Supplemental Table 1. Results from Subsearchesperformed in HERO1 That Searched Pubmed

Supplemental Table 1. Results from subsearchesperformed in HERO1 that searched PubMed, Web of Science, and Toxnet2.

Subsearch title / Goal to identify / Search terms (PubMed format3) / Records4 / Findings
Approaches and reviews / Approaches for using genetic susceptibility data in HHRA (review and primary studies) / (("polymorphism" OR "SNP" OR "genetic" or "gene") AND ("risk assessment") AND ("use"OR "using"OR utiliz* OR "utility" OR "incorporate") AND ("susceptibility" OR "variability") AND ("information"OR "data") (("approach" OR "review") NOT ("study")) AND ("1900/01/01"[Date - Publication]: "3000"[Date - Publication])) / 85 / Majority records were reviews; Minority records were case studies or primary data.
Data sources for genetic susceptibility to environmental chemicals / Information on human genetic susceptibility after exposure to environmental chemicals (review and primary studies) / (("polymorphism" OR "SNP" OR "genetic" or "gene") AND ("human" OR "humans") AND ("susceptible" OR "susceptibility" OR "variable" OR "variability" OR "variation") AND ("chemical" OR "drug" OR "pharmaceutical") AND ("exposure") AND ("individual" OR "population" OR "interindividual") AND ("response" OR "outcome" OR "toxicity") AND ("data" OR "study" OR "studies") AND ("1900/01/01"[Date - Publication]: "3000"[Date - Publication])) / 497 / Identified a number of human studies that assessed genetic susceptibility after environmental chemical exposure.
Data sources for genetic susceptibility / Data sources for human genetic susceptibility even if not specifically after environmental chemical exposure. / (("polymorphism" OR "SNP" OR "genetic" or "gene") AND ("human" OR "humans") AND ("susceptible" OR "susceptibility") AND ("individual" OR "population" OR "interindividual") AND ("response" OR "outcome" OR "disease") AND ("database" OR "resource") AND ("1900/01/01"[Date - Publication]: "3000"[Date - Publication])) / 443 / Identified a number of data sources for human genetic susceptibility.
Databases of genetic susceptibility information / Databases for human or animal genetic susceptibility data / (("polymorphism" OR "SNP" OR "genetic" OR "gene") AND ("human" OR "humans") AND ("susceptible" OR "susceptibility" OR "variable" OR "variability" OR "sensitive" OR "variation") AND ("chemical" OR "drug" OR "pharmaceutical") AND ("individual" OR "population" OR "interindividual") AND ("response" OR "outcome" OR "effect") AND ("database" OR "resource") AND ("1900/01/01"[Date - Publication]: "3000"[Date - Publication])) / 87 / Identified a number of publicly available human genetic susceptibility databases.
AOP and HHRA / Studies or approaches that have used the AOP approach for genetic susceptibility information in HHRA. / (("adverse outcome pathway" OR "AOP") AND ("human" AND "health" AND "risk" AND "assessment") AND ("1900/01/01"[Date - Publication]: "3000"[Date - Publication])) / 43 / No prior approach using AOP concept for genetic susceptibility data in HHRA was identified.

1The Health and Environmental Research Online (HERO) is a database of published references used to develop EPA's risk assessments that was developed and managed in EPA's NCEA) in ORD.

2Simultaneously searched PubMed, Web of Science, and Toxnet on March 30, 2017.

3ToxNet and Web of Science used the same search terms but in their specified format.

4HERO identifies “records,” which include articles, documents, and reports.