Master's Thesis
석사 학위논문
Thesis Title
Gildong Hong(홍 길 동洪 吉 東)
Department of
Energy Science & Engineering
DGIST
2018
Master's Thesis
석사 학위논문
Thesis Title
Gildong Hong(홍 길 동洪 吉 東)
Department of
Energy Science & Engineering
DGIST
2018
Thesis Title
Advisor:Professor Sunsin Yi
Co-advisor: Professor Yakyong Jeong
By
Gildong Hong
Department of Energy Science & Engineering
DGIST
A thesis submitted to the faculty of DGIST in partial fulfillment of the requirements for the degree of Master of Science in the Department of Energy Science & Engineering. The study was conducted in accordance with Code of Research Ethics[1]
01. 01. 2018
Approved by
Professor Sunsin Yi (signature)
(Advisor)
Professor Yakyong Jeong (signature)
(Co-Advisor)
Thesis Title
Gildong Hong
Accepted in partial fulfillment of the requirements for the degree of Master of Science.
30. 11. 2017
Head of Committee
Committee Member
Committee Member / (signature)
Prof. Sunsin Yi
(signature)
Prof. Yakyong Jeong
(signature)
Prof. Saimdang Shin
MS/ES
201700000 / 홍 길 동.Gildong Hong. Thesis Title.Department of Energy Science & Engineering. 2018. 70p. Advisors Prof. Sungsin Yi, Co-Advisors Prof. Yakyong Jeong
ABSTRACT
Huntington’s disease (HD) is an autosomal dominant inherited disease characterized clinically by a progressive movement and psychiatric disorder. HD is caused by mutations in exon 1 of the huntingtin gene (> 36 CAG). In patients with HD, the GABAergic medium-sized spiny neurons (MSNs) in the striatum show selective dysfunction and degeneration associated with the involuntary movement of HD.
The neuropathological hallmark of HD is the ubiquitin-positive neuronal intranuclear inclusions (NIIs) of mutant huntingtin. One potential cause for such abnormal protein aggregation is dysfunction of the ubiquitin-proteasome system (UPS), which is essential for the degradation of abnormal, mutated or misfolded proteins.
Previous evidences demonstrated the inhibited proteasome activities in several brain regions of HD patients including striatum. Herein we attempt to improve proteasome activity and neuronal survival in HD model systems for therapeutic approach for HD.
Keywords:Proteasome activator, PA28gamma, Baclofen
List of Contents
Abstract·······················································i
List of contents··················································ii
List of tables···················································iii
List of figures··················································vi
Ⅰ. Introduction
1.1······················································1
1.1.1····················································1
1.1.2····················································1
1.1.3····················································2
1.1.4····················································2
1.2·······················································3
1.3·······················································4
1.4·······················································5

- 1 -

Ⅰ. INTRODUCTION
1.1
References
학위논문(Theses)의 경우 예시
[1] Chang, I. “Biopolymer treated Korean Residual Soil: Geotechnical behavior and Applications”, Ph.D. Thesis, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea, 2010, 320 pages.
단행본(Book)의 경우 예시
[2] Grim, R. Applied clay mineralogy, McGraw-Hill, NewYork, 1962, 160 pages.
특허(Patents)의 경우 예시
[3] J.L. Lee et al. "GaAs Power Semiconductor Device Operating at a Low Voltage and Method for Fabricating the Same", US Patent 5, 760, 418, to ETRI, Patent and Trademark Office, Washington D.C., 1998.
학회논문(Conference proceeding)의 경우 예시
[4] Mgangira, M.B. "Evaluation of the effects of enzyme-based liquid chemical stabilizers on subgrade soils." 28th Annual Southern African Transport Conference (SATC) 2009, Pretoria, South Africa, 2009, pp. 192-199.
저널아티클(Periodicals)의 경우 예시
[5] Noborio, K., McInnes, K. J., and Heilman, J. L. "Measurements of Soil Water Content, Heat Capacity, and Thermal Conductivity With A Single Tdr Probe1." Soil Science, 161(1), 1996, pp. 22-28.

학위논문(Theses)의 경우 예시

[1] Chang, I. “Biopolymer treated Korean Residual Soil: Geotechnical behavior and Applications”, Ph.D. Thesis, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea, 2010, 320 pages.

단행본(Book)의 경우 예시

[2] Grim, R. Applied clay mineralogy, McGraw-Hill, NewYork, 1962, 160 pages.

특허(Patents)의 경우 예시

[3] J.L. Lee et al. "GaAs Power Semiconductor Device Operating at a Low Voltage and Method for Fabricating the Same", US Patent 5, 760, 418, to ETRI, Patent and Trademark Office, Washington D.C., 1998.

학회논문(Conference proceeding)의 경우 예시

[4] Mgangira, M.B. "Evaluation of the effects of enzyme-based liquid chemical stabilizers on subgrade soils." 28th Annual Southern African Transport Conference (SATC) 2009, Pretoria, South Africa, 2009, pp. 192-199.

저널아티클(Periodicals)의 경우 예시

[5] Noborio, K., McInnes, K. J., and Heilman, J. L. "Measurements of Soil Water Content, Heat Capacity, and Thermal Conductivity With A Single Tdr Probe1." Soil Science, 161(1), 1996, pp. 22-28.

요 약 문
논문 제목
본 논문은 ...
핵심어:

[1] Declaration of Ethical Conduct in Research: I, as a graduate student of DGIST, hereby declare that I have not committed any acts that may damage the credibility of my research. These include, but are not limited to: falsification, thesis written by someone else, distortion of research findings or plagiarism. I affirm that my thesis contains honest conclusions based on my own careful research under the guidance of my thesis advisor.