Suppl Table 1: ERα target genes downregulated in MPP treated C-CAFs

Sl. No / GeneName / Description / Entrez ID / logFC / P.Value
1 / SERPINE1 / serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 / 5054 / -4.514965141 / 1.09E-05
2 / HSPA2 / heat shock 70kDa protein 2 / 3306 / -3.856779879 / 0.003
3 / THBS1 / thrombospondin 1 / 7057 / -3.599083863 / 0.015
4 / HBEGF / heparin-binding EGF-like growth factor / 1839 / -3.117725987 / 0.0005
5 / TACSTD2 / tumor-associated calcium signal transducer 2 / 4070 / -2.658153298 / 0.0002
6 / STC2 / stanniocalcin 2 / 8614 / -2.572771034 / 0.006
7 / INPP4B / inositol polyphosphate-4-phosphatase, type II, 105kDa / 8821 / -2.46968426 / 4.63E-05
8 / ADCY7 / adenylate cyclase 7 / 113 / -2.422446527 / 0.0001
9 / AREG / amphiregulin (schwannoma-derived growth factor) / 374 / -2.41773329 / 0.005
10 / CRABP2 / cellular retinoic acid binding protein 2 / 1382 / -2.20985566 / 0.003
11 / MYBL1 / v-myb myeloblastosis viral oncogene homolog (avian)-like 1 / 4603 / -1.923229198 / 0.018
12 / HSPC111 / hypothetical protein HSPC111 / 51491 / -1.659768377 / 0.002
13 / ORC1L / origin recognition complex, subunit 1-like (yeast) / 4998 / -1.628163936 / 0.03
14 / ESPL1 / extra spindle pole bodies homolog 1 (S. cerevisiae) / 9700 / -1.431965294 / 0.005
15 / ATP2A2 / ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 / 488 / -1.396492696 / 0.004
16 / SHC4 / SHC (Src homology 2 domain containing) family, member 4 / 399694 / -1.35086673 / 0.007
17 / CISH / cytokine inducible SH2-containing protein / 1154 / -1.304623368 / 0.007
18 / AMD1 / adenosylmethionine decarboxylase 1 / 262 / -1.293032555 / 0.018
19 / FUBP1 / far upstream element (FUSE) binding protein 1 / 8880 / -1.221642317 / 0.004
20 / SLC38A4 / solute carrier family 38, member 4 / 55089 / -1.16830704 / 0.005
21 / HSP90B1 / heat shock protein 90kDa beta (Grp94), member 1 / 7184 / -1.162701202 / 0.024
22 / NRAS / neuroblastoma RAS viral (v-ras) oncogene homolog / 4893 / -1.148649982 / 0.015
23 / CREB3 / cAMP responsive element binding protein 3 / 10488 / -1.134493756 / 0.007
24 / P4HA2 / procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide II / 8974 / -1.130050794 / 0.019
25 / KIAA0182 / KIAA0182 / 23199 / -1.123698819 / 0.04
26 / PDHB / pyruvate dehydrogenase (lipoamide) beta / 5162 / -1.104720517 / 0.009
27 / PICALM / phosphatidylinositol binding clathrin assembly protein / 8301 / -1.097340131 / 0.003
28 / STK17A / serine/threonine kinase 17a / 9263 / -1.078468698 / 0.007
29 / B4GALT1 / UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 / 2683 / -1.076214759 / 0.014
30 / PLCB3 / phospholipase C, beta 3 (phosphatidylinositol-specific) / 5331 / -1.025681144 / 0.036
31 / NOL5A / nucleolar protein 5A (56kDa with KKE/D repeat) / 10528 / -0.971005379 / 0.015
32 / DDEF1 / development and differentiation enhancing factor 1 / 50807 / -0.960417238 / 0.019
33 / MAP2K1 / mitogen-activated protein kinase kinase 1 / 5604 / -0.951232796 / 0.006
34 / ADAM7 / ADAM metallopeptidase domain 7 / 8756 / -0.911723759 / 0.033
35 / EIF4EBP1 / eukaryotic translation initiation factor 4E binding protein 1 / 1978 / -0.905403533 / 0.017
36 / CALM1 / calmodulin 1 (phosphorylase kinase, delta) / 801 / -0.874031436 / 0.037
37 / DKC1 / dyskeratosis congenita 1, dyskerin / 1736 / -0.85361891 / 0.027
38 / CREB3L2 / cAMP responsive element binding protein 3-like 2 / 64764 / -0.834391991 / 0.026
39 / TXNL2 / thioredoxin-like 2 / 10539 / -0.739505901 / 0.040
40 / HIG2 / hypoxia-inducible protein 2 / 29923 / -0.644820536 / 0.030
41 / GRB2 / growth factor receptor-bound protein 2 / 2885 / -0.612484872 / 0.038
42 / PAFAH1B1 / platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit 45kDa / 5048 / -0.559918302 / 0.026

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