Nagalakshmi, M.L., Rascle, A., Zurawski, S., Menon, S., De Waal Malefyt, R. (2004). IL-22

PUBLICATIONS:

Nagalakshmi, M.L., Rascle, A., Zurawski, S., Menon, S., de Waal Malefyt, R. (2004). IL-22 activates STAT3 and induces IL-10 by colon epithelial cells. Intl. Immunopharmacology 4 679-691.

Hurst,H. D., Muchamel,T., Gorman,D., Gilbert,J.M., Clifford,T,, Kwan, S., Menon, S., Seymour, B., Jackson, C., Kung, T.T., Brieland, J.K., Zurawski, S., Chapman, R.W., Zurawski, G. and Coffman, R.,L (2002).New Il-17 family members promoteTh1 or Th2 responses in the lung: In vivo function of the novel cytokine Il-25. J. Immunol 169: 443-453.

Debets,R.,Timans,J.C. , Homey,B., Zurawski,S., Sana,T.R., Lo,S., Wagner,J,Edwards,G., Cifford,T., Menon,S.,Bazan,J.F. and Kastelein, R.A.(2001) Two novel IL-1 family members, IL-1 delta and Il-1epsilon,function as an antagonist and agonist of NF-kappa b activation through the orphan IL-1 receptor-related protein 2. J.Immunol 167:1440-1446.

Fort, M.M.,Lesley, R., Davidson,N.J., Menon, S., Brombacher,F., Leach, M.W.and Rennick, D.M.(2001) Interleukin 4 exacerbates disease in aTH1 T cell transfer model of colitis. J. Immunol 166:2793-2800.

Fort M.M.,Cheung,J., Yen,D.,Li,J., Zurawski,S.M., Lo,S., Menon,S., Clifford,T., Hunte,B., Lesley,R., Muchamel,T., Hurst,S.D., Zurawski,G., Leach,M.W., Gorman,D.M. and Rennick,D.M.(2001) Mouse Il17E: a unique member of the IL17 family that induces TH2-associated responses in vivo.Immunity 50: 985-995.

Rossi, D. L., Hurst, S. D., Xu,Y.,Wang, W., Menon, S., Coffman, R. L. and Zlotnik, A. (1999) Lungkine, a novel CXC chemokine, specifically expressed by lung bronchoepithelial cells. J.Immunol 162 : 5490-5497.

Namikawa, R., Muench, M. O., Firpo,M. T., Humeau, L.,Xu, Y., Menon,S. and Roncarolo,M.G. (1999) Administration of Flk2/Flt3 ligand induces expansion of human highly-Proliferative potentialcolony-forming cells in the SCID hu mouse. Exp. Hematology 27: 1029-1037.

Hoover,D. M., Schalk-Hihi,C., Chou, C-C, Menon, S., Wlodawer, A. and Zadanov, A. Purification of receptor complexes of Interleukin-10.(1999) Eur. J. Biochem.262, 134-141.

Boyaka, P. N., Marinaro, M., Jackson, R.J., Menon, S., Kiyono, H., Jirillo,E., and McGhee, J. R. (1999) IL-12 is an effective adjuvant for induction of mucosal immunity . J. Immunol. (1999) 162:122-128.

Halfon,S., Ford, J., Foster,J., Dowling, L., Lucian, L., Sterling, M., Xu, Y.,Weiss, M., Ikeda, M., Ligget,D.,Helms,A., Caux, C., Lebecque,S., Hannum,C., Menon,S., McClanahan, T., Gorman, D., and Zurawski, G. (1998) Leukocystatin, a new class II cystatin expressed selectively by hematopoitic cells. J. Biol. Chem. 273(26): 16400-08.

Davidson, N. J., Hudak, S. A., Lesley, R.E., Menon,S., Leach, M.W. and Rennick, D. I L-12, but not IFN -g, plays a major role in sustaining the chronic phase of colitis in IL-10 deficient mice. (1998) J Immmunol 161:3143-3149.

Hunter, C.A., Timans,J., Piscane,P., Cai, G., Walker, W., Aste-Amezaga, R., Bazan,J.F. and Kastelein, R. (1997) Comparison of the effects of interleukin-1alpha, interleukin-1 beta and I interferon-gamma -inducing factor on the production of interferon gamma by natural killer cells. Eur.J Immunol 27(11): 2787-92.

Hudak, S.,Leach, M.W., Xu, Y., Menon, S. and Rennick, D. (1998) Radioprotective effects of the FLK2/FLK3 ligand. J. Exp Hematol. 26:515-522.

Robinson,D., Shibuya, K., Zonin, F., Murphy, E., Sana, T., Hartley, S., Menon, S. Kastelein, K., Bazan, F. and O'Garra, A. (1997). IGIF does not drive Th1 development, but synergizes with IL-12 for Interferon gamma production through activation of IRAK and NF-B. Immunity 7(4):1533-40.

Bernardini, G. Hedrick, J., Sozzani, S., Luini, W., Spinetti, G., Weiss, M., Menon, S., Zlotnik, A., Mantovani, A., Santoni, A. and Napolitano, M. (1997). Identification of C-C chemokine TARC, Macrophage inflammatyory protein -1 beta as novel functional ligands for the CCR8 receptor. Eur. J. Immunol. 1998 28:582-588

Vicari, A. P., Figueroa, D. J., Hedrick, J. A., Foster, J. F., Singh, K. P., Menon, S., Copeland, N. G., Gilbert, D. J., Jenkins, N. A., Bacon, K. B. and Zlotnik, A. (1997). TECK: A novel CC chemokine specifically expressed by thymic dendritic cells and potentially involved in T cell development. Immunity 7:1-20.

Adema G. J., Hartgers, F., Verstraten, R., de Vries, E., Marland, G., Menon, S., Foster, J., Xu, Y., Nooyen, P., McClanahan, T., Bacon, K. and Figdor, C. G. (1997) A dendritic-cell-derived C-C chemokine that preferentially attracts naive T cells. Nature 387 (6634): 713-717.

Zadnov, A., Schalk-Hihi, C., Menon, S., Moore, K. and Wlodawer, A. (1996). Crystal structure of Epstein-Barr virus protein BCRF1, a homolog of cellular Interleukin-10. (1997) J. Mol. Biol. 268 (2): 460-467.

Berg, D.J., Davidson, N., Kuhn, R., Muller, W., Holland, G., Thompson-Snipes, L., Leach, M. W. and Rennick, D. (1996). Enterocolitis and colon cancer in Interleukin-10-deficient mice are associated with abberant cytokine production and CD4+ TH1-like responses. J. Clin. Invest. 98 (4): 1010-1020.

Hedrick, J.A. Saylor,V., Figueroa, D. Mizoue, L. Xu, Y., Menon,S., Abrams, J., Handel, T. and Zlotnik, A. (1997). Lymphotactin attracts NK cells and T cells in vivo. J. Immunol 158 (4): 1533-1540.

Muchamuel, T., Menon, S., Pisacane, P.,Howard, M. C. and Cockayne, D. (1997). Interleukin-13 protects mice against lipopolysaccharide-induced lethal endotoxemia: Correlation with down-modulation of TNF-, IFN-, and IL-12 production. J. Immunol 158 (6): 2898-2903.

Hudak, S., Hunte, B., Culpepper, J., Menon, S., Hannum, C., Thomson-Snipes, L. and Rennick, D. (1995). FLT3/FLK2 ligand promotes the growth of murine stem cells and spleen colony forming units. Blood 85 (15): 2774-2955.

Berg, D.J., Kuhn, R., Rajewsky, K., Muller, W., Menon, S., Davidson, N., Grünig, G. and Rennick, D. (1995). Interleukin-10 is a central regulator of the response to LPS in murine models of endotoxic shock and the Shwartzman reaction but not endotoxin tolerance. J. Clin. Invest. 96: 2339-2347.

Muench, M.O., Roncarolo, M.G., Menon, S., Xu, Y., Kastelein, R., Zurawski, S., Hannum, C.H., Culpepper, J., Lee, F. and Namikawa, R. (1995). Flt-2/Flt-3 ligand regulates the growth of early myeloid progenitors isolated from human fetal liver. Blood 84 (4): 963-972.

Powrie, F., Leach, M.W., Mauze, S., Menon, S., Caddle, L.B., Coffman, R.L. (1994). Inhibition of Th1 responses prevents inflammatory bowel-disease in SCID mice reconstituted with CD45RB(HI) CD4+ T-cells. Immunity 1 (7): 553-562.

Hannum, C., Culpepper, J., Campbell, D., McClanahan, T., Zurawski, S., Bazan, F., Kastelein, R., Hudak, S., Wagner, J., Mattson, J., Luh, J., Duda, G., Martina, N., Peterson, D., Menon, D., Shanafelt, A., Muench, M., Kelner, G., Namikawa, R., Rennick, D., Roncarolo, M.G., Zlotnik, A., Rosnet, O., Dubreuil, P., Birnbaum, D. and Lee, F. (1994) Ligand for FLT3/FLK2 receptor tyrosine kinase regulates growth of hematopoietic stem-cells and is encoded by variant RNAs. Nature 368 (6472): 643-648.

Culpepper, J., Hannum, C., Mattson, J., Luh, J., McClanahan, T., Campbell, D., Zurawski, S., Wagner, J., Hudak, D., Martina, N., Rennick, D., Peterson, D., Kastelein, R., Menon, S., Dang, W., Bazan, F., Muench, M., Kelner, G., Roncarolo, M.G., Zlotnik, A., Rosnet, O., Dubreuil, P., Birnbaum, D. and Lee, F. (1994). Characterization of the ligand for FLT3/FLK2 receptor. FASEB Journal8 (5): 963. Abstract.

Hannum, C., Culpepper, J., Campbell, D., McClanahan, T., Duda, G., Zurawski, S., Rennick, D., Wagner, J., Martina, N., Kastelein, R., Shanafelt, A., Peterson, D., Menon, S., Dang, W., Mattson, J., Luh, J., Bazan, F., Rosnet, O., Dubreuil, P., Birnbaum, D. and Lee, F. (1994). The ligand for FLT3/FLK2. J. Cell. Biochem. S18A: 19. Abstract.

Muench, M., Menon, S., Kastelein, R., Hannum, C., Culpepper, J., Zurawski, S., Cupp, J., Lee, F., Roncarolo, M.G. and Namikawa, R. (1994). FLT3/FLK2-ligand stimulates the growth of human fetal liver progenitors. Experimental Hematology (Charlottsville)22 (8): 737. Abstract.

Hunte, B., Hudak, S., Menon, S., Hannum, C., Lee, F., Campbell, D., Culpepper, J. and Rennick, D. (1994). The effects of FLT3 ligand on the growth of myeloid and lymphoid progenitor cells. Experimental Hematology (Charlottsville)22 (8): 720. Abstract.

Doherty, T.M., Kastelein, R., Menon, S., Andrade, S. and Coffman, R.L. (1994). Modulation of murine macrophage function by Interleukin-13. J. Cell. Biochem. Suppl 0 (18D): 301. Abstract.

Ishida, H., Muchamel, T., Sakaguchi, S., Andrade, S., Menon, S. and Howard, M. (1994). Continuous administration of anti-IL-10 antibodies delays onset of autoimmunity in NZB/W F1 mice. J. Exp. Med. 179 (1): 305-310.

Powrie, F., Menon, S. and Coffman, R.L. (1993). Cooperation between IL-4 and IL-10 results in inhibition of DTH responses. J. Immunol. 150 (8 part 2): 203A. Abstract.

Bean, A., Freiberg, R., Andrade, S., Menon, S., and Zlotnik, A. (1993). IL-10 and/or IL-4 protect mice against staphylococcal enterotoxin B SEB-induced lethal shock. J. Immunol. 150 (8 part 2): 173A. Abstract.

Grimaldi, C., Menon, S., Muchamuel, T., Santos, L.and Howard, M. (1993). Production of soluble murine CD38 for studying its biological functions. J. Cell Biochem. Suppl. 0 (17 part B): 213. Abstract.

Doherty, T.M., Kastelein, R., Menon, S., Andrade, S. and Coffman, r.L. (1993). Modulation of murine macrophage function by IL-13. J. Immunol. 151 (12): 7151-7160.

Powrie, D., Menon, S., and Coffman, R.L. (1993). Interleukin-4 and interleukin-10 synergize to inhibit cell-mediated immunity in vivo. Eur. J. Immunol. 23 (11) 3043-3049.

Bean, A.G., Freiberg, R.A., Andrade, S., Menon, S. and Zlotnik, A. (1993). Interleukin 10 protects mice against staphylococcal enterotoxin B-induced shock. Infect. Immunol.61 (11): 4937-4939.

McKenzie, A.N., Culpepper, J., de Waal Malefyt, R., Briere, F., Punnonen, J., Aversa, G., Sato, A., Dang, W., Cocks, B.G., Menon, S. et al. (1993). Interleukin 13, a T-cell-derived cytokine that regulates human monocyte and B-cell function. Proc. Natl. Acad. Sci. U.S.A. 90 (8): 3735-3739.

Punnonen, J., Aversa, G., Cocks, B.G., McKenzie, A.N., Menon, S., Zurawski, S., de Waal Malefyt, R. and de Vries, J.E. (1993). Interleukin-13 induces interleukin- 4-independent IgG4 and IgE synthesis and CD23 expression by human B cells. Proc. Natl. Acad. Sci. U.S.A. 90 (8): 3730-3734.

Howard, M., Muchamuel, T., Andrade, S. and Menon, S. (1993). Interleukin-10 protects mice from lethal endotoxemia. J. Exp. Med. 177 (4): 1205-1208.

Menon, A.S., Driscoll, J. Chung, C.H. and Goldberg, A.L. (1988). ATP-dependent proteases in bacterial and mammalian cells. In: Ubiquitin Systems (M. Schlesinger and A. Hershko, eds.) ColdSpringHarbor Laboratories Press, Cold Spring Harbor, New York.

Goldberg, A.L., Menon, A.S., Goff, S.A. and Chin, D.T. (1987). The mechanism and regulation of the ATP-dependent protease La. From Escherchia coli Biochem. Soc. Trans. UK 15: 809-811.

Menon, A.S. and Goldberg, A.L. (1987). Protein substates activate the ATP- dependent protease La by promoting nucleotide binding and release of bound ADP. J. Biol. Chem. 262: 14929-14934.

Menon, A.S. and Goldberg, A.L. (1987). The binding of nucleotides to the ATP-dependent protease La. From Escherchia coli. J. Biol. Chem. 262: 14921-14928

Menon, A.S., Waxman, L. and Goldberg, A.L. (1987). The energy utilized in protein breakdown by the ATP-dependent protease La. From Escherchia coli. J. Biol. Chem. 262: 722-726.

Menon, A.S. and Goldberg, A.L. (1987). Proteins activate their own degradation by protease La by promoting nucleotide binding and ADP release. Fed. Proc. 46: 2087. Abstract.

Goldberg, A.L., Menon, A.S., Chin, S.T., Waxman, L., Edmunds, T.E. and Goff, S.A. (1987). The mechanism and regulation of the ATP-dependent protease La. From E. coli. Fed. Proc. 46: 2056. Abstract.

Goldberg, A.L., Voellmy, R., Chung, C.H., Menon, A.S., Desautels, M., Meixsell, T. and Waxman, L. (1985). The ATP-dependent pathway for protein breakdown in bacteria and mitochondria. Prog. Clin. Biol. Res. 180: 33-45.

Goldberg, A.L., Waxman, L., Menon, A.S. and Goff, S.A. (1985). ATP-dependent proteases and their role in intracellular protein degradation. International Union of Biochemistry Congress, Amsterdam. Abstract

Menon, A.S. and Goldberg, A.L. (1985). Studies on the role of ATP in protein degradation by protease La, the lon gene product. Fed. Am. Soc. Exp. Biol. 44: 1092. Abstract.

Menon, A.S., Usha Devi, S. and Ramasarma, T. (1984). Purification and characterisation of Fermodulin, an Fe2+-dependent inhibitor protein of 3-Hydoxy 3-Methylglutaryl CoA reductase. Arch. Biochem. Biophys 239: 342-351.

Menon, A.S., Usha Devi, S. and Ramasama, T. (1984). Fe2+-dependent modulation of HMGCoA reductase by a cytosolic protein-Fermodulin. Indian J. Biochem. Biophys.21: 27-38.

Goldberg, A.L., Waxman, L., Menon, A.S. and Goff, S.A. (1984). The role of protease La (the lon gene product) and ATP in protein degradation in E. coli. American Society for Microbiology, Conference on Genetics and Molecular Biology of Industrial Micro-organisms. Abstract.

Ramasarma, T., Menon, A.S. and Usha Devi, S. (1983). Fermodulin, a protein that inhibs HMGCoA reductase in the presence of Fe2. Proceeding of the HMGCoA Reductase III Meeting, San Francisco, CA, USA. J. Lipid. Res. 24(10): 1412. Abstract.

Menon, A.S., Usha Devi, S. and Ramasarma, T. (1982). Inhibition of HMGCoA reductase by cytosolic proteins: Real or artifact. Biochem. Biophys. Res. Comm. 109: 619-625.

Usha Devi, S. and Menon, A.S. (1982). Nature of the inhibition of hepatic HMGCoA reductase by Fe2+ and a cytosolic protein factor: Purification of the protein factor. Proc. Soc. Biol. Chem. (India) 41: 156. Abstract.

Vijaya, S., Rau, M., Manjunath, R., Menon, A.S., Kurup, C.K.R. and Ramasarma, T. (1980). Changes in the activities of two membrane-bound enzymes. Current Science 49 (16): 620-622.

Menon, A.S. and Ramasarma, T. (1980). Adriamycin treatment increases HMGCoA reductase and isoprene biosynthesis in the rat liver. Biochem. Biophys. Res. Comm. 99: 939-949.

Menon, A.S., Rau, M. and Ramasama, T. (1980). Vandadate inhibits mevalonate synthesis and stimulates NAD(P)H oxidase. FEBS Letts.114: 139-142.

George, R., Menon, A.S. and Ramasarma, T. (1979). Regulation of HMGCoA reductase by adenosine compounds and fatty-acyl CoA. Indian J. Biochem. Biophys. 17: 1-8.

George, R., Menon, A.S. and Ramasarma, T. (1979). Desensitization of HMGCoA reductase to ATP-Mg by heat treatment of microsomes. Biochem. Biophys. Res. Comm. 84: 544-549.

Ramasama, T., George, R. and Menon, A.S. (1979). Prevention of the ATP-Mg inhibition of HMGCoA reductase by adenosine compounds. J. Lipid. Res.20: 1046. Abstract.

Menon, A.S. (1979). Desensitization of HMGCoA reductase by heat treatment of microsomes. Proc. Soc. Biol. Chem. (India) Indian J. Biochem. Biophys. 16 (Supplement): 62. Abstract