Supplemental Table 2. All Pathways Tested for NPG Association Using PARIS

Supplemental Table 2. All pathways tested for NPG association using PARIS

Pathway Name / Total SNP Count / Description / P-Value / Gene Count / Gene Count* / Complex Feature Count / Complex Feature Count* / Simple Feature Count / Simple Feature Count*
hsa00072 / 237 / Synthesis and degradation of ketone bodies / < 0.001 / 9 / 6 / 32 / 12 / 18 / 4
hsa00400 / 165 / Phenylalanine, tyrosine and tryptophan biosynthesis / < 0.001 / 5 / 4 / 21 / 6 / 20 / 6
hsa00534 / 1136 / Glycosaminoglycan biosynthesis - heparan sulfate / < 0.001 / 26 / 16 / 188 / 35 / 220 / 22
hsa00650 / 992 / Butanoate metabolism / < 0.001 / 35 / 18 / 142 / 37 / 137 / 13
hsa04010 / 9196 / MAPK signaling pathway / < 0.001 / 267 / 139 / 1482 / 244 / 1956 / 116
hsa04340 / 1622 / Hedgehog signaling pathway / < 0.001 / 56 / 25 / 265 / 49 / 332 / 25
hsa04664 / 2851 / Fc epsilon RI signaling pathway / < 0.001 / 79 / 39 / 453 / 80 / 638 / 39
hsa00591 / 728 / Linoleic acid metabolism / 0.001 / 29 / 14 / 83 / 21 / 102 / 9
hsa00680 / 225 / Methane metabolism / 0.001 / 7 / 3 / 26 / 10 / 22 / 2
hsa04510 / 8262 / Focal adhesion / 0.001 / 200 / 112 / 1333 / 230 / 1732 / 101
hsa04912 / 4351 / GnRH signaling pathway / 0.001 / 101 / 56 / 695 / 125 / 903 / 48
hsa04960 / 1526 / Aldosterone-regulated sodium reabsorption / 0.001 / 42 / 23 / 257 / 47 / 357 / 25
hsa05223 / 2501 / Non-small cell lung cancer / 0.001 / 54 / 28 / 417 / 73 / 579 / 36
hsa05410 / 4347 / Hypertrophic cardiomyopathy (HCM) / 0.001 / 84 / 52 / 707 / 103 / 961 / 75
hsa00062 / 166 / Fatty acid elongation in mitochondria / 0.003 / 8 / 5 / 23 / 7 / 35 / 4
hsa00903 / 264 / Limonene and pinene degradation / 0.003 / 8 / 5 / 38 / 10 / 38 / 6
hsa05130 / 1302 / Pathogenic Escherichia coli infection / 0.003 / 57 / 19 / 197 / 48 / 242 / 9
hsa00250 / 985 / Alanine, aspartate and glutamate metabolism / 0.004 / 32 / 22 / 161 / 34 / 201 / 12
hsa00640 / 1184 / Propanoate metabolism / 0.004 / 33 / 24 / 162 / 36 / 186 / 13
hsa04514 / 6086 / Cell adhesion molecules (CAMs) / 0.004 / 130 / 67 / 922 / 145 / 1538 / 94
hsa05214 / 2317 / Glioma / 0.004 / 65 / 35 / 381 / 66 / 482 / 34
hsa00232 / 230 / Caffeine metabolism / 0.005 / 7 / 4 / 32 / 10 / 56 / 4
hsa00520 / 1426 / Amino sugar and nucleotide sugar metabolism / 0.006 / 44 / 24 / 205 / 43 / 254 / 14
hsa00360 / 465 / Phenylalanine metabolism / 0.007 / 17 / 10 / 60 / 11 / 54 / 9
hsa05200 / 11709 / Pathways in cancer / 0.007 / 324 / 165 / 1857 / 282 / 2384 / 137
hsa00310 / 1146 / Lysine degradation / 0.008 / 46 / 26 / 174 / 35 / 176 / 13
hsa04810 / 7392 / Regulation of actin cytoskeleton / 0.008 / 214 / 107 / 1150 / 186 / 1421 / 78
hsa05217 / 1558 / Basal cell carcinoma / 0.008 / 55 / 27 / 247 / 46 / 347 / 20
hsa00472 / 24 / D-Arginine and D-ornithine metabolism / 0.009 / 1 / 1 / 6 / 1 / 6 / 2
hsa04110 / 2993 / Cell cycle / 0.009 / 125 / 59 / 443 / 87 / 484 / 25
hsa00270 / 875 / Cysteine and methionine metabolism / 0.01 / 34 / 21 / 126 / 27 / 155 / 11
hsa03450 / 360 / Non-homologous end-joining / 0.01 / 13 / 10 / 45 / 14 / 43 / 2
hsa04612 / 1443 / Antigen processing and presentation / 0.011 / 69 / 34 / 160 / 38 / 605 / 29
hsa05416 / 2226 / Viral myocarditis / 0.011 / 69 / 33 / 306 / 59 / 709 / 36
hsa04012 / 3779 / ErbB signaling pathway / 0.012 / 87 / 45 / 623 / 108 / 709 / 36
hsa04930 / 2137 / Type II diabetes mellitus / 0.013 / 47 / 23 / 344 / 58 / 529 / 30
hsa05212 / 1998 / Pancreatic cancer / 0.014 / 70 / 36 / 312 / 56 / 328 / 20
hsa00350 / 1122 / Tyrosine metabolism / 0.015 / 41 / 20 / 175 / 28 / 166 / 17
hsa04370 / 2263 / VEGF signaling pathway / 0.015 / 76 / 33 / 354 / 59 / 468 / 29
hsa05412 / 4990 / Arrhythmogenic right ventricular cardiomyopathy (ARVC) / 0.015 / 75 / 48 / 810 / 116 / 1053 / 71
hsa00670 / 669 / One carbon pool by folate / 0.016 / 17 / 11 / 100 / 19 / 121 / 9
hsa04140 / 564 / Regulation of autophagy / 0.02 / 35 / 12 / 80 / 17 / 82 / 7
hsa04320 / 1042 / Dorso-ventral axis formation / 0.023 / 24 / 15 / 166 / 27 / 260 / 18
hsa00620 / 1281 / Pyruvate metabolism / 0.024 / 40 / 25 / 175 / 34 / 162 / 11
hsa04666 / 3752 / Fc gamma R-mediated phagocytosis / 0.026 / 94 / 46 / 602 / 102 / 813 / 40
hsa04512 / 3912 / ECM-receptor interaction / 0.027 / 84 / 53 / 628 / 103 / 843 / 46
hsa04260 / 3079 / Cardiac muscle contraction / 0.03 / 80 / 34 / 509 / 71 / 700 / 48
hsa04650 / 3733 / Natural killer cell mediated cytotoxicity / 0.03 / 132 / 54 / 560 / 92 / 986 / 52
hsa04144 / 6982 / Endocytosis / 0.03 / 201 / 105 / 1103 / 181 / 1629 / 76
hsa04310 / 5065 / Wnt signaling pathway / 0.03 / 151 / 78 / 823 / 129 / 1024 / 57
hsa05414 / 4693 / Dilated cardiomyopathy / 0.031 / 91 / 52 / 764 / 105 / 1019 / 70
hsa04964 / 557 / Proximal tubule bicarbonate reclamation / 0.032 / 23 / 11 / 91 / 19 / 135 / 7
hsa00532 / 1131 / Glycosaminoglycan biosynthesis - chondroitin sulfate / 0.034 / 22 / 12 / 186 / 35 / 246 / 12
hsa03050 / 1028 / Proteasome / 0.035 / 47 / 21 / 143 / 29 / 193 / 11
hsa04722 / 4095 / Neurotrophin signaling pathway / 0.04 / 126 / 59 / 616 / 103 / 835 / 44
hsa03320 / 2069 / PPAR signaling pathway / 0.042 / 69 / 32 / 335 / 60 / 360 / 18
hsa00780 / 129 / Biotin metabolism / 0.045 / 2 / 2 / 20 / 4 / 10 / 2
hsa05140 / 1835 / Leishmaniasis / 0.045 / 70 / 31 / 248 / 43 / 491 / 28
hsa05220 / 2209 / Chronic myeloid leukemia / 0.045 / 73 / 37 / 331 / 58 / 424 / 23
hsa04670 / 4428 / Leukocyte transendothelial migration / 0.047 / 116 / 56 / 693 / 115 / 877 / 43
hsa00592 / 510 / alpha-Linolenic acid metabolism / 0.052 / 19 / 10 / 75 / 15 / 88 / 5
hsa00524 / 199 / Butirosin and neomycin biosynthesis / 0.053 / 4 / 4 / 31 / 8 / 46 / 2
hsa00061 / 207 / Fatty acid biosynthesis / 0.064 / 6 / 4 / 34 / 7 / 41 / 3
hsa05120 / 1967 / Epithelial cell signaling in Helicobacter pylori infection / 0.075 / 68 / 33 / 304 / 56 / 386 / 17
hsa00280 / 1446 / Valine, leucine and isoleucine degradation / 0.077 / 44 / 24 / 207 / 35 / 183 / 14
hsa00563 / 620 / Glycosylphosphatidylinositol(GPI)-anchor biosynthesis / 0.08 / 25 / 13 / 86 / 19 / 91 / 4
hsa04910 / 4085 / Insulin signaling pathway / 0.083 / 137 / 59 / 630 / 89 / 839 / 54
hsa05211 / 2167 / Renal cell carcinoma / 0.086 / 70 / 34 / 319 / 52 / 372 / 22
hsa04115 / 1880 / p53 signaling pathway / 0.093 / 68 / 32 / 287 / 48 / 336 / 18
hsa04350 / 2377 / TGF-beta signaling pathway / 0.108 / 85 / 41 / 363 / 53 / 497 / 32
hsa00051 / 1171 / Fructose and mannose metabolism / 0.109 / 34 / 19 / 181 / 35 / 284 / 10
hsa00410 / 883 / beta-Alanine metabolism / 0.11 / 22 / 15 / 115 / 20 / 142 / 10
hsa04120 / 3640 / Ubiquitin mediated proteolysis / 0.118 / 135 / 55 / 535 / 86 / 617 / 33
hsa00565 / 1020 / Ether lipid metabolism / 0.119 / 35 / 18 / 152 / 24 / 193 / 12
hsa00071 / 1024 / Fatty acid metabolism / 0.12 / 42 / 15 / 154 / 22 / 143 / 14
hsa03030 / 842 / DNA replication / 0.121 / 36 / 16 / 138 / 21 / 155 / 12
hsa01100 / 31239 / Metabolic pathways / 0.122 / 1120 / 477 / 4800 / 714 / 5685 / 282
hsa00300 / 91 / Lysine biosynthesis / 0.125 / 4 / 3 / 12 / 3 / 14 / 1
hsa00531 / 741 / Glycosaminoglycan degradation / 0.128 / 21 / 11 / 104 / 17 / 139 / 9
hsa03060 / 776 / Protein export / 0.129 / 23 / 14 / 108 / 21 / 118 / 6
hsa03440 / 905 / Homologous recombination / 0.131 / 28 / 14 / 131 / 21 / 145 / 11
hsa00471 / 59 / D-Glutamine and D-glutamate metabolism / 0.142 / 4 / 2 / 13 / 2 / 11 / 1
hsa00380 / 1168 / Tryptophan metabolism / 0.152 / 39 / 18 / 174 / 29 / 145 / 10
hsa04920 / 2036 / Adipocytokine signaling pathway / 0.153 / 67 / 33 / 339 / 47 / 468 / 27
hsa00330 / 1243 / Arginine and proline metabolism / 0.162 / 54 / 22 / 198 / 32 / 228 / 12
hsa04146 / 2238 / Peroxisome / 0.164 / 78 / 36 / 346 / 48 / 373 / 27
hsa05100 / 3218 / Bacterial invasion of epithelial cells / 0.173 / 71 / 34 / 475 / 83 / 583 / 23
hsa05010 / 5787 / Alzheimer's disease / 0.174 / 167 / 76 / 861 / 134 / 1088 / 55
hsa04630 / 3568 / Jak-STAT signaling pathway / 0.175 / 150 / 62 / 557 / 86 / 690 / 34
hsa04710 / 382 / Circadian rhythm - mammal / 0.191 / 13 / 8 / 63 / 13 / 90 / 2
hsa04620 / 2172 / Toll-like receptor signaling pathway / 0.192 / 102 / 37 / 340 / 49 / 378 / 25
hsa04520 / 3652 / Adherens junction / 0.193 / 74 / 41 / 560 / 86 / 753 / 38
hsa04660 / 3414 / T cell receptor signaling pathway / 0.194 / 108 / 51 / 533 / 84 / 665 / 32
hsa04672 / 1300 / Intestinal immune network for IgA production / 0.198 / 46 / 24 / 175 / 25 / 373 / 23
hsa05222 / 3474 / Small cell lung cancer / 0.206 / 84 / 38 / 575 / 79 / 741 / 41
hsa04916 / 3642 / Melanogenesis / 0.209 / 101 / 49 / 584 / 85 / 770 / 41
hsa00970 / 1165 / Aminoacyl-tRNA biosynthesis / 0.221 / 41 / 15 / 152 / 25 / 203 / 12
hsa00010 / 1688 / Glycolysis / Gluconeogenesis / 0.229 / 64 / 27 / 234 / 41 / 296 / 12
hsa04740 / 4753 / Olfactory transduction / 0.236 / 388 / 73 / 715 / 112 / 911 / 41
hsa04330 / 1563 / Notch signaling pathway / 0.237 / 47 / 26 / 237 / 38 / 393 / 18
hsa04150 / 1492 / mTOR signaling pathway / 0.244 / 52 / 20 / 225 / 33 / 265 / 17
hsa04070 / 3718 / Phosphatidylinositol signaling system / 0.249 / 78 / 47 / 601 / 92 / 825 / 37
hsa04720 / 3673 / Long-term potentiation / 0.252 / 70 / 37 / 582 / 86 / 755 / 39
hsa00512 / 1855 / O-Glycan biosynthesis / 0.253 / 30 / 21 / 320 / 46 / 382 / 20
hsa05218 / 2404 / Melanoma / 0.26 / 71 / 37 / 379 / 55 / 465 / 26
hsa00740 / 448 / Riboflavin metabolism / 0.261 / 16 / 8 / 72 / 11 / 87 / 5
hsa04640 / 2385 / Hematopoietic cell lineage / 0.271 / 82 / 36 / 364 / 51 / 521 / 30
hsa05320 / 1359 / Autoimmune thyroid disease / 0.276 / 50 / 17 / 163 / 24 / 516 / 26
hsa05210 / 2120 / Colorectal cancer / 0.278 / 62 / 35 / 315 / 46 / 435 / 25
hsa04270 / 5726 / Vascular smooth muscle contraction / 0.295 / 116 / 53 / 891 / 131 / 1271 / 60
hsa04142 / 3273 / Lysosome / 0.297 / 121 / 56 / 499 / 79 / 587 / 25
hsa00603 / 509 / Glycosphingolipid biosynthesis - globo series / 0.308 / 14 / 9 / 86 / 13 / 77 / 4
hsa00040 / 587 / Pentose and glucuronateinterconversions / 0.309 / 28 / 6 / 70 / 10 / 84 / 7
hsa05340 / 805 / Primary immunodeficiency / 0.311 / 35 / 17 / 121 / 21 / 204 / 7
hsa00100 / 456 / Steroid biosynthesis / 0.319 / 17 / 8 / 72 / 14 / 62 / 1
hsa04662 / 2662 / B cell receptor signaling pathway / 0.32 / 75 / 38 / 432 / 59 / 611 / 32
hsa03018 / 1460 / RNA degradation / 0.321 / 59 / 25 / 187 / 32 / 208 / 10
hsa03022 / 757 / Basal transcription factors / 0.325 / 36 / 14 / 106 / 20 / 105 / 3
hsa00430 / 302 / Taurine and hypotaurine metabolism / 0.33 / 10 / 5 / 43 / 6 / 44 / 3
hsa04940 / 1592 / Type I diabetes mellitus / 0.334 / 41 / 20 / 191 / 26 / 629 / 33
hsa00590 / 1650 / Arachidonic acid metabolism / 0.335 / 58 / 26 / 237 / 32 / 276 / 19
hsa04730 / 3761 / Long-term depression / 0.336 / 70 / 44 / 598 / 82 / 825 / 44
hsa00900 / 435 / Terpenoid backbone biosynthesis / 0.337 / 15 / 8 / 54 / 11 / 45 / 1
hsa01040 / 595 / Biosynthesis of unsaturated fatty acids / 0.343 / 21 / 12 / 102 / 18 / 114 / 3
hsa00562 / 2171 / Inositol phosphate metabolism / 0.346 / 57 / 33 / 343 / 56 / 458 / 16
hsa05131 / 1875 / Shigellosis / 0.355 / 62 / 23 / 281 / 46 / 372 / 14
hsa00290 / 305 / Valine, leucine and isoleucine biosynthesis / 0.372 / 11 / 4 / 37 / 9 / 84 / 1
hsa00920 / 424 / Sulfur metabolism / 0.375 / 13 / 6 / 69 / 12 / 84 / 2
hsa00830 / 1255 / Retinol metabolism / 0.384 / 64 / 17 / 159 / 27 / 175 / 7
hsa04962 / 1423 / Vasopressin-regulated water reabsorption / 0.414 / 44 / 17 / 227 / 35 / 287 / 12
hsa00450 / 680 / Selenoamino acid metabolism / 0.416 / 26 / 14 / 103 / 18 / 103 / 2
hsa04614 / 552 / Renin-angiotensin system / 0.422 / 17 / 10 / 77 / 15 / 117 / 2
hsa04950 / 790 / Maturity onset diabetes of the young / 0.428 / 25 / 11 / 122 / 22 / 155 / 3
hsa00785 / 72 / Lipoic acid metabolism / 0.43 / 3 / 1 / 12 / 0 / 13 / 2
hsa04742 / 1594 / Taste transduction / 0.438 / 51 / 16 / 256 / 39 / 346 / 14
hsa00053 / 522 / Ascorbate and aldarate metabolism / 0.462 / 25 / 5 / 66 / 12 / 72 / 2
hsa03010 / 1622 / Ribosome / 0.473 / 88 / 33 / 238 / 38 / 247 / 10
hsa00600 / 1179 / Sphingolipid metabolism / 0.476 / 40 / 20 / 188 / 22 / 251 / 15
hsa04020 / 8864 / Calcium signaling pathway / 0.479 / 177 / 93 / 1440 / 199 / 1950 / 92
hsa05020 / 1032 / Prion diseases / 0.48 / 35 / 12 / 154 / 22 / 191 / 10
hsa00564 / 2641 / Glycerophospholipid metabolism / 0.491 / 79 / 39 / 428 / 60 / 538 / 24
hsa00910 / 545 / Nitrogen metabolism / 0.492 / 23 / 11 / 92 / 14 / 99 / 3
hsa00120 / 544 / Primary bile acid biosynthesis / 0.499 / 16 / 7 / 78 / 9 / 76 / 6
hsa05213 / 2220 / Endometrial cancer / 0.5 / 52 / 25 / 328 / 52 / 403 / 15
hsa04621 / 1323 / NOD-like receptor signaling pathway / 0.501 / 62 / 22 / 207 / 32 / 239 / 9
hsa05330 / 1093 / Allograft rejection / 0.502 / 35 / 15 / 109 / 13 / 505 / 26
hsa05012 / 3316 / Parkinson's disease / 0.504 / 130 / 43 / 484 / 74 / 527 / 23
hsa05014 / 1979 / Amyotrophic lateral sclerosis (ALS) / 0.512 / 53 / 27 / 297 / 49 / 363 / 12
hsa00790 / 284 / Folate biosynthesis / 0.52 / 11 / 3 / 42 / 4 / 66 / 4
hsa00760 / 765 / Nicotinate and nicotinamide metabolism / 0.534 / 24 / 12 / 124 / 13 / 124 / 10
hsa00630 / 567 / Glyoxylate and dicarboxylate metabolism / 0.558 / 16 / 8 / 82 / 9 / 99 / 7
hsa04080 / 10288 / Neuroactive ligand-receptor interaction / 0.571 / 270 / 131 / 1597 / 232 / 1942 / 88
hsa00340 / 852 / Histidine metabolism / 0.572 / 29 / 15 / 127 / 22 / 122 / 2
hsa05322 / 2226 / Systemic lupus erythematosus / 0.575 / 138 / 29 / 313 / 36 / 541 / 33
hsa00770 / 701 / Pantothenate and CoA biosynthesis / 0.581 / 16 / 9 / 87 / 12 / 99 / 6
hsa00980 / 1432 / Metabolism of xenobiotics by cytochrome P450 / 0.595 / 70 / 18 / 170 / 28 / 214 / 8
hsa00130 / 175 / Ubiquinone and other terpenoid-quinone biosynthesis / 0.603 / 7 / 3 / 20 / 2 / 16 / 1
hsa00510 / 1549 / N-Glycan biosynthesis / 0.609 / 48 / 20 / 241 / 32 / 276 / 13
hsa00533 / 543 / Glycosaminoglycan biosynthesis - keratan sulfate / 0.609 / 15 / 6 / 74 / 11 / 75 / 2
hsa04060 / 5825 / Cytokine-cytokine receptor interaction / 0.613 / 260 / 98 / 932 / 131 / 1149 / 51
hsa00140 / 1310 / Steroid hormone biosynthesis / 0.614 / 55 / 14 / 167 / 27 / 198 / 8
hsa00730 / 269 / Thiamine metabolism / 0.619 / 8 / 3 / 43 / 7 / 73 / 1
hsa04530 / 5861 / Tight junction / 0.633 / 133 / 62 / 945 / 133 / 1205 / 53
hsa05332 / 1091 / Graft-versus-host disease / 0.644 / 37 / 15 / 110 / 14 / 509 / 23
hsa04130 / 1054 / SNARE interactions in vesicular transport / 0.655 / 37 / 15 / 158 / 23 / 230 / 8
hsa00983 / 1332 / Drug metabolism - other enzymes / 0.665 / 51 / 16 / 174 / 24 / 242 / 11
hsa05219 / 1233 / Bladder cancer / 0.666 / 42 / 19 / 194 / 28 / 225 / 8
hsa00260 / 711 / Glycine, serine and threonine metabolism / 0.67 / 31 / 14 / 118 / 10 / 135 / 11
hsa00052 / 859 / Galactose metabolism / 0.682 / 26 / 14 / 132 / 19 / 178 / 5
hsa04540 / 4123 / Gap junction / 0.691 / 90 / 46 / 672 / 93 / 900 / 37
hsa04622 / 1292 / RIG-I-like receptor signaling pathway / 0.692 / 71 / 23 / 206 / 29 / 229 / 8
hsa05310 / 720 / Asthma / 0.713 / 28 / 9 / 87 / 7 / 282 / 15
hsa03040 / 2765 / Spliceosome / 0.72 / 127 / 53 / 400 / 57 / 482 / 21
hsa00982 / 1427 / Drug metabolism - cytochrome P450 / 0.722 / 72 / 17 / 165 / 26 / 201 / 7
hsa03430 / 665 / Mismatch repair / 0.728 / 23 / 10 / 99 / 10 / 123 / 7
hsa05142 / 3379 / Chagas disease / 0.752 / 104 / 46 / 544 / 69 / 686 / 33
hsa05221 / 1567 / Acute myeloid leukemia / 0.759 / 57 / 22 / 233 / 29 / 313 / 15
hsa03020 / 646 / RNA polymerase / 0.775 / 29 / 10 / 91 / 14 / 148 / 3
hsa04210 / 2317 / Apoptosis / 0.775 / 86 / 31 / 337 / 47 / 451 / 17
hsa03420 / 1009 / Nucleotide excision repair / 0.777 / 44 / 19 / 151 / 19 / 190 / 8
hsa00190 / 3060 / Oxidative phosphorylation / 0.781 / 133 / 44 / 442 / 62 / 471 / 20
hsa05215 / 2864 / Prostate cancer / 0.785 / 89 / 40 / 469 / 61 / 557 / 23
hsa05110 / 1944 / Vibrio cholerae infection / 0.795 / 55 / 23 / 310 / 37 / 430 / 20
hsa00561 / 1940 / Glycerolipid metabolism / 0.817 / 49 / 25 / 301 / 40 / 383 / 15
hsa04114 / 3713 / Oocyte meiosis / 0.837 / 113 / 46 / 573 / 77 / 742 / 32
hsa04610 / 1943 / Complement and coagulation cascades / 0.846 / 69 / 25 / 295 / 38 / 347 / 14
hsa00500 / 1270 / Starch and sucrose metabolism / 0.847 / 52 / 15 / 178 / 23 / 219 / 8
hsa00514 / 143 / O-Mannosyl glycan biosynthesis / 0.848 / 3 / 1 / 13 / 1 / 16 / 0
hsa00511 / 425 / Other glycan degradation / 0.85 / 16 / 5 / 69 / 8 / 90 / 1
hsa04744 / 745 / Phototransduction / 0.855 / 29 / 13 / 129 / 12 / 176 / 8
hsa00601 / 785 / Glycosphingolipid biosynthesis - lacto and neolacto series / 0.886 / 26 / 13 / 131 / 15 / 142 / 4
hsa05016 / 5116 / Huntington's disease / 0.89 / 182 / 65 / 777 / 108 / 924 / 35
hsa00460 / 185 / Cyanoamino acid metabolism / 0.914 / 7 / 1 / 25 / 1 / 26 / 1
hsa00240 / 2762 / Pyrimidine metabolism / 0.924 / 98 / 37 / 383 / 50 / 514 / 20
hsa02010 / 2666 / ABC transporters / 0.924 / 44 / 21 / 294 / 44 / 466 / 15
hsa03410 / 865 / Base excision repair / 0.933 / 34 / 12 / 141 / 14 / 190 / 7
hsa04623 / 998 / Cytosolic DNA-sensing pathway / 0.941 / 56 / 14 / 159 / 18 / 170 / 5
hsa00604 / 753 / Glycosphingolipid biosynthesis - ganglio series / 0.949 / 15 / 6 / 116 / 11 / 147 / 4
hsa04914 / 2717 / Progesterone-mediated oocyte maturation / 0.955 / 86 / 31 / 413 / 50 / 533 / 22
hsa00030 / 651 / Pentose phosphate pathway / 0.959 / 27 / 6 / 98 / 9 / 139 / 4
hsa04360 / 6464 / Axon guidance / 0.962 / 129 / 72 / 1047 / 134 / 1326 / 53
hsa00860 / 890 / Porphyrin and chlorophyll metabolism / 0.967 / 42 / 10 / 114 / 13 / 138 / 4
hsa05216 / 873 / Thyroid cancer / 0.972 / 29 / 13 / 137 / 15 / 191 / 4
hsa00480 / 1115 / Glutathione metabolism / 0.974 / 50 / 16 / 162 / 15 / 192 / 8
hsa00020 / 789 / Citrate cycle (TCA cycle) / 0.976 / 31 / 8 / 120 / 11 / 122 / 4
hsa00750 / 183 / Vitamin B6 metabolism / 0.979 / 6 / 1 / 32 / 1 / 24 / 0
hsa04062 / 5837 / Chemokine signaling pathway / 0.987 / 189 / 73 / 936 / 130 / 1112 / 31
hsa04966 / 759 / Collecting duct acid secretion / 0.994 / 27 / 10 / 124 / 8 / 152 / 6
hsa00230 / 6052 / Purine metabolism / 0.996 / 159 / 70 / 936 / 122 / 1215 / 37

Supplemental Table 2. All pathways are human (Homo sapiens). The number of features (simple, complex or whole gene) that include at least one SNP with nominal significance (p< 0.05) are shown in columns next to the total number of features (*). Complex features are the number of LD (linkage disequilibrium) blocks. Simple features are SNPs in linkage disequilibrium. Abbreviations: NPG, normal pressure glaucoma.