Postdoctoral/Engineer Position

Postdoctoral/engineer position

Biostatistician

Bally-Cuif laboratory

(Institut Pasteur, Paris, France)

The laboratory of Zebrafish Neurogenetics, led by Dr. Laure Bally-Cuif at the Pasteur Institute in Paris, is seeking an outstanding and highly motivated biostatisticianto contribute to our ongoing research on adult neural stem cells. Our lab is interested in identifying the molecular and cellular mechanisms underlying basic adult neural stem cell properties (quiescence, self-renewal, fate…), and is using the adult zebrafish as main model system. Our analyses involve comparing, and the single cell and at the cell population levels, the transcriptome of neural stem cells under physiological, genetically modified or pharmacologically perturbed conditions. The recruited biostatistician, working in close association with the biologists of the team and with the Biomics platform and the Bioinformatics and Biostatistics Hub of Institut Pasteur, will be involved in processing single cell and bulk RNAseq data to extract biologically meaningful information on candidate neural stem cell maintenance pathways.

Tasks and responsibilities

. Provide support to the team for the analysis of RNAseq data using bioinformatics and statistics approaches

. Advise and guide in the use of existing statistical methods and tools

. Maintain an active bibliographical survey and evaluate existing tools and methods

. Develop new methods and tools when necessary

Requirements

Candidates must hold a Ph.D. or an engineer or equivalent degree in biostatistics or bioinformatics, and should be seeking their first professional experience. Previous experience with applying biostatistical methods to RNAseq data is preferred. Knowledge of the following tools is appreciated: exploratory data analysis and dimensionality reduction, geneset enrichment analysis, statistical modeling, hypothesis testing and inferential statistics, functional genomics,Python. Proficiency in R programming is mandatory.

Proficiency in English is required.

The position is funded by the European Research Council and Labex Revive, for a duration of 1 year, starting Sept. 1st, 2018.

The Bally-Cuif team is one of the 16 research groups of the “Developmental and Stem Cell Biology” Department of the Pasteur Institute, focusing on evolutionary, developmental and stem cell biology in various animal models. It is also co-affiliated with the Pasteur “Neuroscience” Department.

To apply, please submit your CV and the name of three references to:

Institut Pasteur, CNRS UMR3738

Dept of Developmental and Stem Cell Biology

25 rue du Dr Roux

75015 Paris France