Supplemental Table 1: Univariate Associations of Histologic Subtype-Associated Features with Pcr

Supplemental Table 1: Univariate Associations of Histologic Subtype-Associated Features with pCR

Predictor / Odds Ratio (OR) / 95% CI / p-value
Age
> 49 years vs. ≤ 49 yrs / 0.8 / 0.56-1.17 / 0.26
Marker status
Other subtypes vs. HR+/HER2- / 10.706 / 6.42-17.87 / <0.001
Tumor stage at presentation (by MRI)
T3/4 vs. T1/2 / .878 / 0.61-1.26 / 0.485
Grade
Grade 3 vs. Grade 1/2 / 3.7 / 2.3-5.8 / <0.001
p53 by IHC
>75% vs. ≤ 75% / 3.9 / 2.6-5.8 / <0.001
Activated wound healing signature
Activated vs. quiescent signature / 3.1 / 1.8-5.4 / <0.001
Intrinsic subtypes
Luminal A / reference
Luminal B / 3.5 / 1.005-11.8 / 0.049
Her 2 / 30.5 / 10-92.5 / <0.001
Basal / 20.1 / 6.9-58.9 / <0.001
Normal / 10 / 2.8-36.1 / <0.001
NKI70gene signature
High risk vs low risk / NA
pCR Rate: High Risk: 91/354 (26%) vs. Low Risk 0/55 (0%), chi-square test p< 0.001
MRI pattern
Mass / reference
Multinodular / .508 / 0.28-0.91 / 0.023
Diffuse / .742 / 0.43-1.27 / 0.280

Supplemental Table 2: Univariate Associations of Histologic Subtype-Associated Features with BCS

Predictor / Odds Ratio (OR) / 95% CI / p-value
Age > 49 years / 1.5 / 1.12-2.1 / 0.007
Marker status
HR+/Her2- / reference
HR+/Her2+ / 1.2 / 0.75-1.9 / 0.47
HR-/Her2+ / 1.15 / 0.7-1.9 / 0.6
HR-/Her2- / 0.97 / 0.67-1.4 / 0.9
Tumor stage at presentation (by MRI)
T1 / reference
T2 / 1.2 / 0.59-2.3 / 0.68
T3 / 0.38 / 0.19-0.76 / 0.006
T4 / 0.2 / 0.09-0.5 / 0.001
Grade 3 / 0.82 / 0.6-1.2 / 0.28
p53 >75% by IHC / 0.79 / 0.58-1.13 / 0.19
High risk 70-gene prognostic profile / 1.05 / 0.59-1.9 / 0.87
Activated wound healing signature / 0.95 / 0.64-1.4 / 0.8
Intrinsic subtypes
Luminal A / reference
Luminal B / 1.1 / 0.6-1.9 / 0.78
Her 2 / 1 / 0.55-1.8 / 1
Basal / 1.1 / 0.66-1.9 / 0.67
Normal / 0.67 / 0.3-1.47 / 0.3
MRI pattern
Mass / reference
Multinodular / 0.26 / 0.15-0.44 / <0.001
Diffuse / 0.43 / 0.26-0.73 / 0.002