 / F
04-293 / 1970 / SP / G3, P3 / 32 / 32 / -/1,350 / F
04-367 / 1974 / SP / G3, P3 / 33 / 33 / -/2,000 / F
04-373 / 1972 / SP / G1, P1 / 36 / 39 / -/2,800 / M
04-405 / 1971 / E / G4, P2 / 34 / 34 / -/1,700 / F
06-234 / 1971 / SP / G1, P1 / 30 / 38 / +/1,900 / M
06-235 / 1982 / SP / G1, P1 / 24 / 28 / +/850 (ex) / F
06-244 / 1982 / MP / G1, P1 / 37 / 39 / -/3,300 / M
SP, severe pre-eclampsia; MP, mild pre-eclampsia; HELLP, HELLP syndrome; E, eclampsia; G, number of pregnancies; P, pregnancies carried to term; GW, gestation week; IUGR, intra-uterine growth retardation; M, male; F, female; *, patients from whom buccal cells were analysed.
Suppl. Table 2. Clinical characteristics of
the controls informative for XCI status
PATIENT / DATEOF BIRTH / PREGNANCY
HISTORY / SEX OF
CHILD
³90 percent skewing
03-733 / 1973 / G2,P2 / M1,F1
03-715 / 1972 / G4,P4 / M2,F2
80-89 percent skewing
03-742 / 1970 / G0,P0 / (-)
03-745 / 1966 / G1,P1 / F1
03-698 / 1965 / G2,P2 / M2
03-772 / 1972 / G3,P3 / M2,F1
03-771 / 1971 / G2,P2 / M1,P1
03-777 / 1970 / G2,P2 / M1,F1
70-79 percent skewing
03-856 / 1970 / G4,P4 / M3,F1
03-861 / 1970 / G1,P1 / M1
03-826 / 1966 / G3,P3 / M3
03-727 / 1974 / G1,P1 / M1
03-840 / 1971 / G2,P2 / M2
03-858 / 1975 / G2,P2 / M2
03-711 / 1970 / G3,P3 / M1,F2
03-726 / 1971 / G4,P4 / M2,F2
03-738 / 1976 / G2,P2 / M1,F1
03-847 / 1978 / G3,P3 / M2,F1
03-716 / 1965 / G3,P3 / M2,F1
03-846 / 1974 / G1,P1 / M1
03-708 / 1971 / G1,P1 / M1
03-841 / 1969 / G1,P1 / F1
03-850 / 1974 / G0,P0 / (-)
60-69 percent skewing
03-712 / 1975 / G2,P2 / M1,F1
03-839 / 1977 / G2,P2 / M2
03-852 / 1964 / G3,P3 / M1,F2
03-862 / 1978 / G3,P3 / M1,F2
03-833 / 1961 / G3,P3 / M3
03-701 / 1970 / G0,P0 / (-)
03-836 / 1974 / G2,P2 / M2
03-363 / 1961 / G2,P2 / M2
03-366 / 1961 / G3,P3 / M2,F1
03-709 / 1977 / G4,P4 / M2,F2
03-746 / 1961 / G1,P1 / M1
03-778 / 1964 / G3,P3 / M2,F1
03-864 / 1974 / G1,P1 / F1
03-731 / 1973 / G3,P3 / M2,F1
03-813 / 1960 / G4,P4 / M2,F2
03-720 / 1968 / G4,P4 / M2,F2
03-821 / 1975 / G2,P2 / M2
03-703 / 1968 / G3,P3 / M1,F2
03-728 / 1974 / G1,P1 / F1
03-760 / 1975 / G0,P0 / (-)
50-59 percent skewing
03-713 / 1969 / G1,P1 / F1
03-784 / 1976 / G0,P0 / (-)
03-768 / 1978 / G1,P1 / M1
03-364 / 1968 / G1,P1 / F1
03-706 / 1974 / G2,P2 / M1,F1
03-717 / 1978 / G2,P2 / M2
03-729 / 1982 / G3,P3 / M2,F1
03-747 / 1975 / G3,P3 / M2,F1
03-855 / 1971 / G2,P2 / M1,F1
03-365 / 1979 / G1,P1 / F1
03-775 / 1978 / G2,P2 / M1,F1
03-822 / 1975 / G2,P2 / M2
03-705 / 1976 / G0,P0 / (-)
03-718 / 1972 / G2,P2 / M2
03-740 / 1981 / G3,P3 / M1,F2
03-761 / 1965 / G4,P4 / M2,F2
03-773 / 1968 / G1,P1 / M1
03-780 / 1979 / G1,P1 / M1
03-816 / 1956 / G3,P3 / M3
03-860 / 1975 / G2,P2 / M2
03-737 / 1975 / G2,P2 / M1,F1
03-700 / 1967 / G3,P3 / M1,F2
03-735 / 1970 / G2,P2 / M2
03-769 / 1965 / G1,P1 / F1
03-830 / 1969 / G2,P2 / M2
03-704 / 1972 / G4,P4 / M3,F1
03-722 / 1971 / G4,P4 / M1,F3
03-744 / 1967 / G2,P2 / M1,F1
03-817 / 1968 / G3,P3 / M3
03-730 / 1977 / G1,P1 / M1
03-734 / 1966 / G3,P3 / M2,F1
03-762 / 1976 / G1,P1 / F1
03-814 / 1971 / G2,P2 / M2
03-832 / 1980 / G2P2 / M2
03-714 / 1974 / G5,P5 / M1,F4
03-725 / 1963 / G4,P4 / M1,F3
03-732 / 1971 / G1,P1 / M1
03-741 / 1980 / G3,P3 / M2,F1
03-776 / 1973 / G2,P2 / M1,F1
03-823 / 1973 / G3,P3 / M3
03-767 / 1981 / G3,P3 / M2,F1
03-820 / 1956 / G4,P4 / M4
03-702 / 1976 / G2,P2 / F2
G, number of pregnancies; P, pregnancies carried to term;
Gestation week: 38±2; Intra-uterine growth retardation was
not observed in any of the pregnancies; M, male; F, female.
Suppl. Table 3. X-chromosome inactivation patterns
and recurrent spontaneous abortion ratios of the
pre-eclampsia patients
Group / Recurrent abortion (percent)³90 percent skewing / 3/10 (30)
80-89 percent skewing / 0/6 (0)
50-79 percent skewing / 3/30 (10)