Supplemental Table1: Actual administered fixed doses of 131I-MIBG
Number (%)131I-MIBG dose in mCi (MBq): / 131I-MIBG therapy I: / 131I-MIBG therapy II:
N: / 66 / 52
<50 (<1850) / 0 (0) / 0 (0)
50 (≈1850) / 7 (11) / 1 (2)
75 (≈ 2775) / 0 (0) / 2 (4)
100 (≈3700) / 14 (22) / 25 (56)
150 (≈5550) / 19 (30) / 17 (38)
200 (≈7400) / 23 (37) / 0 (0)
Missing / 3 / 7
Supplemental table 2: Medication during radio protective isolation
Number (%):Therapy I: / Therapy II:
N / 66 / 52
Standard:
Pain medication: / Acetaminophen / 38 (58) / 16 (31)
NSAID / 6 (9) / 2 (4)
Chloralhydrate / 15 (23) / 9 (17)
Tramadol / 6 (9) / 1 (2)
Morphine / 4 (6) / 0 (0)
Sedative medication: / Benzodiazepine / 3 (5) / 2 (4)
Histamine blocking agents
(promethazine, alimemazine) / 31 (47) / 18 (35)
Anti-emetic medication: / Ondansetron / 26 (39) / 17 (33)
Domperidone / 14 (21) / 6 (12)
Thyroid protection / Potasiumidode / 59 (89) / 33 (63)
Levothyroxine / 28 (42) / 17 (33)
Methimazole / 28 (42) / 17 (33)
Extra:
Pain medication: / Acetaminophen / 0 (0) / 0 (0)
NSAID / 1 (2) / 0 (0)
Sedative medication: / Benzodiazepine / 3 (5) / 5 (10)
Chloralhydrate / 5 (8) / 2 (4)
Histamine blocking agents
(promethazine, alimemazine) / 2 (3) / 0 (0)
Chlorpromazine / 1 (2) / 0 (0)
Codeïne / 4 (6) / 0 (0)
Antihypertensives: / α blocker / 1 (2) / 0 (0)
β blocker / 2 (3) / 0 (0)
AT2-antagonist / 1 (2) / 0 (0)
Calcium antagonist / 0 (0) / 1(2)
Antibiotics: / Antibiotics / 7 (11) / 1 (2)
Antifungal: / Fungizone / 1 (2) / 1 (2)
Anti-epileptics: / Phenobarbital / 1 (2) / 0 (0)
Steroids: / Dexamethasone / 1 (2) / 1 (2)
Prednisone / 7 (22) / 1 (2)
Supplemental figure 1: Patient flow chart
Supplemental Figure 2: Patient time lines for patients with haematological toxicity grade IV
2A: Patient time line for neutrophil count
2B: Patient time line for platelet count