Supplemental Table 2. Sequence Comparison of Human and Porcine Collagen Type Iα2 Chain

Supplemental table 2. Sequence comparison of human and porcine collagen Type Iα2 chain.

BLAST search result: sequence identity 1280/1366 (94%), positives hits1311/1366 (95%). Signal sequence, N-Propeptide and N-Propeptideare absent in mature collagen and the difference locus in these region have no role in immunogenicity or antigenicity. Mature collagen. Difference locus. Similar locus

a: At position 244 of the human peptide, glycine (Gly-Pro-Ala) leads to helix formation. In the porcine peptide, there is an aspartic acid residue at this position (Asp-Pro-Ala), which precludes a helix structure, that is likely to be a antigenic determinant.

b1, b2 and b3:It will be easier to recognize a single Gly-X-Y triplet at which both X and Y residues diverge between human and porcine