SUMMER 2016: UTHealth-Innovation in Cancer Prevention Research Fellowship: Research Opportunity
(This is a Word table; use Tab to go from one blank to the next)

Faculty Name / Andrew Bean, PhD
Phone: Office: / 713-500-9860 / Cell:
Faculty E-mail /
School/Campus / Medical School / Department: / NBA

Research Projects

Each fellow is expected to spend an average of 40 hours/week on their research project, organized seminars and innovation generation course
Students will click on the titles of projects they are interested in to see the description. Give your project an inviting name!
Projects that are not funded can also be submitted.
1 / Title: / Role of UBE4B in Neuroblastoma Chemotherapy Resistance / Funding Source: / NIH R01
Project Description:
(100 words max)
Use this space to entice students to your project. It is meant to be an advertisement. They will select projects they are interested in based off these descriptions. / This project studies how changes in ubiquitin ligase UBE4B levels, which can regulate the amount of EGF receptor (EGFR) on the surface of neuroblastoma cells, affects the response of those cells to chemotherapy drugs that target EGFR. This is based on an earlier study of gene expression data that showed that patients with high UBE4B levels had an improved chemotherapy response. A trainee will get exposure to mammalian cell culture, DNA purification, molecular manipulations of cells, in vitro cell assays, and Western blot protein analysis.
This project welcomes use of tools of innovation and other insight/learning from the Massive Open Online Course.
Contact with: / public / patients / lab samples / x / animals / none
Project Status / IRB / Yes / No / Laboratory safety protocol / Yes / No
IRB Number / Protocol Number
Will the fellow be added to the protocol? / Yes / No / x
Source of trainee funding: / CPRIT Training grant / x / Preceptor
If preceptor funding, the fellow will take part in innovation course, seminars and cancer prevention related research.
  1. Trainee Activities:

A. All fellows
  1. Dr. Ness’s course: Innovation Generation

  1. Participate in 1 hourweekly group meetings and seminars in Houston and via ITV

  1. Meet with preceptor weekly to discuss training experience and progress (day and time):

  1. Complete CITI training and senda copy of the certificate in to within the first week.

B. Project specific fellows activities
mentors, please specify additional fellow activities, e.g., Propose alternative solutions to current project problems
  1. Work with CPRIT pre-doctoral fellow to plan, run, and analyze experiments to characterize role of UBE4B in chemotherapy response

  1. Attend weekly lab meetings each Wednesday

  1. Attend enrichment activities offered throughout the summer by the NBA deptand neuroscience program at the medical school (invited speakers, journal clubs, etc.)

  1. Learning Objectives: By the end of the summer experience, fellow will demonstrate that they can

A. All fellows:
  1. Describe the skills to increase innovative thinking

  1. Describe, in the reflection paper, at least 3 instances of applying an innovative thinking skill

  1. Recognize potential conflict(s) of interest in scenarios provided in CITI training

  1. Recognize activities that violate UTHealth’s policy on information technology as part of
CITI training
B. Project specific learning objectives:
mentors, please specify additional learning objectives, e.g. fellows will be able to write instructions for low literacy audiences
  1. Learn selected literature related to chemotherapy resistance & receptor recycling in neuroblastoma

  1. Learn to design hypothesis-driven experiments to learn more about the role of UBE4B in chemotherapy response

  1. Learn essential lab techniques to this project – Western blotting, cell culture, DNA purification, in vitro cell assays

  1. End Product(s):

  1. All Fellows:

  1. Mid-course review of training experience (trainee and preceptor)

  1. Oral presentation at the end of training with appropriate audio/visual accompaniment

  1. 3-page reflection paper, describing the summer experience, including instances of applying skills for innovative thinking, and in what way, if any, the experience has affected career plans, goals (due one week before his/her last day)

  1. Evaluation of the trainee (preceptor)

  1. Finalreview of training experience (trainee and preceptor)

  1. Project specific end products:
mentors’ please specify, e.g., manuscript to be submitted to xxx, abstract to be submitted to yyy
  1. Abstract describing the project and critical findings of the summer experiments by the end of summer 2016

  1. PowerPoint presentation to our lab group at our weekly meeting by the end of
summer 2016
Note to preceptors: Any confidentiality agreements regarding the project or data you are using (e.g. unpublished results) should be arranged between you and your trainee.
  1. Are there special trainee characteristics e.g., major, interests, language, culture or other preferences that would be desirable? Please specify:
We are looking for a student with interest in cancer and molecular biology research, and a student who is interested in potentially using this summer experience as a stepping-stonetoward graduate school.
V. Mentor Availability
NB: For adequate trainee exposure, the preceptor should not be away for more than 2 weeks.
Will you be out for more than 2 weeks during the training period? / Yes / No / X
If yes, when would you be gone and for how long?

Who would serve as preceptor during your absence (name and credentials, please specify)?

Name:
Job title:
E-mail:
Phone number: office: Cell:

NB: Please do not submit more than two projects. Fill out one form per project