Pao-Luh Tao

Pao-Luh Tao

Professor, Department of Pharmacology, NationalDefenseMedicalCenter

PROFESSIONAL MEMBERSHIPS

International Narcotics Research Conference (1985-present)

Chinese (Taiwan) Pharmacological Society (1974-present)

Neuroscience Society, R.O.C. (1994-present)

MAJOR INTERESTS IN RESEARCH

Mechanisms of morphine tolerance and dependence

How to prevent tolerance, dependence and chronic toxicities of morphine

Drug addiction

Publications (Tao, Pao-Luh):

1. Chow, S.-Y. and P.-L. Tao, 1977, Effects of diuretics on thyroid function of guinea pigs. Eur. J. Pharmacol. 45: 377-379.

2. Wang, Y.-C., P.-L. Tao, L.-D. Lee and P.-C. Chu, 1977, Inverse relation of plasma insulin concentration and opamine-hydroxylase activity in Diabetics. Chinese M. J. 24: 213-221.

3. Huang, H.-W., Y.-C. Wang and P.-L. Tao, 1977, The relation of nephrotic syndrome and 3',5'-adenosine monophosphate. Med. Res. papers of Tri-Service General Hospital 1: 65-70.

4. Chow, S.-Y. and P.-L. Tao, 1978, Effects of diuretics on the Na-K-activated ATPase and the transport of iodide and sodium in guinea-pig thyroid glands. Chinese Med. J. 25: 249-256.

5. Chow, S.-Y. and P.-L. Tao, 1978, Bioavailability studies of ampicillin, amoxicillin and penicillin V in Chinese young adults. Chinese M. J. 25: 6-12.

6. Tao, P.-L. and S.-Y. Leu, 1980, Induction of antiserum specifically binding triiodothyronine and thyroxine by bovine thyroglobulin and its application in radioimmunoassay. Chinese M. J. 27: 547-556.

7. Tao, P.-L., 1980, Drugs for treatment of asthma. Med. Res. 3(4): 1089-1093.

8. Chu, P.-C., S.-Y. Leu, T.-B. Chen and P.-L. Tao, 1981, Radioimmunoassay for triiodothyronine. Chin. Med. J. 28: 124-128.

9. Tao, P.-L., C.-K. Lee, W.-T. Chen and H.-K. Lee, 1981, Mechanism of in vitro uterine contraction induced by sparteine. Med. Res. 4(2): 1199-1205.

10. Liao, J.-F., P.-L. Tao, S.-Y. Chow and C.-F. Chen, 1983, Interactions between digoxin and furosemide or hydrochlorothiazide on the distribution of 3H-digoxin, water, and electrolytes in guinea-pigs. chin. Med. J. 31: 96-105.

11. Tao, P.-L. and P.-Y. Law, 1984, Down regulation of opiate receptor in rat brain after chronic etorphine treatment, Proc. West. Pharmacol. Soc. 27: 557-560.

12. Tao, P.-L., C.-K. Lee, Y.-S. Chen, W-T. Chen and H.-K. Lee, 1985, The action of morphine and meperidine on the isolated human myometrium. Chin. Med. J. 35, 278-83.

13. Chen, Y. S., P.-L. Tao, H. K. Lee, Y. F. Yang, W.T. Chen and C.K. Lee, 1985, The effect of ketamine on the isolated human myometrium. Chin. Med. J. 35, 273-77.

14. Tao, P.-L., L.-R. Chang, H. K. Lee and H. H. Loh, 1986, Determination of the sizes of the opioid receptors in their membrane environment by radiation inactivation. Proc. Natl. Sci. Counc. B. R.O.C. 10(3): 184-190.

15. Tao, P.-L., L.-R. Chang, H. K. Lee , 1986, Heterogeneity of [3H] ethyl-- carboline--carboxylate binding sites and [3H]--aminobutyric acid binding sites. Chinese J. Physiol. 29(1): 13-29.

16. Tao, P.-L., P.Y. Law and H.H. Loh, 1987, Decrease in delta and mu opioid receptor binding capacity in rat brain after chronic etorphine treatment. J. Pharmacol. Exp. Ther. 240(3): 809-816.

17. Tao, P.-L., L.-R. Chang, P.Y. Law and H.H. Loh, 1988, Decrease in -opioid receptor density in rat brain after chronic D-Ala2, D-Leu5-enkephalin treatment. Brain Research, 462, 313-320.

18. Loh H. H., P.-L. Tao and A.P. Smith, 1988, Invited Review: Role of receptor regulation in opioid tolerance mechanisms. Synapse 2: 457-462.

19. Lin C.-I., P.-L. Tao, Y.-F. Chang and B.N. Chiang, 1989, Pacemaker activity is modulated by tissue levels of cyclic adenosine 3', 5'-monophosphate in human atrial fibers. Int. J. Cardiol. 25: 39-46.

20. Tao, P.-L., H.Y. Lee, L.-R. Chang and H.H. Loh, 1990, Decrease in -opioid receptor binding capacity in rat brain after chronic PL017 treatment. Brain Reserch 526, 270-275.

21. Tao, P.-L., C.-L. Tsai, L.-R. Chang and H.H. Loh, 1991, Chronic effect of [D-Pen2, D-Pen5]enkephalin on rat brain opioid receptors. Eur. J. of Pharmacol. 201: 209-214.

22. Tao, P.-L. and C.-F. Liu, 1992, Chronic morphine treatment causes down-regulation of spinal A1-adenosine receptors in rats. Eur. J. Pharmacol. 215: 301-304.

23. Tao, P.-L.,V. S. Seybold and H.H. Loh, 1993, Autoradiographic evidence for decrease in binding of - and -opioid receptors after subchronic [D-Ala2, D-Leu5]enkephalin treatment in rats. Eur. J. Pharmacol. 231: 145-149.

24. Chern, J.-W., P.-L. Tao, M.-H. Yen, G.-Y. Lu, C.-Y. Shiau, Y.-J. Lai, S.-L. Chien and C.-H. Chan, 1993, Studies on quinazolines. 5. 2,3-dihydroimidazo[1,2-c]quinazoline derivatives: a novel class of potent and selective 1-adrenoceptor antagonists and antihypertensive agents. J. Med. Chem. 36: 2196-2207.

25. Lin, C.-I., S.-L. Wu, P.-L. Tao, H.-M. Chen and J. Wei, 1993, The role of cyclic AMP and phosphodiesterase activity in the mechanism of action of tetramethylpyrazine on human and dog cardiac and dog coronary arterial tissues. J. Pharm. Pharmacol. 45: 963-966.

26. Tao, P.-L., L.-R. Chang, Y.-P. Chou, P.-Y. Law and H.H. Loh, 1993, chronic opioid treatment may uncouple opioid receptors and G proteins: evidence from radiation inactivation analysis. Eur. J. Pharmacol. 246: 233-238.

27. Tao, P.-L., C.-R. Lee, P.-Y. Law and H. H. Loh, 1993, The interaction of mu-opioid receptor and G protein is altered after chronic morphine treatment in rats. Naunyn-Schmiedeberg's Arch. Pharmacol. 348: 504-508.

28. Tao, P.-L., M.-H. Yen, W.-S. Shyu and J.-W. Chern, 1993, Doridosine derivatives: binding at adenosine receptors and in vivo effects. Eur. J. Pharmacol. 243: 135-139.

29. Tao, P.-L., and C.-L. Hwang, 1994, Low dose of U-50,488H blocks the development of morphine tolerance and dependence in guinea pigs. Regul. Pept. Suppl. 1 : s203-s204.

30. Tao, P.-L., C.-L. Hwang and C.-Y. Chen, 1994, U-50,488 blocks the development of morphine tolerance and dependence at a very low dose in guinea pigs. Eur. J. Pharmacol. 256: 281-286.

31. Tao, P.-L., C.-F. Liu and H.-C. Tsai, 1995, Chronic intracerebroventricular administration of morphine down-regulates spinal adenosine A1 receptors. Eur. J. Pharmacol. 278: 233-237.

32. Hung, H.C., P.-L. Tao and E.H.Y. Lee, 1995, 1-methyl-4 phenyl-pyridinium (MPP+) uptake does not explain the differential toxicity of MPP+ in the nigrostriatal and mesolimbic dopaminergic pathways. Neurosci. Lett. 196: 93-96.

33. Tao, P.-L., W.-M. Lue, C.-H. Chen and M.-J. Lin, 1995, Nalbuphine block the development of morphine tolerance but not dependence in rats. Analgesia 1: 781-784.

34. Yeh, G.-C., C.-H. Chen and P.-L. Tao , 1995, Pre- and post-natal exposure to morphine induces an alteration in the developmental expression of the N-Methyl-D-Aspartate receptor in neonatal rat brain. Analgesia 1: 850-853.

35. Tao, P.-L., W.-M. Lue, C.-R. Lee and L.-R. Chang, 1995, Alteration of the interaction of mu-opioid receptor and G protein after chronic PL017 treatment in rats. Chin. J. Physiol. 38: 193-199.

36. Tseng, C.-J., S.-Y. Chen, P.-L. Tao , J.-W. Chern and M.-H. Yen, 1995, Antihypertensive effects of AT-112, a newly synthesized quinazoline derivative, in spontaneously hypertensive rats. Proc. Nat. Sci. Coun., ROC. Part B: Life Sci. 19: 159-165.

37. Cheng, C.-Y., L.-W. Hsin, Y.-P. Lin, P.-L. Tao and T.-T. Jong, 1996, N-cubylmethyl substituted morphinoids as novel narcotic antagonists. Bioorganic & Medicinal Chemistry 4: 73-80.

38. Cheng, C.-Y., L.-W. Hsin and P.-L. Tao, 1996, 1,4-Bis[(17-normorphinyl)methyl]cubane, a morphine dimer linked by cubane. Chin. Pharm. J. 48: 139-147.

39. Tao, P.-L., C.-S. Wong and M.-C. Lin, 1996, Chronic intrathecal morphine treatment does not cause down-regulation of spinal adenosine A1 receptors in rats. Naunyn-Schmiedeberg's Arch. Pharmacol. 354: 187-191.

40. Wang, Y.-C., M.-C. Kao, P.-L. Tao, W.-L. Ho, C.-H. Yang and Y.-M. Fu, 1996, Evaluation of laser and radiofrequency induced dorsal root entry zone lesion for pain control in rats. Chin Med. J. 58: 421-427.

41. Tao, P.-L., W.-C. Liu, Y.-S. Tsuei and C.-Y. Cheng, 1997, The role of vasopressin on the effect of U-50,488 to block the development of morphine tolerance and physical dependence. Naunyn-Schmiedeberg's Arch. Pharmacol. 355: 281-287.

42. Cheng, C.-Y., C.Y. Chen and P.-L. Tao, 1997, Synthesis and structure-opioid activity relationships of trans-(±)-3,4-dichloro-N-methyl-N-[4- or 5-hydroxy-2-(1-pyrrolidiny)cyclohexyl] benzeneacetamides. J. Pharm. Pharmacol. 49: 835-842.

43. Lee, S.-C., J.-J. Wang, S.-T Ho and P.-L. Tao, 1997, Nalbuphine coadministered with morphine prevents tolerance and dependence. Anesth. Analg. 84: 810-815.

44. Su, M.-T., W.-B. Lin, W.-M. Lue, C.-Y. Cheng and P.-L. Tao*, 1998, Blockade of the development of morphine tolerance by U-50,488, an AVP antagonist or MK-801 in the rat hippocampal slice. Br. J. Pharmacol. 123: 625-630.

45. Tao, P.-L.*, K.-F. Han, S.-D. Wang, W.-M. Lue, R. Elde, P.-Y. Law and H. H. Loh, 1998, Immunohistochemical evidence of down-regulation of -opioid receptor after chronic PL-017 in rats. Eur. J. Pharmacol. 344: 137-142.

46. Chern, J.-W., P.-L. Tao, K.-C. Wang, A. Gutcait, S.-W. Liu, M.-H. Yen, S.-L. Chien and J.-K. Rong, 1998, Studies on quinazolines and 1,2,4-benzothiadiazine 1,1-dioxides. 8. Synthesis and pharmacological evaluation of tricyclic fused quinazolines and 1,2,4-benzothiadiazine 1,1-dioxides as potential 1-adrenoceptor antagonists. J. Med. Chem. 41: 3128-3141.

47. Tsai, Y.-C., J.-P. Liou, R. Liao, C.-Y. Cheng, and P.-L. Tao, 1998, C-alkylated spiro[benzofuran-3(2H), 4'-1'-methyl-piperidine-7-ols] as potent opioids: a conformation-activity study. Bioorg. Med. Chem. Lett. 8: 1813-1818.

48. Yeh, G.-C., H.L. Chen, T.-L. Wang and P.-L. Tao*, 1998, Alteration in transcripting the gene encoding the delta-opioid receptor in rat brain is not underlying the development of tolerance to [D-Ala2, D-Leu5] enkephalin. Chin. J. Physiol. 41: 217-221.

49. Lue, W.M., Su, M.T., Lin, W.B. and Tao, P.-L.*, 1999, The role of nitric oxide in the development of morphine tolerance in rat hippocampal slices. Eur. J. Pharmacol. 383:129-135.

50. Wong, C.-S., Wu, C.-T., Yu, J.-C., Lee, M.M.-S. and Tao, P.-L., 1999, Preincisional dextromethorphan decreases postoperative pain and opioid requirement after modified radical mastectomy. Can. J. Anesth. 46:1122-1126.

51. Tao, P.-L.*, Neu, H.S., Lue, W.M. and Wang, S.D., 2000, Immunohistochemical study of opioid receptor after chronic morphine treatment in rats. Proc. Natl. Sci. Coun. 24: 14-19.

52. Wu, C.T., Yeh, C.C., Yu, J.C., Lii, M.M.S., Tao, P.L., Ho, S.T. and Wong, C.S., 2000, Pre-incisional epidural ketamine, morphine and bupivacaine combined with epidural and general anaesthesia provides pre-emptive analgesia for upper abdominal surgery. Acta. Anaesthesiol. Scand. 44: 63-68.

53. Yang, S.N., Yang, J.M., Wu, J.N., Kao, Y.H., Hsieh, W.Y., Chao, C.C. and Tao, P.L.*, 2000, Prenatal exposure to morphine alters kinetic properties of NMDA receptor-mediated synaptic currents in the hippocampus of rat offspring. Hippocampus 10: 654-662.

54. Tao, P.L.*,Wu, S.C., Yang, C.H. and Wu C.C., 2000, Study the mechanisms of U-50,488 to prevent the development of morpnine tolerance in guinea pigs. Chin. J. Physiol. 43: 179-184.

55. Wong, C.S., Hsu, M.M., Chou Y.Y.,Tao, P.L. and Tung, C.S., 2000, Morphine tolerance increases [3H]MK-801 binding affinity and constitutive neuronal nitric oxide synthase expression in rat spinal cord. Br. J. Anaesth. 85: 587-591.

1. Kao, Y.H., Wu, J.N., Hsieh, W.Y., Tao, P.L., Yang, J.M. and Yang, S.N., 2001, Chronic morphine exposure enhanced NMDA receptor-mediated cytotoxicity in primary cortical cells. J. Med. Sci. 21: 159-168.

57. Wang, J.Y., Yang, J.M., Wang, J.Y., Tao, P.L. and Yang, S.N., 2001, Synergistic apoptosis induced by bacterial endotoxin lipopolysaccharide and high glucose in rat microglia. Neurosci. Lett. 304: 177-180.

58. Tao, P.L.*, Yeh, G.C., Su, C.H. and Wu, Y.H., 2001, Co-administration of dextromethorphan during pregnancy and throughout lactation significantly decreases the adverse effects associated with chronic morphine administration in rat offspring. Life Sci. 69:2439-2450.

59. Chan, S.L., Chou, C.C., Wong, C.S., Wu, C.C. and Tao, P.L.*, 2002, Study the effect and mechanism of dextromethorphan on preventing the development of morphine tolerance and dependence in rats. J. Med. Sci. 22:171-176.

60. Yeh, G.C., Tao, P.L., Chen, J.Y.-R., Lai, M.C., Gao, F.S., Hu, C.L., 2002, Dextromethorphan attenuates morphine withdrawal syndrome in neonatal rats passively exposed to morphine. Eur. J. Pharmacol. 453:197-202.

61. Yang, S.N., Huang, L.T., Yang, C.H., Wang, C.L., Lai, M.C., Chen, S.J., Tao, P.L.*, 2002, Prenatal administration of morphine decreases CREBSerine-133 phosphorylation and synaptic plasticity range-mediated by glutamatergic transmission in the hippocampal CA1area of cognitive deficient rat offspring. Hippocampus (in press).

62. Chiou, L.C., Yeh, G.C., Fan, S.H., How, C.H., Chuang, K.C., Tao, P.L.*, 2003, Prenatal morphine exposure decreases analgesia but not K+ channel activation. NeuroReport 14 (2): 239-242.

63., Chen, J.C., Tao, P.L., Li, J.Y., Wong, C.H., Huang, E.Y.-K., 2003, Endomorphin-1 and –2 induce naloxone-precipitated withdrawal syndromes in rats. Peptides 24:477-481.

64. Huang, E.Y.-K., Liu, T.C., Tao, P.L.*, 2003, Coadministration of dextromethorphan with morphine attenuates morphine rewarding effect and related dopamine releases at nucleus accumbens. Naunyn-Schmiedeberg's Arch. Pharmacol. 368:386-392.

65. Yeh, G..C., Tao, P.L., Ho, H.O., Lee, Y.J., Chen, J.Y., Sheu, M.T., 2003, Analysis of pharmacokinetic parameters for assessment of dextromethorphan metabolic phenotypes. J. Biomed. Sci. 10: 552-564.

66. Wen, Z.H., Chang, Y.C., Cherng, C.H., Wang, J.J., Tao, P.L., Wong, C.S., 2004, Increasing of intrathecal CSF excitatory amino acids concentration following morphine challenge in morphine-tolerant rats. Brain Res. 995:253-259.

67. Hung, E.Y.-K., Chen, C.M., Tao, P.L.*, 2004, Supraspinal anti-allodynic and rewarding effects of endomorphins in rats. Peptides 25:577-583.

68. Chow, L.H., Hung, E.Y.-K., Ho, S.T., Lee, T.Y., Tao, P.L.*, 2004, Dextromethorphan potentiates morphine antinociception at the spinal level in rats. Can. J. Anesth. 51:905-910. (SCI)

69. Chow, L.H., Hung, E.Y.-K., Ho, S.T., Tsai, S.K., Tao, P.L.*, 2004, Dextromethorphan potentiates morphine-induced antinociception at both spinal and supraspinal sites but not related to descending serotoninergic or adrenergic pathways. J. Biomed. Sci. 11:717-725. (SCI)

70. Chen, S.L., Hung, E.Y.-K., Chow, L.H., Tao, P.L.*, 2005, Dextromethorphan differentially affects opioid antinociception in rats. Br. J. Pharmacol. 144:400-404. (SCI)

71. Tao, P.L., Lai, Y.S., Chow, L.H., Hung, E.Y.-K.*, 2005, Effects of morphine and endomorphins on the polysynaptic reflex in the isolated spinal cord preparation of rats. Naunyn-Schmiedeberg's Arch. Pharmacol. 371:72-80. (SCI)

72. Wu, C.C., Chen, J.Y.-R., Tao, P.L., Chen, Y.A., Yeh, G.C.*, 2005, Serotonin reuptake inhibitors attenuate morphine withdrawal syndrome in neonatal rats passively exposed to morphine. Eur. J. Pharmacol. 512:37-42. (SCI)