RESEARCH METHODS 2009<181>
Database EMBASE
Accession Number 2008514170
Authors Homish G.G. Leonard K.E.
Institution
(Homish) Department of Health Behavior, School of Public Health and Health Professions, University at Buffalo, 3435 Main Street, Buffalo, NY 14214-8028, United States.
(Homish, Leonard) Research Institute on Addictions, University at Buffalo, The State University of New York, 1021 Main Street, Buffalo, NY 14203-1016, United States.
(Leonard) Department of Psychiatry, School of Medicine, University at Buffalo, 1021 Main Street, Buffalo, NY 14203-1016, United States.
Country of Publication
United Kingdom
Title
Testing methodologies to recruit adult drug-using couples.
Source
Addictive Behaviors. 34(1)(pp 96-99), 2009. Date of Publication: January 2009.
Publisher
Elsevier Ltd
Abstract
Given the increased reliance on caller id, caller blocking, and answering machines, random digit dialing has become a less successful recruiting technique, especially among younger individuals. This pilot study tested the feasibility of using multi-step mailed survey methodology to obtain a random sample of adult, substance-using couples. Feasibility was assessed in terms of response rates and generalizability of the sample. A sample of 1000 names and addresses was purchased from a professional survey company. Half of the sample received a $1 incentive and the rest did not receive the incentive. There were no other differences between the other procedures used. The response rate for the incentive group was significantly higher compared to the non-incentive group (66% vs. 47%, p < .001). Past month marijuana use was 4.6% compared to estimates from the US National Survey on Drug Use and Health for this region of 5.0%. Similarly, rates of heavy drinking and attitudes about drug use were also similar to other estimates. There were no differences on substance use for the incentive group compared to the non-incentive group. This pilot study demonstrated the feasibility of using a multi-step mailed survey to recruit a representative sample of adult, substance-using couples. copyright 2008 Elsevier Ltd. All rights reserved.
ISSN 0306-4603
Publication Type Journal: Article
Journal Name Addictive Behaviors
Volume 34
Issue Part 1
Page 96-99
Year of Publication 2009
Date of Publication January 2009
RESEARCH METHODS 2009<688>
Database Ovid MEDLINE(R) In-Process & Other Non-Indexed Citations and Ovid MEDLINE(R)
Unique Identifier 19356245
Status MEDLINE
Authors Vecchi S. Belleudi V. Amato L. Davoli M.PerucciCA.
Authors Full Name Vecchi, Simona. Belleudi, Valeria. Amato, Laura. Davoli, Marina. Perucci, Carlo A.
Institution
Department of Epidemiology, Italian National Health Service, Local Health Unit Rome E, Via di S, Costanza, 53, 00198 Rome, Italy.
Title
Does direction of results of abstracts submitted to scientific conferences on drug addiction predict full publication?
Source
BMC Medical Research Methodology. 9:23, 2009.
Journal Name
BMC Medical Research Methodology
Other ID
Source: NLM. PMC2674061
Country of Publication
England
Abstract
BACKGROUND: Data from scientific literature show that about 63% of abstracts presented at biomedical conferences will be published in full. Some studies have indicated that full publication is associated with the direction of results (publication bias). No study has looked into the occurrence of publication bias in the field of addiction. OBJECTIVES: To investigate whether the significance or direction of results of abstracts presented at the major international scientific conference on addiction is associated with full publication METHODS: The conference proceedings of the US Annual Meeting of the College on Problems of Drug Dependence (CPDD), were handsearched for abstracts of randomized controlled trials and controlled clinical trials that evaluated interventions for prevention, rehabilitation and treatment of drug addiction in humans (years searched 1993-2002). Data regarding the study designs and outcomes reported were extracted. Subsequent publication in peer reviewed journals was searched in MEDLINE and EMBASE databases, as of March 2006. RESULTS: Out of 5919 abstracts presented, 581 met the inclusion criteria; 359 (62%) conference abstracts had been published in a broad variety of peer reviewed journals (average time of publication 2.6 years, SD +/- 1.78). The proportion of published studies was almost the same for randomized controlled trials (62.4%) and controlled clinical trials (59.5%) while studies that reported positive results were significantly more likely to be published (74.5%) than those that did not report statistical results (60.9%.), negative or null results (47.1%) and no results (38.6%), Abstracts reporting positive results had a significantly higher probability of being published in full, while abstracts reporting null or negative results were half as likely to be published compared with positive ones (HR = 0.48; 95%CI 0.30-0.74) CONCLUSION: Clinical trials were the minority of abstracts presented at the CPDD; we found evidence of possible publication bias in the field of addiction, with negative or null results having half the likelihood of being published than positive ones.
Publication Type Journal Article.
Date of Publication 2009
Year of Publication 2009
Volume 9
Page 23
RESEARCH METHODS2009<695>
Database Ovid MEDLINE(R) In-Process & Other Non-Indexed Citations and Ovid MEDLINE(R)
Unique Identifier 19320669
Status MEDLINE
Authors Vahabzadeh M. Lin JL. Mezghanni M. Epstein DH.Preston KL.
Authors Full Name Vahabzadeh, Massoud. Lin, Jia-Ling. Mezghanni, Mustapha. Epstein, David H. Preston, Kenzie L.
Institution
Biomedical Informatics Section, Administrative Management Branch, Intramural Research Program, National Institute on Drug Abuse, NIH/DHHS, Baltimore, Maryland 21224, USA.
Title
Automation in an addiction treatment research clinic: computerised contingency management, ecological momentary assessment and a protocol workflow system.
Source
Drug & Alcohol Review. 28(1):3-11, 2009 Jan.
Journal Name
Drug & Alcohol Review
Other ID
Source: NLM. NIHMS90510 [Available on 01/01/10]
Source: NLM. PMC2746007 [Available on 01/01/10]
Country of Publication
England
Abstract
INTRODUCTION AND AIMS: A challenge in treatment research is the necessity of adhering to protocol and regulatory strictures while maintaining flexibility to meet patients' treatment needs and to accommodate variations among protocols. Another challenge is the acquisition of large amounts of data in an occasionally hectic environment, along with the provision of seamless methods for exporting, mining and querying the data. DESIGN AND METHODS: We have automated several major functions of our outpatient treatment research clinic for studies in drug abuse and dependence. Here we describe three such specialised applications: the Automated Contingency Management (ACM) system for the delivery of behavioural interventions, the transactional electronic diary (TED) system for the management of behavioural assessments and the Protocol Workflow System (PWS) for computerised workflow automation and guidance of each participant's daily clinic activities. These modules are integrated into our larger information system to enable data sharing in real time among authorised staff. RESULTS: ACM and the TED have each permitted us to conduct research that was not previously possible. In addition, the time to data analysis at the end of each study is substantially shorter. With the implementation of the PWS, we have been able to manage a research clinic with an 80 patient capacity, having an annual average of 18,000 patient visits and 7300 urine collections with a research staff of five. Finally, automated data management has considerably enhanced our ability to monitor and summarise participant safety data for research oversight. DISCUSSION AND CONCLUSIONS: When developed in consultation with end users, automation in treatment research clinics can enable more efficient operations, better communication among staff and expansions in research methods.
Publication Type Journal Article. Research Support, N.I.H., Intramural.
Date of Publication 2009 Jan
Year of Publication 2009
Issue/Part 1
Volume 28
Page 3-11
RESEARCH METHODS 2009<135>
Database EMBASE
Accession Number 2009123125
Authors Pan J.-J. Nahm M. Wakim P. Cushing C. Poole L. Tai B. Pieper F.C.
Institution
(Pan) Veterans Health Administration, Washington, DC, United States.
(Wakim, Cushing, Tai) Duke Translational Medicine Institute, 2424 Erwin Road, Durham, NC27705, United States.
(Nahm) National Institute on Drug Abuse, Center for the Clinical Trials Network, Bethesda, MD, United States.
(Poole) Duke Clinical Research Institute, Durham, NC, United States.
(Pieper) Biostatistics and Bioinformatics Department, DukeUniversityMedicalCenter, Durham, NC, United States.
Country of Publication
United Kingdom
Title
A centralized informatics infrastructure for the National Institute on Drug Abuse Clinical Trials Network.
Source
Clinical Trials. 6(1)(pp 67-75), 2009. Date of Publication: 2009.
Publisher
SAGE Publications Ltd
Abstract
Background: Clinical trial networks (CTNs) were created to provide a sustaining infrastructure for the conduct of multisite clinical trials. As such, they must withstand changes in membership. Centralization of infrastructure including knowledge management, portfolio management, information management, process automation, work policies, and procedures in clinical research networks facilitates consistency and ultimately research. Purpose: In 2005, the National Institute on Drug Abuse (NIDA) CTN transitioned from a distributed data management model to a centralized informatics infrastructure to support the network's trial activities and administration. We describe the centralized informatics infrastructure and discuss our challenges to inform others considering such an endeavor. Methods: During the migration of a clinical trial network from a decentralized to a centralized data center model, descriptive data were captured and are presented here to assess the impact of centralization. Results: We present the framework for the informatics infrastructure and evaluative metrics. The network has decreased the time from last patient-last visit to database lock from an average of 7.6 months to 2.8 months. The average database error rate decreased from 0.8% to 0.2%, with a corresponding decrease in the interquartile range from 0.04%-1.0% before centralization to 0.01-0.27% after centralization. Centralization has provided the CTN with integrated trial status reporting and the first standards-based public data share. A preliminary cost-benefit analysis showed a 50% reduction in data management cost per study participant over the life of a trial. Limitations A single clinical trial network comprising addiction researchers and community treatment programs was assessed. The findings may not be applicable to other research settings. Conclusions: The identified informatics components provide the information and infrastructure needed for our clinical trial network. Post centralization data management operations are more efficient and less costly, with higher data quality. copyright 2009 Sage Publications.
ISSN 1740-7745
Publication Type Journal: Article
Journal Name Clinical Trials
Volume 6
Issue Part 1
Page 67-75
Year of Publication 2009
Date of Publication 2009
RESEARCH METHODS<185>
Database EMBASE
Accession Number 2009000503
Authors Kreek M.J. Schlussman S.D. Reed B. Zhang Y. Nielsen D.A. Levran O. Zhou Y. Butelman E.R.
Institution
(Kreek, Schlussman, Reed, Zhang, Nielsen, Levran, Zhou, Butelman) Laboratory of the Biology of Addictive Diseases, The Rockefeller University, 1230 York Avenue, New York, NY 10065, United States.
Country of Publication
United Kingdom
Title
Bidirectional translational research: Progress in understanding addictive diseases.
Source
Neuropharmacology. 56(SUPPL. 1)(pp 32-43), 2009. Date of Publication: 2009.
Publisher
Elsevier Ltd
Abstract
The focus of this review is primarily on recent developments in bidirectional translational research on the addictions, within the Laboratory of the Biology of Addictive Diseases at The Rockefeller University. This review is subdivided into major interacting aspects, including (a) Investigation of neurobiological and molecular adaptations (e.g., in genes for the opioid receptors or endogenous neuropeptides) in response to cocaine or opiates, administered under laboratory conditions modeling chronic patterns of human self-exposure (e.g., chronic escalating "binge"). (b) The impact of such drug exposure on the hypothalamic-pituitary-adrenal (HPA) axis and interacting neuropeptidergic systems (e.g., opioid, orexin and vasopressin). (c) Molecular genetic association studies using candidate gene and whole genome approaches, to define particular systems involved in vulnerability to develop specific addictions, and response to pharmacotherapy. (d) Neuroendocrine challenge studies in normal volunteers and current addictive disease patients along with former addicts in treatment, to investigate differential pharmacodynamics and responsiveness of molecular targets, in particular those also investigated in the experimental and molecular genetic approaches as described above. copyright 2008.
ISSN 0028-3908
Publication Type Journal: Review
Journal Name Neuropharmacology
Volume 56
Issue Part SUPPL. 1
Page 32-43
Year of Publication 2009
Date of Publication 2009
RESEARCH METHODS 2009<300>
Database EMBASE
Accession Number 2009280116
Authors Oudejans S.C.C. Schippers G.M. Merkx M.J.M. Schramade M.H. Koeter M.W.J. Van Den Brink W.
Institution
(Oudejans) Department of Psychiatry, Amsterdam Institute for Addiction Research (AIAR), AcademicMedicalCenter, Meibergdreef 5, 1105 AZ Amsterdam, Netherlands.
(Oudejans, Schippers, Merkx, Koeter, Van Den Brink) Department of Psychiatry, Amsterdam Institute for Addiction Research (AIAR), University of Amsterdam, Amsterdam, Netherlands.
(Oudejans, Schippers, Schramade) JellinekMentrum, Amsterdam, Netherlands.
(Schippers) And Brijder Verslavingszorg, Alkmaar, Netherlands.
Country of Publication
United Kingdom
Title
Feasibility and validity of low-budget telephonic follow-up interviews in routine outcome monitoring of substance abuse treatment.
Source
Addiction. 104(7)(pp 1138-1146), 2009. Date of Publication: July 2009.
Publisher
Blackwell Publishing Ltd
Abstract
Aims Routine outcome monitoring (ROM) is receiving growing attention. However, follow-up interviews are time-consuming and costly. This study examines the feasibility and validity of low-budget telephonic follow-up interviews for ROM in a substance abuse treatment centre (SATC). Design Observational study using data collected for routine outcome monitoring. Setting The study was performed in a SATC in an urban area in the Netherlands. Participants Feasibility and validity were assessed on data of 2325 patients. Measurements Data on pre-treatment socio-demographic and clinical characteristics were collected using electronic patient records (EPRs) and the European version of the Addiction Severity Index (EuropASI). Data on intensity of treatment were also collected through the EPRs. Telephonic follow-up interviews were conducted between 9 and 10 months after intake. Findings A 53% follow-up rate was achieved; 35% of the patients could not be contacted, 3% explicitly refused and in 8% other reasons accounted for non-participation. About 50% of the interviews took place in the intended time-frame. Costs were [euro]40 ($57) per completed interview. There were indications of selection bias, because patients with cocaine as their primary problem and patients with polysubstance abuse were under-represented in the follow-up sample; the presence of these disorders is associated with negative treatment outcome. Conclusions Implementing telephonic low-budget follow-up interviews for ROM is feasible, but selection bias threatens internal validity of data, limiting generalization to the total treatment population. Increased efforts to track patients for follow-up may improve generalization. copyright 2009 Society for the Study of Addiction.
ISSN 0965-2140
Publication Type Journal: Article
Journal Name Addiction
Volume 104
Issue Part 7
Page 1138-1146
Year of Publication 2009
Date of Publication July 2009
NICOTINE 2009<553>
Database EMBASE
Accession Number 2009478756
Authors Hughes J.R.
Institution
(Hughes) Department of Psychiatry, University of Vermont, UHC Campus, 1 So Prospect Street, Burlington, VT 05401, United States.
Country of Publication
United Kingdom
Title
How confident should we be that smoking cessation treatments work?
Source
Addiction. 104(10)(pp 1637-1640), 2009. Date of Publication: October 2009.
Publisher
Blackwell Publishing Ltd
Abstract
Aim To determine (i) the concordance among recent meta-analyses about which treatments for smoking cessation are efficacious; (ii) the similarity of odds ratios (ORs) across meta-analyses; and (iii) among the validated treatments, the proportion of studies that found higher quit rates. Methods Computerized literature search for meta-analyses during the last 5 years in PubMed and PsychInfo. Data were extracted from summary tables of overall effect of validated treatments. Results Fourteen meta-analyses agreed 100% on the presence/absence of efficacy of 17 proven treatments. The ORs differed by <0.5 in 72/76 of the comparisons of meta-analyses. Among 37 comparisons in 33 comparisons, >85% of the studies reported numerical superiority for the active treatment. Conclusions The efficacy of treatments for smoking cessation are extremely reliable. This argues for inclusion of treatment as an essential feature of tobacco control and clinical practice and argues for reimbursement of smoking cessation treatments on a par with other medical and behavioral disorders. copyright 2009 Society for the Study of Addiction.
ISSN 0965-2140
Publication Type Journal: Review
Journal Name Addiction
Volume 104
Issue Part 10
Page 1637-1640
Yearof Publication 2009
Date of Publication October 2009
RESEARCH METHODS 2009<554>
Database EMBASE
Accession Number 2009478755
Authors Spijkerman R. Knibbe R. Knoops K. Van De Mheen D. Van Den Eijnden R.
Institution
(Spijkerman) Behavioural Science Institute, PO Box 9104, 6525 HE Nijmegen, Netherlands.
(Knibbe) MaastrichtUniversity, Department of Health Promotion, Maastricht, Netherlands.
(Knoops) Statistics Netherlands, Heerlen, Netherlands.
(Van De Mheen) ErasmusMc, Department of Public Health, IVO Addiction Research Institute, Rotterdam, Netherlands.
(Van Den Eijnden) UtrechtUniversity, Department of Interdisciplinary Social Sciences, Utrecht, Netherlands.
Country of Publication
United Kingdom
Title
The utility of online panel surveys versus computer-assisted interviews in obtaining substance-use prevalence estimates in the Netherlands.
Source
Addiction. 104(10)(pp 1641-1645), 2009. Date of Publication: October 2009.
Publisher
Blackwell Publishing Ltd
Abstract
Aims Rather than using the traditional, costly method of personal interviews in a general population sample, substance-use prevalence rates can be derived more conveniently from data collected among members of an online access panel. To examine the utility of this method, we compared the outcomes of an online survey with those obtained with the computer-assisted personal interviews (CAPI) method. Design Data were gathered from a large sample of online panellists and in a two-stage stratified sample of the Dutch population using the CAPI method. Setting The Netherlands. Participants The online sample comprised 57 125 Dutch online panellists (15-64 years) of Survey Sampling International LLC (SSI), and the CAPI cohort 7204 respondents (15-64 years). Measurements All participants answered identical questions about their use of alcohol, cannabis, ecstasy, cocaine and performance-enhancing drugs. The CAPI respondents were asked additionally about internet access and online panel membership. Both data sets were weighted statistically according to the distribution of demographic characteristics of the general Dutch population. Findings Response rates were 35.5% (n = 20 282) for the online panel cohort and 62.7% (n = 4516) for the CAPI cohort. The data showed almost consistently lower substance-use prevalence rates for the CAPI respondents. Although the observed differences could be due to bias in both data sets, coverage and non-response bias were higher in the online panel survey. Conclusions Despite its economic advantage, the online panel survey showed stronger non-response and coverage bias than the CAPI survey, leading to less reliable estimates of substance use in the general population. copyright 2009 Society for the Study of Addiction.