Running Title: Clinical and Biological Phenotypes of Sarcoidosis

Supplementary Material

Clinical and Biological Insights from the University of California San Francisco Prospective and Longitudinal Cohort

Running Title: Clinical and Biological Phenotypes of Sarcoidosis

1Bryan S. Benn MD, PhD, 1Zoe Lehman BA, 1Sharon A. Kidd MPH, PhD, 1Melissa Ho BS, 1Sara Sun BA, 1Joris Ramstein BA, 1Nicholas K. Arger MD, 1Christine P. Nguyen, BS, 2Robert Su, MD, 3Antonio Gomez, MD, 4Jeffrey M. Gelfand, MD, MAS, 1Laura L. Koth MD

1University of California, San Francisco, Division of Pulmonary and Critical Care, San Francisco, CA

2Palo Alto Medical Foundation, Palo Alto, CA

3Zuckerberg San Francisco General Hospital & Trauma Center, Division of Pulmonary and Critical Care Medicine, San Francisco, CA

4University of California, San Francisco, Department of Neurology, Multiple Sclerosis and Neuroinflammation Center, San Francisco, CA

Online Resource-1: Age at biopsy determined by gender (n=77 Female and n=49 Male) and race/ethnicity (n=90 white, n=11 mixed/other, n=7 Hispanic, and n=18 black). White includes all subjects who identified as white non-Hispanic. Mixed/other includes Asian (n=2), Native American (n=4), and those subjects who identified as multiple races/ethnicities (n=5). *, p<0.05.

Online Resource-2: Subject self-report of historical or current organs with sarcoidosis involvement.

Online Resource-3: Subject self-report of total number of organs with sarcoidosis involvement.

Online Resource-4: Comparison of pulmonary function test values for sarcoidosis subjects based on Scadding stage. Data are displayed as box plots where boxes equal the 25th and 75th percentile range, the middle band represents the median, and the whiskers represent the 10th and 90th percentile values. Abbreviations: FVC = Forced Vital Capacity; TLC = Total Lung Capacity; DLCO = Diffusing Capacity for Carbon Monoxide.

Online Resource-5: Use of immunosuppression by sarcoidosis subjects prior to, or at, the time of enrollment. Other immunosuppressive agents not shown include colchicine (n=4), dexamethasone (n=3), methylprednisolone (n=2), and pentoxifylline (n=1).

Online Resource-6: Comparison of pulmonary function values for sarcoidosis subjects based on use of immunosuppression. Data are displayed as box plots where boxes equal the 25th and 75th percentile range, the middle band represents the median, and the whiskers represent the 10th and 90th percentile values; P = 0.07. Ever = current or prior use of immunosuppression, Never = never on immunosuppression. Abbreviations: TLC = Total Lung Capacity.