2015 Inter-CFAR HIV/TB Symposium

November 4, 2015

Seattle Grand Hyatt Hotel – Princessa Ballroom Section 1

7:30-8:00 Breakfast / Poster set-up

8:00 -8:15 am:Welcome remarks – Goalsof the meeting - Ron Collman(Penn CFAR) and Tom Hawn (Univ. Washington CFAR)

8:15-9:00 am:Keynote Lecture - Willem Hanekom – Deputy Director, TB Unit – Bill & Melinda Gates Foundation “Update on TB Vaccines – the Global Landscape and Research Priorities”

9:00-9:30am:Speaker–Jerrold Ellner(Boston University / Lifespan-Tufts-BrownCFAR):“TB Biomarkers”

9:30– 10:15 am:Oral Abstracts in TB Biomarkers: Three 10 min/speaker segments & 5 min for questions: Session moderator: TBN

Toidi Adekembi – Emory CFAR

T Cell Biomarkers during Treatment of HIV/TB

Christina Yoon – UCSF-GIVI CFAR

C-reactive Protein-based TB Screening to Improve the Efficiency and Reduce the Cost of Intensified Case-finding Among People Living with HIV

George Makedonas –Baylor-UT CFAR

Correlates of TB Disease Progression in People Living with HIV

10:15–10:30 am:Break and Networking

10:30– 11:00 am: Speaker –Tom Hawn(Univ. Washington / UW CFAR):“TB Susceptibility”

11:00 – 11:30am: Speaker - Anne Goldfeld (Harvard CFAR):“TB/HIV Immune Pathogenesis”

11:30– 12:15 pm:Oral Abstracts in Immunology: Three 10 min/speaker segments & 5 min for questions:Session moderator: TBD

Cheryl Day –Emory CFAR

Distinct Subsets of Mycobacterium tuberculosis-specific CD4 T Cells are Depleted in HIV co-Infected Individuals with Latent TB Infection

Carina Marquez – UCSF-GIVI CFAR

TB Infection in Early Childhood in Uganda and the Influence of HIV Exposure

Elisa Nemes – Univ. of Cape Town / Miami CFAR

Host Correlates of Risk of BCG Immune Reconstitution Inflammatory Syndrome (IRIS) in HIV+ Children Starting ART

12:15–1:45 pm:Poster Session and Lunch

1:45 – 2:15 pm:Speaker Richard Chaisson (Johns Hopkins CFAR): “Latent TB in HIV”

2:15–2:45 pm:Speaker David Tobin (Duke CFAR): “TB Host-Directed Therapy (HDT)”

2:45– 3:15 pm:Oral Abstracts in HDT: Two 10 min/speaker segments & 5 min for questions: Session moderators: TBN

Stefan Oehlers –Duke CFAR

The Role of Vascular Dysfunction during Mycobacterial Infection

Jim Sun –Univ. of Alabama CFAR

Altered PPM1A Phosphatase Expression Directly Links Mycobacterium tuberculosis Infection to Increased HIV-1 Susceptibility in Macrophages

3:15– 3:30 pm:Break and Networking

3:30– 4:00 pm:Speaker –David Horne(Univ. Washington CFAR) –Diagnosis of TBin HIV

4:00– 4:30 pm:Speaker – Gregory Bisson(Penn CFAR) – Empiric TB treatment in HIV

4:30– 5:15 pm:Oral abstracts in Diagnosis/Treatment: Three 10 min/speaker segments & 5 min for questions: Session moderators: TBN

Daniel Meressa – Global Health Committee, Addis Ababa / Harvard CFAR

Achieving High Treatment Success for Multidrug-Resistant Tuberculosis with HIV co-infection in Africa: Initiation and Scale-up of MDR-TB Care in Ethiopia

Sumona Chaudhury – Harvard CFAR

Predictors of Mortality Among Children co-Infected with HIV and TB in Tanzania

Lydia Nakiyingi – Makerere University, Kampala / Lifespan-Tufts-BrownCFAR)

Predictors of Outcomes of Mycobacteremia among HIV-infected Smear-Negative Presumptive TB Patients in Uganda

5:15 – 5:45 pm:Discussion & Wrap-up: Inter-CFAR Collaborations & Opportunities - Ron Collmanand Tom Hawn

5:45– 6:15 pm:Break and Networking / Remove Posters

6:15- 8:30 pm:Dinner

6:45- 8:15 pmDinner Program Presentations:

Peter Kim, NIH/NIAID – Funding Priorities & Initiatives at NIH/NIAID (10 minutes)

Robert Mahon, NIH/NIAID- Integrating Immunometabolism and Immuno-oncology Advances into the Development of MTB HDT (20 minutes)

Lakshmi Jayashankar, NIH/NIAID–HIV/TB: Biomarkers and TB vaccines (20 minutes)

15 minutes open discussion

Willem Hanekom, Gates Foundation–Funding Priorities & Initiatives at the Gates Foundation(15 minutes followed by 10 minutes discussion)