Principal Investigator/Program Director (Last, First, Middle): Rama Rao, Anil, Prasad

BIOGRAPHICAL SKETCH

Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2.
Follow this format for each person. DO NOT EXCEED FOUR PAGES.
NAME
Rama Rao Anil Prasad / POSITION TITLE
Associate Professor of Pathology
eRA COMMONS USER NAME
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)
INSTITUTION AND LOCATION / DEGREE
(if applicable) / YEAR(s) / FIELD OF STUDY
Armed Forces Medical College, India / M.B.B.S. / 1980-1985 / Medicine & Surgery
St. Martha’s Hospital, Bangalore, India / M.D. / 1985-1987 / Internal Medicine
JIPMER, Pondicherry University, India / Residency / 1989-1995 / Anatomic & Clinical Pathology
Henry Ford Hospital, Detroit, MI / Residency / 1996-1999 / Anatomic & Clinical Pathology (Residency)
Henry Ford Hospital, Detroit, MI
Mayo Clinic, Rochester, MN / Fellowship
Fellowship / 1999-2000
2000-2000 / Cytopathology
Surgical Pathology

PHS 398/2590 (Rev. 09/04) Page 7 Biographical Sketch Format Page

Principal Investigator/Program Director (Last, First, Middle): Rama Rao, Anil, Prasad

A. Positions and Honors

Positions and Employment

1987-1988 House Officer, Intensive Care Unit, Bangalore Heart Center, India

1988-1989  Medical Officer In-Charge, Primary Health Care Center, Bangalore, India

1995-1996 Assistant Professor, Pathology, Pondicherry Dental College, India

2001- 6/2008 Clinical Assistant Professor, Pathology, University of Arizona Health Science Center, Tucson, AZ

7/2008-present Clinical Associate Professor, Pathology, University of Arizona Health Science Center, Tucson, AZ

2002-2004 Staff Pathologist & Director, Surgical Pathology & Cytopathology, Southern Arizona Veterans Affairs Health Care System, Tucson, AZ

2002-present Co-Director, Arizona Molecular Diagnostic & Research Laboratory (AMDRL), Southern Arizona Veterans Affairs Health Care System, Tucson, AZ.

2004-present Staff Pathologist & Director of Pathology Research and Development at the Southern Arizona Veterans Affairs Health Care System, Tucson, AZ.

HONORS:

Certificate of Distinction, Pathology, K.J. Hospital, Madras, India 1991

Gold Medal, Pathology, Pondicherry University, India, 1992

B.  Selected peer-reviewed publications (in chronological order).

1. Jaisankar TJ, Garg BR, Reddy BS, Riba B, Prasad, AR (1994). Penile lupus vulgaris. International Journal of Dermatology 33 (4) 272-4.

2. Prasad AR, Narasimhan, R, Sankaran V & Veliath AJ. (1996). Fine needle aspiration cytology in the

diagnosis of superficial lymphadenopathy – and analysis of 2418 cases. Diagnostic Cytopathology 15(5),

382-6.

3. Prasad AR, Ratnakar C, Veliath AJ, Srinivasan K (1995). Eccrine carcinoma of the forearm.

International Journal of Dermatology 34(12), 859-60.

4. Prakash RM, Prasad AR, Sharma P, Seetharaman ML (1995). Tuberculous pleurisy mimicking pleural

Mesothelioma. J Assoc. Physicians India 43 (3), 223.

5. Prasad AR, Bhatnagar RK, Ratnakar C, Veliath AJ (1996). Alport’s syndrome. The Indian Journal of Pathology and Microbiology 39(3), 225-7.

6.  Thappa MD, Garg RB, Prasad AR, Ratnakar C (1996). Multiple leiomyoma cutis associated with Becker’s Nevus. Letter to the Editor. Journal of Dermatology 23 (10), 719-20.

7. Simpson RH., Prasad A, Lewis JE., Skalova A., David L (2003) Mucin-rich variant of salivary duct carcinoma: a clinicopathologic and immunohistochemical study of four cases. Am J Surg Pathol. 27 (8):1070-9.

8. Prasad AR, Savera AT, Zarbo RJ (1999). Antimitochondrial antibody – a diagnostic discriminant of salivary gland oncocytic tumors and acinic cell carcinomas. Mod Pathol. 12 (13) Vol. 12, No.1: 130, 1999.

9. Prasad AR, Amin MB, Randolph TL, Lee CS, Ma CK.: Retrorectal cystic hamartoma: report of 5 cases with malignancy arising in 2. Arch Pathol Lab Med.124(5):725-9, 2000.

10.  Prasad AR, Savera AT and Zarbo RJ. (1999). The myoepithelial immunophenotype in 135 benign and malignant salivary gland tumors other than pleomorphic adenoma. Arch. Pathol & Lab. Med. 123 (9), 801-6.

11. Prasad AR, Ma CK (1999). Nodular regenerative hyperplasia of the liver: Report of three cases with hepatocellular carcinoma arising in one. American Journal of Gastroenterology 9.

12. Zarbo RJ, Prasad AR, Regezi JA, Gown AM, Savera AT (2000). Salivary gland basal cell and canalicular adenomas: immunohistochemical demonstration of myoepithelial cell participation and morphogenetic considerations. Arch. Pathol & Lab . Med. 124(3), 401-5.

13.  Ananthasubramanian K, Shurafa M, Prasad A (2000) Heparin induced thrombocytopenia. Review article. Prog. In Cardiovas. Dis 42(4).

14.  Prasad AR, Divine G, Zarbo RJ (2001). Two color cytokeratin labeled DNA flow cytometric analysis of 332 breast cancers: Lack of prognostic value with 7-12 year follow up. Arch. Pathol. & Lab. Med 125 (3), 364-74.

15.  Prasad AR, Seetharaman M. (2001). Respiratory distress caused by a hydatid cyst. Arch. Pathol & Lab.

Med. 125(4), 580.

16.  Herbst A, Padilla M, Prasad AR, Morales M, Copeland J (2003). Cardiac Wegener’s granulomatosis masquerading as left atrial myxoma. Ann. Thorac. Surg. 75: 1321-3.

17.  P Sharma, S Wani, AP Weston, A Bansal, M Hall, S Mathur, A Prasad, RE Sampliner: A randomized controlled trial of ablation of Barrett’s oesophagus with multipolar electrocoagulation vs Argon Plasma Coagulation in combination with Acid Suppression: Long term results: GUT 2006;55: 1233-1239

18.  R.E. Sampliner, L.Camargo and A.R. Prasad: Association of Ablation of Barrett’s Esophagus with High Grade Dysplasia and Adenocarcinoma of the Gastric Cardia. Dis. of Esophagus, 19: 277-279, 2006.

19.  K Dvorakova, C. Payne, L.. Ramsey, H. Holubec, R. Sampliner, J. Dominguez, B. Dvorak, H. Bernstein, C. Bernstein, A. Prasad, R. Fass. H Cui and H. Garewal. (2004). Increased Expression and secretion of Interleukin-6 in patients with Barrett’s Esophagus, Clinical cancer Research Vol 10, 2020-2028.

24. Dvorakova K, Payne CM, Ramsey L., Bernstein H, Holubec H, Chavarria M, Bernstein C, Sampliner RE,

Riley C, Prasad AR, Garewal H. (2005). Apoptosis resistance in Barret’s esophagus: ex vivo bioassay of

live stressed tissue. Am J Gastroenterol. 100 (2), 424-31.

25. Schmelz M, Moll R, Hesse U, Prasad AR, Gandolfi J, Hasan SR, Bartholdi M, Cress AE. (2005).

Identification of a stem cell candidate in the normal human prostate gland. Eur. J. Cell Biol. 84 (2-3),

341-54.

26. Shen L, Kondo Y, Rosner GL, Xiao L, Hernandez NS, Vilaythong J, Houlihan PS, Krouse RS, Prasad, AR,

Einspahr JG, Buckmeier J, Alberts DS, Hamilton SR, Issa JP. (2005). MGMT promoter methylation and field defect

in sporadic colorectal cancer. J Natl. Cancer Inst. 97 (18): 1330-8.

27. Schmelz M, AR Prasad. (2006). Cytokeratin 6 expression in prostate stem cells. In “

Adhesion and Cytoskeletal Molecules in Metastasis”, Anne E. Cress & Raymond B Nagle

(editors), Springer Science & Business Media, Dordrecht, The Netherlands.

28. Bernstein H, Prasad A, Holubec H, Bernstein C, Payne CM, Ramsey L, Dvorakova K, Wilson M, Warneke JA, Garewal H Reduced Pms2 expression in non-neoplastic flat mucosa from patients with colon cancer correlates with reduced apoptosis competence. Appl Immunohistochem Mol Morphol. 2006 Jun;14(2):166-72.

29. Dvorak K, Ramsey L, Payne C,Sampliner R , Fass R, Bernstein H, Prasad A, Garewal H. (2006).

Abnormal expression of cancer risk associated biomarkers in incompletely ablated Barrett’s esophagus.

Ann. Surg. 2006, 244(6):1031-1036,

30. Anil R. Prasad, MD, Jerome K. Steck, DPM, and A. Lee Dellon, MD, PhD. Zone of Traction Injury of the Common Peroneal Nerve. Ann Plast Surg 2007;59(3): 302–306

31. RE Sampliner, L.Camargo, Prasad AR: Association of Ablation of Barrett’s Esophagus with High Grade Dysplasia and Adenocarcinoma of the Gastric Cardia. Dis. of Esophagus, 19: 277-279, 2006.

32. K. Dvorak, C.M. Payne, M. Chavarria, L. Ramsey, B. Dvorakova, H. Bernstein, H. Holubec, R.E. Sampliner, G. Naisuan, A. Condon, C. Bernstein, S.B. Green, A.R. Prasad and H. Garewal. Bile Acids in Combination with Low pH Induced Oxidative Stress and Oxidative DNA Damage: Relevance to the Pathogenesis of Barrett’s Esophagus. GUT GUT ,2007, 56(6): 763-771.

33.Leon LR Jr, Hughes JD, Psalms SB, Guerra R, Biswas A, Prasad A, Krouse RS. Portomesenteric reconstruction during Whipple procedures: review and report of a case. European Journal of Vascular and Endovascular Surgery. 2007 Dec-2008 Jan;41(6):537-46.

34. David S. Alberts, Janine G. Einspahr, Robert S. Krouse, Anil Prasad, James Ranger-Moore, Peter Hamilton, Ayaaz Ismail, Peter Lance, Steven Goldschmid, Lisa M. Hess, Michael Yozwiak, Hubert G. Bartels, and Peter H. Bartels. Karyometry of the Colonic Mucosa. Cancer Epidemiol Biomarkers Prev 2007; 16(12):2704-16).

C.  Research Support

Ongoing Research Support

P50 CA 95060 Gerner (PI) 4/1/2007-3/31/2012

NIH

Specialized Program of Research Excellence (SPORE) in GI

The goal of this interdisciplinary Specialized Program of Research Excellence in GI cancer is to prevent and cure GI cancers, through studies in prevention, genetics and therapeutics.

Role: Co-investigator

PO1 CA 27502-28 Alberts (PI) 7/1/2004-6/30/2009

NIH

Quantitative Relationship of Histopathologic Changes, Genotypic Changes, Immunohistochemical Surrogate Endpoint Biomarkers (SEBS), and Morphometric Changes to Multistep Carcinogenesis in Skin Cancer.

This project studies patterns of gene expression, karyometric changes and biomarker expression in actinic keratosis and squamous cell carcinoma of the skin.

Role: Co- investigator

CSP# 501 Prasad (PI) 3/1/2006-2/28/2009

Department of Veterans Affairs Cooperative Studies Program

The Veterans Affairs Gulf War Biorepository Trust

The goal of this project is to establish a human tissue biorepository center for gulf war veterans tissues with annotated clinical data for translational research.

Role: Principal Investigator

VA Cooperative Studies Program. Dawn Provenzale (P.I.) 4/1/08-3/31/09

VA Cancer Tissue Repository and Linked Epidemiological and Clinical Database: To establish a genomic medicine resource

within CSP to advance cancer research and healthcare for veterans

Role: Co-PI

Arizona Biomedical Research Center Dvorak (PI) 9/1/2005-8/31/2008

Barrett’s esophagus, esophageal adenocarcinoma and apoptosis.

The goal of this project is to study apoptotic related pathways and biomarker expression in Barrett’s esophagus and associated dysplasia and carcinoma of the esophagus.

Role: Co-Investigator

VA Merit Review Grant Garewal (P.I.) 7/1/2007 - 6/30/2010.

Unique, hypothesis-driven biomarkers of colon cancer risk.

Role: Collaborator.

Completed Research Support

W81XWH-04-1-0921 Schmelz (PI) 10/15/04 - 10/14/07

Department of Defense

The Plasticity of Human Normal Prostate Glandular Homeostasis

This project investigates the role of growth factors in the regulation of cytokeratin 6 positive cells, a newly discovered prostatic epithelial cell type.

Role:Co-Investigator

VISN 18 (10N18) Leyva (PI) 7/1/2005-6/30/2006

New Investigator Pilot Grant

Department of Veterans Affairs

Patterns of Gene Expression, Clinicopathologic and karyometric Features of Aggressive Cutaneous Squamous Cell Carcinoma.

The goal of this project is to study clinical and pathological features of aggressive cutaneous squamous cell carcinomas along with gene expression patterns.

Role: Co-Principal Investigator

PO1 CA 41108 Alberts (PI) 7/23/2002-7/22/2005

NIH

Detection of Methylated Tumor Suppressor Genes in colorectal tumors and matched plasma samples: Development of a potential marker of colorectal cancer in the plasma.

The major goals of this program are to develop new preventive strategies to prevent colon cancer and to recuce the morbidity and mortality rate caused by colorectal cancer.

Role: Co-Investigator

VISN 18 (10N18) Prasad (PI) 4/1/2004-3/31/2005

New Investigator Pilot Grant

Department of Veterans Affairs

A New prostatic epithelial cell phenotype: a stem cell candidate

This projects characterized the properties of a new prostate epithelial cell type and demonstrated that this new cell type possesses stem cell characteristics.

Role: PI

PHS 398/2590 (Rev. 09/04) Page 9 Continuation Format Page