Mutation Worksheet

NAME ______DATE ______

Mutation Worksheet

1.  List the two types of mutations: ______and ______.

2.  A point mutation usually involves a ______, which can be a nonsense or ______.

3.  Frameshift mutations can either be an ______or ______.

In the chart below, transcribe the DNA sequence into mRNA. Then use your codon chart to indicate what amino acids are being coded for by the base sequences listed for the mRNA. Then, tell what type of gene mutation is being illustrated. Choose from point mutation or frameshift mutation.

DNA sequence / T A C G C C A G T G G T / Original
mRNA sequence
Amino acid sequence
DNA sequence / T A C C C C A G T G G T
mRNA sequence
Amino acid sequence
DNA sequence / T A C C C A G T G G T
mRNA sequence
Amino acid sequence

Complete the protein synthesis for the following DNA strands and show how mutations can cause problems.

Original DNA sequence / T A C C C C G T C A C C G C C T A T A T C
Original mRNA sequence
Original Amino acid sequence
Mutated DNA #1 / T A C C C C G T C C A C C G C C T A T A T C
Mutated mRNA #1
Mutated AA #1
Type of Mutation (circle) / Point Frameshift
Kind of Mutation (circle) / Insertion Deletion Substitution
Mutated DNA #2 / T A C C C C G T ___ A C C G C C T A T A T C
Mutated mRNA #2
Mutated AA #2
Type of Mutation (circle) / Point Frameshift
Kind of Mutation (circle) / Insertion Deletion Substitution
Mutated DNA #3 / T A C C A C G T C A C C G C C T A T A T C
Mutated mRNA #3
Mutated AA #3
Type of Mutation (circle) / Point Frameshift
Kind of Mutation (circle) / Insertion Deletion Substitution