Myoung Sook Kim
MYOUNG SOOK KIM, Ph.D.
Assistant Professor, Department of Pathology
Marlene & Stewart Greenebaum Cancer Center
University of Maryland School of Medicine
DateNov. 14, 2016
Contact Information
Business Address:University of Maryland School of Medicine
Greenebaum Cancer Center, Bressler Research Building
655 W Baltimore Street, Baltimore, MD 21201
Business Phone: 410-706-1347
Fax: 410-328-6559
Email:
Foreign Languages:Korean (native)
Education
1993B.S., Pusan National University School of Pharmacy
Major: Pharmaceutical Science
1996M.S., Pusan National University School of Pharmacy
Major: Pharmaceutical Science
2000Ph.D., Natural Science, Pusan National University, South Korea
Major: Cellular and Molecular Biology
Adviser: Kyu-Won Kim, Ph.D.
Title of thesis - Functional Studies of Histone Deacetylase Inhibitors and Multidrug
Resistance-Reversing Compounds as Novel Angiogenesis Inhibitors
Post Graduate Education and Training
2001–2002Post-Doctoral Fellow, Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine (Cancer Biology)
2002–2003Post-Doctoral Fellow, Department of Biomedical Engineering, Johns Hopkins University (Stem Cell Engineering)
2003–2007Post-Doctoral Fellow, Department of Otolaryngology– Head and Neck Cancer Research Division, Johns Hopkins University School of Medicine (Cancer Epigenetics)
Employment History
2012–2013Senior Scientist, Champions Oncology(R & D of Personalized Medicine)
2013–2013Chief Scientist, JS Yoon Memorial Cancer Research Institute (Cancer Biology)
Academic Appointments
2007–2012Instructor, Department of Otolaryngology– Head and Neck Cancer Research Johns Hopkins University School of Medicine (Cancer Biology & Epigenetics)
2014 –2015 Post-doctoral Fellow, University of Maryland School of Medicine (Oncology)
2015– 2016Research Associate, University of Maryland School of Medicine(Pathology)
2016 – Present Assistant Professor, University of Maryland School of Medicine(Pathology)
Professional Society Membership
1996–2000Associate Member at Korean Society of Molecular Biology
2000–presentMember in the American Association of Cancer Research (AACR)
2013 – presentMember, Maryland Cancer Collaborative group
2015– presentMember Hormone-responsive Cancer Program (HRC)
University of Maryland Greenebaum Cancer Center (UMGCC)
Honors And Awards
2002Women inCancer Research, Brigid G. Leventhal Scholar-in-Training Award, American Association for Cancer Research
2007–2012 Young Clinical Scientist Award, Flight Attendant Medical Research Institutions (FAMRI)
2012–2013 Young Investigator Award, Elsa U. Pardee Foundation
National Service
2008–Present Ad Hoc Reviewer, International Journal of Cancer, Journal of Cell Biology, Cancer Biology and Therapy, Molecular Cancer Therapeutics, PLOS ONE, Journal of Cellular Biochemistry
Educational Activities
Served as a teaching assistant in the Department of Molecular Biology at Pusan National University (Korea) while obtaining a PhD
Served as a mentor for high school, undergraduate, and PhD students both at the Johns Hopkins University and the University of Maryland (Schnaper Summer Research Program).
Involved in mentoring 13 different post-doctoral fellows at the Department of Otolaryngology - Head &Neck Surgery, Johns Hopkins University.
Teaching
Teaching Assistant (March 1st, 1994– February 28th, 1997)
Employer: PUSAN NATIONAL UNIVERSITY
One of fiveflagship Korean national universities and a leading university in South Korea.
Address:Jangjeondong, Geumjeong-gu, Pusan, 609-735, South Korea
Paid, 20 hours/week
Supervisor: Kyu-Won Kim, Ph.D.,82-2-880-6988, may be contacted.Provided instruction on experimental molecular biology for the Department of Molecular Biology. Also taught experimental pharmacy and microorganism courses for the College of Pharmacy
Mentoring (pre- and post-doctoral)
Pre-doctoral
- 2011 David Moon, High School Summer Student
- 2006-2008 Jang-Hee Woo, M.D. (Ph.D. student). Jang-Hee got his M.D. at Seoul National University, South Korea, and came to our lab a few years before applying for Ph.D. program in the US. I taught him cellular and molecular biology and supervised him for two years. We publish ed 8 papers together. He is now a Ph.D. student at Harvard Medical School, Boston.
- 2007-2012 Juna Lee (Ph.D. student) – When I joined the lab, she was a lab technician. During her Ph.D. studies, I provided guidance for her projects. I shared my knowledge and experience for problem-solving and trouble-shooting on technical and scientific issues.
- 2012-2013Victoria Crawley, M.S. A current Research technician at Champions Oncology, Inc.
- 2015 Luisa Silva, University of Maryland (Schnaper Summer ResearchProgram)
- 2016 Olamide Adebowale, University of Maryland (Schnaper Summer Research Program)
Post-doctoral
- 2005-2012 Xiaofei Chang, M.D., Ph.D. Dr. Chang came to our division as a postdoctoral fellow after she received her Ph.D. degree at UC Berkley. We worked together very closely for 7 years after I trained her for a year. We have published 19 papers together. Dr. Chang is currently working as a Senior Scientist in BD Biosciences.
- 2006-2012 Mariana Brait, (Ph.D., student). Mariana came to our division as a Ph.D., student from Ludwig Institute for Cancer Research, Sao Paulo, Brazil to perform part of her Ph. D thesis.. After she completed one year research in our lab (2004-2005), she joined our lab again as a postdoctoral fellow. We collaborated together on 3 projects (e.g., Cysteine Dioxygenase). Dr. Brait is currently an Assistant professorat the Johns Hopkins University-Otolaryngology Department. She received the 2010 Scholar-in-Training Award (8th AACR-Japanese Cancer Association Joint Conference, Cancer Genomics, Epigenomics, and theDevelopment of Novel Therapeutics), American Association for Cancer Research (AACR), February 5-9, 2010 • Waikoloa, HI.
- 2007-2010 Cynthia LeBron, Ph.D. Dr. LeBron joined our lab as a postdoctoral fellow after she received her Ph.D. at the University of Florida. I trained her for 6 months and we worked together for 2 years. She is now working in Amgen and her job title is Regional Medical Liaison.
- 2006-2008 Heike Bernert, Ph.D.. Dr. Bernert joined our lab from the University of Tennessee. I trained and supervised her in molecular biology and translational research. She received her Ph.D. degree from University of Tennessee in 2009. The title of her thesis was “Promoter Hypermethylation of Candidate Tumor Suppressor Genes in Urinary Bladder and Prostate Cancer”.
- 2009-2011 Yong Gu Cho, Ph.D. Postdoctoral fellow, Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University. He is co-mentored by me and Dr. David Sidransky.
- 2008-2011 Xiaoli Zhong, M.D., Ph.D. Dr. Zhong joined our lab as a postdoctoral fellow after he received his Ph.D. degree at the Johns Hopkins University. I trained him for 2 months and we worked together for a year.
- 2006-2008 Young Kwang Chae, M.D., MPH. Dr, Chae was a postdoctoral fellow, Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University.
- 2008-2009 Il-Seok Park, M.D.. He came to our lab as a postdoctoral fellow and I trained him for 6 months I helped him design projects, and with data analysis and paper writing.
- 2007-2008 Rafael Guerrero-Preston MPH. He joined our lab as a postdoctoral fellow and I trained him on promoter methylation and molecular biology. A year later he became a Research Associate.
- 2008-2011Yiping Huang, Ph.D. Dr. Huang was a Research Associate when we began to work together.. I trained her with my knowledge of function of tumor suppressors in human cancer.
- 2011-Present Jun Okamura, M.D.. He is a surgeon in Japan and joined our lab as a postdoctoral fellow. I trained him for 6 months. He is co-mentored by me and Dr. David Sidransky.
- 2012-present Luciane Kagohara, Ph.D. A current postdoctoral fellow, Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University. She is co-mentored by me and Dr. David Sidransky.
- 2011-present Christina Michailidi Ph.D.A current postdoctoral fellow, Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University.
Grant Support
Active Grants
10/01/2011 – 09/30/2016(Co-Inv; PI – Cullen)
NCI Cancer Center Support Grant (CCSG)
NIH/NCI P30 CA134274-04, Cullen (PI)
10/01/2015 – 06/30/2016 (Co-Inv; PI – Passaniti)
“Transcriptional targeting as a therapeutic strategy to restrain
breast cancer progression”
UMGCC Pilot Grant
Total Direct Costs: $40,000
10/01/2013 – 06/30/2017(Co-Inv; PI – Passaniti)
“Transcriptional regulation of tumor growth”
VA Merit Review I01 BX002205A
Total Direct Costs: $1,023,109
Pending Grants
07/01/2016 – 06/30/2018(Co-Inv, 50%; PI – Passaniti)
“Targeting RUNX2-regulated metabolic pathways for
breast cancer therapy”
NIH NCI 1R21CA209187-01
Annual Direct Costs: $150,000
Total Direct Costs: $275,000
07/1/2016 – 06/30/2018(Co-Inv, 20%; PI – Passaniti)
“Breast cancer mechanistic models to define angiogenic
and metastatic potential”
NIH NCI 1R03 CA208216-01
Annual Direct Costs: $50,000
Total Direct Costs: $100,000
07/01/2016 – 06/30/2018(PI, 30%)
“The role of RUNX2 and mitochondria in breast cancer”
NIH NCI 1R03 CA208220-01
Annual Direct Costs: $50,000
Total Direct Costs: $100,000
01/01/2017 – 12/31/2019(PI, 20%)
“Targeting RUNX2: A novel strategy to restrict breast cancer"
DOD BCRP Breakthrough Level 1-BC160644
Annual Direct Costs: $145,000
Total Direct Costs: $375,000
Completed Grants
07/01/2007 to 06/30/2012(PI, 70 %)
“Epigenetic Alterations in Progression of Esophageal Squamous
Cell Carcinoma by Tobacco Smoking”
Flight Attendant Medical Research Institutions (FAMRI)
Annual Direct Costs: $100,000
Total Direct Costs: $500,000
04/01/1998 to 02/28/2012(Co-PI, 5%; PI – Sidransky)
Molecular progression model for HNSCC
NIH R375R37DE012588-10
Annual Direct Costs: $______
Total Direct Costs: $______
06/01/2012 to 05/31/2013 (PI, 25%)
“In vitro and in vivo characterization of miR-675 in esophageal
squamous cell carcinoma”
Elsa U. Pardee Foundation
Annual Direct Costs: $125,000
Total Direct Costs: $125,000
Publications(Peer-reviewed journal articles)
1.Kim JS, Shim KH, Kim MS, Kim KW, Lee KY and Chung HY. Study on TheAntioxidative Activity of Human Milk. J. Korean Soc. Food Nutr. 1995 Oct;24:651-657.
2.Myoung Sook Kim, Kyeng Mi Jung, Jung-Won Kim, Hyun-Kyung Kang, Kyu-Won Kim, Kyung-Hee Lee, Sung-Cheul Hong, and Hae-Young Chung. Interaction of Nitric Oxide and Superoxide in Liver Cells, Pusan Bull. Pharm. Sci.1997 Feb;31, 35-47.
3.Hae Young Chung, Bong Sook Baek, Myoung Sook Kim, Jung Im Huh, Kyung Hee Shim, Kyu-Won Kim and Kyung Hee Lee, Xanthine Dehydrogenase/Xanthine Oxidase and Oxidative Stress. AGE. 1997;20:127-139.
4.Moon-Kyoung Bae, Yoo-Wook Kwon, Myoung Sook Kim, Soo-Kyung Bae, Myung-Ho Bae, You Mie Lee, Yung-Jin Kim, and Kyu-Won Kim, Identification of Genes Differentially Expressed by hypoxia in Hepatocellular Carcinoma Cells. Biochem. Biophys. Res. Commun. 1998Feb:243(1): 158-162.
5.Hyun-Kyung Kang, Myoung Sook Kim, Nam-Deuk Kim, Mi-Ae Yoo, Kyu-Won Kim, Jong Kim, Yuji Ikeno, Byung-Pal Yu, and Hae-Young Chung. Downregulation of Telomerase in Rat during the Aging Process. Mol. Cells. 1999 Jun:9(3):286-291.
6.Myoung Sook Kim, You Mie Lee, Eun Joung Moon, Se Eun Kim, Jung Joon Lee, and Kyu-Won Kim, Anti-Angiogenic activity of Torilin, a Sesquiterpene Compound isolated from Torilis japonica. Int. J. Cancer, 87 (2), 269-275 (July, 2000).
7.Hae Young Chung, Takako Yokozawa, Myoung Sook Kim, Kyoung Hee Lee, Kyu Won Kim, Ryung Yang, and Jin Ho Choi. The mechanism of nitric oxide and/or superoxide cytotoxicity in endothelial cells. Exp. Toxicol Pathol., 52 (3), 227-233 (June, 2000).
8.Myoung Sook Kim, Jin Hyen Baek, Moon-Taek Park, Tae-Kwon Sohn, Se Eun Kim, Jung Joon Leeand Kyu-Won Kim. Anti-invasive Activity of Torilin, a Sesquiterpene Compound isolated from Torilis japonica. Oncol. Rep., 8 (2), 359-364 (Mar-Apr, 2001).
9.Myoung Sook Kim, Jin Hyen Baek, Moon-Kyoung Bae,and Kyu-Won Kim. Human rad21 gene, hHR21SP, is downregulated by Hypoxia in human tumor cells. Biochem. Biophys. Res. Commun., 281 (5), 1106-1112 (Mar, 2001).
10.Myoung Sook Kim, Ho Jeong Kwon, You Mie Lee, Jin Hyen Baek, Jae-Eun Jang, Sae-Won Lee, Eun-Joung Moon, Hye-Sun Kim, Seok-Ki Lee, Hae Young Chung, Chul-Woo Kim, Kyu-Won Kim.Histone Deacetylases Induce Angiogenesis by Negative Regulation of Tumor Suppressor Genes. Nat. Med., 7 (4), 437-443 (Apr, 2001).
11.Mi-Sook Lee, Eun-Joung Moon, Sae-Won Lee, Myoung Sook Kim, Kyu-Won Kim, Yung-Jin Kim. Angiogenic activity of pyruvic acid in in vivo and in vitro Angiogenesis models. Cancer Res., 61 (8), 3290-3293 (Apr 15, 2001).
12.Sun-Hee Park,Kyu-Won Kim, Yong Su Lee, Jin Hyen Baek, Myoung Sook Kim, You Mie Lee, Mi-Sook Lee, Yung-Jin Kim. Hypoglycemia-induced VEGF expression is mediated by intracellular Ca2+ and protein kinase C signaling pathway in HepG2 human hepatoblastoma cells. Int. J. Mol. Med., 7 (1), 91-96 (Jan, 2001).
13.Ho Jeong Kwon, Myoung Sook Kim, Min Jung Kim, Hidenori Nakajima, Kyu-Won Kim. Histone deacetylase inhibitor FK228 inhibits tumor angiogenesis. Int. J. Cancer, 97 (3), 290-296 (Jan 20, 2002).
14. Myoung Sook Kim, Mellissa Blake, Jin Hyen Baek, Glenda Kohlhagen, Yves Pommier, and France Carrier. Inhibition of histone deacetylaseincreases cytotoxicity to anticancer drugs targeting DNA. Cancer Res., 63 (21), 7291-7300 (Nov, 2003).
15.Myoung Sook Kim, Nathaniel S. Hwang, Lee J, Tae-Kyun Kim, Leong K, Michael J Shamblott, John Gearhart, Jennifer Elisseeff.Musculoskeletal differentiation of cells derived from human embryonic germ cells. Stem Cells, 23 (1), 113-123 (Jan, 2005).
16.Myoung Sook Kim, Jin Hyen Baek, Devulapalli Chakravarty, David Sidransky and France Carrier. Sensitization to UV-induced apoptosis by the histone deacetylase inhibitor Trichostatin A (TSA). Exp. Cell Res. 306, 94-102 (March, 2005).
17.Diana L. Mandelker, Keishi Yamashita, Yutaka Tokumaru, Koshi Mimori, David L. Howard, Andre Lopes Carvalho, Wei-Wen Jiang, Hannah Lui Park, Myoung Sook Kim, Motonobu Osada, Masaki Mori, David Sidransky. PGP9.5 promoter methylation is an independent prognostic factor for esophageal squamous cell carcinoma. Cancer Res., 65 (11), 4963-4968 (June, 2005).
18.Myoung Sook Kim, Jin Hyen Baek, Jeong Ae park, Bang Yeon Hwang, Se Eun Kim, Jung Joon Lee and Kyu-Won Kim. Wilfoside K1N isolated from Cynanchum wilfordii inhibits angiogenesis and tumor cell invasion. Int. J. Oncol., 26 (6), 1533-1539 (June, 2005).
19.Motonobu Osada, Yuichi Nagakawa,Hannah Lui Park, Keishi Yamashita, Guojun Wu, Myoung Sook Kim, Alexey Fomenkov, Barry Trink and David Sidransky. p63-specific activation of the BPAG-1e promoter. J. Investigative Dermatol, 125 (1), 52-60, (July, 2005).
20.Motonobu Osada, Hannah Lui Park,Yuichi Nagakawa, Keishi Yamashita, Alexey Fomenkov, Myoung Sook Kim, Guojun Wu, Shuji Nomoto, Barry Trink and David Sidransky. Differential recognition of response elements determines target gene specificity for p53 and p63. Mol. Cell. Biol., 25 (14) 6077-7089 (July, 2005).
21.Nathaniel S. Hwang, Myoung Sook Kim, Somponnat Sampattavanich, Jin Hyen Baek, Zijun Zhang and Jennifer Elisseeff. The effects of three dimensional culture and growth factors on the chondrogenic differentiation of murine embryonic stem cells. Stem Cells, 24(2):284-291 (Feb, 2006).
22.Motonobu Osada, Hannah Lui Park,Yuichi Nagakawa,Begum S, Keishi Yamashita, Guojun Wu, Myoung Sook Kim, Barry Trink and David Sidransky. A novel response element confers p63-and p73-specific activation of the WNT4 promoter.Biochem. Biophys. Res Commun., 339(4):1120-1128 (Jan, 2006).
23.Keishi Yamashita, Hannah Lui Park, Myoung Sook Kim, Yutaka Tokumaru,Motonobu Osada, Hiroshi Inoue,Masaki Mori,David Sidransky. PGP9.5 methylation in diffuse type gastric cancer.Cancer Res., 66(7); 3921-3927 (April, 2006).
24.Myoung Sook Kim, Keishi Yamashita, Jin Hyen Baek, Hannah Lui Park, Andre Lopes Carvalho, Motonobu Osada, Mohammad Obaidul Hoque, Sunil Upadhyay, Masaki Mori, Chul-so Moon, David Sidransky. NMDA Receptor Type 2B, at 12p12, is epigenetically inactivated and exhibits tumorsuppressive activity in human esophageal cancer. Cancer Res., 66(7): 3409-3418 (April, 2006).
25.Sunil Upadhyay, Chunyan Liu, Russell Finley, Aditi Chatterjee, Elizabeth Mambo, Mohammad O. Hoque, Myoung Sook Kim, James Engles, Uwe Schlattner, D Neumann, Edward Ratovitski, David Sidransky. LKB1/STK11 suppresses COX-2 induction and cellular invasion through PEA3. Cancer Res,,66(16):7870-7879 (Aug, 2006).
26.Guojun Wu, Zhongmin Guo, Aditi Chatterjee, Xin Huang, Ethel Rubin, Feng Wu, Elizabeth Mambo, Xiaofei Chang, Myoung Sook Kim, Chulso Moon, Joseph A. Califano, Edward A. Ratovitski, Susanne M. Gollin, Saraswati Sukumar, David Sidransky and Barry Trink. Overexpression of glycosylphosphatidylinositol (GPI) transamidase phosphatidylinositol glycan class T and/or GPI anchor attachment 1 induces tumorigenesis and contributes to invasion in human breast cancer. Cancer Res., 66(20):9829-9836 (Oct, 2006).
27.Guojun Wu, Zhongmin Guo, Xiaofei Chang, Myoung Sook Kim,Jatin K. Nagpal, Junwei Liu, Joni M. Maki, Kari I. Kivirikko, Stephen P Ethier,Barry Trink,, David Sidransky.LOXL1 and LOXL4 are epigenetically silenced and can inhibit RAS/ERKsignaling pathway in human bladder cancer.Cancer Res., 67(9):4123-4129 (May, 2007).
28.Junwei Liu, Myoung Sook Kim, Jatin Nagpal, Keishi Yamashita, Luana Poeta, Xiaofei Chang, Juna Lee, Hannah Lui Park, Carmen Jeronimo, William H. Westra, Masaki Mori, Chulso Moon, Barry TrinkDavid Sidransky. Quantitative hypermethylation of NMDAR2B in human gastric cancer. Int J Cancer, 121(9):1994-2000 (Jul, 2007).
29.Myoung Sook Kim, Keishi Yamashita, Young Kwang Chae, Yutaka Tokumaru, Xiaofei Chang, Marianna Zahurak, Motonobu Osada,Hannah Lui Park, Alice Chuang , Joseph A. Califano, and David Sidransky. NMDA receptor 2B promoter methylation predicts poor prognosis in esophageal squamous cell carcinoma. Clin Cancer Res., 13(22):6658-65 (Nov, 2007).
30.Keishi Yamashita,Myoung Sook Kim, Hannah L. Park, Yutaka Tokumaru, Motonobu Osada, Hiroshi Inoue, Masaki Mori, David Sidransky. HOP/OB1/NECC1 promoter DNA is frequently hypermethylated and involved in tumorigenic ability in esophageal squamous cell carcinoma.Mol Cancer Res., 6(1):31-41 (Jan, 2008).
31.Jong Chul Park, Young Kwang Chae, Choon Hee Son, Myoung Sook Kim, Juna Lee, Kimberly Ostrow, David Sidransky, Mohammad Obaidul Hoque, and Chulso Moon. Epigenetic silencing of human T (brachyury homologue) gene in non-small-cell lung cancer. Biochem Biophys Res Commun., 365(2):221-6 (Jan, 2008).
32.Jang-Hee Woo, Young Kwang Chae, Se Jin Jang, Myoung Sook Kim, Jin Hyen Baek, Jongchul Park, Barry Trink, Edward Ratovitski, Taekyeol Lee, Beom Park, Minjoo Park, Ji Hye Kang, Jean-Charles Soria, Juna Lee, Joseph Califano, David Sidransky, Chulso Moon. Membrane trafficking of AQP5 and cAMP dependent phosphorylation in bronchial epithelium. Biochem Biophys Res Commun., 366(2):321-7 (Feb, 2008).
33.Jun-Wei Liu, Jatin K. Nagpal, Carmen Jeronimo, Ji Eun Lee, Rui Henrique, Myoung Sook Kim, Kimberly L Ostrow, Keishi Yamashita, Vim van Criekinge, Guojun Wu, Chulso Moon, Barry Trink, David Sidransky. Hypermethylation of MCAM gene is associated with advanced tumor stage in prostate cancer. Prostate. 68(4):418-26 (Mar, 2008).
34.Jang-Hee Woo, Juna Lee, Myoung Sook Kim, Se Jin Jang, David Sidransky, Chulso Moon. The effect of aquaporin 5 overexpression on the Ras signaling pathway. Biochem Biophys Res Commun., 367(2):291-8 (Mar, 2008).
35.Hannah Lui Park, Myoung Sook Kim, Keishi Yamashita, William Westra, Andre Lopes Carvalho, Juna Lee, Wei-Wen Jiang, Jin Hyen Baek, Junwei Liu, Motonobu Osada, Chulso Moon, Joseph A. Califano, Masaki Mori, and David Sidransky. DCC promoter hypermethylation in esophageal squamous cell carcinoma. Int J Cancer, 122(11):2498-2502 (Feb, 2008).
36.Myoung Sook Kim, Xiaofei Chang, Jatin K. Nagpal, Keishi Yamashita, Jin Hyen Baek, Santanu Daspguta, Guojun Wu, Jang-Hee Woo, Motonobu Osada, William H. Westra, Barry Trink, Edward A. Ratovitski, Chulso Moon and David Sidransky. The N-Methyl-D-Aspartate Receptor Type 2A Promoter is frequently methylated in human colorectal carcinoma and suppresses cell growth. Oncogene, 27(14):2045-54(Mar, 2008).