Name : Atef Abdel-Monem Abdel-Hafez

Current Status : Professor

Date of Birth : November 15, 1966

Place of Birth :Assiut, Egypt

Work Address : Department of Pharmaceutical Medicinal Chemistry, Faculty of

Pharmacy, AssiutUniversity, Assiut, Egypt.

Home Address : Ismail El-Kabani Street, MekkaEl-mokaramaTower, 3rd floor,

Appartment No. 307, Assiut, Egypt.

Telephone: (2088)-2303006 Fax : (2088)-2332776

Mobile Phone : 0127433154 (In Egypt)

E-mail:

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Educations:

  • B.Pharm.Sci. (Pharmaceutical Sciences) May 1989; Faculty of Pharmacy, AssiutUniversity, Assiut, Egypt,
  • M. Pharm. Sci. (Pharmaceutical Medicinal Chemistry) December 1995; Faculty of Pharmacy, AssiutUniversity, Assiut, Egypt

“Synthesis and investigation of 3(5)-amino (Chloro)-1,2,4 triazole-5(3)-carboxylic acidderivatives”

  • Ph.D. (Pharmaceutical Medicinal Chemistry) March 1999; Faculty of Pharmacy, AssiutUniversity, Assiut, Egypt.

“ Chemical and biochemical modifications of paeoniflorin and its major metabolite paeonimetabolin-I, targeting neuropharmacological activities”

Societies and Boards:

1990 Member of the Pharmaceutical Society of Egypt

1996-1998 Predoctoral work with Professor Masao Hattori, Department of Cell

Resources Engineering, Institute of Natural Medicine, Toyama

Medical and PharmaceuticalUniversity, 2630 Sugitani, Toyama 930-

0194, Japan.

1989 Member of the Egyptian Syndicate of Pharmacists

2000 Membership of the Pharmaceutical Society of Japan

2001 A referee in Bioorganic & Medicinal Chemistry Journal

2000-2002 Postdoctoral fellowship under the "Japan society for the promotion

of science postdoctoral fellowship program for foreign researchers

in Japan for a period of 24 consecutive months" with Professor

Masao Hattori, Toyama Medical and PharmaceuticalUniversity,

2630 Sugitani, Toyama 930-0194, Japan.

2003 Member of Who,sWho in Science and Engineering Encyclopedia 7th

Edition. 2003-2004

Research Interest:

  • Design, synthesis of novel medium-sized Macrolides.
  • Biotransformation of bioactive compounds by using human intestinal bacteria.
  • Bio-activation of naturally isolated compounds by using human intestinal bacteria.
  • Isolation and structural elucidation of naturally bioactive compounds.
  • Chemical and biochemical modifications of lead compounds to maximize the biological activity and reduce toxicity.
  • Design and synthesis of organic compounds of potential biological activities.
  • Prodrugs and chemical delivery systems

Research Experiences:

  • Anaerobic fermentation methods
  • Enzymatic metabolism
  • Separation techniques of bacterial metabolites
  • Isolation and purification techniques
  • Chromatography (HPLC, GC, etc.
  • Modern spectroscopic techniques (2D-NMR, MS, CD, etc.)
  • Personal experience in carrying out the oral glucose tolerance test in mice or rats, the anticonvulsant activity using Sc PTZ seizure test and Scopolamine-induced amnesia using passive avoidance task.

Review articles and Books:

  1. Review article on “Anti-aging Drugs”.
  2. Topics in Medicinal Chemistry Volume I and II.
  3. Practical Pharmaceutical Chemistry Volume I and II.

List of Publications

  1. Synthesis and Investigation of Certain 3(5)-Substituted-1,2,4-Triazole-5(3)-Carboxylic Acid Derivatives. Atef Abdel-Monem Abdel-Hafez, H. M. Mohameds, H.Y. Hassan, G. S. El-Karamany, N. A. El-Koussi and A. F. Youssef. Bulletin of Pharmaceutical Sciences, AssuitUniversity, 20 (1997), 47-61.
  2. Potent Anticonvulsant Paeonimetabolin-I Derivatives Obtained by incubation of Paeoniflorin and Thiol Compounds with Lactobacillus brevis.

Atef Abdel-Monem Abdel-Hafez, Meselhy R. Meselhy, Norio Nakamura, Masao Hattori, Hiroshi Watanabi, Tarek A. Mohamed, Nadia M. Mahfouz and Mahmoud A. El-Gendy

Chemical Pharmaceutical Bulletin, 46 (1998), 1486-1487.

  1. Effects of Paeoniflorin Derivatives on Scopolamine-Induced Amnesia Using a Passive Avoidance Task in Mice; Structure-Activity Relationship.

Atef Abdel-Monem Abdel-Hafez, Meselhy R. Meselhy, Norio Nakamura, Masao Hattori, Hiroshi Watanabi, Yukihisa Murakami, Mahmoud A. El-Gendy, Nadia M. Mahfouz, and Tarek A. Mohamed. Biological Pharmaceutical Bulletin, 21 (1998), 1174-1179.

  1. Anticonvulsant Activity of Paeonimetabolin-I Adducts Obtained by Incubation of Paeoniflorin and Thiol Compounds with Lactobacillus brevis.

Atef Abdel-Monem Abdel-Hafez, Meselhy R. Meselhy, Norio Nakamura, Masao Hattori, Hiroshi Watanabi, Yukihisa Murakami, Mahmoud A. El-Gendy, Nadia M. Mahfouz, and Tarek A. Mohamed

  1. Biological Pharmaceutical Bulletin, 22 (1999), 491-497New Paeonilactone-A Adducts Formed by Anaerobic Incubation of Paeoniflorin with Lactobacillus brevis in the Presence of Arylthiols.

Atef Abdel-Monem Abdel-Hafez, Meselhy R. Meselhy, Norio Nakamura, Masao Hattori, Mahmoud A. El-Gendy, Nadia M. Mahfouz, and Tarek A. Mohamed

Chemical Pharmaceutical Bulletin, 49 (2001), 918-920.

  1. Biotransformation of Phorbol by Human Intestinal Bacteria.

Atef Abdel-Monem Abdel-Hafez, Norio Nakamura, and Masao Hattori

Chemical Pharmaceutical Bulletin, 50 (2002), 160-164.

  1. Inhibition of Cytopathic Effect of Human Immuondeficiency Virus Type-I by Various Phorbol Derivatives.

Sahar El-Mekkawy, Meselhy Ragab Meselhy, Atef Abdel-Monem Abdel-Hafez, Norio Nakamura, Masao Hattori, Takuya Kawahata, and Toru Otake

Chemical Pharmaceutical Bulletin, 50 (2002), 523-529.

  1. An Efficient, Convenient Synthysis of Novel Medium-Sized 13H-Dibenzo[d,h][1,3,7] oxadiazecine-8,14-dione Macrolides as Anticipated Antineoplastic Agents.

Atef Abdel-Monem Abdel-Hafez. Bioorganic & Medicinal Chemistry, 10 (2002), 2297-2302.

  1. Synthesis and Evaluation of Anti-HIV-I and Anti-HSV-I Activities of 4H-[1,2,4]-Triazolo [1,5-a]pyrimidin-5-one. Atef Abdel-Monem Abdel-Hafez, Hosny A. H. Elsherief, Michiko Jo, Masahiko Kurokawa, Kimiyasu Shiraki, Takuya Kawahata, Toru Otake, Norio Nakamura, and Masao Hattori . Arzniem-Forsch/Drug Res., 52 (2002) 833-839.
  2. Transformation of Arctiin to Estrogenic and Antiestrogenic Substances by Human Intestinal Bacteria. Li-Hua Xie, Eun-Mi Ahn, Teruaki Akao, Atef Abdel-Monem Abdel-Hafez, Norio Nakamura, and Masao Hattori. Chemical Pharmaceutical Bulletin, 51 (2003), 378-384.
  3. Synthesis and Anticonvulsant Evaluation of Some N-substituted-isoindolinedione

Derivatives. Atef Abdel-Monem Abdel-Hafez.Archives of Pharmacal Reseach, 27 (2004), 495-501.

  1. Design and Synthesis of Some Styrylisoxazole carboxylic Acid Derivatives as Anti- inflammatory Agents. Farghaly A. Omer, Atef Abdel-Monem Abdel-Hafez, and

Montaser S. Ahmed. Bulletin of Pharmaceutical Sciences, AssuitUniversity, 51 (2004), 171-188.

  1. Benzimidazole Condensed Ring Systems: New Synthesis and Antineoplastic Activity of Substituted 3,4-Dihydro- and 1,2,3,4-Tetrahydro-benzo[4,5]imidazo [1,2-a]pyrimidine Derivatives. Atef Abdel-Monem Abdel-Hafez

Archives of Pharmacal Reseach, 30 (2007), 678-684.

  1. Design, synthesis and docking studies of new 1,3,4-thiadiazole-2-thione derivatives with carbonic anhydrase inhibitory activity.

Mohammed K. Abdel-Hamid, Atef A. Abdel-Hafez, Nawal, A. El-Koussi, Nadia M.

Mahfouz, and Claudiu T. Supuran. Bioorganic & Medicinal Chemistry, 15 (2007), 6975-6984.