Supplementary Results

Overlapping neural systems mediating extinction, reversal and regulation of fear

Daniela Schiller1,2 and Mauricio R. Delgado3

1Center for Neural Science, 2Psychology Department, New York University, New York, NY; 3Department of Psychology, Rutgers University, Newark, NJ

Corresponding author: Schiller, D. ()


Table S1:

Overlapping brain regions across the extinction and reversal tasks (All events > fixation; False discovery rate < 0.05)

Coordinates / Volume
Region / Side / x / y / z / BA / (mm3)
Striatum / R / 11 / 5 / 8 / - / 211
Striatum / L / -8 / 1 / 7 / - / 1658
Ventromedial prefrontal cortex / M / -2 / 40 / -3 / 10,32 / 1516
Subgenual anterior cingulate cortex / M / 3 / 17 / -1 / 24 / 10
Dorsal anterior cingulate cortex / M / 0 / 6 / 38 / 24 / 6888
Posterior cingulate cortex / M / -2 / -49 / 29 / 23 / 20
Occipital cortex / M / 3 / -77 / 3 / 17 / 7062
Inferior parietal cortex / L / -54 / -54 / 32 / 40 / 73
Fusiform gyrus / L / -27 / -47 / -14 / 37 / 820
Fusiform gyrus / R / 30 / -57 / -11 / 37 / 2697
Amygdala / L / -16 / -7 / -16 / - / 187
Insula / L / -34 / 12 / 7 / - / 8076
Insula / R / 37 / 16 / 6 / - / 7695
Thalamus / L / -6 / -12 / 2 / - / 3639
Thalamus / R / 9 / -14 / 3 / - / 3833
Midbrain / M / 2 / -16 / -11 / - / 441

Overlapping brain regions across the reversal and regulation tasks (All events > fixation; False discovery rate < 0.05)

Coordinates / Volume
Region / Side / x / y / z / BA / (mm3)
Striatum / L / -8 / -4 / 6 / - / 3299
Striatum / R / 12 / 4 / 9 / - / 103
Ventromedial prefrontal cortex / M / -1 / 42 / 1 / 10,32 / 2888
Subgenual anterior cingulate cortex / M / 3 / 17 / 1 / 24 / 71
Dorsal anterior cingulate cortex / M / 0 / 6 / 38 / 32 / 6888
Posterior cingulate cortex / M / -3 / -54 / 24 / 23 / 517
Occipital cortex / M / 0 / -75 / 0 / 17 / 22680
Inferior parietal cortex / L / -44 / -55 / 38 / 40 / 33
Fusiform gyrus / L / -27 / -53 / -11 / 37 / 5245
Fusiform gyrus / R / 26 / -54 / -10 / 37 / 8199
Amygdala / R / 20 / -7 / -17 / - / 5
Amygdala / L / -15 / -7 / -16 / - / 261
Insula / R / 36 / 15 / 7 / - / 8480
Insula / L / -34 / 12 / 7 / - / 8542
Thalamus / L / -8 / -12 / 4 / - / 2557
Thalamus / R / 9 / -14 / 3 / - / 3627
Midbrain / M / 0 / -16 / -11 / - / 551
Cerebellum / L / -29 / -60 / -37 / - / 10

Abbreviations: M, middle; L, left; R, right; BA, Brodmann area


Table S2:

Brain regions showing BOLD responses positively correlated with SCR (False discovery rate < 0.05)

Coordinates / Volume
Region / Side / x / y / z / BA / (mm3)
Striatum / L / -8 / 2 / 8 / - / 125
Striatum / R / 9 / 5 / 9 / - / 56
Thalamus / L / 6 / -16 / 5 / - / 717
Thalamus / R / -7 / -16 / 5 / - / 1091
Superior frontal gyrus / M / 0 / -5 / 51 / 6 / 1910
Insula / L / -33 / 16 / 11 / - / 586
Insula / R / 35 / 19 / 7 / - / 800
Midbrain / R / 8 / -10 / -6 / - / 43
Fusiform gyrus / L / -34 / -45 / -14 / 37 / 1296
Fusiform gyrus / R / 33 / -45 / -13 / 37 / 2270
Occipital cortex / M / 1 / -75 / -2 / 17 / 6066

Brain regions showing BOLD responses negatively correlated with SCR (False discovery rate < 0.05)

Coordinates / Volume
Region / Side / x / y / z / BA / (mm3)
Ventromedial prefrontal cortex / M / 0 / 45 / 5 / 10,32 / 5422
Inferior frontal gyrus / L / -42 / 37 / 2 / 45 / 1053
Middle frontal gyrus / L / -27 / 14 / 48 / 8 / 2683
Posterior cingulate cortex / M / -6 / -51 / 24 / 23 / 846
Inferior parietal cortex / L / -45 / -59 / 29 / 40 / 5498
Inferior parietal cortex / R / 48 / -61 / 32 / 40 / 440
Hippocampus / L / -20 / -16 / -12 / - / 376
Hippocampus / R / 19 / -11 / -13 / - / 160
Cerebellum / L / -31 / -62 / -33 / - / 425
Cerebellum / R / 32 / -70 / -31 / - / 661

Abbreviations: M, middle; L, left; R, right; BA, Brodmann area


Table S3:

Overlapping brain regions across the extinction, reversal and regulation tasks (All events > fixation; False discovery rate < 0.05)

Coordinates / Volume
Region / Side / x / y / z / BA / (mm3)
Striatum / L / -9 / 1 / 7 / - / 1463
Striatum / R / 11 / 4 / 9 / - / 859
Ventromedial prefrontal cortex / M / 0 / 40 / -3 / 32 / 2083
Dorsal anterior cingulate cortex / M / 0 / 6 / 38 / 24 / 6888
Subgenual anterior cingulate cortex / M / 2 / 15 / 0 / 24 / 3
Posterior cingulate cortex / M / -2 / -49 / 29 / 23 / 6
Fusiform gyrus / R / 30 / -57 / -11 / 37 / 2263
Fusiform gyrus / L / -26 / -48 / -13 / 37 / 723
Occipital cortex / M / 1 / -76 / 2 / 17 / 4054
Amygdala / L / -16 / -7 / -16 / - / 121
Insula / L / -34 / 13 / 7 / - / 7817
Insula / R / 37 / 16 / 6 / - / 7564
Thalamus / L / -7 / -12 / 4 / - / 2174
Thalamus / R / 9 / -14 / 3 / - / 3396
Midbrain / M / 1 / -16 / -11 / - / 388

Abbreviations: M, middle; L, left; R, right; BA, Brodmann area

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