SCHEDULE of LEctureS on Analytical Chemistry
for Second Year Pharmacy Students
Spring
Module 3. «Quantitative analysis. Gravimetry. neutralisation titration and redoximetry»
No / Theme of Lecture / Hours1. / Quantitative analysis. Classification of methods. Errors of quantitative analysis and origin of the errors. Statistical data of chemical analysis and results treatment. Gravimetric analysis. / 2
2. / Titration analysis. Classification of techniques. Acidic-basic titration. Acidic-basic titration curves. Indicators. Concepts of indicators using. Application of acidic-basic titration method. / 2
3. / Redox titration. Classification of methods. Requirements to reactions. Indicators and redox titration curves. Practice application of method. / 2
Total: 6 hrs.
Module 4. «Quantitative analysis. Precipitation titration and complexation. Instrumental methods of analysis.»
No / Theme of Lecture / Hours4. / Precipitation titration (sedimentary). Classification. Titration curves. Titrants. End points and indicators. Applications.
Complex-formation titration (complexation). Classification. Titration curves. Titrants. End points and indicators. Applications. / 2
5. / Instrumental methods. Classification. Spectrochemical methods. Theory. Classification. Absorption spectroscopy. Infra-red spectroscopy. Optical spectroscopy in visible region. Law of light absorption. Applications for drugs analysis. Accuracy of method and errors. Extraction-photometric analysis. Refractometry. Polarimetry. Theory and applications. / 2
6. / Electrochemical methods of analysis. Theory and applications. / 2
Total: 6 hrs.
Acting chief of Toxicological and Analytical Chemistry department M. Kucher, PhD
SCHEDULE of LABORATORY LESSONS on Analytical Chemistry
for Second Year Pharmacy Students Autumn
Module 3. «Quantitative analysis. Gravimetry. neutralisation titration and redoximetry»
No / Theme of lesson / HoursSubstantial module 5. «Gravimetry»
1. / Gravimetric analysis. Determination of magnesium and iron percentage. / 4
2. / Gravimetric analysis. Determination of moisture in BaCl2, KCl, NaCl in pharmaceutical preparations. / 4
Substantial module 6. «Neutralisation titration»
3. / Titrimetry. Volumetric equipment. Burette calibration. Titrants and its preparation. Preparation of 0,1 N NaOH and 0,1 N HCl solutions. Calculations in titrimetry. / 4
4. / Acid-basic titration. Titrants standardisation. Preparation of Na2B4O7 solution and standardisation of HCl solution. Quantitative determination of NaOH. / 4
5. / Acid-basic titration. Quantitative determination of NaHCO3, Na2B4O7, H2C2O4, NaOH+K2CO3, KHCO3+K2CO3. Calculations. / 4
6. / Acid-basic titration. Reverse titration. Quantitative determination of NH3·H2O and CH3COOH. / 4
Substantial module 7. «Redox titration»
7. / Redox titration. Permanganatometry. Preparation of KMnO4 solution. Quantitative determination of H2O2, salts of iron (II), H2C2O4·2H2O, Na2C2O4, NaNO2. / 4
8. / Redox titration. Iodometry. Preparation of Na2S2O3 and I2 solutions. Quantitative determination of formaldehyde, iodine and chlorine. / 4
9. / Redox titration. Bromo- and bromatometry. Preparation of 0,1 N KBrO3 solution. Quantitative determination of As2O3, Na3AsO3, sodium salicylate. Nitritometry. Preparation of titrants. Quantitative determination of streptocide. / 4
10 / Final modular control. / 2
Total: 38 hrs
Module 4. «Quantitative analysis. Precipitation titration and complexation. Instrumental methods of analysis»
No / Theme of lesson / HoursSubstantial module 8. «Precipitation titration and complexation».
1. / Precipitation titration. Argentometry. Preparation and standardisation of AgNO3, Hg2(NO3)2 solutions. Quantitative determination of KCl, KBr, NaCl, NaBr. / 4
2. / Complex-formation titration. Complexonometry. Preparation and standardisation of Hg(NO3)2, EDTA solutions. Quantitative determination of KCl, NaCl with mercurimetry. Complexonometric determination of Ca2+, Mg2+, water hardness.
Substantial modular control. / 4
Substantial module 9. «Instrumental methods of analysis».
3. / UV-spectrophotometry. Detection of p-aminobenzoic acid derivates. Quantitative determination of amidopyrine, coffeine, K2CrO4, KMnO4. / 4
4. / Photometric determination of K2CrO4, KMnO4, iron(II) salts. / 4
5. / Potentiometry. Ionometric determination of halogen-ions, ions of alkali metals. Potentiometric determination of iron(II) salts, components in mixture of boric and hydrochloric acids. / 4
6. / Ion-exchange chromatography. Quantitative determination of KCl, NaBr. / 4
7. / Research students’ work. Unknown dry salt investigation. / 6
8. / Final modular control. / 2
Total: 32 hrs
Acting chief of Toxicological and Analytical Chemistry department M. Kucher, PhD
SCHEDULE of INDIVIDUAL WORK on Analytical Chemistry
for Second Year Pharmacy Students
Autumn
Module 3. «Quantitative analysis. Gravimetry. neutralisation titration and redoximetry»
No / Theme / Hours1. / Gravimetry. Calculations in gravimetry. Application for medicines analysis. / 4
2. / Titrimetry. Classification. Standard solutions and their preparation. Calculations in titrimetry. / 4
3. / Acid-base titration. Primary and secondary standards. Strong bases and acids titration. End titration point fixing. pH-indicators. Choosing of pH indicators. / 4
4. / Acid-base titration. Weak bases and acids titration. Polybasic acids, polyacidic bases, and mixtures of acids titration. / 4
5. / Acid-base titration. Ampholytes titration. Errors of titration. Classification of indicators errors and cause of the errors. / 4
6. / Non-aqueous titration. Application of non-aqueous acid-base titration. / 3
7. / Red-ox titration. Permanganatometry. Iodometry. / 4
8. / Red-ox titration. Bromo- and bronatometry. Nitritometry. / 4
9. / Red-ox titration. Dichromatometry. Cerimetry. Iodo-chlorometry. Iodatomtry. / 4
Total: 35 hrs
Module 4. «Quantitative analysis. Precipitation titration and complexation. Instrumental methods of analysis»
No / Theme of lesson / Hours1. / Sedimetry. Argentometry. Mercurometry. / 5
2. / Complexing titration. Complexonometry. / 5
3. / Classification of physical methods of analysis. Optical method of analysis. Atomic absorption spectrometry. / 5
4. / Optical method of analysis. Plasma emission analysis. / 5
5. / Optical method of analysis. Nephelometry and turbidimetry. IR-spectrometry. / 5
6. / Electrochemical methods of analysis. General description. Application in pharmaceutical and cosmetics analysis. / 5
7. / Voltammetry. Polarography. Conductometry. Coulometry. Amperometric titration / 5
Total: 35 hrs
Acting chief of Toxicological and Analytical Chemistry department M. Kucher, PhD