Supplemental Table 3. Genes co-regulated by Hap4p overexpression and caloric restriction. Genes shown were up regulated > 2-fold in 2/2 experiments by Hap4p overexpression, and > 1.5-fold in 2/2 experiments in 0.5% glucose and in a single hxk2 experiment.

Gene / Function / Fold Change
YNL223W /

AUT2

/ Protein that mediates attachment of autophagosomes to microtubules; in combination with Aut7p, also required for sporulation
YHL038C / CBP2 / Protein required for splicing of the COB aI5 intron and for efficient splicing of 21S mitochondrial rRNA (LSU) intron
YLR330W / CHS5 / Protein required for chitin synthase III activity
YDL101C / DUN1 / Protein kinase required for induction of Rnr3p and DNA repair genes after DNA damage
YDR424C / DYN2 / Cytoplasmic dynein light chain
YPL021W / ECM23 / Protein with similarity to Srd1p
YAL003W / EFB1 / Translation elongation factor EF-1beta; GDP/GTP exchange factor for Tef1p/Tef2p
YAL007C / ERP2 / Component of COPII-coated vesicles, forms an Erp1p-Erp2p-Emp24p-Erv25p heteromeric complex, has similarity to Emp24p and Erv25p "
YOR382W / FIT2 / Protein possibly involved in iron uptake
YPL262W / FUM1 / Fumarate hydratase; mitochondrial and cytoplasmic fumarase, converts L-malate to fumarate as part of the TCA cycle
YDR158W / HOM2 / Aspartate-semialdehyde dehydrogenase (L-aspartate-beta-semialdehyde
YDL181W / INH1 / Inhibitor of mitochondrial ATPase; forms complex with ATPase to inhibit enzyme activity
YLL002W / KIM2 / Protein involved in resistance to mutagens such as diepoxybutane and mitomycin C
YER146W / LSM5 / U6 snRNA-associated protein of the Sm-like group
YDL087C / LUC7 / U1 snRNA-associated protein, also involved in exit from mitosis
YOL009C / MDM12 / Mitochondrial inheritance protein which may function in a complex with Mdm10p at the mitochondrial surface
YDR462W / MRPL28 / Mitochondrial ribosomal protein of the large subunit;
YPL104W / MSD1 / Aspartyl-tRNA synthetase, mitochondrial
YDR176W / NGG1 / Component of the nucleosomal histone acetyltransferase (Spt-Ada-Gcn5-Acetyltransferase or SAGA) complex
YOL001W / PHO80 / Cyclin that interacts with Pho85p protein kinase; regulates the phosphate pathway through phosphorylation of Pho4p
YCL001W / RER1 / Component of COPII-coated vesicles, involved in retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment
YIL052C / RPL34B / Ribosomal protein L34B (rat L34)
YIL084C / SDS3 / Component of the Rpd3p-Sin3p histone deacetylase complex, required for the integrity and activity of the complex
YIL076W / SEC28 / Coatomer (COPI) complex epsilon chain (epsilon-COP) of secretory pathway vesicles; required for retrograde transport from Golgi to endoplasmic reticulum
YLR378C / SEC61 / Component of the Sec61p-Sss1p-Sbh1p complex, involved in protein translocation into the endoplasmic reticulum
YFR031C / SMC2 / Subunit of condensin protein complex required for chromosome condensation and segregation, coiled-coil protein of the SMC family"
YOR159C / SME1 / Component of U1 and U2 snRNPs of the Sm class; required for mRNA splicing
YER150W / SPI1 / Protein induced in stationary phase, has similarity to Sed1p
YPL230W / USV1 / Putative transcription factor that contains two tandem C2H2-type zinc fingers
YDR219C / Protein of unknown function, contains an F-box
YDR282C / Protein of unknown function
YDR372C / Protein of unknown function
YDR525W / Protein of unknown function
YER134C / Protein of unknown function
YFR048W / Protein of unknown function
YIL080W / Protein of unknown function
YIL089W / Protein of unknown function
YLR412W / Protein of unknown function
YLR454W / Protein of unknown function
YNL313C / Protein of unknown function
YNR018W / Protein of unknown function
YOL002C / Protein of unknown function
YOL003C / Protein of unknown function
YOR009W / Possible cell wall mannoprotein
YPR136C / Protein of unknown function